Principal Coordinates Analysis (PCoA).

Nhung Le (489803), Melissa Cregger (280178), Veronica Brown (11846324), Julio Loret de Mola (11846327), Pamela Bremer (11846330), Lyn Nguyen (11846333), Kathleen Groesch (8275584), Teresa Wilson (638463), Paula Diaz-Sylvester (3638278), Andrea Braundmeier-Fleming (4245838)
2021 · doi:10.1371/journal.pone.0261362.g002 · W6960422170
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Principal coordinates analysis visualized the distribution of gastrointestinal and urogenital bacterial communities in endometriosis patients and controls, comparing those receiving versus not receiving hormonal treatment at surgery and post-surgery.

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The study analyzes the association between microbial dynamics and urinary estrogens in patients with endometriosis using Principal Coordinates Analysis. Researchers compared gastrointestinal and vaginal bacterial communities between endometriosis patients and controls, stratified by whether they were receiving hormonal treatment or not. The analysis plotted data from fecal and vaginal samples collected on the day of surgery and after post-surgery intervention to visualize community distribution across different axes. This paper is centrally about endometriosis — specifically examining how gut and vaginal microbiomes correlate with estrogen levels in these patients.

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Abstract

PCoA shows the distribution of GI (fecal samples) and UG (vaginal samples) bacterial communities on the day of surgery (DOS) and post-surgery intervention (PSI) for patients with endometriosis (P-EOSIS) and controls subjects (control) that were receiving or not receiving hormonal treatment (OCPs). PC1, PC2 and PC3 were plotted on the x, y and z axes. A., E. (DOS), B., F. (PSI): Non-hormone (fecal: n = 9, vagina: n = 14). C., G. (DOS), D., H. (PSI): Hormone (fecal: n = 20, vagina: n = 15).
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Association of microbial dynamics with urinary estrogens and estrogen metabolites in patients with endometriosis Fig 2 Principal Coordinates Analysis (PCoA). PCoA shows the distribution of GI (fecal samples) and UG (vaginal samples) bacterial communities on the day of surgery (DOS) and post-surgery intervention (PSI) for patients with endometriosis (P-EOSIS) and controls subjects (control) that were receiving or not receiving hormonal treatment (OCPs). PC1, PC2 and PC3 were plotted on the x, y and z axes. A., E. (DOS), B., F. (PSI): Non-hormone (fecal: n = 9, vagina: n = 14). C., G. (DOS), D., H. (PSI): Hormone (fecal: n = 20, vagina: n = 15).

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endometriosis

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