Modeling the Risk of Insulin Resistance in Borderline Personality Disorder with Romantic Pathological Jealousy in Females: A Lyfas Empirical Study

Abstract Borderline Personality Disorder (BPD) with Romantic pathological jealousy (rPAJ) influences the heart rate variability (HRV) and its cardiovascular optical biomarkers (COBs), which the Lyfas mobile application captures through smartphones. The COBs surrogate insulin resistance (IR), a marker of cardiometabolic risks. The paper aims to non-invasively study the IR risk in BPD-rPAJ affected females. Personality-based Questionnaire (PBQ) and the Multidimensional jealousy scale (MDJS) and Lyfas tests were taken by the participants under psychologists’ supervision. The VO2Max (COB of heart-lung coherence after stressful exercise), LF/HF (COB of IR), and Arterial stiffness index (ASI), a marker of early vascular aging, are chosen as the IR biomarkers. HRVScore, SD1/SD2, and pNN50 are chosen as the mood, anxiety, and sleep (MAS) biomarkers. Finally, each of the MAS-IR COBs is regressed to examine the causality. The R2 value > = 25 is considered the significant causative. Furthermore, the relative risk (RR) is computed between significant MAS-IR COBs. The study observes that HRVScore and pNN50 possess high causal relationships with ASI (R2 = 47% and 25%, respectively). The RR shows an increased risk of premature arterial stiffness (PAS) with mood dysregulations (RR = 10.5, p 0.02) and sleep issues (RR = 135, p 0.19) when compared to the baseline population. The study concludes that mood dysregulations and poor sleep quality are associated with a high risk of IR in females suffering from BPD-rPAJ disorder. The onset of the deterioration of their arterial health starts as early as an average of five-and-a-half years.