[Difficult contraceptions].

Choosing a contraceptive method is difficult in women with a disease or presenting specific risk factors. The possible life-threatening effects of the contraceptive on the disease and the possible drug interactions should be taken into consideration. In this article, we will address the issues faced in patients with neurological diseases (epilepsy, brain tumor, migraine, prolactin-secreting adenoma), vascular diseases (venous thrombosis, biological thrombophilia, arterial diseases), metabolic disorders (obesity, dyslipemias, diabetes), uterine diseases (fibromas, endometriosis), renal failure, benign and malignant breast diseases as well as in HIV-positive women. Unfortunately, the available scientific data are insufficient for several of these conditions, which leads to a non-validated management. Controlled studies are needed to improve knowledge.