Ni-Catalyzed Hydroaminoalkylation of Alkynes with Amines

Abstract Hydroaminoalkylations of alkenes with amines have been widely explored, while analogous reactions of alkynes have been a formidable challenge. Herein, a late transition metal nickel-catalyzed hydroaminoalkylation of alkynes with amines was developed, providing a series of allylic amines in up to 94% yield. The use of double ligands (IPr and PCy3) and bulky amino protecting group proved critical to the reaction efficiency.