WITHDRAWN: Preoperative clinical characteristics scoring system for the Differentiation of Uterine Leiomyosarcoma from Leiomyoma

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Abstract Purpose: Preoperative diagnosis of uterine leiomyosarcoma (ULMS) is challenging because the disease can mimic benign leiomyoma (LM). The objective of the present study was to investigate the role of preoperative clinical characteristics and hematologic parameters in differentiating ULMS fromLM. Methods: Preoperative clinical and laboratory variables were retrospectively reviewed forpatients with ULMS or LM, and the significance of the intergroup differences was assessed. Receiver operating characteristic (ROC) curves were used to determine the optimal cutoffvalues for each variable. Logistic regression analysis was applied to identify variables predicting the presence of ULMS. Results: The preoperative clinical and laboratory variables of 288 patients with uterine tumorswere analyzed. 64 patients had ULMS,and 224 had LM. A significant difference was observed between ULMS and LM. Multivariate analysis revealed that increased systemic immune-inflammation index (SII > 500), the controlling nutritional status score (CONUT≥3), larger tumor size (> 9.7 cm), and older age (>48 years) were independent risk factors for ULMS (P=0.007, <0.001, 0.001, <0.001,respectively). Thepreoperative clinical characteristic score was calculated by summing the number of risk factors with a total score of 4 points. A score≥ 2 points was a useful predictor for distinguishing ULMS from LM (sensitivity 0.688, specificity 0.888). Conclusion: Our results suggest that the SII, CONUT score, tumor size, age and preoperative Hb level could be useful for differentiating between ULMS and LM, which indicates that the preoperative clinical characteristics scoring system could be helpful in the preoperative diagnosis of indiscoverable ULMS.
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WITHDRAWN: Preoperative clinical characteristics scoring system for the Differentiation of Uterine Leiomyosarcoma from Leiomyoma | Research Square window.SnipcartSettings = { analytics: { enabled: false } }; (function() { var accessVector = localStorage.getItem('access_vector') || ''; window.dataLayer = window.dataLayer || []; if (accessVector) { window.dataLayer.push({ user: { profile: { profileInfo: { snid: accessVector } } } }); } })(); (function(w,d,s,l,i){w[l]=w[l]||[];w[l].push({'gtm.start':new Date().getTime(),event:'gtm.js'});var f=d.getElementsByTagName(s)[0],j=d.createElement(s),dl=l!='dataLayer'?'&l='+l:'';j.async=true;j.src='https://www.googletagmanager.com/gtm.js?id='+i+dl;f.parentNode.insertBefore(j,f);})(window,document,'script','dataLayer','GTM-K279D39R'); Browse Preprints In Review Journals COVID-19 Preprints AJE Video Bytes Research Tools Research Promotion AJE Professional Editing AJE Rubriq About Preprint Platform In Review Editorial Policies Our Team Advisory Board Help Center Sign In Submit a Preprint Cite Share Download PDF Research Article WITHDRAWN: Preoperative clinical characteristics scoring system for the Differentiation of Uterine Leiomyosarcoma from Leiomyoma Yuanqiu Wang, Xiaowan Huang, Ying Su This is a preprint; it has not been peer reviewed by a journal. https://doi.org/ 10.21203/rs.3.rs-4213695/v2 This work is licensed under a CC BY 4.0 License Status: Posted Version 2 posted You are reading this latest preprint version Show more versions Editorial Note The full text of this preprint has been withdrawn by the authors as it was submitted and made public without the full consent of all the authors. Therefore, the authors do not wish this work to be cited as a reference. Questions should be directed to the corresponding author. Editorial notes are used to provide important context regarding the topic of a preprint or to alert readers to potential issues concerning that preprint or a downstream publication associated with it. For more information on editorial notes, see our Editorial Policies . Abstract The full text of this preprint has been withdrawn by the authors as it was submitted and made public without the full consent of all the authors. Therefore, the authors do not wish this work to be cited as a reference. Questions should be directed to the corresponding author. Full Text The authors have withdrawn this preprint from Research Square. Additional Declarations No competing interests reported. Cite Share Download PDF Status: Posted Version 2 posted You are reading this latest preprint version Show more versions Research Square lets you share your work early, gain feedback from the community, and start making changes to your manuscript prior to peer review in a journal. As a division of Research Square Company, we’re committed to making research communication faster, fairer, and more useful. We do this by developing innovative software and high quality services for the global research community. Our growing team is made up of researchers and industry professionals working together to solve the most critical problems facing scientific publishing. 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