WCN25-1602 "Epigenetic and Metabolic Regulation: The Role of HDAC2 and AMPK1 in Drug Resistance in Steroid Resistant Nephrotic syndrome"

Drug resistance remains a formidable challenge in the treatment of various diseases. The action of glucocorticoids is to switch off activated inflammatory genes. The activated glucocorticoid receptors (GR) interact with co-repressor molecules to impair NFκB-associated coactivator activity, reducing histone acetylation, chromatin remodelling. Reduction in histone acetylation occurs via recruitment of histone deacetylase (HDAC) 2 to the activated inflammatory gene complex by activated GR, resulting in efficacious suppression of activated inflammatory genes within the nucleus.