Ion channels in somatosensory transmission: an introduction to the collection

Excitation of peripheral endings of sensory nerves is a primary event in most types of somatosensation, including pain. This excitation and transmission of action potentials within somatosensory pathways is brought about by the concerted action of the wide array of plasmalemmal ion channels, some of which are specific to somatosensory nerves. Accordingly, ion channel deficiencies or ‘channelopathies’ often underlie sensory disorders and pathological pain states and many current and prospective analgesics target ion channels. This F1000Research article collection is focused on the current advances in understanding function and regulation of ion channels controlling excitability and synaptic transmission within somatosensory pathways. The focus is on the peripheral neurons but studies of central mechanisms that integrate peripheral inputs are also welcome. We also welcome discussions of emerging approaches, methods and techniques in somatosensory physiology.