Correlation Study on IGF-I and IGFBP-3 with Ovary Endometriosis

Objective:To investigate insulin-like growth factor I(IGF-I)and Insulin-like growth factor binding protein-3(IGFBP-3)which are distributed and expressed in eutopic and ectopic endometrial from endometriosis of the ovary patients,by this way,explore mechanisms of occurrence and invasion.Methods:Tissue specimens of ectopic endometrial were obtained from 40 patients and eutopic endometrial were obtained from 25 patients with ovarian adenomyosis.20 specimens of the normal endometrial serve as controls.They were tested for the distribution and expression of IGF-I and IGFBP-3 by immunohistochemical analysis.Results:demonstrated that IGF-I and IGFBP-3 were present in normal,ectopic and eutopic endometrial tissue.For IGF-1,the immunostaining score was higher in ectopic and eutopic endometrial tissue(P0.05);for IGFBP-3,the immunostaining score was higher in normal endometrial than in ectopic and eutopic endometrial(P0.05).Conclusion: IGF-I and IGFBP-3 could possibly take part in mechanisms of development and sustainance of ovarian adenomyosis.