Chronic bacterial prostatitis treatment using quadruple regimen therapy: a preliminary prospective observational study

Abstract Background This study explored the data collected from 27 patients who underwent a new treatment combination of drugs using quadruple regimen therapy with tadafil 5 mg, N-acetylcysteine 200 mg, diclofenac sodium, and a targeted antibiotic for chronic bacterial prostatitis treatment. Methods Twenty-seven Pakistani patients underwent a three-glass test. Those who tested positive received quadruple therapy, while negative cases were treated with triple therapy minus antibiotics, using a gradual tapering off technique for a duration of 20 weeks, and followed for 1 year to observe the recurrence of the disease. Patients were evaluated for international prostatic score, improvement in quality of life, uroflowmeteric studies, improvement in symptoms, and disease recurrence. Chi-square test was used to analyze the data, and p value < 0.05 was considered significant. Results This study yielded favorable results with significant improvements in symptoms, IPSS score, quality of life, urinary flow rate, and post-micturition residual volume (p < 0.05). Of the 19 participants with positive three-glass tests, 14/19 (73%) saw a complete resolution of symptoms; however, three (26%) had a reemergence six months later. The remaining eight patients (29%) who tested negative did not show the same level of effectiveness as the positive cases, but still observed improvements in quality of life and IPPS score (P < 0.05). However, their symptoms were not fully resolved. Conclusions Our study resulted in significant improvement in the patients’ IPSS score, disease symptoms and quality of life after 20 weeks of therapy, with five visits each. All medications were gradually tapered.