Recent Developments in Biomaterial-Based Hydrogel as the Delivery System for Repairing Endometrial Injury

Guiyang Cai, Zhipeng Hou, Wei Sun, Peng Li, Jinzhe Zhang, Liqun Yang, Jing Chen
In: Frontiers in Bioengineering and Biotechnology · 2022 · vol. 10 , pp. 894252 · doi:10.3389/fbioe.2022.894252 · PMID:35795167 · PMC9251415 · W4283156301
review OA: gold CC0 ⤵ 2 in-corpus citations
📄 Open PDF View on OpenAlex View on PubMed View at publisher
⚙ AI-generated summary by claude@2026-06, 2026-06-09 ⓘ

This review details biomaterial-based hydrogel delivery systems for repairing endometrial injury, summarizing their preparation, therapeutic efficacy, and mechanisms for improved outcomes in reproductive medicine.

One-sentence paraphrase of the abstract; not a substitute for reading it. No clinical advice. How this works

⚙ AI-generated deep summary by claude@2026-06, 2026-06-09 ⓘ

This paper is a narrative review of biomaterial-based hydrogel delivery systems for repairing endometrial injury caused by intrauterine surgery, where damage to the endometrial basal layer can lead to intrauterine adhesions, infertility, and poor pregnancy outcomes. It surveys high-level evidence that hydrogels can act as anti-adhesion barriers or as carriers for stem cells and other bioactive substances, emphasizing their proposed benefits in providing mechanical support, improving the intrauterine microenvironment, enhancing delivery efficiency, prolonging retention, and enabling targeted repair, with noted advantages over ordinary drug or stem cell approaches. The review also highlights explicit limitations for the field, including shortcomings of stem cell transplantation such as preservation difficulty, tumorigenicity concerns, and low homing rates, as well as the lack of unified clinical guidance and the need for consideration of hydrogel design factors (biocompatibility, mechanics, controlled release, gelation time, and sterilization). This paper does not explicitly discuss endometriosis or adenomyosis; it was included in the corpus via a keyword match in the upstream search index.

Read from the paper's body, not the abstract. Not a substitute for reading the paper. No clinical advice. How this works

Abstract

Endometrial injury caused by intrauterine surgery often leads to pathophysiological changes in the intrauterine environment, resulting in infertility in women of childbearing age. However, clinical treatment strategies, especially for moderate to severe injuries, often fail to provide satisfactory therapeutic effects and pregnancy outcomes. With the development of reproductive medicine and materials engineering, researchers have developed bioactive hydrogel materials, which can be used as a physical anti-adhesion barrier alone or as functional delivery systems for intrauterine injury treatment by loading stem cells or various active substances. Studies have demonstrated that the biomaterial-based hydrogel delivery system can provide sufficient mechanical support and improve the intrauterine microenvironment, enhance the delivery efficiency of therapeutic agents, prolong intrauterine retention time, and perform efficiently targeted repair compared with ordinary drug therapy or stem cell therapy. It shows the promising application prospects of the hydrogel delivery system in reproductive medicine. Herein, we review the recent advances in endometrial repair methods, focusing on the current application status of biomaterial-based hydrogel delivery systems in intrauterine injury repair, including preparation principles, therapeutic efficacy, repair mechanisms, and current limitations and development perspectives.

My notes (saved in your browser only)

Condition tags

infertility

Citation neighborhood

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

References (99)

Cited by (2)

Source provenance

europepmc
last seen: 2026-06-19T06:14:56.452680+00:00
openalex
last seen: 2026-06-10T17:14:06.276822+00:00
License: CC0 · commercial use OK