Expression and clinical significance of P27 in endometriosis

Objective:To investigate the expression and clinical significance of P27 in endometriosis.Methods:Immunohistochemistry was used to detect the expression of P27 in the endometriosis group including the ectopic endometrium from 30 cases with endometriosis(ectopic endometrium group) and the eutopic endometrium from 30 cases(eutopic endometrium group),and in 30 cases of normal endometrium without endometriosis(control group).Results:We revealed the decreased expression of P27 in the endometriosis group(ectopic endometrium group and eutopic endometrium group)compared with that in control group.The decreased expression of P27 was detected in the ectopic endometrium group compared with that in the eutopic endometrium group.The P27 expression in secretory phase was slightly higher than that in proliferative phase in the control group.Conclusion:The down-regulation of P27 in endometriosis suggests that P27 may play a role in the pathogenesis of endometriosis.