57th EASD Annual Meeting of the European Association for the Study of Diabetes.

257 Associations of hypoglycaemia and glycaemic variability with cardiac arrhythmias using a long-term monitoring approach in insulin-treated patients with type 2 diabetes A. Andersen 1,2 , J.I. Bagger 1,2 , S.K. Sørensen 3 , M.P.A. Baldassarre 4,2 , U. Pedersen-Bjergaard 5,6 , J.L. Forman 7 , G. Gislason 3,6 , T.B. Lindhardt 3,6 , F.K. Knop 2,8 , T. Vilsbøll 1,6 ; 1 Steno Diabetes Center Copenhagen, Hellerup, Denmark,  2 Center for Clinical Metabolic Research, Gentofte Hospital, University of Copenhagen, Hellerup, Denmark,  3 Department of Cardiology, Herlev and Gentofte Hospital, University of Copenhagen, Hellerup, Denmark,  4 Department of Medicine and Aging Sciences, G. d'Annunzio University, Chieti, Italy,  5 Department of Endocrinology and Nephrology, Nordsjællands Hospital, University of Copenhagen, Hillerød, Denmark,  6 Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark,  7 Deparment of Biomedical Sciences, University of Copenhagen, Copenhagen, Denmark, 8 Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark. Background and aims:  Insulin-treated patients with type 2 diabetes (T2D) are at risk of hypoglycemia, which is associated with an increased risk of cardiovascular disease and mortality. Using a long-term monitoring approach, we investigated the association between episodes of hypoglycemia, glycemic variability and cardiac arrhythmias in a real-life setting. Materials and methods:  Insulin-treated patients with T2D (N=21) and microvascular complications ([mean±SD] age 66.8±9.6 years, BMI 30.1±4.5 kg/m 2 , HbA1c 6.8±0.4% [51.0±4.8 mmol/mol]) were included for a one-year observational study employing continuous glucose monitoring (118±6 days) and implantable cardiac monitors (ICMs), which provide continuous electrocardiographic monitoring with reporting of arrhythmic events according to an inbuild algorithm. Results:  Time spend in hypoglycemia was higher during nighttime than during daytime ([median and interquartile range] 0.7% [0.7-2.7] vs. 0.4% [0.2-0.8]). The ICMs detected 724 episodes of clinically relevant arrhythmias in 12 (57%) patients, with atrial fibrillation and pauses accounting for 99% of the episodes. No association between hypoglycaemia and cardiac arrhythmia was found during daytime. During nighttime, subject-specific hourly incidence of cardiac arrhythmias tended to increase with the occurrence of hypoglycaemia but only slightly with increasing time in hypoglycaemia (Figure). Subject-specific incidence of cardiac arrhythmias during nighttime increased with increasing glycaemic variability as estimated by coefficient of variation and standard deviation. Conclusion:  Cardiac arrhythmias were common in insulin-treated patients with T2D and were associated with glycemic variability with distinctive diurnal differences, whereas arrhythmias were not strongly associated with hypoglycemia. Clinical Trial Registration Number: NCT03150030 Supported by: Novo Nordisk Foundation and the Capital Region of Denmark Disclosure:   A. Andersen:  None. 258 The impact of acute fluctuations in plasma glucose on echocardiographic derived measures of systolic function in patients with type 1 diabetes C.R. Andreasen 1,2 , A. Andersen 1,2 , P.G. Haqelqvist 1,2 , K. Abelin 1,2 , J.V. Lauritsen 1,2 , P.G. Jørgensen 3 , S. Engberg 1 , J. Faber 4,5 , J.J. Holst 6 , U. Pedersen-Bjergaard 5,7 , F.K. Knop 2,5 , T. Vilsbøll 1,2 ; 1 Clinical Reseach, Steno Diabetes Center Copenhagen, Hellerup, 2 Center for Clinical Metabolic Research, Herlev and Gentofte Hospital, University of Copenhagen, Hellerup, 3 Clinical Reseach, Department of Cardiology, Gentofte Hospital, Hellerup, 4 Department of Endocrinology, Herlev Hospital, Herlev, 5 Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, 6 Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, 7 Department of Endocrinology and Nephrology, Nordsjællands Hospital Hillerød, University of Copenhagen, Hillerød, Denmark. Background and aims:  Patients with type 1 diabetes (T1D) and poor glycaemic control have an increased risk of cardiovascular disease, including heart failure. Rapid fluctuations in plasma glucose (PG) are an inevitable consequence of insulin-treatment in T1D, but the effects of fluctuations in PG on cardiac function remains uncertain. Here evaluated cardiac function change in patients with T1D during acute hypoglycaemia followed by rebound hyperglycaemia or euglycaemia. Materials and methods:  Patients with T1D (n=23, [mean±SD] age 52.8±11.4 years, HbA1c 7.5±0.8% [57.6±8.9 mmol/mol], BMI 25.7±3.1 kg/m²) underwent two clamp days in random order in a cross-over design. Both clamp days included three steady-state phases, with the two first phases being identical on both clamp days: 1) a hyperinsulinemic-euglycemic phase (PG=6 mmol/l) for 45 min; 2) a hyperinsulinemic-hypoglycaemic phase (PG=2.5 mmol/l) for 60 min and 3) a recovery phase (Clamp A: PG: 20 mmol/l; Clamp B: PG:6 mmol/l) for 60 min. Cardiac function was evaluated with echocardiography during steady-state at each phase. Results:  Acute hypoglycaemia significantly increased left ventricular ejection fraction (LVEF) and global longitudinal strain (GLS) from baseline (Table 1). LVEF and GLS were significantly increased during acute hyperglycaemia compared with baseline euglycemia. During the recovery phase, LVEF was significantly greater during hyperglycaemia compared with euglycaemia, although LVEF during euglycaemia was significantly increased compared with baseline. Conclusion:  Our findings suggest that acute fluctuations in PG affect echocardiographic derived measures of systolic function in patients with T1D. Hypoglycaemia, recent hypoglycaemia, or subsequent hyperglycaemia may result in overestimation of left ventricular contractile function and thereby be of importance when evaluating LVEF in patients with T1D. Supported by: This work was supported by a research grant from the Danish Diabetes Academy, which is funded by the Novo Nordisk Foundation, grant number NNF17SA0031406. Disclosure:   C.R. Andreasen:  None. 259 Investigating the blood flow responses of different thalamic nuclei to hypoglycaemia in intact and impaired awareness of hypoglycaemia P. Jacob , S.A. Amiel, M. Nwokolo, F. Zelaya, O. O'Daly, P. Choudhary; King’s College London, London, UK. Background and aims:  The brain is critical in the recognition and physiological responses to hypoglycaemia. Differences in regional cerebral blood flow have been observed in people with no diabetes (ND), type 1 diabetes and normal awareness of hypoglycaemia (NAH) and type 1 diabetes and impaired awareness of hypoglycaemia (IAH) with the thalamus shown to have an important role in symptomatic awareness. The thalamus has numerous distinct nuclei each with separate roles involved in the relay and filtering of sensory or motor signals. We wanted to evaluate which of the functionally distinct nuclei within the thalamus played a dominant role in driving the known blood flow responses to hypoglycaemia. Materials and methods:  Fifty-one participants (15 ND, 15 NAH and 21 IAH) underwent a two-step hyperinsulinaemic hypoglycaemic clamp. Thalamic and global CBF was estimated using pcASL MRI at 6 timepoints: two euglycemic, two intermediate and two hypoglycaemic. Mixed linear models were performed in R using the lme4 package in which global cerebral blood flow was controlled for as well as an interaction term allowing estimation of the effect of each region by group. Results:  The mean glucose at the six timepoints were 5.32, 5.30, 3.06, 2.82, 2.54 and 2.55 mmol/L. Symptom responses to hypoglycaemia were brisk and similar in ND and NAH, however they were absent in IAH. After adjusting for the global increase in cerebral blood flow, the mixed linear models demonstrated significantly different regional cerebral blood flow responses between the distinct nuclei. The region with the largest effect was the medial dorsal nucleus which has been shown to have a crucial role in attention and planning (p < 2*10 -16 ). The region by group interaction, showed that the medial dorsal nucleus underwent a significantly reduced increment in CBF in the IAH group compared to NAH (p = 0.015). Conclusion:  In this first analysis of distinct thalamic nuclei responses, we show that regions involved attention and planning show the greatest blood flow response to hypoglycaemia. The specific nuclei involved indicate the critical role of the thalamus in attention towards key sensory signals during hypoglycaemia. These responses are reduced in IAH, further highlighting the importance of normal thalamic responses in the generation of hypoglycaemic symptom generation. Supported by: JDRF, DUK Disclosure:   P. Jacob:  None. 260 Differential symptoms and hormonal counter-regulation during hypoglycaemia in people with type 1 diabetes and post bariatric hypoglycaemia V. Lehmann , A. Tripyla, T. Zueger, D. Herzig, N. Styger, C. Albrecht, J. Meier, L. Bally, C. Stettler; Department of Diabetes, Endocrinology, Nutritional Medicine and Metabolism, Inselspital Bern, University Hospital and University of Bern, Bern, Switzerland. Background and aims:  Hypoglycemia is one of the most cumbersome acute complications of diabetes. However, hypoglycemia is not restricted to diabetes but is increasingly recognized also after bariatric surgery (postbariatric hypoglycemia, PBH). There is currently little evidence on mechanisms and symptom perception in PBH. We compared symptoms during hypoglycemia in people with type 1 diabetes (T1D) and PBH, and assessed counter-regulatory response. Materials and methods:  This analysis comprised 18 subjects with T1D (age 30 [26;40] yrs, 12 males, HbA 1c  7.1[6.6;7.4] %), and 10 subjects with PBH after gastric bypass (age 34.2 [23.5;48.9] yrs, 2 males, HbA 1c  5.2 [5.1;5.4] %). Hypoglycemia was induced in T1D using i.v. insulin, and in PBH by the ingestion of 75g glucose. All individuals rated hypoglycemic symptoms in 5 domains (3 autonomic domains: sweating, palpitations, tremor; and 2 neuroglycopenic domains: incoordination and drowsiness) at baseline (t base ) and hypoglycemia (t hypo ) on a 7-point scale (1=absent, 7=extreme). Sum scores were calculated for overall, autonomic and neuroglycopenic domains. Epinephrine, norepinephrine, glucagon, cortisol, and growth hormone [GH] were measured at t base  and t hypo . Results are shown as median [IQR] and groups were compared using two-sample Wilcoxon test. Results:  Venous blood glucose (BG) at t base  in T1D and PBH was 5.6 [5.1;6.2] and 4.7 [4.6;5.0] mmol/L ( p <0.001), respectively. BG values at t hypo  were 2.5 [2.2;2.7] and 2.6 [2.3;3.2] mmol/L ( p =0.20), respectively. Symptom perception at t base  was comparable between T1D and PBH (6.5[5;7] vs. 6[5;7],  p =0.32), and did not change during hypoglycemia in PHB .  Conversely, people with T1D reported higher overall, autonomic and neuroglycopenic symptom scores in hypoglycemia: 10 [9;20] vs. 6 [5;9], ( p =0.003), 8[6;12] vs. 3[3;6], ( p =0.001), 4[3;7] vs. 2[2;4], ( p =0.05). In T1D, epinephrine, glucagon, cortisol, and GH increased from t base  to t hypo , but decreased in PBH (epinephrine 682.1[326.9;1450.0] % vs. -25.9[-30.8;-16.2] % ( p <0.001), glucagon 45.3 [2.2;73.3] % vs. -25.9 [-30.8;-16.2] % ( p =0.002), cortisol 33.1 [-8.4;65] % vs. -21.2 [-56.1;-14.1] % ( p =0.004), GH 1740.1 [238.7;12067] % vs. -93.5 [-96.;47.1] % ( p <0.001), respectively). Change in norepinephrine was comparable between the two groups (15.8 [5.5;48.9] % vs. 26.8 [14.4;31.7] % ( p =1.0)). Conclusion:  Hypoglycemia was associated with significantly more symptoms in well-controlled people with T1D compared to age-matched people with PBH. This difference may be at least partially related to differences in counter-regulatory response. Whether such differential regulation may also indicate hypoglycemia unawareness in PBH (where permanent glucose control is not widely performed) compared with T1D (where continous glucose monitoring is well established) needs to be confirmed. Clinical Trial Registration Number: NCT04035993 and NCT04330196 Supported by: Swiss National Science Foundation (PCEGP3_186978, CRSII5_183569) Disclosure:   V. Lehmann:  None.

696 Obesity and decreased vibration perception associated with premature cardiovascular mortality in a single centre prospective of study of people with diabetes D.S. Tesic 1 , D. Andric 2 , M.T. Tomic 3 , S. Andric 4 , M.D. Tomic 5 ; 1 Clinic of Endocrinology and Diabetes, Clinical Center of Vojvodina(CCV), Novi Sad, 2 Clinic of Cardiology, Institute for Cardiovascular Diseases(ICVD), Sremska Kamenica, 3 Clinic of Plastic Surgery, CCV, Novi Sad, 4 Clinic of Cardiology, ICVD, Sremska Kamenica, 5 Clinic of Haematology, CCV, Novi Sad, Serbia. Background and aims:  The aim of this prospective, single centre study was to define factors associated with early cardiovascular mortality in diabetes. Materials and methods:  1345 patients under age 75 were included who were undergoing assessment of their diabetes between January 2008 and May 2010 as part of standard practice in a specilaist clinic at a regional teaching hospital in Serbia. Peripheral artery disease (PAD) was assessed by audible Doppler waveform and ABPI with cut-offs >1.4 and <0.9. Peripheral neuropathy was assessed by vibration perception threshold (VPT, using a semi-quantitative tuning fork: abnormal if ≤5), ankle reflexes (AR) and sudomotor function (Neuropad®) of the foot. Diabetic retinopathy (DR) was assessed by fundoscopy. Evidence of vascular disease: thrombendarterectomy and/or cerebrovascular insult (TEA/CVI), myocardial infarction (MI), heart failure (HF), diabetic foot ulcer (DFU), minor amputations (sAMP) and major amputations (mAMP) was also collected. Outcome was determined in 2021 and baseline characteristics were compared between those who had and had not suffered cardiovascular death under age 75 years within 10 years of review in two casually selected cohorts. Results:  Those who died (n 2 =70) were more frequently male (60 vs. 45.3%, p=0.08), younger (66.4±7.4 vs. 79.9±3.4, p<0.000), had a shorter period of follow-up (3.6±2.3 vs. 11.2±1.7 years, p<0.000) when compared to those still alive (n 1 =75). Those who died were also significantly (p<0.01) more likely to have had TEA/CVI (34.3 vs. 10.7%), HF (21.4 vs. 1.3%), MI (44.3 vs. 20%), PAD (48.6 vs. 9.3%), DFU (25.7 vs. 9.3%), mAMP (17.1 vs. 1.3%) at baseline. Minor amputations were significantly more likely (8.6 vs. 1.3%, p<0.04) but there were no differences in parameters of end-organ damage: proliferative DR (17.1 vs. 8%, p=0.10), laser photocoagulation (25.7 vs. 13.3%, p=0.06). Following multivariable logistic regression analysis significant differences between groups remained for only creatinine (123±45 vs. 88.9±16.9 mmol/L, p<0.003) and VPT  6.2 mmol/l (2.0 [95% CI: 1.0-4.0)], p<0.05), estimated maximum lifetime BMI (3.4 [95% CI: 1.7-6.8)], p<0.000), alcohol usage (4.7 [95% CI: 1.5-14.7)], p=0.005), smoking habit (2.2 [95% CI: 1.1-4.3)], p 6 and there were significant differences in TEA/CVI (4.2 [95% CI:1.6-10.9)], p=0.003) and PAD (3.9 [95% CI: 1.8-8.8)], p<0.001) and estimated maximum lifetime BMI (9.4 [95% CI: 3.4-25.7), p<0.000). Finally, when those who had had a previous MI at baseline (n=46) were compared with those who hadn't (n=99), MI was associated with increased death rate (3.2[95% CI: 1.5-6.6)], p=0.002), as was PAD (2.9[(1.3-6.1)], p=0.007). Conclusion:  Decreased VPT, the presence of PAD on clinical testing and higher maximum estimated lifetime BMI are strongly associated with premature cardiovascular death. These measures may be independent markers of greater risk of reduced life expectancy. Disclosure:   D.S. Tesic:  None. 697 Impact of prediabetes in heart failure with preserved ejection fraction: the NetDiamond cohort M. Borges-Canha 1 , F. Vasques-Nóvoa 2 , F. A. Saraiva 3 , A. Leite 3 , A. Oliveira 3 , J. Neves 1 , M. von Hafe 4 , C. Vale 2 , D. Carvalho 1 , A. Leite-Moreira 3 ; 1 Serviço de Endocrinologia, Diabetes e Metabolismo, Centro Hospitalar Universitário de São João, Porto, 2 Serviço de Medicina Interna, Centro Hospitalar Universitário de São João, Porto, 3 Fisiologia e Cirurgia, Faculdade de Medicina da Universidade do Porto, Porto, 4 Serviço de Pediatria, Centro Hospitalar Universitário de São João, Porto, Portugal. Background and aims:  Heart Failure with Preserved Ejection Fraction (HFpEF) is a growing challenge due to the population aging and the rising prevalence of cardiovascular risk factors. Our group has previously described the influence of diabetes diagnosis on the signs and symptoms, comorbidities and echocardiographic and vascular evaluation of patients with HFpEF in a stable phase. Patients with diabetes have more comorbidities and morphologic cardiovascular changes, comparing to non-diabetic patients. However, the association of prediabetes with clinical and echocardiographic features in HFpEF is still unclear.We aimed to evaluate the influence of the diagnosis of prediabetes on the signs and symptoms, comorbidities and echocardiographic and vascular evaluation of patients with HFpEF in a stable phase. Materials and methods:  Cross-sectional study including 40 patients with HFpEF in stable phase, followed in our center. Signs, symptoms and comorbidities were obtained by anamnesis, physical examination and patient medical records. The cardiac function was evaluated by echocardiography performed by expert cardiologists. Endothelial function (Reactive Hyperemia Index) was evaluated with the EndoPAT TM 2000 device and carotid-femoral pulse wave velocity. The associations between prediabetes, defined as A1C 5.7-6.4% or fasting plasma glucose 100-125 mg/dL, and the previously described outcomes were assessed through linear and logistic regression models, adjusted for sex, age, systolic blood pressure (SBP) and body mass index (BMI). Results:  The included population (n=40) had an average age of 74.6±9.6 years and 60.0% were males. The average BMI was 28.1±5.1 kg/m 2  and 48.7% had prediabetes. Concerning signs and symptoms, no significant differences were recorded regarding oedema, orthopnea NYHA class or nocturnal paroxysmal dyspnea. About comorbidities, no differences were recorded concerning blood pressure, lipid profile, peripheral, cerebral and cardiovascular atherosclerotic diseases. The echocardiographic evaluation showed that patients with prediabetes have a thinner interventricular septum (ß=-1.23 [-2.2 to -0.24]; p=0.016) and a tendency to have a higher tricuspid annular plane systolic excursion (TAPSE). Conclusion:  Opposing to diabetes, in our cohort, prediabetes was not associated with deleterious changes in cardiac or endothelial functions. Those are continuous diseases, and our results highlight the importance of preventing progression of prediabetes to diabetes in HFpEF. Supported by: POCI-01-0145-FEDER- 016385 Disclosure:   M. Borges-Canha:  None. 698 Respective role of NT-proBNP and coronary artery calcium score for the detection of silent coronary disease in asymptomatic patients with diabetes S. Pinto 1 , N. Berkane 1 , M. Nguyen 1 , N. Sellier 2 , E. Cosson 1 , P. Valensi 1 ; 1 Department of Endocrinology Diabetology Nutrition, Jean Verdier hospital, Bondy, 2 Department of Radiology, Jean Verdier hospital, Bondy, France. Background and aims:  BNP (B-type natriuretic peptide) is an indicator of pressure load, functional and structural left ventricle alterations, and severity of myocardial ischemia. Plasma NT-proBNP level has a good diagnostic value for heart failure and is a risk marker for cardio-vascular events. The present study aimed to analyse the predictive value of NT-proBNP and coronary artery calcification score (CACS) for the detection of silent coronary disease in asymptomatic patients with diabetes. Materials and methods:  We included 416 asymptomatic patients with diabetes at high or very high coronary risk but free of cardiac history and symptom. Silent coronary disease was assessed by measuring CACS (CT-scan), and performing a stress myocardial scintigraphy to detect silent myocardial ischemia (SMI), and a coronary angiography in the patients with SMI. NT-proBNP was measured in 243 of them. Results:  The prevalence of a high CACS (≥100 AU) was 44%, NT-proBNP ≥125 pg/mL 23% and SMI 9.6% (40 patients, including 15 with significant coronary stenoses (CS) on angiography). The prevalence of SMI and CS was higher among the patients with CACS ≥100 AU than among those with CACS <100 AU (15.4%  vs  5.1% and 6.6%  vs  1.3%; p<0.001 for both comparisons). The sensitivity and the specificity of CACS ≥100 AU for the detection of SMI were 70% and 59%, respectively. The proportion of patients with NT-proBNP ≥125 pg/mL was higher among the patients with CACS ≥100 AU than among those with CACS <100 AU (30%  vs  16.5% ; p<0,05). This threshold of NT-proBNP offered sensitivity, specificity and positive predictive value of 30%, 84% and 61%, respectively, for the detection of a CACS ≥100 AU. NT-proBNP did not predict the presence of SMI nor CS. Conclusion:  In asymptomatic diabetic patients, a NT-proBNP level ≥125 pg/mL, cut-off point for heart failure diagnosis, may help making decision to measure CACS but, at variance with CACS, does not contribute to identify the patients with SMI or CS. Among the patients with high CACS, 30% are at risk of developing heart failure. Disclosure:   S. Pinto:  None. 699 Rewind data on obesity and cardiovascular health: waist-to-hip ratio independently predicted cardiovascular outcomes E. Franek 1 , P. Pais 2 , J.N. Basile 3 , S. Raha 4 , N. Ahmad 4 , H. Kan 4 , M. Konig 4 ; 1 Mossakowski Medical Research Centre, Polish Academy of Sciences and Central Clinical Hospital MSWiA, Warsaw, Poland,  2 St. John's Research Institute, Bangalore, India,  3 Medical University of South Carolina, Charleston, USA,  4 Eli Lilly and Company, Indianapolis, USA. Background and aims:  Obesity is a major risk factor for health outcomes such as major adverse cardiovascular events (MACE) and cardiovascular disease (CVD)-related mortality. Waist-to-hip ratio (WHR) is a validated measure of central adiposity and has been shown to predict CVD events. The aim of this post hoc analysis was to evaluate if WHR, adjusted for age and sex, was an independent risk factor for developing MACE-3 (non-fatal myocardial infarction (MI), non-fatal stroke, or CV death) and CVD-related mortality. Materials and methods:  Data from the REWIND trial placebo group (N=4952) were analysed. All participants had type 2 diabetes, were aged 50 or older, and had either a previous CV event or CV risk factors. During the median follow-up of 5.4 years, there were 663 patients with MACE-3 and 346 CVD-related deaths. A Cox proportional hazard model was used to investigate if WHR, adjusted for age and sex, was a significant risk factor for MACE-3 and CVD-related mortality, followed by testing additional baseline risk factors (demographic, CVD history, and biochemical characteristics) using a stepwise variable selection method where WHR, age, and sex were forced into the model. BMI was tested similarly to WHR. Results:  WHR, but not BMI, was an independent risk factor for MACE-3 and CVD-related mortality. As expected, age and sex were significant risk factors for both endpoints and were therefore adjusted in the model. Urinary albumin:creatinine ratio (UACR), non-HDL-C, and race (white) were significant risk factors for MACE-3. UACR, LDL-C, history of MI, and race (American Indian/Alaska Native) were significant risk factors for CVD-related mortality. In the resulting adjusted model, for every unit increase in WHR, there was an estimated 3.50-fold increase in MACE-3 risk (p=0.013) and 5.51-fold increase in CVD-related mortality risk (p=0.005). Conclusion:  WHR was an independent predictor of MACE-3 and CVD-related mortality, indicating that central adiposity should be assessed and addressed in patients with or who have a high risk of CVD. Clinical Trial Registration Number: NCT01394952 Supported by: Eli Lilly and Company Disclosure:   E. Franek:  Employment/Consultancy; Boehringer Ingelheim, Novo Nordisk. Other; Boehringer Ingelheim, Novo Nordisk, AstraZeneca, Bioton, Eli Lilly, Polfa Tarchomin, Servier. 700 To study the relationship between the mean platelet volume, immature platelet fraction, and glycaemic control in type 2 diabetes patients S. Ahsan 1 , R. Roy 2 , M. Prasad 3 , A. Gaurav 4 ; 1 Indira Gandhi Institute of Medical Sciences, Patna, 2 Cardio Clinic, Patna, 3 Diabetes Clinic, Darbhanga, 4 Diabetes Clinic, Begusarai, India. Background and aims:  Mean platelet volume (MPV) and immature platelet fraction (IPF) have been shown to be surrogate markers of platelet size and activity, respectively. In patients with diabetes mellitus, altered platelet activity is one of the contributing factors for atherothrombosis. We studied the effect of chronic hyperglycemia on MPV and IPF in patients with type 2 diabetes mellitus (T2DM). The objective of the study was to find the correlation between MPV, IPF, and HbA1c in patients with T2DM and to study the impact of improvement in glycemic control on MPV and IPF. Materials and methods:  We prospectively evaluated 60 patients with T2DM and 38 nondiabetic healthy controls. Patients were divided into two groups based on their glycemic status (Group A [n = 23]: HbA1c ≤7% and Group B [n = 37]: HbA1c >7%). MPV, IPF, and HbA1c were measured in the study and control populations at baseline and only in Group B patients at 3 months. Results:  In diabetic patients, average MPV (Group A: 9.82 ± 0.62 fl, Group B: 10.14 ± 0.77 fl, vs. controls: 9.51 ± 1.35 fl, P = 0.02) and IPF (Group A: 1.78 ± 0.79, Group B: 2.47 ± 1.4 vs. controls: 1.59 ± 0.82, P = 0.001) values were significantly higher compared to controls. Seventeen of 37 patients (46%) in Group B achieved a target HbA1c level (<7%) on follow-up. MPV was significantly decreased in these 17 patients compared to their baseline MPV (9.72 ± 0.70 fl vs. 10.15 ± 0.72 fl, P = 0.00153); however, the reduction in mean IPF was not significant (2.42 ± 1.67 vs. 2.13 ± 1.11, P = 0.152). Conclusion:  Platelet activity, as measured by MPV and IPF, is significantly higher and correlates with glycemic control in T2DM patients when compared to healthy nondiabetic controls. Disclosure:   S. Ahsan:  None. 701 Type 2 diabetes significantly modulates the power of lipoprotein (a) to predict cardiovascular events and mortality in young coronary artery disease patients A. Vonbank 1,2 , A. Mader 2,1 , M. Maechler 2,1 , B. Larcher 2,1 , L. Sprenger 2,1 , B. Mutschlechner 1,2 , M. Benda 1,2 , A. Muendlein 1,3 , A. Leiherer 3,4 , H. Drexel 5,1 , C.H. Saely 3,1 ; 1 Vorarlberg Institute for Vascular Investigation and Treatment (VIVIT), Feldkirch, Austria, 2 Academic Teaching Hospital Feldkirch, Feldkirch, Austria,  3 Private University of the Principality of Liechtenstein, Triesen, Liechtenstein,  4 Medical Central Laboratories, Feldkirch, Austria,  5 County Hospital Bregenz, Bregenz, Austria. Background and aims:  Lipoprotein(a) [Lp(a)] is an important cardiovascular risk factor especially in young individuals. The power of Lp(a) to predict cardiovascular events in young coronary artery disease (CAD) patients with type 2 diabetes (T2DM) however is unclear and is addressed in the present study. Materials and methods:  Lp(a) was measured in a cohort of 731 patients with angiographically proven CAD who were aged <65 years. Vascular events were recorded over a mean follow-up of 6.6±3.2 years. Results:  At baseline, 216 patients had T2DM, and 515 did not have diabetes. During follow-up, 30.2% of our patients suffered cardiovascular events. Lp(a) proved to be a strong and independent predictor of vascular events in the total study cohort (standardized adjusted HR=1.30 [1.07-1.56]; p=0.007). In subgroup analyses by diabetes status, Lp(a) significantly predicted vascular events in non-diabetic patients (standardized adjusted HR= 1.39 [1.12-1.74]; p=0.003) but not in diabetic patients (standardized adjusted HR=0.93 [0.63-1.38]; p=0.731). An interaction term Lp(a)xT2DM was significant (p=0.002), indicating that T2DM significantly modulated the power of Lp(a) to predict cardiovascular events. Conclusion:  We conclude that Lp(a) significantly modulates the power of Lp(a) to predict cardiovascular events in CAD patients <65 years. Disclosure:   A. Vonbank:  None. 702 Remnant cholesterol in patients with established cardiovascular disease predicts cardiovascular events both among patients with type 2 diabetes and among non-diabetic subjects H. Drexel 1,2 , A. Mader 3,2 , L. Sprenger 3,2 , A. Vonbank 2,3 , B. Larcher 3,2 , M. Maechler 3,2 , B. Mutschlechner 2,3 , M. Benda 2 , A. Leiherer 4,5 , A. Muendlein 2,4 , C.H. Saely 4,2 ; 1 County Hospital Bregenz, Bregenz, Austria,  2 Vorarlberg Institute for Vascular Investigation and Treatment (VIVIT), Feldkirch, Austria,  3 Academic Teaching Hospital Feldkirch, Feldkirch, Austria, 4 Private University of the Principality of Liechtenstein, Triesen, Liechtenstein,  5 Medical Central Laboratories, Feldkirch, Austria. Background and aims:  Remnant cholesterol, which is calculated as total cholesterol minus LDL cholesterol minus HDL cholesterol has attracted interest as a marker of cardiovascular event risk. The power of remnant cholesterol to predict cardiovascular events in patients with established cardiovascular disease is unclear and is addressed in the present study. Materials and methods:  We enrolled 1822 consecutive patients with established cardiovascular disease, including 1472 with angiographically proven stable CAD 350 with sonographically proven peripheral artery disease. Prospectively, cardiovascular events were recorded over a mean follow-up period of 6.2±3.2 years. Results:  At baseline, remnant cholesterol was significantly higher in patients with T2DM (n=608) than in non-diabetic subjects (27±25 vs. 21±21 mg/dl; p<0.001). During follow-up, 584 of our patients suffered cardiovascular events; the event rate was significantly higher in patients with T2DM than in non-diabetic subjects (45.4 vs. 32.2%; p<0.001). Remnant cholesterol in Cox regression models adjusting for age, sex, hypertension, smoking, body mass index and LDL cholesterol independently predicted cardiovascular events in the total study population (standardized adjusted HR 1.15 [1.07-1.23]; p<0.001), and in patients with T2DM as well as in non-diabetic subjects (standardized adjusted HRs 1.17 [1.03-1.34]; p=0.013 and 1.12 [1.01-1.23]; p=0.028, respectively). Conclusion:  From our data we conclude that remnant cholesterol in patients with established cardiovascular disease predicts cardiovascular events both among patients with T2DM and among non-diabetic subjects. Disclosure:   H. Drexel:  None. Author Index Aagaard, N. K. 423 Aalders, J. 403 Aan de Stegge, W. B. 577 Abd El Aziz, M. 211 Abdul Sultan, A. 314 Abe, M. 618 Abelin, K. 258 Aberle, J. 568 Abildlund, M. T. 480, 492 Abramczyk, O. 461 Abramovich, I. 231 Abubaker, J. 384 Abu-Farha, M. 384 Abukiwan, A. 291 Achenbach, S. 203 Acosta, S. 198 Adamczewski, H. 276 Adams, A. 692 Adamson, K. 457 Adamsons, I. A. 52 Adderley, N. J. 78, 654 Addington, A. K. 627 Adenis, A. 554 Adeshara, K. 655 AFFIRM-AHF investigators 685 Afi Leslie, K. 217, 330 Afolabi, P. R. 671 Afshar, N. 657 AG019-T1D-101 Trial Investigators 220 Agesen, R. M. 458, 516 Agha-Jaffar, R. 342 Aguadé, S. 61 Agudelo, L. Z. 90 Aguilar-Diosdado, M. 604 Ahern, A. L. 264 Ahlqvist, E. 210, 282 Ahluwalia, T. S. 94, 193, 202 Ahmad, N. 699 Ahmed, F. 408, 421 Ahmed, I. 129, 301 Ahmed, M. 81 Ahola, A. J. 283 Ahrén, B. 112 Ahsan, S. 700 Aiello, E. 375 Aihara, K.-I. 618 Aikaterini, B. 523 Aitken, R. J. 75 Aizawa, T. 287 Ajdari, S. 464 Ajie, M. 613 Ajjan, R. A. 653 Akalestou, E. 430 Åkerlund, M. 206 Akhbari, P. 330 Akhtar, M. 363 Akhyari, P. 371 Akil, A. A. 129, 301 Akobe, S. F. 588 Akturk, H. 236 Al-Ali, W. 384 Alam, M. 590 Alberiche Ruano, M. D. P. 535 Albert, L. 167 Albrecht, C. 260 Al-Dabet, M. 230 Alderson, S. 531 Aleppo, G. 214 Alfieri, S. 119 Alfredsson, L. 282 Algara González, M. A. 535 Alhadj Ali, M. 602 Al-Hasani, H. 622, 624 Ali, H. 384 Ali, L. 529 Alibegovic, A. C. 516 Al Khairi, I. 384 Al-khaledi, G. 384 AlKurd, A. 249 Allen, J. M. 233 Allison, M. 676 Almeida, M. 275 Almeida, M. 275 Almqvist, C. 267 Al-Mrabeh, A. 41, 110 Al-Mulla, F. 384 Alonso, G. T. 549 Al-Rubeaan, K. 296 Al-Sabah, S. 384 Al-Saoudi, E. F. 55 Al-Sari, N. 157 Alsayed, M. 296 Al Shawaf, E. 384 Alshehri, Z. 78, 654 Al Sifri, S. 212 Alsina-Fernandez, J. 221 Alssema, M. 393 Altamura, S. 173, 623, 664 Altimira, L. 406 Alvarado Martel, D. 535 Alvarez, A. 212 Alves, A. 428, 603 Amadou, C. 551 Ambery, P. 460 Ambery, P. 476 Ambrojo-López, A. 553 Amiel, S. A. 259 Amiri, N. 628 Ämmälä, C. 368 Amor, A. 341 A. Morfin, V. 317 Ampudia-Blasco, F. 497 Anagnostis, P. 313 Anderlova, K. 566 Andersen, A. 257, 258 Andersen, B. 639 Andersen, E. S. 295 Andersen, G. S. 527, 589 Andersen, G. 133, 511 Andersen, H. U. 516, 519 Andersen, M. S. 403 Andersen, U. B. 232 Andersson, M. 310 Andersson, T. B. 368 Anděl, M. 640 Andorra, M. 657 Andreasen, C. R. 258 Andreeva, A. T. 294 Andrén Aronsson, C. 278 Andrew, T. 274 Andrews, R. 281 Andric, D. 696 Andric, S. 696 Andriessen, C. 433 Ang, L. 688 Angoulvant, D. 64, 239 Anholm, C. 187 Anjana, R. M. 286 Anker, S. D. 489, 685 Annersten Gershater, M. 310 Anouar, Y. 380 Anstee, Q. M. 676 Antikainen, A. 32, 127, 302 Antonucci, A. 288 Antza, C. 567 Anubhav, N. 590 Apostolopoulou, K. 279 Apostolopoulu, M. 101 Aprile, M. 34, 46 Arabo, A. 380 Araki, E. 418 Arany, Z. 39 Araszkiewicz, A. 360 Arendt-Nielsen, L. 592 Argemi, L. 378 Argenti, S. 555 Armandi, A. 192 Ärnlöv, J. 91, 614, 615 Aroda, V. R. 448, 481, 482, 484, 485 Aronson, R. 557, 558 Arora, R. 24 Arroba, A. I. 604 Arroyo-Díez, F. J. 553 Arrubla, J. 504 Artner, I. 271 Asamoa, E. 530 A. Saraiva, F. 697 Asfa, A. 396 Ashcroft, F. M. 116 Ashik, T. 316 Asif, A. 567 Asiku, J. 493 Aslam, R. 121 Asong, M. 135 Asplund, O. 158, 271 Astiarraga, B. 40 Astrup, A. 109, 114 Asuaje Pfeifer, M. 353 Åsvold, B. O. 282 Atabaki Pasdar, N. 67, 90 Atageldiyeva, K. 262 Atanes, P. 316 Ataoglu, H. 678 Atisso, C. 5 Atkinson, M. 219 Atsumi, T. 585 Avgerinos, I. 148, 491 Awadh, M. 601 Awala, O. 537, 567 Ayine, M. L. 131 Ayis, S. 150, 570 Azar, S. 249 Azharuddin, M. 436 Azizad, M. 692 Azzouz, M. 666 Baar, B. 525 Babaeva, D. 636 Babinsky, V. 657 Babwah, F. 567 Bader, G. 335, 336, 370 Badillo, E. 303 Bae, S. 412, 668 Bæch-Laursen, C. 248 Baekdal, M. 177 Bækdal, T. A. 468 Bagger, J. I. 257 Bagur, A. 89 Bai, Y. 123 Baidya, A. 532 Baig, A. A. 524 Bailey, T. 236, 557, 558 Baillot-Rudoni, S. 407 Bain, S. 21, 485 Bain, S. C. 483 Baity, M. 330 Bajaj, H. S. 509 Bakker, S. J. L. 95 Bakulin, I. 190 Bala, C. 512 Balampanis, K. 565, 660 Balbo, S. L. 338 Balboa, D. 253, 254 Baldassarre, M. P. A. 257, 270 Baldi, S. 40 Balkau, B. 207 Balkay, L. 663 Balkhiyarova, Z. 208 Ballabeni, C. 93 Ballesta, S. 691 Bally, L. 96, 260, 429, 560 Balogun-Katung, A. 531 Bancher-Todesca, D. 401 Bandet, C. L. 171 Bañeras, J. 661 Banerjee, R. 89 Banu, B. 529 Banu, I. 237 Bany Bakar, R. 317 Bao, J. 376, 641 Baraghithy, S. 269 Barahona, M. 36 Barbarash, O. 652 Barbé, F. 189 Barbet-Massin, M.-A. 638 Barbetseas, J. 373 Barbieri, C. 192 Barbone, A. 534 Barbosa, P. 408 Barchetta, I. 42, 390 Bardtrum, L. 458, 484, 495 Bardugo, A. 249 Baricevic-Jones, I. 48, 252 Barkhof, F. 533, 536, 643, 646 Barleen, N. A. 541 Barmpagianni, A. 373, 565 Barnard-Kelly, K. 562 Barnes, A. 41, 110 Barnes, D. 457 Barnett, A. H. 464 Barnett, J. 651 Baron, M. 207 Baroni, M. G. 42, 390 Barraso, M. 36 Barsby, T. 253, 254 Barth, M. 371 Bartley, C. 152 Barton, M. 510 Basile, J. N. 699 Basu, A. 227, 247, 385, 396 Basu, M. 128 Basu, R. 227, 247, 385, 396 Batista, M. C. 91, 614, 615 Battelino, T. 470, 557, 558 Battezzati, P. 240 Baudoux, F. 404 Bauer, R. 485 Bauer, S. 368 Baumann, S. 677 Bayazit, B. 256 Bayram, F. 296 Bazydlo-Guzenda, K. 223, 461 Beam, C. 242 Beato-Víbora, P. I. 553 Beck Bang, R. 508, 509 Beckers, J. 102 Beck- Nielsen, H. 516 Bedair, K. F. E. 175 Begtrup, K. 135 Beguinot, F. 126 Beiglböck, H. 72, 266 Bekiari, E. 148, 491, 689 Belew, G. D. 172, 415 Beli, E. 33 Bell, J. D. 90 Bellart, J. 345 Bellass, S. 531 Bellili, D. 672 Bem, R. 197, 576 Benaiges, D. 691 Benani, A. 380 Benas, D. 565, 660 Ben Cnaan, E. 269 Benda, M. 612, 658, 659, 662, 679, 701, 702 Bendszus, M. 591 Benes, M. 568 Benhalima, K. 346 Benhamou, P.-Y. 551, 554 Ben-Haroush Schyr, R. 249 Benito, M. 318 Bennakhi, A. 296 Bennet, L. 149, 311 Benova, A. 627 Benson, C. T. 222 Bentley, L. 123 Bentzen, M. J. 409 Ben-Zvi, D. 249 Berends, E. 628 Berends, F. J. 250 Berendschot, T. T. J. 111, 280 Berg, T. J. 29 Bergel, M. 249 Bergen, S. E. 28 Bergenstal, R. M. 470, 509, 541 Berger, M.-A. 397 Berggren, P.-O. 182 Bergman, B. K. 22 Bergman, M. 169 Bergmann, T. 300 Berikov, V. B. 159 Berk, E. 112 Berka, V. 354 Berkane, N. 698 Bernal-Mizrachi, E. 377 Berra, C. 49, 240 Berse, M. 677 Bertoccini, L. 42, 390 Bertolino, A. 534 Bertram, P. 686 Bertrand, G. 153 Best, F. 300 Betancort Acosta, J. C. 535 Betella, N. 49 Bethel, M. A. 5, 456 Beulens, J. W. J. 2, 206, 209, 285, 635 Bezdenezhnykh, A. 652 Bezdenezhnykh, N. 652 Bezzecchi, E. 44 Bhagat, A. 573 Bhat, B. A. 129 Bhattacharya, A. 277 Bhattacharyya, N. P. 128 Bianco, E. 240 Bianconi, E. 650, 680 Bickerton, A. 424, 457 Biegański, G. 360 Bierwirth, R. 695 Bignotto, M. 240 Bigot, G. 505 Billeskov, T. 374 Billot, L. 277 Bilo, H. J. G. 263 Bilson, J. 671 Bindels, L. B. 671 Binns, H. 656 Biondi, G. 383, 469 Birkeland, K. I. 205 Birkenfeld, A. L. 38, 98, 102, 225, 326, 369, 382, 405 Birot, S. 450 Birukov, A. 312 Bishop, K. 579 Bispham, J. 161 Bissolati, M. 44 Bisson, A. 64, 239 Bjerg, L. 63 Bjerre, J. 178 Blachnio-Zabielska, A. 171 Black, J. E. 694 Blackbourn, L. A. K. 77 Blair, M. 39 Bleken Oestergaard, H. 65 Block, T. J. 165 Bloechlinger, M. 560 Blomme, S. 220 Blüher, M. 46, 335 Boavida, J. M. 79 Bocchino, L. 233 Bode, B. 236 Bodholdt, U. 447, 450 Bodin, A. 64 Bodis, K. 225 Boesen, M. P. 365 Bogdani, M. 219 Bojer, A. S. 178 Bojic, M. 459 Bojsen-Møller, K. N. 387 Bolla, A. M. 555 Bolotskaya, L. 571 Bonadonna, R. C. 487, 505 Bond, J. M. 627 Bönhof, G. J. 56, 595 Bonifaci, N. 414 Bonnefond, A. 207, 251, 274 Bonnemaire, M. 212, 505 Bonora, E. 435, 456 Bonou, M. 373 Boonpattrawong, N. 18 Borges-Canha, M. 697 Bornat, Y. 339 Bornstein, S. R. 369 Boronat, M. 535 Borrelli, A. 383, 469 Bos, C. 209 Bosch, A. 203, 490 Boschero, A. C. 100 Boschmann, M. 83 Bosdou, J. K. 313 Bosi, E. 10, 7 Boss, A. 501 Boss, M. 250 Bothou, C. 313 Botz, I. 677 Boughton, C. K. 96, 233, 234 Bouillet, B. 407 Boulgaropoulos, J. 371 Bouman, E. J. 285 Bourry, J. 404 Boyce, R. 488 Boye, K. 471, 475 Brabec, M. 354 Bracken, R. M. 357, 498, 683 Brady, M. 89 Braga, M. 434 Brahma, M. K. 379 Bramlage, P. 261, 300 Braun, A. 534 Bray, R. 426, 470, 472 Brazg, R. 236 Bredahl Mogensen, P. 268 Bredow, J. 83 Breitschaft, A. 468 Briant, L. J. 116 Brito, J. 381 Broccoli, V. 305 Broe Honoré, J. 65, 448 Bronczek, G. A. 100, 338 Brønden, A. 177, 422 Brosa, H. 36 Brøsen, J. M. B. 516 Bross, P. 374 Brouri, M. 666 Brouwers, B. 426 Brouwers, M. C. G. 82, 86 Brown, J. V. E. 531 Brown, K. 22, 470, 472 Brown, S. A. 564 Broz, J. 354 Brozzi, F. 256 Bruls, Y. M. H. 169, 366 Brun, T. 152 Brüning, D. 399 Brunner, E. J. 589 Brusco, N. 375 Bucci, M. 420 Bucciarelli, L. 49 Buda, P. 461 Bueno, M. 290 Bugianesi, E. 192, 676 Buhl, E. S. 29, 139 Bulgheroni, M. 49 Bulkescher, R. 166, 183 Burade, V. 467 Burdsall, K. 218 Burgoyne, T. 304 Burillo, J. 318 Burkart, V. 225 Burrage, J. 272 Bus, S. A. 577 Bus-Kwasnik, K. 223 Busquets Net, R. 582 Butler, J. 685 Butrym, M. 298 Butwicka, A. 28 Buur Stougaard, E. 606 Buziau, A. M. 86 Buzzetti, R. 138 Byberg, S. 162 Byrne, C. D. 671 Bystrova, A. A. 294 Bytoft, B. 17 Caballé, T. 406 Cabrera, O. 221 Caccioppoli, C. 687 Caixàs, A. 290 Calder, P. C. 671 Caluwaerts, S. 220 Camaya, I. 334 Campbell, A. 524 Campbell, A. 48, 252 Campbell, F. M. 233 Campbell, M. D. 354, 653 Campos, M. 400 Cannata, F. 168 Cannistraci, R. 650, 674 Cannon, C. P. 50, 52, 425, 439 Cano, A. 167 Cano-Cano, F. 604 Canonica, J. 462 Canouil, M. 207, 251, 274 Cantley, J. 317 Cao, J. 355 Caparrotta, T. M. 69, 77 Capece, U. 119, 337 Capehorn, M. 23, 180 Cardellini, M. 288 Cardellini, S. 44 Card-Gowers, J. 615 Cardozo, A. K. 333, 379 Carfì, A. 337 Cariou, B. 480 Carli, F. 79, 192 Carlson, A. L. 561 Carlson, T. 431 Carlsson, S. 73, 74, 241, 282 Carmody, L. A. 402 Carneiro, E. M. 100, 338 Carrera, M. 691 Carroll, L. 244 Carswell, C. 531 Carter, P. 488 Carter, R. 247 Caruso, I. 534 Carvalho, C. 648 Carvalho, D. 697 Carvalho, E. 194, 195 Carvalho, R. A. 428 Casagrande, V. 288 Casajust, P. 444 Casas, A. 341 Casas, B. 368 Casero, R. 123 Castagna, M. 103 Castellanos-Rubio, A. 12 Castells-Nobau, A. 414 Castera, L. 672 Castillo-Armengol, J. 186 Castro, F. 275 Cataldi, S. 34, 46 Cataldo, L. R. 325, 378 Catapano, A. L. 120 Catargi, B. 339 Catarig, A.-M. 23, 446, 447, 450 Cater, N. B. 425 Catrina, S.-B. 446 Caunt, S. 520 Cavallo, M. G. 42, 390 Ceccarelli, V. 390 Cedersund, G. 368 Cefalo, C. M. A. 119, 337, 375 Cerasi, E. 231, 377 Cereceres, S. 544 Cerghizan, A. 512 Cerosaletti, K. 220 Chabanova, E. 109 Chabosseau, P. 304 Chadban, S. 91, 614, 615 Chakarova, N. 673 Chakera, A. J. 160 Chan, J. C. 66, 144, 293, 675 Chan, S. 537 Chan, Y.-P. 133 Chander, G. 656 Chandra, V. 253 Chang, A. 214, 550, 563 Chang, A. R. 236 Chang, S.-C. 196 Chapman, K. 161 Charalampidis, K. 689 Charbonnel, B. 50, 52, 425, 438, 439 Charleer, S. 543 Charlwood, C. 443 Charpentier, G. 207, 551, 554 Chartrel, N. 380 Chaudry, A. 104 Chaves, C. 275 Chawla, P. 9 Chaykivska, Z. 690 Chee, P. 289 Chen, C. 355 Chen, G. 488 Chen, H. 314 Chen, L. 118 Chen, L. 200 Chen, M. 238 Chen, P.-Y. 122 Chen, P. 692 Chen, W. 463 Chen, Y. 229, 352 Cheng, A. Y. Y. 458 Cheng, F. 8 Cheng, S. 355 Cherian, P. 384 Cherney, D. Z. I. 50, 51, 52, 425, 438, 439 Chertow, G. M. 51, 91, 614, 615 Cheung, C. Y. Y. 132 Cheung, R. 304 Chew, Y. 8 Chia-Hui Tan, E. 445 Chien, J. 134, 216 Chigutsa, E. 134, 216 Chigutsa, F. 507 Chiheb, S. 237 Child, C. J. 299, 556 Chillarón, J.-J. 691 Chimienti, R. 305 Chioma, L. 35 Chittajallu, S. 657 Cho, J. 507 Cho, K. 585 Chodankar, D. 140 Choi, H. 610 Choi, I. 191, 412, 668 Choi, J. 191, 412 Choudhary, P. 259 Chow, E. 144, 675 Chow, W. 132 Chowdhury, S. 140 Christensen, M. H. 403 Christensen, M. M. B. 55 Christensen, M. S. 63 Christensen, M. B. 37, 179, 409, 494 Christiansen, E. 480, 484, 495 Christiansen, M. 236 Chudasama, J. 443 Cianfarani, S. 35 Ciardullo, S. 93, 650, 674, 680 Ciccodicola, A. 34, 46 Cidade-Rodrigues, C. 275 Cieluch, A. 360 Cignarelli, A. 383, 469, 534, 687 Cimini, F. A. 42, 390 Cinque, G. 362 Cinquegrani, G. 487 Cinti, F. 119, 337, 375 Ciotti, S. 598 Ciudin, A. 189, 290, 644 Claesson, T. 645 Claudi, T. 29 Clausen, T. D. 295 Claussnitzer, M. 306 Clemente-Postigo, M. 45 Clemmesen, K. K. B. 527 Climent, E. 691 Cnop, M. 7, 10, 337 Coate, K. C. 499 Cobelli, C. 41, 227, 247, 385, 396, 569 Cogliati, I. 555 Cohen, R. 568 Coin-Araguez, L. 45 Colbert, K. 431 Coldewey, S. 331 Cole, J. B. 210 Colé, N. 462 Colhoun, H. M. 31, 69, 77 Coll-Iglesias, L. 414 Collins, J. 150, 570 Cömert, C. 374 Conde, S. V. 389 Conget, I. 345 Connell, N. 433 Consoli, A. 21 Cooper, J. G. 29 Cooper, M. E. 165 Copetti, M. 288 Coppini, D. 542 Corbin, K. D. 425 Corcoy, R. 16, 401, 406 Cordero-Vázquez, E. 36, 644 Cordiner, R. L. M. 175 Cormont, M. 46 Cornejo-Pareja, I. M. 45 Corrêa, D. G. 533 Correa-Rotter, R. 51 Corsini, C. 44 Cosentino, C. 256 Cosentino, F. 50, 52, 270, 425, 438, 439 Coskun, T. 221, 222 Cosson, E. 237, 698 Cossu, E. 42 Costa, V. 34, 46 Costa-Júnior, J. M. 100 Costea, T. C. 580 Costes, S. 153 Coudert, M. 506 Coulden, A. 567 Coutant, D. 503 Coventry, P. A. 531 COVID-MAR study group 691 Cowan, E. 323 Cox, D. 435, 456 Cox, R. D. 123 Crabtree, T. S. J. 424, 457 Craige, S. M. 627 Crenier, L. 27 Criego, A. B. 561 Croosu, S. S. 592, 597, 600 Cruciani-Guglielmacci, C. 339 Cucinotta, D. 138 Cui, C. 463 Cui, X. 22, 474, 475 Cunha, D. 89 Cunha, F. M. 275 Curovic, V. R. 188, 587 Cusi, K. 190, 426 Cvecka, J. 99 Cyganek, K. 343, 693 Cypryk, K. 344, 347 Czarnik, K. 344 Czerlau, C. 96 Da Dalt, L. 120 Dadson, P. 420 Dagenbach, N. 562 Dagnelie, P. C. 82, 111 Dagogo-Jack, S. 50, 52, 425, 438, 439 Dahl, D. 20 Dahl-Jørgensen, K. 218 Dahlström, E. H. 164, 243 Dai, D. L. 107 Dakhel, A. 421 Dalamaga, M. 523 Dal Canto, E. 2 Dalgaard, L. T. 8, 194 Dalla Man, C. 227, 247, 385, 396, 429, 560 Dalle, S. 153 Dalmases, M. 189 Dalton, J. P. 334 Daly, A. 96 D'Amato, C. 583 Dambeck, U. 113 Damm, P. 16, 17, 295 DAN05 Consortium 234 Dandekar, T. 151 Danilova, T. 106 Danne, T. 300, 557, 558 D'Antuono, A. 487 Darling, A. 443 Darsalia, V. 4 Das, A. 573 Das, A. K. 140 Dashkin, M. V. 630 Dave, J. 542 Davies, A. L. 480, 485 Davies, M. J. 19, 22, 452, 479, 484 Dawed, A. Y. 286 Day, G. 327 Dayan, C. 602 Deanfield, J. E. 479 de Baaij, J. H. F. 209 de Barsy, M. 251 de Beaufort, C. 233 De Block, C. 364, 482, 543 De Cosmo, S. 288 Deden, L. N. 250 Deenadayalan, S. 458 De Franco, E. 272 de Galan, B. E. 280, 517, 521 De Gale, B. 84 de Graaf, R. A. 366 de Gregório, L. H. 112 Dehennis, A. 236 Dei Cas, A. 487 Dei Cas, M. 240 Dejardin, E. 333 Dejgaard, T. F. 494 Dejgaard, T. 495 de Jonge, C. 568 Dela, F. 37, 494 de la Fuente, M. 290 Delahaye, F. 274 Delgadillo Silva, L. 363 Del Guerra, S. 7, 10 Delibegovic, M. 195 Dellva, M. A. 504 Del Prato, S. 336, 370, 673 De Luca, C. 7, 10 de Melo, J. M. L. 232 Demidova, T. Y. 391 Demidova, T. 642 Demil, N. 212 Demir, S. 170 den Braver, N. R. 285 Deng, Y. 463 Denham, D. 236 De Nicola, L. 91, 614, 615 de Paoli, F. 374 De Remigis, A. 21, 180 Derevyanko, O. 636 Derhourhi, M. 207 Derop, J. 251 Deruaz-Luyet, A. 444 Deshmukh, A. S. 398 Desiderio, A. 126 Desouza, C. 483 Desoye, G. 401 Deswysen, Y. 251 Dettmer, R. 328 Deutsch, G. 219 Devis-Jáuregui, L. 414 Devlin, A. M. 18 DEVOTE Study Group 688 DeVries, J. H. 133 Dewidar, B. 88, 629 de Wit, M. 522 de Wit-Verheggen, V. 174 Dex, T. 501 Dhatariya, K. 424 Dhayal, S. 330 Diabetic Retinopathy Clinical Research Network 31 DIAMONDS Research Team 531 Diaz, L. J. 527 Dickmann, S. 83 Diekmann, F. 341 Dieuwertje, M. M. 303 Di Gioia, L. 469, 534 Di Giuseppe, G. 119, 337 Dijkgraaf, M. G. W. 577 DiMeglio, L. 557 DiMeglio, L. A. 558 Dimitriadis, G. 565, 660 Dimova-Draganova, R. 673 Ding, L. 238 Di Paola, R. 288 di Pietrantonio, N. 270 D'Ippolito, I. 583 Dirinck, E. 364, 543, 578 Dirksen, C. 387 di Tomo, P. 270 Dixon, R. F. 541 Djekic, D. 459 Dmitriev, I. 609 Doggen, K. 578 Dolgin, K. 538 Domaszewska, K. 360 Donath, M. Y. 429 Dong, X. 515 Dong, Z. 416 Donn, R. 252, 48 Donnelly, L. A. 206, 286 Donnelly, S. 334 D'Onofrio, B. M. 28 Doolan, G. A. 656 Dor, Y. 269 Dora, N. 590 D'Oria, R. 687 Dornhorst, A. 342 Doron, M. 552 dos Santos, C. N. 381 dos Santos, R. S. 320, 329 dos Santos Silva, J. 646 Dotta, F. 333, 375 Dougan, M. 692 Draper, M. 362 Dreher, S. I. 102 Drexel, H. 612, 658, 659, 662, 679, 701, 702 Droste, P. 199 Drummond, R. 568 Drzazga, E. 461 Dsouza, C. 384 Du, Y. 222 Duarte, R. 79 Dubey, V. 542 Dubsky, M. 197, 576 Duchateau, G. 393 Ducluzeau, P. 64, 239 Dudel, C. 77 Duff, C. J. 30, 526 Duffus, S. H. 499 Duhamel, D. 152 Duijnhouwer, A. L. 521 Duinkerken, E. V. 536 Dule, N. 103, 120 Dule, S. 42 Dullaart, R. P. F. 95 Dunne, F. 16, 528, 402 Dutt-Ballerstadt, R. 546 Duvillard, L. 407 Dvir, H. 493 Ebbehøj, A. L. 372 Ebendorff-Heidepriem, H. 324 Eberle, C. 13, 308 Echalar, B. 576 Echtay, A. 296 Eckstein, S. 382 Edagawa, S. 585 Eder, A. 349 Edstorp, J. 282 Eeg-Olofsson, K. 70, 142, 539 Efremov, E. E. 665 Egan, A. M. 402 Ehall, B. 321 Eichelter, J. 266, 72 Eickhoff, H. 389 Eickhoff, M. K. 202 Eisenga, M. F. 95 Eizirik, D. L. 7, 10 Ejskjaer, N. 592, 597, 600 Ekelund, J. 198 Ekelund, M. 16 E. Kemp, B. 317 Ekim Ustunel, B. 170 El-Agroudy, N. 369 Elders, P. 2 Elders, P. J. M. 209, 285 Elebra, S. 155 Eleftheriadou, I. 523 Eliasson, B. 4, 70, 142, 198 Eliasson, L. 323 Elissen, A. M. J. 263 Elliott, J. 424 Ellis, S. L. 549 Eloy, R. 133 Elpers, J. 507 Elshorbagy, A. 82 Elvira, B. 332 ElWakiel, A. 230 EMPRISE EU and East Asia Study Group 445 EMPRISE group 444 Emral, R. 212 Emri, M. 647, 663 Endo, I. 618 Engberg, S. 258 Englisch, C. 629 Eppel, D. 681, 348, 349 Erazo Tapia, E. 39 Eremkina, A. 609 Erhan, U. 446, 447, 450 Erhardt, A. 183 Eriksson, J. W. 125, 228, 408, 421 Eriksson, M. I. 164, 619 Ermer, M. 514 Esmatjes, E. 341 Esposito, I. 88, 629 Essex, M. N. 52 Estlin, A. 264 Esze, R. 647, 663 Etter, T. 562 Eussen, S. 280 Eussen, S. J. P. 82, 86, 111 Evans, M. 268 Evans, M. 460 EXPECT study group 16 Faber, J. 258 Fabien, V. 685 Fabricius, T. W. 517 Fachim, H. 48, 252 Fadhel Dhaher, N. 311 Fadini, G. P. 138 Færch, L. 19, 453, 455, 478 Fahlbusch, P. 622, 624 Fajardy, I. 76 Fakhro, K. A. 129, 301 Falkowski, B. 637 Fall, K. 267 Fall, T. 267 Famulla, S. 133 Fan, B. 144 Fan, H. 411 Fan, L. 549 Fangel, M. V. 162 Fanni, G. 228, 408, 421 Fantuzzi, F. 337, 487 Faraj, M. 168 Farkas, Á. 437 Farup, J. 374 Fatima, S. 230 Fauchier, G. 64, 239 Fauchier, L. 64, 239 Faurby, M. 24, 268 Favacchio, G. 49 Fealy, C. 433 Federici, M. 288 Feig, D. S. 15, 16, 350 Fejfarova, V. 197, 576 Fellinger, P. 72, 266, 548 Fenton, S. 575 Ferch, M. 548 Ferencakova, M. 627 Fermin, D. 210 Fernandes, J. 24 Fernández, C. 322 Fernández, C. 406 Fernández, N. 691 Fernández, N. 582 Fernández Landó, L. 22, 426, 470, 472, 474, 475 Fernández-Real, J. M. 12, 414 Fernández-Veledo, S. 167 Ferrannini, E. 501 Ferrannini, G. 5 Ferrazza, G. 288 Ferré, P. 171 Ferreira, J. P. 54 Ferreira, S. 381 Ferrer-Fàbrega, J. 341 Ferreria-González, I. 661 Fex, M. 325, 378 Ficorilli, J. 221 Fidilio, E. 290 Fiema, M. 690 Fignani, D. 375 Figueiredo, A. 195 Figueiredo, O. 275 Filippatos, G. 685 FinnDiane Study Group 32, 127, 164, 283, 302, 616, 619, 620, 645 Fiorina, P. 49, 555 Fisher, L. 161 Fishman, S. 568 Fitchett, D. 489 Flanagan, S. E. 160 Flatt, P. R. 184, 315, 388, 392, 465 Flaxman, C. 219 Fledelius, C. 186 Fleischer, J. 55 Flekac, M. 633 Fleming, T. 55, 57, 291, 400, 605, 623 Flindt Kreiner, F. 495 Flodström-Tullberg, M. 218, 298 Flor, A. 476 Florese, P. 126 Flores-Guerrero, J. L. 95 Flores-Le Roux, J. A. 691 Florez, J. C. 210 Florissi, C. 530 Flotynska, J. 360 Foghsgaard, S. 295 Folli, F. 240 Fondevila, C. 341 Fong, C. H. Y. 132 Fontaine, P. 76 Fontana, F. Y. 357 Foos, V. 488 Forlenza, G. P. 564 Forman, J. L. 257, 295 Formoso, G. 270 Forsblom, C. 32, 127, 164, 243, 244, 283, 302, 616, 619, 620, 645, 655 Forst, T. 677 Fos-Domènech, J. 419 Foufelle, F. 171 Foulquier, S. 628 Fountoulakis, N. 611 Foxton, R. 462 Fragoso-Bargas, N. 205 Franc, S. 207, 551, 554 Francque, S. 364 Franek, E. 562, 699 Franey, B. 136, 215, 224, 466 Franklin, A. 272 Franks, P. W. 67, 90, 149, 306 Franzén, S. 4, 70, 142 Fraunberger, P. 658 Frederich, R. 50, 425, 438, 439 Free, W. L. 464 Freemantle, N. 505 Frenkel, O. 23 Frey, O. 361 Frias, J. 134, 216 Frias, J. P. 22, 435, 452, 456, 472, 474 Frier, B. M. 299 Frimodt-Møller, M. 193, 232 Fritsche, A. 38, 225, 261, 382, 405 Fritsche, L. 225, 382, 405 Froehlich-Reiterer, E. 233 Froekjaer, J. B. 592 Froguel, P. 207, 274 Frøkjær, J. B. 597, 600 Frontino, G. 305 Frontoni, S. 35, 598 Früh, E. 399 Fry, A. 96 Frydenberg, H. 568 Fryer, A. A. 30, 526, 651 Frystyk, J. 109, 114 Fuchs, J. 233 Fuchs, K. 560 Fujihara, K. 581 Fujikawa, J. 500 Fuks, O. 3 Fukuda, K. 418 Fukuda, T. 504 Fukui, M. 496 Furlong, N. 307 Furse, S. 350 Gacesa, R. 163 Gadi, I. 230 Gæde, P. 178 Gaeta, A. 189 Gaffney, G. 402 Gaggini, M. 192, 676 Gaipov, A. 262 Gaitan, J. 117, 339 Galiyeva, D. 262 Gallagher, A. 424 Gallego-Gamero, F. 553 Gallen, I. W. 424, 457 Galli, A. 103, 120 Galstyan, G. 506 Gamsey, S. 544 Gan, S. 286 Gan, Z. 463 Gancheva, S. 101 Gandolfi, A. 49, 555 Ganss, K. 115 Gantz, I. 50, 438, 439 Gao, B. 451 Gao, L. 518 Gao, W. 451 Garai, I. 647, 663 García, G. 318 García-Arumí, J. 36 Garcia-Fernandez, J. M. 604 Garcia Garrido, M. 462 Garcia-Ocana, A. 467 García-Pérez, L.-E. 454 García-Ramírez, M. 189 Garcia Sanchez, J. 314 Gardete-Correia, L. 79 Garg, S. 236 Garvey, L. F. 226 Garvey, W. T. 455, 479 Garzon, P. 377 Gasbjerg, L. S. 37, 179, 387 Gaspari, S. 386 Gastaldelli, A. 79, 192, 426, 676 Gatos, I. 667 Gaudier, M. 133 Gault, V. A. 388 Gaurav, A. 700 Gaus, B. 156 Gautier, J.-F. 672 Gawrecki, A. 360 GDS Group 43, 56 Geary, B. 48, 252 Gehr, B. 137 Geissler, F. 349 Gemmink, A. 174 Genchi, V. A. 687 Geng, D. 378 GENIE consortium 210 Gennemark, P. 368 George, J. 423 Gerbracht, C. 85, 113, 279 Gerling, I. 218 Gerst, F. 326 Gerstein, H. 5, 158, 434, 436 Gether, I. M. 177 Geurten, R. J. 263 Gheibi, S. 325, 378 Gholap, N. N. 537, 649 Ghosh, R. 140 Ghosh, S. 25 Ghosh, S. 128 Giaccari, A. 119, 337, 375 Gibson, M. 48, 252 Gidlow, C. 651 Gierczak-Pachulska, A. 223 Gilbert, R. E. 686 Gill, J. 213 Gillard, P. 346, 543 Gillespie, K. M. 75 Gillum, M. P. 177 Gil-Poch, E. 553 Giménez, M. 345 Gimenez, P. 551 Giménez-Palop, O. 167 Giordano, F. 534 Giordano, G. N. 90, 206 Giorgetti-Peraldi, S. 46 Giorgino, F. 383, 469, 472, 534, 687 Giovenzana, A. 44 Girelli, A. 49 Gislason, G. 257 Gjela, M. 600 Glaser, B. 269 Glintborg, D. 403 Gloyn, A. L. 123 Gluud, L. L. 190, 365 Gmitrov, J. 584 Gnudi, L. 130, 611 Göbl, C. S. 348, 681 Godang, K. 14 Goebl, C. S. 349 Gogate, J. 440, 441 Gojda, J. 640 Gokhale, K. M. 78, 654 Goldenberg, R. 434, 453 Golubic, R. 460 Golubkina, Y. 571 Gomes, P. 603 Gomes Neto, A. 95 Gomez, M. F. 158 Gomez-Jaramillo, L. 604 González, C. 318 González-Clemente, J.-M. 167 González-Moro, I. 12 Gooley, T. A. 547 Gordin, D. T. 164, 645, 655 Gorgani, N. N. 464 Gormsen, L. C. 201, 204, 372, 432 Gorritz, M. 299 Gotthardt, M. 250 Gottlieb, E. 231 Gottlieb, R. 692 Gottsäter, A. 198 Goulis, D. G. 313 Gourdy, P. 505 Gowda, A. 509 Gowen, R. 530 Grahn, M. 310 Gräler, M. 331 Grarup, N. 248 Gravholt, C. H. 17 Greco, C. 583 Greene, C. R. L. 146 Gregory, J. M. 499 Greig, M. 58, 59 Greiner, G. G. 276 Greve, J. 568 Grieco, G. E. 375 Griffin, S. J. 264 Grill, V. E. R. 74, 282 Grimm, M. 224, 466 Grinbaum, R. 249 Gritskevich, E. 642 Grittner, U. 83 Groeneveld, L. 285 Grønbæk, H. 423 Groop, L. C. 158, 205, 206, 282 Groop, P.-H. 32, 127, 164, 210, 232, 243, 244, 283, 302, 616, 619, 620, 645, 655 Grupe, K. 351, 353 Gu, S. 515 Gu, W. S. 229, 626 Guarini, F. 469, 534 Guay, C. 256 Guccio, N. 327 Guerci, B. 309 Güerri, R. 691 Guha, S. 573 Guida, C. 116 Guillén, C. 318 Guja, C. 512 Guo, L. 631 Guo, X. 513, 515 Gupta, N. 434 Gurgul-Convey, E. 105, 328, 331 Gurzov, E. N. 332, 333, 379 Gusmanov, A. 262 Gustafson, B. 126 Gustavsson, S. 26 Gustenhoff, P. 516 Gutiérrez-Carrasquilla, L. 290 Gysemans, C. 332 Ha, K. 445 Haastert, B. 276 Haazen, L. 220 Habib, T. 129 Hadad, R. 588 Hadaoui, A. 666 Haddock, B. 232 Haddouchi, A. E. 422 Hadjiyianni, I. 550, 563 Hafidh, K. 296 Hagemann, C. A. 37 Hägg-Holmberg, S. 302 Hajduch, E. 171 Hajselova, L. 27 Hakonen, E. 106 Halimi, J.-M. 91, 614, 615 Hall, S. 434, 436 Haluzík, M. 566 Hamaguchi, M. 496 Hamasaki, A. 500 Hamilton, A. 325 Hammar, N. 74 Hammes, H. 623 Han, C. 118 Han, D. J. J. 121 Han, F. 47, 594, 684 Han, K. 610 Han, L. 411 Hanif, W. 567 Hankaniemi, M. M. 298 Hankosky, E. R. 549 Hanna, F. 651 Hannah, K. 549 Hannelius, U. 242 Hannukainen, J. C. 97, 356, 358 Hans, P. 608 Hansen, C. 226 Hansen, C. S. 55, 63, 587, 589 Hansen, D. L. 527 Hansen, L. 460, 476 Hansen, L. B. 639 Hansen, T. M. 592, 597, 600 Hansen, T. W. 6, 188, 572, 587 Hansen, T. 248 Hansen, T. K. 201, 204 Hantel, S. 489 Haqelqvist, P. G. 258 Hara, T. 618 Harada, M. Y. 581 Haraguchi, T. 500 Harajli, A. 155 Haran, A. 249 Hardikar, A. A. 8 Hardy, T. 504 Harer, C. 321 Häring, H.-U. 326, 382 Harjutsalo, V. 32, 127, 283, 302, 616, 619, 620, 655 Harmsen, J.-F. 246 Harmsen, M. 303 Harreiter, J. 72, 266, 401 Harris, S. 436, 694 Hart, H. E. 525 Hartmann, B. 109, 114, 177, 179, 248, 387, 409, 494 Hartmut, R. 90 Hartnell, S. 96 Hartwig, S. 622 Hasebe, M. 500 Hasegawa, G. 496 Hashimoto-Kameda, R. 585 Hassid, J. 407 Hatam, S. 77 Hatano, R. 395 Hatem, G. 271 Hattersley, A. T. 15, 160, 272, 281 Haugaard, S. B. 109, 114, 187, 365, 442, 588 Haukka, J. 32, 127, 302 Hauner, H. 695 Haupt, A. 134, 216 Hausser, I. 183 Havekes, B. 87 Hawthorne, W. J. 8 Hayek, S. 688 Hazebroek, E. J. 250 He, J. 625 He, L. 284 He, S. 410 He, T. 572 Heald, A. H. 30, 48, 252, 265, 526 Hedbäck, N. 387 Hedegaard Andersen, J. 193 Hedetoft, C. 516 Hefetz, L. 249 Heiberg-Gibbons, F. 601 Heidenreich, E. 623 Heier, M. 595 Heimbürger, S. M. N. 37, 409, 494 Hein Zobel, E. 6 Heise, T. 133, 510, 511, 514 Heiskanen, M. A. 97, 356, 358 Hejlesen, O. 68 Heller, S. R. 135, 520, 557 Hellmann, P. H. 177 Heni, M. 38, 98, 225, 382 Hennayake, C. K. 124, 413 Henrich, W. 348, 681 Henriksen, M. M. 519 Henry, R. M. A. 86, 280 Henson, J. 464 Hentilä, J. 97, 356, 358 Hepprich, M. 429 Herance, J. R. 61 Herbert, J. 64, 239 Herbsthofer, L. 321 Herder, C. 43, 595 Hermes, D. J. H. 628 Hernández, C. 36, 61, 189, 290, 582, 661 Hernández, I. 582 Hernandez, M. 136, 215 Hernandez Hernandez, I. 644 Hernandez Pascual, C. 644 Herold, K. C. 220 Herrero, L. 419 Herrou, A.-F. 672 Herzig, D. 96, 260, 429, 560 Herzig, S. 166, 170, 183, 605 Herzog, K. 74 Hess, S. 158 Hesselink, M. K. C. 39, 169, 174, 366 Hetty, S. 125, 421 Heywood, S. 398 H-H Sheu, W. 445 Hikmat, D. 579 Hilgard, D. 137 Hill, T. G. 116 Hiller, J. 580 Himathongkam, T. 293 Hinden, L. 231 Hindsø, M. 387 Hirani, D. 342 Hirota, Y. 235 Hirsch, I. B. 547, 550, 563 Hirschhorn, J. N. 210 Hirst, T. R. 464 Hjerling-Leffler, J. 11 Hjorthøj, C. 442 Hjortkjær, H. 94 Hnatiuk, A. 9 Höckele, S. 102 Hod, M. 16 Hoe, B. 494 Hoeks, J. 39, 246, 433 Hoekstra, T. 635 Hoelting, L. 361 Hoenderop, J. G. J. 209 Hoene, M. 98 Hoesli, I. 349 Hofer, S. E. 233 Hoff, R. 488 Hoffman, B. G. 104 Hoffmann, C. 102 Høgh-Schmidt, E. 365 Hohendorff, J. 690 Höhn, A. 77 Højlund, K. 17, 403 Holan, V. 576 Holbikova, E. 125 Holl, R. W. 261, 300, 445 Holland, D. 30, 526 Hollander, M. 525 Holliman, S. 123 Hollingsworth, K. G. 41, 110 Holm, S. 37 Holmes, P. 447 Holst, B. 37 Holst, J. J. 109, 114, 119, 177, 179, 226, 248, 258, 295, 365, 387, 409, 422, 494 Holst-Hansen, T. 455 Holt, R. I. G. 531 Hommel, E. E. 55 Hompesch, M. 136, 215, 224, 466 Hong Kong Diabetes Biobank Study Group 66 Honjo, S. 500 Honkala, S. M. 97, 356, 358 Honsek, C. 113 Horn, D. 453 Hosoda, K. 235 Hossain Khan, M. 529 Hou, N. 47, 594, 684 Houben, A. J. H. 111, 280 Houghton, J. A. L. 160 Houtkooper, R. H. 246 Houttu, N. 420 Hovelmann, U. 557, 558 Hovorka, R. 96, 233, 234 Howell, A. 602 Hrabě de Angelis, M. 102, 326 Hramiak, I. 434, 436 Hu, C. 98 Hu, M. 430 Hu, X. 518 Huang, J. 411 Huang, J. 284 Huang, M. 306 Huang, W. 324 Huang, Y. 66 Huang, Y.-C. 122 Huang, Z. 410 Hucz-Kalitowska, J. 461 Hufgard-Leitner, M. 72, 266 Hughes, A. E. 160 Hughes, A. 161 Hughes, P. 281 Huh, R. 20, 471 Huhn, E. A. 349 Huhn, G. 692 Hulman, A. 63 Hummel, J. 405 Hummel, M. 261 Hummel, S. 274, 278 Humphreys, V. 65 Huneker, E. 552, 554 Huras, H. 343 Hurtier, A. 339 Husain, M. 21, 486 Husakova, J. 197, 576 Huschto, T. 657 Huse, S. 213 Husemoen, L. L. N. 448 Hussain, I. 651 Hustig, A. 113 Huth, C. 595 Huyett, L. M. 550, 563 Huypens, P. 102 Hyöty, H. 298 Hypo-RESOLVE consortium 69 Hytönen, V. P. 298 Iannozzi, N. 487 Ibberson, M. 206 Ibragimova, L. 636 Ibrahim, H. 253, 332 Icks, A. 276 Idevall-Hagren, O. 151 Igata, M. 418 Ignaut, D. 507 IJzerman, R. G. 176, 533, 536, 643, 646 Ikonomidis, I. 565, 660 Im, D. 669, 670 IMI DIRECT Consortium 90 IMI-RHAPSODY 206 Impronta, F. 337 Incedal, C. 151 Inkeri, J. 655 INSPIRED Research Group 528 Inzucchi, S. E. 54, 489 Iozzo, P. 358 Iqbal, Z. 48, 252 IQED-Foot COVID-19 Working Group 578 Irvine, K. M. 41, 110 Irwin, D. E. 449 Irwin, N. 315, 388, 465 ISCHIA study group 235 Isermann, B. 230 Ishii, M. 496 Israeli, H. 249 Israeli, T. 377 Issanov, A. 262 Italiani, P. 46 Itariu, B. 72, 266 Ito, M. 599 Ivaska, K. K. 356 Iwasaki, K. 500 Iwasaki, Y. 500 Jackson, C. A. 146 Jacob, P. 259 Jacob, S. 453 Jacob, S. 622, 624 Jacobsen, L. V. 177 Jacovetti, C. 256 Jaffredo, M. 117 Jäger, S. 312 Jain, A. 453 Jakubowska, A. 574 Jamal, M. 384 Jandeleit-Dahm, K. 165 Jang, A. 18 Janíčková Žďárská, D. 354 Janiszewski, M. 461 Jankowska, E. A. 685 Jansen, J. F. A. 82 Jantz, J. 550, 563 Januszewski, A. S. 244 Jarak, I. 428 Järbrink, K. 314 Jarman, I. 307 Jarosikova, R. 197, 576 Jarus-Dziedzic, K. 223 Jarvelin, M.-R. 274 Jaschinski, F. 230 Jaser, S. S. 499 J. DeSalvo, D. 214 Jeffries, A. R. 272 Jende, J. M. E. 591 Jendle, J. 26 Jenkins, A. J. 244 Jensen, A. B. 448 Jensen, D. M. 17, 403 Jensen, J. B. 374 Jensen, M. S. 37 Jensen, M. H. 68 Jensen, N. J. 114, 365 Jensen, T. B. 468 Jensen, T. 516 Jenssen, H. 194 Jenum, A. K. 29, 139, 205 Jeon, E. 297 Jeon, H. 53 Jeong, J. 224, 466 Jeppesen, O. K. 19, 453, 479 Jermutus, L. 460, 476 Jernow, H. 125 Jespersen, N. Z. 398 Jessen, N. 201, 204, 248, 374, 423, 432 Jeya, S. S. P. 129 Jeyam, A. 69, 77 Jha, J. C. 165 Ji, Q. 451 Jia, T. 16 Jiménez, B. 318 Jimenez-Chillaron, J. C. 419 Jiménez-Sánchez, C. 152 Jin, Q. 66 Jirkovska, A. 197, 576 Jódar, E. 472, 481 Joensen, L. E. 162, 527 Joergensen, M. E. 527 Joglekar, M. V. 8 Johannsen, M. 432 Johansen, O. 112 Johansen, R. F. 520 Johansson, I. 67 Johansson, U.-B. 539 Johnson, A. 25 Johnson, K. 227, 385 Jokitalo, E. 253 Jones, A. 281 Jones, B. 342 Jones, J. G. 172, 415 Jones, P. L. S. 52 Jonsson, M. 4 Joosten, L. A. B. 163 Jørgensen, M. E. 55 Jørgensen, N. B. 387 Jørgensen, P. G. 258 Jörns, A. 331 Joshi, S. 140 Jozefiak, T. 431 Juhl, C. B. 516 Julla, J.-B. 672 Jumpertz-von Schwartzenberg, R. 83 Juneja, R. 549 Jung, H. 435 Jung, H. 319 Jung Kim, D. 445 Junker, J. P. 9 Juntti-Berggren, L. 182 Just, J. 17, 374 Jylha, A. 658 Kaakinen, M. 208 Kabisch, S. 113 Kader, T. 563 Kadolsky, U. 255 Kadosh, L. 231, 377 Kadyrzhanuly, K. 262 Kahl, S. 88 Kahn, C. R. 464 Kaiser, G. 326 Kajantie, E. 274 Kakotrichi, P. 148, 491, 689 Kalaidzidis, I. 115 Kalaidzidis, Y. 115 Kalamajski, S. 306 Kalathil, D. 307 Kallenbach, K. 468, 484 Kalliokoski, K. 420 Kalousova, M. 633 Kalra, S. 140 Kaltheuner, M. 276 Kaltoft, M. 481, 482 Ka-Lung Chan, A. 362 Kalyanam, B. 16 Kalyesubula, M. 493 Kamble, P. G. 125, 421 Kameda, H. 585 Kamel, M. 9 Kamiński, M. 360 Kampmann, U. 248, 374 Kan, C. 47, 594 Kan, H. 299, 699 Kanapka, L. 234 Kanda, E. 91, 614, 615 Kandaswamy, L. 567 Kanebratt, K. 368 Kaneko, M. 581 Kaneko, S. 474 Kang, L. 124, 413 Kania, M. 690, 693 Kannenkeril, D. 203, 490 Kantartzis, K. 225, 405 Kantharidis, P. 165 Kantonen, T. 420 Kapelios, C. 373 Kapellen, T. M. 233 Káplár, M. 647, 663 Kapoor, D. 277 Kaprio, J. 97, 356, 358 Kar, S. 16 Karabarinde, A. 281 Karacay, C. 321 Karagiannis, T. 148, 491, 689 Karakoc, I. 361 Karalliedde, J. 150, 570, 611 Karamanakos, G. 373 Karamat, M. 78, 654 Karasik, A. 445 Karjalainen, T. 420 Karlsdotter, K. 26, 444 Karonova, T. L. 3, 294 Karpe, F. 81, 640 Karusheva, Y. 56, 101 Kashima, K. 607 Kato, K. 235 Katogiannis, K. 565, 660 Katoh, S. 92 Katra, B. 690 Katsogiannos, P. 228 Kaufman, F. R. 236 Kautzky, A. 72 Kautzky-Willer, A. 16, 72, 266, 401, 548 Kawashima, S. 235 Kawata, S. 585 Kazda, C. 134, 216 Keegan, M. 649 Keidai, Y. 500 Keikkala, E. 274 Kellar, I. 531 Kelly, T. L. 41, 110 Kelsall, A. 601 Kempegowda, P. 25 Kemper, M. 113 Kempf, K. 1 Kender, Z. 591 Kennedy, B. 267 Kennet, J. 460 Képes, Z. 647, 663 Keuthage, W. 550 Kgosidialwa, O. 528 Khalid, U. 479 Khalzova, A. 3 Khamis, A. 274 Khan, D. 184, 392 Khan, N. 506 Khan, W. A. 165 Khan, Z. 567 Khapchaev, A. Y. 665 Khatun, R. 5 Khawaja, H. 230 Khunti, K. 453 KidsAP Consortium 233 Kietsiriroje, N. 653 Killner, J. 243 Kim, D. 191, 412, 668 Kim, J. 191, 412, 668 Kim, K.-A. 610 Kim, M. 319 Kim, M.-K. 224, 466 Kim, M. 319 Kim, M. 669, 670 Kim, R. 669, 670 Kim, S. 297 Kim, W. 273 Kim, Y. 273 Kim, Y. 191, 668 Kim, Y. 669, 670 Kim†, K. H. S. 464 Kimura, I. 395 Kimura, S. 500 Kirjavainen, A. 420 Kirk, A. R. 483 Kirwan, B. B. 402 Kirwan, B.-A. 685 Kitagawa, N. 496 Kitazawa, M. 581 Kitchen, C. 531 Kivimäki, M. 589 Kjaer, A. 188, 587 Kjeldsen, S. A. S. 365 Klaff, L. J. 557, 558 Klar, R. 230 Klein, M. 533, 536, 643, 646 Kleinridders, A. 369 Klekotka, P. 692 Klimontov, V. V. 159, 630 Klinkhammer, B. M. 199 Klupa, T. 359, 690 Klüter, H. 303 Knebel, B. 622, 624 Knoch, K.-P. 115 Knop, F. K. 37, 177, 179, 226, 257, 258, 295, 409, 422, 450, 480, 494 Knorr, S. 17 Knudsen, L. 527 Knudsen, L. B. 177 Knudsen, S. T. 446 Kobor, M. S. 18 Kodama, S. 581 Koenig, H. 657 Koenig, W. 595 Kogot-Levin, A. 231 Koike, H. 287 Koivula, R. W. 90 Kok, A. 296 Kolb, H. 1 Kolotkin, R. L. 477, 478 Kolwelter, J. 203 Kombargi, L. 538 Kondo, T. 418 Kong, A. 144 Konig, M. 435, 699 Kooi, E. 82 Kooi, M. 86 Kopf, S. 291, 591, 605, 664 Kopka, M. 690 Korakas, E. 565, 660 Kornips, E. 433 Koroleva, A. 455 Korpachev, V. V. 634 Kose, Y. 481 Kosiborod, M. N. 440, 448, 479, 686 Kosinski, M. 347 Kossl, J. 576 Kosta, O. 523 Kostelli, G. 565, 660 Kostev, K. 695 Kostrzycka, M. 690 Kotzaeridi, G. 348, 681 Kotzbeck, P. 321 Kotzka, J. 622, 624 Koulman, A. 350 Kountouri, A. 565, 660 Kousathana, F. 565, 660 Koussis, P. 667 Kouyama, K. 235 Kouyama, R. 235 Kovalchuk, A. V. 634 Kowall, B. 695 Kowluru, A. 155 Kozinetz, R. M. 159 Krarup, T. 109 Krebs, M. 72, 266 Kreiner, E. B. 485, 492 Krejčí, H. 566 Krentz, N. A. J. 123 Kretzler, M. 210 Krishnan, S. 140 Kristensen, J. K. 162 Kristensen, K. B. 498 Kristensen, P. L. 516, 520, 521 Kristensen, S. L. 442 Kristiansen, V. B. 387 Kristófi, R. 408, 421 Krittiyawong, S. 293 Krogh, J. 442 Krogvold, L. 218 Kroon, B. 280 Kršek, M. 566 Krumpolec, P. 99 Ku, E. 53 Kuensting, T. 562 Kuja-Halkola, R. 28 Kulkarni, S. 431 Kullmann, S. 38 Kumar, M. 608 Kumar, P. 78, 654 Kumar, S. 314 Kumarathurai, P. 588 Kumaraturai, P. 187 Kuo, F.-C. 122 Kuo, M.-L. 196 Kurahashi, K. 618 Kurihara, Y. 585 Kuroda, A. 235, 618 Kurstjens, S. 209 Kurz, F. T. 591 Kurzbach, A. 369 Kushnareva, N. N. 634 Kushner, P. 314 Kushner, R. F. 455, 477, 478, 479 Kusmartseva, I. 219 Kuz’mina, A. 652 Kvist, J. 254 Kwan, A. 456 Kwiatkowska, M. 693 Kwon, H. 191, 668 Kyaw, M. H. 444, 445 Kyheng, M. 76 Kzhyshkowska, J. 303 Laakso, S. 292 Laaksonen, R. 658 Laaperi, M. 658 LaBell, E. 503, 504 Labouèbe, G. 386 Lachal, S. 551, 552 Lacquaniti, F. 598 Ladelund, S. 190 Ladha, T. 342 Laher, I. 18 Lahti, L. 97, 356, 358 Lai, M. 289 Laimer, M. 261, 300 Laitinen, K. 420 Lakshmi, J. K. 277 Lalic, N. 212 Lam, K. S. L. 132 Lamacchia, O. 288 Lambadiari, V. 565, 660 Lambers Heerspink, H. J. 51 Lampousi, A.-M. 73 Landgraf, R. 695 LANDMARC Study Group 140 Landry, J. 427 Landschulz, W. 134, 216 Lane, C. 396 Lang, J. 117, 339 Langkilde, A. M. 51, 686 Lankin, V. Z. 665 Lanzinger, S. 300, 445 Laporte, M.-E. 538 Larcher, B. 612, 658, 659, 662, 679, 701, 702 Larina, I. 609 Larosa, M. 138 Larsen, M. B. 639 Larsen, T. M. 109, 114 Larsson, H. 28 Latorre, J. 414 Latsou, D. 667 Lattuada, G. 650 Latva-Rasku, A. 420 Lau, E. 66, 144, 675 Lauand, F. 214 Laubner, K. 568 Laurberg, T. 639 Laurenti, M. C. 201 Lauritsen, J. V. 258 Lauritsen, K. M. 201, 204 Lauro, D. 583 Laursen, J. C. 232 Laursen, P. N. 452, 479 Lause, P. 251 Lautamäki, R. 97, 356, 358 Lauwers, P. 578 Lavallard, V. 152 Laviola, L. 383, 469, 534, 687 Lawlor, E. R. 264 Lawrence, D. 52 Lawson, J. 482, 483 Layne, J. E. 541 Lazendic, M. 462 Le, S. 355 Leal, E. C. 194, 195 Leal Fischer, K. 117 Lean, M. E. J. 110 Leanza, G. 168 Leclerc, I. 304, 430 Lecube, A. 189, 290 Lee, C. 132 Lee, C. J. 473, 474, 475 Lee, D. 224, 466 Lee, D.-H. 53 Lee, E. 395 Lee, H. 66 Lee, J. 238, 289 Lee, J. 575 Lee, J.-H. 297 Lee, J. 191 Lee, J. 191, 412, 668 Lee, S. 412 Lee, S. 412, 668 Lee, S. 610 Lee, V. 316 Lee-Ødegård, S. 205 Leete, P. 75, 219 Legido-Quigley, C. 193, 206, 617 Le Grazie, G. 469, 534 Lehmann, R. 98 Lehmann, V. 260 Lehr, L. 36 Lehr, S. 622 Lehrke, M. 199 Lehto, M. 244 Leibowitz, G. 231, 377 Leiherer, A. 612, 658, 659, 662, 679, 701, 702 Leite, A. 697 Leite-Moreira, A. 697 Leiter, L. A. 486 Leksell, J. 539 Lekva, T. 14 Lemaitre, M. 404 Le Marois, M. 57 Lembo, E. 192 Lemoine, T. 76 Lenardi, C. 103 Leohr, J. 503, 504 Leonardini, A. 687 Leone, A. 34 Leone, M. 28 Leoni, M. 583 Lepak, C. 544 Lerche, S. S. 516 Lerin, C. 419 le Roux, C. W. 452, 455 Leroy, C. 76 Le Solliec, M.-A. 380 Le Stunff, H. 171 Li, C. 625 Li, D. 625 Li, G. 91, 614, 615 Li, H. 106 Li, J. 340 Li, L. 80, 340, 376, 641 Li, T. 200 Li, T. 417 Li, W. 284 Li, X. 200 Li, X. 213 Li, Y. 118 Li, Y. 215 Li, Y. 284 Liakos, A. 148, 491, 689 Liarakos, A. L. 649 Liatis, S. 373, 523, 565 Libby, P. 486 Liberati-Pso, A.-M. 546 Liberatori, S. 317 Licata, G. 333, 375 Lichtenberg, A. 371 Lichtenstein, P. 28 Liebkind, R. 645, 655 Liebl, A. 24, 137 Liebmann, M. 351, 353 Lietzén, M. S. 97, 356, 358 Liew, A. 402 Lilja, E. 198 Liljenquist, D. 236 Lim, C. K. 66, 293 Lim, J. 319 Lim, S. 455 Lin, L. 374 Lin, P. 485 Lin, S. 518 Lind, M. 4 Lindahl, M. 106 Lindeboom, L. 87, 366 Linden, F. H. 365 Linder, E. 539 Linder, T. 348, 349, 681 Lindhardt, T. B. 257 Lindqvist, A. 11 Ling, C. 323 Ling, J. 143 Lingvay, I. 19, 448, 452, 455, 483, 508, 688 Linkens, A. 280 Linnemann Jensen, M. 445 Linnenkamp, U. 276 Lip, G. 64 Lipovsky, B. 300 Lisboa, P. 307 Lissenberg-Witte, B. I. 2 Lister, J. 531 Lithovius, V. 253, 254 Liu, B. 22 Liu, B. 327 Liu, H. 210 Liu, H. 503 Liu, J. 52, 425, 438, 439 Liu, J. 161 Liu, L. 135, 508, 509 Liu, S. 28 Liu, S. 238 Liu, X. 278 Liu, X. 200 Liu, X. 340 Liu, Y. Y. 434, 436 Liu, Y. 131 Liu, Y. 47 Liutkus, J. F. 436, 447 Livadas, S. 313 Llanera, D. 307 Llauradó, G. 167, 691 Llobet, F. J. 414 Llobet-Navas, D. 414 Lluch, A. 12, 414 Lobanova, K. G. 391 Loche, S. 42 Lochnan, H. 436 Löffler, D. 405 Löfvenborg, J. E. 73, 241 Logan Ellis, H. 443 Loghin, C. 222, 427 Löhnert, M. 13 Lohse, Z. 17 Lombardo, M. T. 305 Long, A. E. 75 Long, S. A. 220 Longo, M. 126 Longuespee, R. 57 Looijmans-van den Akker, I. 525 López-Cano, C. 189 Lopez-Noriega, L. 206, 430 Lopez-Pascual, A. 11 Lorusso, S. 487 Lorza-Gil, E. 326 Loudovaris, T. 8 Loumaye, A. 251 Loureiro, L. M. 536 Løvaas, K. F. 29 Lowen, S. 550, 563 Löyttyniemi, E. 97, 356, 358 Lu, J. 510, 511, 514 Lu, J. 355 Lu, Q. 355 Lu, Y. 515 Luan, C. 323 Luciani, D. S. 104, 107 Ludvigsson, J. 242 Ludvik, B. 472 Ludwig, L. 309 Lui, D. T. W. 132 Luk, A. 66, 144, 675 Luk, C. T. 121 Lukomska, E. 574 Luna, A. 290 Lunati, M. E. 49, 555 Lund, A. 226 Lund, S. S. 489 Lundberg, T. P. 403 Luo, D. 460 Luong, T. V. 372 Lupo, L. G. 383 Lv, Y. 641 Ly, T. T. 550, 561, 563, 564 Lybaert, P. 332 Lyngfelt, L. 142 Lyssenko, V. 206 Ma, P. T. 544 Ma, R. C. W. 8, 66, 144, 675 Ma, X. 427 Ma, Y. 684 Maalmi, H. 43, 595 Maasen, K. 111 Mabunay, M. A. N. 506 MacCalman, A. 272 Macdougall, I. C. 685 Macedo, M. 415 Macedo, M. P. 79 Mach, F. 65 Machann, J. 38, 85, 113, 405 Machineni, S. 452 Mackenbach, J. D. 635 Macut, D. 313 Madaro, L. 374 Madec, A.-M. 397 Mader, A. 612, 658, 659, 662, 679, 701, 702 Mader, J. K. 508, 562 Madrolle, S. 554 Madsbad, S. 109, 114, 365, 387, 495 Madsen, C. M. 486 Madsen, P. L. 178 Maechler, M. 612, 658, 659, 662, 679, 701, 702 Maechler, P. 152, 154 Małecki, M. 343, 359 Małecki, M. T. 690 Magalhães, P. 572 Maganeva, I. 609 Magkos, F. 109, 114 Magnan, C. 339 Magnusson, L. 368 Magrill, J. 269 Mahaffey, K. W. 440, 441 Mahajan, A. 123 Mahapatra, A. 621 Mahmoud, E. A. 575 Mai, K. 83, 85, 279 Maina, J. G. 208 Mäkitie, O. 292 Makrilakis, K. 523 Maldonado, J. M. 5, 454 Maldonado, M. 50 Malek, R. 296, 666 Malhotra, A. 335 Malik, M. 589 Malik, R. 449, 456 Malm, T. 97, 356, 358 Malmström, H. 74 Malowicka, M. 574 Malysheva, N. 636 Man, C. D. 201 Mancilla, R. F. 169 Mancuso, J. P. 50, 438, 439 Mandatori, D. 270 Manenti, F. 305 Manesis, E. 667 Mangelis, A. 150, 570 Manjelievskaia, J. 449 Mann, P. A. 199 Mann, S. 150, 570 Manolakopoulos, S. 667 Mansour, W. 84 Manzoni, G. 650 Mao, D. 144 Mao, E. 594 Mao, H. 473, 474, 475 Marchetti, P. 7, 10 Marchlewicz, E. H. 449 Marciani, P. 103 Marés, R. 61 Margo Hengeveld, E. 65 Mari, A. 40, 90, 175, 375, 501 Marini, G. 42 Marinova, C. 673 Marku, A. 103, 120 Marmentini, C. 338 Marques, D. 389 Marques, O. 173 Marqués, P. 318 Marrano, N. 383, 469 Marre, M. 23, 207 Marroqui, L. 320, 329 Marselli, L. 7, 10 Martí, R. 189 Martin, J. A. 427 Martin, R. L. 488 Martin, S. 1 Martinez, J. 332 Martínez-López, J. A. 11 Martinez-Sanchez, A. 304 Martinho, M. 275 Martin-Nuñez, G. M. 45 Martín-Romo, I. 553 Martinussen, C. 387 Martola, J. 164, 645, 655 Marton, L. 437 Marx, N. 199 Marx, U. 368 Mascardi, C. 49 Masiukiewicz, U. 50 Masó, S. 322 Massari, G. 49 Mastrototaro, L. 88, 101, 629 Masuda, S. 618 Matafome, P. 389 Matejko, B. 343, 359 Mateva, L. 673 Mathiesen, E. R. 16, 295 Mathieu, C. 220, 346, 495, 497, 508, 543 Matoba, Y. 235 Matsubara, T. 599 Matsuhisa, M. 618 Mattern, Y. 394 Mattheus, M. 54, 489 Matthews, C. 218 Matthews, D. R. 336, 370 Matthiessen, K. S. 448 Mattila, I. 193 Mattila, M. 278 Mattis, K. K. 123 Maucotel, J. 380 Mauquoi, C. 505 Mauricio, D. 505 Maxwell, A. 243 Mayer, B. 261 Mayordomo, R. 341 Mazarico, I. 167 Mazur, K. 690 Mazur, M. 218 Mazzetti, S. 674 McCarthy, O. M. 357, 683 McCrimmon, R. J. 212 McDonald, T. J. 15, 245 McEwan, P. 488 McGuiness, C. B. 299 McGuire, D. K. 50, 52, 425, 438, 439 McGurnaghan, S. J. 77 McHugh, C. M. 402 McInnes, N. 434, 436 McKay, G. J. 243 McKeigue, P. M. 31, 69, 77 McKnight, A. 243 McMurray, J. J. V. 51 McQueen, R. B. 549 Mdala, I. 29 Medina, J. L. 79 Medina-Gali, R. 320, 329 Meek, C. L. 15, 350 Meex, S. J. R. 82 Mégret, C. 133 Mehmeti, I. 328 Meier, J. 260 Meier, J. J. 458 Meiffren, G. 133 Meincke, H. H. 477, 478 Meinicke, T. 54 Melander, O. 390 Melgaard, A. E. 557, 558 Melillo, D. 46 Mellor, J. 31 Melo, A. 275 Melson, E. 25 Melzer-Cohen, C. 445 Menchi, S. 119 Mendoza, L. 401 Mendoza, L. M. 12 Menduni, M. 35, 583, 598 Meneses, M. J. 79, 172, 415 Menezes, R. 381 Meng, R. 545 Menghini, R. 288 Mengozzi, A. 40 Mennini, F. S. 91, 614, 615 Menshikov, M. Y. 665 Mentxaka, J. 12 Menzaghi, C. 288 Meritsi, A. 667 Mertens, J. 364 Mertens, P. R. 230 Meschi, F. 305 Messaaoui, A. 27 Metra, M. 685 Meulebrouck, S. 207 Mevenkamp, J. 87, 366 Meyer, A. S. P. 21 Meyer, N. 85, 279 Meyers, J. 547 Mezza, T. 119, 337, 375 M. Huyett, L. 214 Michailidis, T. 491 Michalak, A. 360 Michalec, J. 354 Michalski, M. 360 Michel, S. 230 Miedziak, B. 461 Miele, C. 34, 126 Miftaraj, M. 70, 142, 198 Mihai, B. 512 Miki, T. 395 Mikulski, H. 657 Milani, P. 103 Milano, A. 687 Milicevic, Z. 222 Mill, J. 272 Minato, T. 599 Mingrone, G. 192 Mirani, M. 49 Mischak, H. 202, 572 Miskowiak, K. W. 114 Mitchell, B. 161 Mitchell, K. 568 Mithal, A. 140 Mitsuhashi, K. 496 Mitsui, Y. 618 Miura, J. 235 Miyabe, M. 599 Miyamoto, J. 395 Miyoshi, H. 585 Mizokami-Stout, K. 688 Moalem, B. 249 Mocciaro, G. 192 Mocherla, B. 692 Mody, R. 449 Moen, G.-H. 205 Moffa, S. 119, 337, 375 Moffett, C. R. 315, 465 Moffett, R. C. 184, 392 Moganti, K. 303 Mohamed, A. Z. 593 Mohamed, S. A. 149 Mohammed, S. 317 Mohan, S. 465 Mohan, V. 147, 212, 286 Moise, M. 512 Molchanova, N. 194 Molina-Andújar, A. 341 Moll, A. C. 533, 643, 646 Møller, A. 387 Møller, A. B. 374 Moller, A. 98, 102 Møller, N. 201, 204, 248, 432 Möllmann, J. 199 Molsted, S. 520 Monroy, G. 406 Montagud-Marrahi, E. 341 Montaigne, D. 174 Montanya, E. 322, 458, 480, 492 Montaser, H. 253, 254 Montedoro, A. 469 Montvida, O. 143 Monyak, J. 686 Moon, S. 319 Mooshage, C. 591 Morales-Villegas, E. C. 484 Moran, A. 569 Morano, C. 240 Morawska, M. 359 Mørch, C. D. 592, 597, 600 Moreira, P. I. 648 Morelli, M. 44 Moreno-Indias, I. 45 Moreno-Navarrete, J. M. 414 Morgado, A. 275 Morgan, N. G. 217, 219, 330 Morgan, S. B. 686 Morgenstern, J. 400 Moritz, T. 378 Moritz, W. 361 Morpurgo, P. S. 49, 555 Morsi, M. 399 Mortara, A. 650, 674 Mörth, E. 72, 266 Moscatelli, A. 598 Mosenzon, O. 65, 180, 231, 455, 492 Moshoyianni, H. 667 Mosnier Pudar, H. 538 Mostafa, S. 567 Mouritzen, M. V. 194 Moyers, J. S. 221, 502 Mramba, L. K. 278 Mráz, M. 566 Mrozińska, S. 359 Muckenthaler, M. U. 173, 623, 664 Müdder, K. 623 Mueller, K. 137 Mueller-Hoffmann, W. 137 Muendlein, A. 612, 658, 659, 662, 679, 701, 702 Mulder, H. 306, 323, 325, 378 Müller-Wieland, D. 505 Multani, J. K. 299 Munro, L. 568 Muraca, E. 93, 650 Murata, T. 235 Murdoch, C. E. 413 Murphy, H. R. 15, 350 Murthy, N. 649 Musale, V. 413 Musharraf, A. 537 Musquera, M. 341 Mutschlechner, B. 612, 658, 659, 662, 679, 701, 702 Mutter, S. 244, 616, 620 Nabec, L. 538 Nadal, A. 320 Nagai, S. 585 Nagorny Holmberg, C. 310 Nahar, A. 567 Nair, A. 140 Nair, K. S. 569 Nair, S. 307 Nair, V. 210 Nakamura, A. 585 Nakamura, N. 599 Nakanga, W. 281 Nakasatien, S. 293 Nakasone, Y. 287 Nandakumar, G. 264 Nandi Jui, B. 408 Nangia, C. 147 Nannsen, A. 639 Napoli, N. 168 Narayanan, R. 307 Narendran, P. 25, 559 Naruse, K. 599 Nascimento, E. B. M. 174 Nash, K. 25 Nasrallah, F. 593 Natali, A. 40 Natalicchio, A. 383, 469, 534, 687 Nauck, M. A. 211 Naujok, O. 328 Navarro, H. 691 Navarro-González, J. F. 91, 614, 615 Navez, B. 251 Navis, G. 95 Nawroth, P. P. 55, 57, 166, 183, 230, 291, 400, 591, 605, 623, 664 Nedelec, E. 380 Neeland, I. J. 112 Negueruela, J. 332, 379 Neinast, M. 39 Nemec, M. 99 Nepom, G. T. 220 Nerild, H. H. 177, 422 Nerstedt, A. 126 Nesti, L. 40 Neutel, J. 112 Neves, J. 697 Newman, C. 402 Newsome, P. N. 190 Nexøe-Larsen, C. C. 177 Nguyen, C. 544 Nguyen, H. T. 544 Nguyen, H.-T. 643 Nguyen, M. 237, 698 Nian, G. 515 Niazy, N. 371 Nicholas, L. M. 324 Nicolò, A. 34 Nicolucci, A. 138 Nielsen, C. B. 432 Nielsen, C. N. 494 Nielsen, O. W. 187 Nieminen, A. 254 Niemoeller, E. 515 Niess, A. M. 98 Nieuwdorp, M. 176 Nigi, L. 375 Nigro, C. 34 Niinistö, S. 278 Nikolic, A. 622, 624 Nikonova, T. 636 Nilsson, K. 26 Nilsson, M. S. D. 365 Nimgaonkar, A. 431 Ninov, N. 9, 363 Nirantharakumar, K. 78, 559, 654 Nirmalakumaran, A. 150, 570 Nirula, A. 692 Nishimura, K. 235 Nishimura, R. 92 Niskanen, L. 444, 445 Niswender, K. D. 499 Niwolik, I. 328 Nizza, J. 307 Nobels, F. 543, 578 Nøkleby, K. 29 Nolan, S. 91 Nomoto, H. 585 Noor, M. A. 464 Norata, D. 120 Nordqvist, A. 380 Nørgaard, K. 498, 516 Norouziyan Cooper, F. 221 Norris, J. M. 278 Norwood, P. 20 Noskov, M. 652 Noutsou, M. 667 Nouwen, A. 208 N.Tebeka, N. 317 Nummenmaa, L. 420 Nunes, M. 354 Nunes, S. 428, 603 Núñez, J. 445 Nurpeissova, A. 262 Nuutila, P. 420 Nwokolo, M. 259 Nybing, J. D. 365 Nyeng, P. 194 Nyirenda, M. 281 Nyström, T. 4, 444, 445 Oberhauser, L. 152 O'Brien, B. 334 O'Daly, O. 259 Odegard, J. 657 O'Farrell, L. 221 Ofori, J. K. 323 Oh, T. 53 O'Harte, F. P. M. 315 Ohlsson, M. 90 Ojala, R. 97, 356, 358 Ojha, T. 121 Ojo, O. O. 184 Okada, H. 496 Okada, S. 367 Okagawa, S. 418 Okubo, Y. 418 Okun, J. G. 183, 605 Olaniru, O. 255 Olazagoitia-Garmendia, A. 12 Olivan, M. 414 Oliveira, A. 697 Oliver, N. 137, 562 Olsen, T. 82 Oltean, S. 131 Omnipod 5 Research Group 561, 564 Omori, K. 585 Onishi, Y. 20 Ooi, C. 579 Ooi, E. 25 Oost, L. J. 209 Opperhuizen, A. 111 Opsahl, J. O. 205 Oral, T. K. 477 Oram, R. A. 15, 245 O'Reilly, J. E. 69, 77 Orioli, L. 251 Ortega, F. J. 12, 414 Ortiz Mellet, C. 604 Ortiz-Zúñiga, A. 582, 644 Osaki, A. 367 Osokina, A. 652 Osté, M. C. J. 95 Osterhoff, M. A. 113 Otoda, T. 618 Otonkoski, T. 106, 253, 254, 332 Ott, C. 203, 490 Otto, R. 434 Ouwens, D. M. 371 Overgaard, J. 494 Owen, G. 651 Owen, K. 226 Owens, D. R. 238, 289 Owens, N. D. L. 272 Ozaki, R. 66 Özkabakçı, S. 678 Pace, C. 49 Padilla, M. 219 Padma Jeya, S. S. 301 Pafili, K. 88 Pais, P. 699 Pais-de-Barros, J.-P. 171 Pařízek, A. 566 Pakseresht, A. 19, 453 Pal, S. 332 Palacios-Marin, I. 419 Palanca, A. 497 Paldánius, P. M. 292, 336, 370 Palm, E. 106 Palmeira, C. M. 428 Palmer, C. N. A. 147, 286 Pandey, A. 227, 385 Pandolfi, A. 270 Pané, A. 341 Pang, C. 530 Pang, W. 515 Pankaj, L. 579 Panthu, B. 397 Paparodis, R. D. 313 Parajuli, A. 218 Parchimowicz, M. 360 Pardo, F. 497 Pare, G. 158 Paredes, S. 275 Parente, E. B. 616, 620 Parikh, H. 278 Pariz, C. G. 533 Park, A. 460 Park, E. 191, 412, 668 Park, K. 319 Park, S. 273 Park, S. 669, 670 Parker, V. 460 Paroni, R. 240 Parravano, M. C. 35 Parra-Vargas, M. 419 Parrillo, L. 126 Parvaresh Rizi, E. 688 Parving, H.-H. 516 Pasricha, P. J. 431 Pastorino, M. 126 Pasula, D. J. 104, 107 Patarrão, R. 79 Patel, A. 277 Patel, D. 692 Patel, H. 20, 471 Patera, P. I. 35 Patrício, B. 79, 192 Patrone, C. 4 Pattanaik, S. 621 Paul, S. K. 143, 464 Paun, B. 61 Pavo, I. 90, 206 Pearson, E. R. 90, 175, 206, 286 Pedersen, B. K. 398 Pedersen, M. H. 295 Pedersen, M. G. B. 372, 432 Pedersen, S. B. 201, 204, 374 Pedersen, S. D. 19, 477, 478 Pedersen-Bjergaard, U. 257, 258, 516, 517, 519, 521 Peijs, L. 398 Pekkarinen, L. 420 Pektasidis, D. 667 Peleshok, J. 435 Pellegrini, S. 305 Pellitero, S. 189 Penfornis, A. 551 Peng, X. 118 Pepe, A. 598 Perea, V. 345 Perego, C. 103, 120 Pereira, C. 275 Pereira, M. J. 125, 228, 408, 421 Pérez Manghi, F. 22 Perez-Nieves, M. 161, 549 Perez-Serna, A. A. 329 Perfetto, C. 34, 46 Perkovic, V. 441 Perlman, J. E. 547 Permyakova, A. 249 Perra, S. 650 Perreault, L. 19, 452, 453 Perrier, J. 397 Perrin, E. 112 Perrini, S. 383, 469, 534, 687 Perry, R. 388 Persaud, S. J. 255, 316, 327 Perseghin, G. 93, 650, 674, 680 Persson, F. 6, 94, 202, 606 Persson, S. 26 Pesta, D. 88, 101, 629 Peter, A. 98, 102, 382, 405 Peter, B. 199 Peters, A. 595 Peters, H. P. F. 87 Petersen, E. 60 Petersen, G. B. 162 Petersen, J. 431 Petit, J.-M. 407 Petkovic, M. 194 Petrelli, A. 44 Petrohoy, T. 476 Petrone, M. 476 Petrosyan, S. 652 Pettus, J. 508 Pfeiffer, A. F. H. 85, 113, 279 Phielix, E. 39, 174 Philis-Tsimikas, A. 482 Phillips, A. 567 Picard, A. 386 Picard, P. 212 Piccoli, A. 168 Picconi, F. 35, 598 Picot, M. 380 Pieber, T. R. 321, 557, 558 Pieczykolan, J. 461 Piemonti, L. 305 Pieter, D. C. 86 Pietiläinen, K. H. 97, 356, 358 Pietschner, R. 203 Pigeyre, M. 158 Pigny, P. 76 Pik-Shan Kong, A. 675 Pilorget, V. 506 Pina, A. F. 79 Pinchuk, A. 609 Ping, F. 284 Ping, L. 515 Pintado, M. M. 428 Pinto, S. 698 Piras de Oliveira, C. 507 Pirog, A. 117, 339 Piron, A. 7 Pitt, J. P. 357, 683 Pizza, G. 304 Planas Vilaseca, A. 661 Plebani, L. 555 Pletsch-Borba, L. 85, 279 Pliouta, L. 565, 660 Plum-Mörschel, L. 504, 510, 511, 514, 557, 558 Podkuychenko, N. V. 665 Poglitsch, M. 490 Pohrt, A. 85, 279 Polák, J. 354 Polemiti, E. 312 Polomoscanik, S. 431 Polonsky, W. H. 24 Pomares-Millan, H. 67, 90 Pong, A. 50, 425, 439 Ponikowski, P. 685 Pons Bartroli, A. 582 Poon, J.-L. 161 Poonprasartporn, A. 362 Popa, M. 379 Pop-Busui, R. 688 Popov, D. 673 Poth, T. 183, 400 Pou, S. 554 Poulletier de Gannes, F. 339 Poveda, A. 67 Power, A. 91, 614, 615 Pozzilli, P. 168 Pozzoli, M. 650 Prada, J. 151 Prager, G. 72, 266 Prakash, B. 627 Prasad, M. 700 Prasad, R. B. 205, 271, 378 Prasanna Kumar, K. M. 140 Pratley, R. 23, 481, 485 Pratley, R. E. 50, 52, 425, 438, 439, 458, 467 Prazny, M. 633 Preguiça, I. 428, 603 Preissl, H. 38 Prentza, V. 565, 660 Preuß, K. 371 Prévost, G. 380 Price, H. 23 Priest, C. 324 Prietl, B. 321 Prokopenko, I. 208 Prusty, P. 573 Prybyla, O. V. 634 Prystupa, K. 225, 382 Przemeck, G. K. H. 326 Psefteli, P.-M. 611 Puginier, E. 339 Punthakee, Z. 436 Puri, P. L. 374 Putaala, J. 164, 302, 645, 655 Puttanna, A. 656 Pützer, J. 88 Pyke, C. 494 Pylypchuk, R. 62 Qi, L. 80 Qian, C. 503 Qian, Y. 463 Qiu, H. 47 Qiu, R. 173, 623 Qu, H. 221 Qu, Y. 238 Quéniat, G. 207 Quero, G. 119 Quezada, E. 108 Quinlan, T. 427 Quinn, L. M. 559 Quinn, M. T. 524 Qureshi, Z. 307 Qvigstad, E. 14, 205 Qvist, K. 194 Rabasa-Lhoret, R. 434 Rabbani, N. 632 Raciti, G. A. 126 Radha, V. 147 Rafferty, J. M. 238, 289 Ragimov, M. 636 Raha, S. 5, 435, 454, 456, 699 Rahelic, D. 354 Raiko, J. 174 Raimundo, A. F. 381 Rajadhyaksha, V. 296 Rajamand Ekberg, N. 447 Rajan, R. 621 Rajan, S. 486 Rajeev, S. 307 Raji, A. 438 Rajnai, L. 647, 663 Rajzer, M. 690 Ramallo Fariña, Y. 535 Rämgård, M. 310 Rami-Merhar, B. 233 Ramon, J. 691 Ramon-Krauel, M. 419 Randeva, H. 537, 649 Ranjan, A. G. 498 Ranta, K. T. 454 Rao-Melacini, P. 5 Raouf, T. 305 Raoux, M. 117, 339 Raposo, J. F. 79 Rapti, S. 667 Raptis, A. 660 Rashu, E. B. 365 Rasmussen, A. 193 Rasmussen, I. K. B. 188, 232 Rasmussen, S. 6, 21, 180, 486 Rasouli, B. 282 Rathmann, W. 43, 595, 695 Ratter, J. M. 43 Ratziu, V. 676 Ratzki-Leewing, A. 694 Rautureau, G. 397 Ravier, M. A. 153 Ray, C. J. 78, 654 Raychaudhuri, A. 128 Rayman, G. 424 Rayner, C. K. 324 Raza, S. 651 Reach, G. 538 Real, J. 497 Rebec, M. 546 Rebelos, E. 420 Rebrin, K. 544 Recio-López, P. 182 Redling, K. 349 Refsum, H. 82 Regazzi, R. 256 Regmi, A. 221 Rehfeld, J. F. 177 Reichardt, B. 72, 266 Reicher, B. 686 Reid, H. 457 Reid, T. 213 Reina Do Fundo, M. 629 Reis, F. 428, 603 Reis-Costa, A. 172 Remen, T. 309 Remmelzwaal, S. 285 Ren, H. 118 Renard, E. 137 Renaud, S. 117, 339 Rendon, A. 190 Rengarajan, L. 25 Renuse, S. 227, 385 Ress, C. 629 Retat, L. 91 Reyes, K. 112 Riahi, Y. 231, 377 Ribas-Aulinas, F. 419 Ribeiro, R. T. 79 Ricciardi, C. 130 Richardson, S. J. 217, 219, 330 Rieger, C. 137 Rieusset, J. 397 Riffelmann, N.-K. 622, 624 Rigoldi, C. 240 Rijnhart, J. J. M. 635 Ringemann, C. 657 Ringqvist, E. E. 218 Rinne, J. O. 97, 356, 358 Ripa, R. S. 188, 587 Risovic, I. 459 Rittig, N. 423, 432 Rivas, M. 36 Riveline, J.-P. 672 Rivera, K. 322 Rix, I. 226 Różańska, O. 360 Robbins, T. 649 Roberts, B. K. 136 Robertson, D. 460 Robinson, M. 334 Robinson, S. 342 Roca, D. 345 Roca-Rodriguez, M. M. 45 Rodemer, C. 183 Roden, M. 43, 56, 88, 101, 225, 595, 629, 681 Rodewald, K. 548 Rodrigues, R. B. 643 Rodríguez, Á. 20, 426, 470, 471, 472 Rodríguez-Barrueco, R. 414 Rodriguez Sanchez-Archidona, A. 186 Rodriguez-Trejo, A. 256 Roeikjer, J. 592 Roell, W. 221 Rogowicz-Frontczak, A. 637 Röhling, M. 1 Røikjer, J. 597, 600 Roitelman, J. 231 Rojano, A. 61 Rojano Toimil, A. 644 Rojas-Márquez, H. 12 Roland, M.-C. P. 14 Rolando, D. 304 Rolo, A. P. 428 Romeres, D. 41, 247, 396 Romero, A. 167 Romero-Ugalde, H. 554 Rönkkö, T. K. E. 202 Rönnemaa, T. 420 Rorsman, P. 116 Rosa, H. 327 Rosano, G. 685 Rosendo-Silva, D. 389 Rosenkilde, M. M. 179, 387 Rosenlund, S. 492 Rosenstock, J. 19, 22, 135, 180, 212, 474, 480, 484 Rosicky, I. 348, 349, 681 Rosov, A. 493 Ross, M. 493 Rossello, F. 332 Rossi, A. 555 Rossi, E. 534 Rossi, G. 305 Rossi, M. C. 138 Rossing, P. 6, 51, 94, 188, 193, 202, 232, 572, 587, 606, 617 Rossmeislová, L. 640 Rosso, C. 192, 676 Rotbain Curovic, V. 572 Rothner, A. 231 Rottiers, P. 220 Roula, D. 666 Rouland, A. 407 Roumans, K. H. M. 87, 433 Roushdy, E. 296 Roussel, R. 207 Roy, R. 700 Royo Serrando, J. 582 Rozendaal, L. 525 Ruban Agarvas, A. 664 Rubino, D. M. 477, 478, 479 Ruchi, R. 227, 385, 396 Rudofsky, G. 447 Rudzki, P. J. 223 Rufer, C. 361 Ruggiero, E. 44 Ruiz, M. 341 Ruiz, S. 341 Rungby, J. 114, 365 Ruschitzka, F. 685 Russell, M. A. 217, 330 Russo, B. 35, 598 Rustenbeck, I. 156, 399 Rutter, G. A. 206, 304, 430, 467 Rutters, F. 2, 285 Ruwaard, D. 263 Ryabov, V. 303 Ryan, B. L. 694 Ryan, C. 598 Ryan, D. H. 477, 478 Rydén, L. 5 Ryder, R. E. J. 424, 457, 568 Saadat, A. 306 Saarimäki-Vire, J. 253, 254 Sabatini, S. 676 Sabo, J. 692 Saboo, B. 540 Saboo, S. 540 Sabrautzki, S. 326 Saely, C. H. 612, 658, 659, 662, 679, 701, 702 Sáenz de Navarrete, G. 406 Safavimanesh, F. 232 Saibene, A. 44 Saiki, T. 599 Saito, T. 367 Saito-Aoki, H. 367 Sajadieh, A. 187, 588 Sakaguchi, M. 418 Sakamoto, Y. 92 Sakane, N. 235 Sakko, Y. 262 Salamon, C. 348 Salas, E. 290 Salli, E. 645 Salowska, A. 304 Salvatore, S. 314 Salvemini, L. 288 Samaniego, J. 582 Samkani, A. 109, 114 Samsonov, M. V. 665 Sánchez, E. 189, 290 Sanchez, G. 151 Sanchez, J. 476 Sanchez, J. J. G. 615 Sanchez-Fernandez, E. M. 604 Sandahl, T. D. 423 Sandbaek, A. 639 Sandberg, S. 29 Sandholm, N. 32, 127, 164, 210, 243, 302 Sango, K. 599 Sankar, S. 537 Santarpino, G. 687 Santin, I. 12 Santos, D. 195 Santos, J. 334 Sarabhai, T. 88 Saraf, S. 656 Sarria-Santamera, A. 262 Sarsenbayeva, A. 408, 421 Sathyapalan, T. 446 Sattar, N. 110 Sauerborn, R. 529 Sauque-Reyna, L. 212 Scarale, M. 288 Schaart, G. 174 Schaarup, J. F. R. 63 Schade, A. 692 Schaefer, C. 524 Schaffner, S. 18 Schalkwijk, C. G. 82, 86, 111, 280, 393, 628 Schaper, N. C. 86 Scharfmann, R. 207 Schattenberg, J. M. 676 Scheijen, J. L. J. 393, 628 Schell, M. 369 Scherneck, S. 351, 353 Scheyer, N. 309 Schiavon, M. 227, 385, 429, 569 Schiffer, M. 203 Schimpfle, L. 591 Schipani, R. 687 Schlensak, M. 88 Schloot, N. C. 43 Schlotterer, A. 623 Schmid, S. M. 261 Schmidt, S. 498 Schmieder, R. E. 203, 490 Schneeweiss, P. 98 Schneider, M. 1 Scholten, B. J. V. 587 Schon, M. 99 Schram, M. T. 86, 111, 280 Schrauwen, P. 39, 87, 169, 174, 246, 366, 433 Schrauwen-Hinderling, V. B. 39, 87, 169, 174, 366 Schultes, B. 446 Schultz, A. 677 Schulze, M. B. 312 Schumann, M. 355 Schwarz, D. 57 Scognamiglio, F. 34 Scorletti, E. 671 Scott, S. 357 Scotti, G. M. 44 Scottish Diabetes Research Network (SDRN) Epidemiology Group 77, 145 SDRNT1BIO Investigators 31 Sebastián-delaCruz, M. 12 Sebastiani, G. 333, 375 Sebert, S. 274 Sedliak, M. 99 Seghieri, M. 40 Segin, V. 586 Seguí, N. 345 Seiça, R. 389 Sejling, A.-S. 190 Selig, J. I. 371 Sellier, N. 698 Selmer, C. 442 Selvais, C. 185 Selvarajah, D. 58, 59, 596, 601 Semaan, C. 64, 239 Semenova, J. F. 159, 630 Sen Gupta, P. 568 Senior, P. 509 Seno, Y. 500 Sentinelli, F. 42 SENZA-PDN Investigators 60 Seppälä, M. 619 Serdarova, M. 673 Serhiyenko, A. 586 Serhiyenko, L. 586 Serhiyenko, V. 586 Serné, E. 522 Seroussi, C. 133 Serra, D. 419 Serti, E. 220 Servera, S. 501 Sethi, B. 140 Sethi, J. K. 671 Settles, J. 299 Seufert, J. 261, 440, 483, 568 Severina, A. 609 Shaat, N. 311 Shah, N. 567 Shah, V. N. 549 Shahzad, K. 230 Shallan, A. 324 Shamanna, P. 464 Shamkhalova, M. 609 Shams, S. 645 Shankar, A. 590 Shankar Chandramouli, A. 268 Sharma, A. 602 Sharma, D. 307 Shaw, A. C. 245 Shaw, J. 165 Shaw, J. A. M. 245 Shaw, V. C. 656 Shen, L. 692 Sheng, X. 210 Shepherd, M. H. 160 Sherifali, D. 434, 436 Shestakova, M. V. 609, 636, 665 Shi, B. 118 Shi, J. 47 Shi, M. 144 Shi, M. 229, 352, 626 Shi, R. 104 Shields, B. 281 Shiers, D. 531 Shih, A. Z. L. 104 Shih, W. J. 50, 52, 425, 438, 439 Shillo, P. 58, 59 Shimada, A. 235 Shimizu, H. 607 Shimizu, T. 367 Shimoda, Y. 367 Shimomura, I. 19 Shimshilashvili, A. 3 Shirinsky, V. P. 665 Shon, H.-S. 297 Shoo, H. 307 Showalter, A. D. 221 Shumliakivska, M. 270 Shuprovich, A. A. 634 Shurzinske, L. 5 Siah, Q. 602 Sibayan, J. 233 Siddiqi, N. 531 Siddiqui, S. 524 Sigal, R. J. 434, 436 Signorile, A. 383 Silk, R. 33 Silva, J. M. 414 Silva, L. D. 9 Silva, M. 381 Silva de Carvalho, T. 394 Silver, R. 135 Simanenkova, A. 3 Šimják, P. 566 Simmons, D. 401 Simó, A. 290 Simó, R. 36, 61, 189, 290, 582, 644, 661 Simões, F. 389 Simó-Servat, A. 36 Simó-Servat, O. 36, 61, 644, 661 Simpson, D. 33 Singh, I. 657 Singh, S. P. 9 Singh, T. 271 Singh-Manoux, A. 141 Sinha, A. 621 Sioofy-Khojine, A.-B. 298 Siow, R. 611 Sivalingam, S. 587 Sivappriyan, S. 457 Skakkebæk, A. 17 Skogsberg, J. 26 Skovronsky, D. 692 Skrha, J. 633 Skrha jr., J. 633 Skrtic, S. 125 Skulachev, M. V. 665 Skytte, M. J. 109, 114 Sletner, L. 205 Slieker, R. C. 206, 209 Sloan, G. 58, 59, 601 Slobodova, L. 99 Sloop, K. W. 221 Smallman, M. 683 Smietana, I. S. 403 Smith, A. 434, 436 Smith, M. P. 84 Smith, U. 126 Smyth, L. J. 243 Snoek, F. J. 161, 522, 533, 536, 643, 646 Snogdal, L. S. 403 So, W. 66 Soares, G. M. 100, 338 Sobel, J. 256 Socci, C. 44 Soerensen, M. H. 178 Solimena, M. 108, 115 Somers, A. G. E. 525 Sommer, C. 205 Sommer Matthiessen, K. 268 Somodi, S. 647, 663 Søndergaard, A. L. 23, 481, 482, 483 Søndergaard, E. 201, 204, 372, 432, 520 Søndergaard Heinrich, N. 232 Sone, H. 581 Song, J. 352 Sönmez, A. 115 Sonne, D. P. 177, 422 Soran, H. 48, 252 Sordi, V. 305 Sørensen, A. E. 8 Sørensen, S. K. 257 Söreskog, E. 444 Sørgjerd, E. P. 282 Sorice, G. P. 375 Sork, H. 218 Soto, A. 189 Souares, A. 529 Souhami, E. 515 Soukhacheva, G. 107 Soula, O. 133 Sourris, K. C. 165 Sowinska, A. 461 Spallone, V. 583 Spanjaard, B. 9 Specht, K. S. 627 Spégel, P. 378 Spigoni, V. 487 Spinelli, R. 126 Spira, D. 279 Spranger, J. 83, 85, 279 Spranger, L. 83 Sprenger, L. 612, 658, 659, 662, 679, 701, 702 Spyer, G. 160 Sridhar, A. 184, 392 Srinivasan, S. 147 Staab, E. M. 524 Staels, B. 174 Stafeev, I. S. 665 Stamm, T. 72, 266 Stedman, M. 265 Steen Carlsson, K. 26 Stefan, N. 225, 312 Stefansson, B. V. 51 Stehouwer, C. D. A. 82, 86, 111, 141, 280, 393 Steidler, L. 220 Steintorsdottir, S. D. 14 Stengel, R. 568 Stensen, S. 179 Stettler, C. 260 Steubl, D. 54 Stevens, M. 131 Stevns Hansen, C. 232 Stewart, Z. A. 350 Stichling, S. 13, 308 Stienstra, R. 163, 517, 613 Stistrup Lauritzen, E. 248 Stitt, A. 33 Stobäus, N. 83 Stoll, L. 256 Stoll, M. 560 Stolovich-Rain, M. 269 Stone, V. M. 298 Stopczyńska-Szymecka, M. 360 Storkey, A. 31 Størling, J. 232, 494 Støy, J. 248 Strassburger, K. 88, 101 Straßburger, K. 43, 56 Stratmann, B. 394, 580 Strelitz, J. 264 Strempler, M.-E. 677 Striepe, K. 490 Strollo, R. 168 Strom, A. 56 Struijs, J. N. 263 Strumph, P. 625 Styger, N. 260 Su, Q. 181 Suades, R. 270 Subramanian, A. 78, 654 Subtil, D. 404 Sulaj, A. 605 Suleiman, M. 7, 10 Sultan, A. A. 614 Sultan, F. 434, 436 Sumin, A. 652 Sun, B. 200 Sun, C. 376 Sun, J. 340 Sun, J. 323 Sun, X. 47, 594, 684 Sun, Z. 417 Surowiec, P. 343 Susztak, K. 210 Suvitaival, T. 193, 617 Svane, M. S. 387 Svare, J. A. 295 Svedbo Engström, M. 539 Svennblad, B. 267 Svensson, A.-M. 4, 70, 142, 198 Svensson, M. K. 125 Swedberg, K. 686 Swinhoe, K. 537 Syed, A. 48, 252 Sykes, L. 342 Syreeni, A. 164, 243, 244 Syring, K. 556 Szabo, M. I. M. 437 Szalanska, M. 574 Szőcs, Á. 437 Szendrödi, J. 43, 56, 57, 101, 166, 170, 183, 225, 291, 400, 591, 605 Szopa, M. 693 't Hart, L. M. 206 Tabák, A. G. 63, 589 Tack, C. J. 163, 209, 517, 613 Tahbaz, A. 692 Tahrani, A. A. 78, 453, 654 Tait, J. 530 Takeuchi, J. 585 Takhlidjt, S. 380 Takiishi, T. 333 Talbäck, M. 74 Tam, J. 231, 249 Tam, Y. 269 Tan, D. 229, 352 Tan, H. 411 Tan, M. 342 Tanaka, T. 496 Tan-Chen, S. 171 Tandon, N. 277 Tandy, N. 315 Tang, C. 118 Tang, M. 107 Tang, Y. 105, 331 Tangri, N. 91, 314, 614, 615 Taniwall, A. 354 Tankova, T. 673 Tanti, J.-F. 46 Tao, H. 503 Taşöz, E. 363 Tarasov, A. 362 Tarasov, A. I. 116 Tares, J. 149 Targher, G. 671 Tariq, M. 446, 447 Tarnow, L. 516 Tatlisumak, T. 164, 645, 655 Taub, P. R. 682 Tavares, G. 389 Tavares, L. C. 172, 415 Taylor, G. S. 245 Taylor, J. 531 Taylor, R. 41, 110 TEDDY Study Group 278 Tedeschi, G. 103 Teh, K. 58, 596, 601 Tehranchi, R. 557, 558 Teleman, A. 605 Téllez, N. 322 Tencerova, M. 627 Ten Kulve, J. 176 Tenoutasse, S. 27 Tentolouris, A. 523 Teodoro, J. S. 428 Terlecki, M. 690 Ternynck, C. 404 Terron Exposito, R. 116 Terulla, A. 44 Tesfaye, S. 58, 59, 596, 601 Tesi, M. 7, 10 Tesic, D. S. 696 Teska-Kaminska, M. 461 Thacker, H. 140 Thadani, P. 537 Thakarakkattil Narayanan Nair, A. 286 Thamilselvan, V. 155 Thankamony, A. 233 Thanopoulou, A. 667 Theilade, S. 94, 193 The Maastricht Study 141 Thennati, R. 467 Theotokas, I. 667 Thewjitcharon, Y. 293 Thiele, R. 291 Thienel, F. 562 Thieu, V. T. 473, 474, 475 Thissen, J.-P. 251 Thivolet, C. 397 Thomaides-Brears, H. 89 Thomas, E. 90 Thomas, H. E. 8 Thomas, L. 25 Thomas, M. K. 222, 473 Thomas, R. L. 238, 289 Thomas, S. M. 150, 570 Thomsen, H. S. 109 Thomsen, M. N. 109, 114 Thorand, B. 595 Thorens, B. 186, 386, 467 Thorn, L. M. 164, 302, 616, 619, 645, 655 Thornalley, P. 632 Thorning, T. K. 468 Thorsteinsson, B. 519 Threlkeld, R. 556 Thymis, J. 565, 660 Tian, J. 355 Tibballs, K. L. 139 Tikkanen-Dolenc, H. 283, 619 Timkina, N. 3 Timofeeva, V. 3 Tinahones, F. J. 45, 189 Tirosh, A. 506 Tirosh, B. 377 Tirpakova, V. 99 Tittel, S. R. 261 Tiwari, V. 33 T. Ly, T. 214 Tůma, P. 640 Toczyska, K. W. 327 Todorcevic, M. 81 Toffolo, G. M. 569 Tofte, N. 94 Tomas, A. 304 Tomic, M. D. 696 Tomic, M. T. 696 Tong, Z. 470 Torchio, S. 305 Tore, E. C. 82 Toresson Grip, E. 444 Torkko, J. M. 115 Tornovsky-Babeay, S. 377 Torres, J. M. 123 Tota, Ł. 359 Toto, R. 51 Tourki, Y. 551, 552, 554 Toyoda, M. 235 Tramontana, F. 168 Tran, N. Q. 544 Tran, P. 649 Trenkamp, S. 43, 225 Trescoli, C. 212 Trevisan, M. 49 Trevisan, R. 93 Trevisi, G. 240 Trico, D. 40 Tripyla, A. 96, 260 Trischitta, V. 288 Trolle, C. 17 Trošt, K. 193 Tsapas, A. 148, 491, 689 Tschoepe, D. 394, 580 Tsepokina, A. 652 Tsilingiris, D. 523, 591 Tsitsopoulos, E. 667 Tsoi, T. F. 293 Tsorlalis, I. 667 Tundidor, D. 345 Tuomela, S. 218 Tuomi, T. 241, 282 Tuovinen, M. 444 Tura, A. 348, 681 Turčáni, P. 99 Tushuizen, M. E. 190 Tweden, K. S. 236 Uhles, S. 462 Uhrmacher, E. 510 Ukropcová, B. 99 Ukropec, J. 99 Ullrich, S. 326 Unnikrishnan, A. G. 140 Upadhyaya, S. 567 Urbanová, J. 354 Urva, S. 221, 222, 427 Ustinov, J. 254 Ustyugova, A. 444 Ustyuzhanina, A. O. 294 Utsunomiya, K. 92 Uusitalo, U. 278 Vääräsmäki, M. 274 Vähäkangas, E. 254 Vaisid, T. 231 Vale, C. 697 Valensi, P. 237, 698 Valkovič, P. 99 Valla, D. 672 Valladolid-Acebes, I. 182 Valldeperas, X. 36 Valo, E. 127, 616, 620 Vambergue, A. 76, 404 Van, J. 435 van Ballegooijen, A. J. 2 van Berkel, M. 209 van Bloemendaal, L. 176 Van Bommel, G. 493 van Dam, A. 81 Vandenbempt, V. 332, 379 van den Berg, K. 522 van der Heijden, A. A. W. 2, 209, 285 van der Kallen, C. J. H. 82, 86 Vanderkruk, B. 104 van der Meer, P. 685 van de Waarenburg, M. P. H. 628 van de Weijer, T. 39, 174 van Dongen, M. C. J. 86 van Duinkerken, E. 533, 643, 646 Vang, S. 17 van Gennip, A. C. E. 141 van Greevenbroek, M. M. J. 82, 86, 111, 280 van Hall, G. 226 van Heck, J. I. P. 163, 613 Vanherwegen, A.-S. 578 Van Huffel, L. 543 Van Huynegem, K. 220 van Nes, F. 346, 497 van Netten, J. J. 577 van Oostenbrugge, R. J. 628 van Poppel, M. N. M. 401 van Raalte, D. 522 Van Ruiten, C. C. 176 van Sloten, T. T. 141 van Tilburg, C. 263 van Weeghel, M. 246 Vanweert, F. 39, 174 vanZuydam, N. 210 Varbo, A. 452 Vargas-Uricoechea, H. 506 Vart, P. 51 Vasiljevic, J. 108 Vasques-Nóvoa, F. 697 Vasudevan, R. S. 682 Vedin, O. 489 Vedtofte, L. 295 Veelen, A. 433 Veeraiah, P. 87 Veit, R. 38 Vejlstrup, N. 178 Vekeriotaite, B. 332 Velasquez, M. 61 Vella, A. 201 Velloso, L. A. 338 Veltman, D. 176 Vendrell, J. 167 Venkataraman, K. 593 Ventura-Aguiar, P. 341 Veprik, A. 317 Verbraak, F. D. 643 Verchere, B. C. 107 Vergès, B. 407 Verhulst, C. E. M. 517, 521 Verma, S. 268, 479, 486 Vermeiren, J. 220 Vermeulen, E. A. 209, 635 Vervloet, M. G. 635 Vestergaard, P. 68, 71 Viana, S. D. 428, 603 Vidal, M. 345 Vidal Trecan, T. 672 Vieira, M. 431 Vieira, M. 275 Vieira, P. 603 Vienneau, T. 214, 550, 563 Viggers, R. 71 Vihinen, H. 253 Vilallonga, R. 290 Vilarrasa, N. 290 Vilén, L. 368 Viljoen, A. 19, 453 Villadsen, G. E. 423 Villeneuve, E. 552 Vilsbøll, T. 37, 177, 179, 226, 257, 258, 295, 422, 467, 486, 492, 494 Vilstrup, H. V. A. 365 Vinagre, I. 345 Vincenti, L. 383 Vinknes, K. 82 Vinter, C. A. 403 Viñuela, A. 90 Viola, V. 168 Violato, N. M. 333 Virtanen, S. M. 278 Visentin, R. 560 Vistisen, D. 63, 162, 589, 606 Vitale, C. 685 Vlasik, T. N. 665 Vlasov, T. 3 Voigt, J. H. 201, 204 Vokatý, E. 640 Volk, C. B. 502 Volk, N. 173, 400, 664 Volpi, G. 555 Vonbank, A. 612, 659, 662, 679, 701, 702 von Eynatten, M. 112 Vonghia, L. 364 von Hafe, M. 697 von Herrath, M. 495 von Scholten, B. J. 6, 188, 495 Vora, J. 431 Vorotnikov, A. V. 665 Vorum, H. 162 Vos, R. C. 525 Vosswinkel, S. 677 Vranic, M. 125, 421 Vuori, N. 32 Wada, Y. 500 Waddell, T. 89 Wadden, T. A. 19, 455 Wade, R. L. 299 Wadén, J. 619 Waechter, S. 685 Wägner, A. M. 535 Wagner, L. 508 Wagner, L. 38 Wagner, R. 225, 382 Waijer, S. W. 51 Wainscott, D. B. 221 Walker, E. M. 272 Walldius, G. 74 Wallenstein, S. O. R. 452 Wallett, L. 25 Walzem, R. L. 109 Wan, H. 451 Wan, W. 524 Wang, D. 513 Wang, H. 625 Wang, H. 411 Wang, J. 145 Wang, J. 284 Wang, J. 215 Wang, Q. 556 Wang, X. 355 Wang, X. 136 Wang, Y. 463 Wang, Z. W. 626 Wanner, C. 54, 489 Wanothayaroj, E. 293 Warburton, S. M. 124 Weaver, A. 227, 385 Webber, L. 614 Weber, D. 276 Weber, P. 588 Webers, C. A. B. 111, 280 Webster, L. 150, 570 Weersma, R. K. 163 Wefers, J. 246 Wei, B. 463 Wei, Y. 241 Weigert, C. 98, 102 Weimers, P. 180 Weinstock, R. S. 550, 563 Weir, M. R. 441 Weisshaupt, K. 348, 681 Wen, X. 411 Weng, X. 124 Wennberg Huldt, C. 368 Wernicke, C. 85, 279 Wernroth, M.-L. 267 Wesselius, A. 86 Wessman, P. 142 West, D. J. 245 Westenfeld, R. 371 Westenskow, P. 462 Westerink, J. 65 Wewer Albrechtsen, N. J. 119, 365 Wharton, S. 477, 478 Wheeler, D. C. 51, 441 Whetton, A. 48, 252 Whyte, M. 265, 443 Wiberg Larsson, H. B. 232 Wieczorek, M. 223, 461 Wiedeman, A. 220 Wieder, A. 170 Wienberg, M. 521 Wierts, R. 174 Wierup, N. 11 Wilbek Fabricius, T. 521 Wild, S. H. 145, 146 Wildberger, J. E. 174, 366 Wilding, J. P. H. 452 Wilinska, M. E. 96, 233 Wilk, M. 343, 690 Wilkins, L. 227 Wilkinson, I. D. 58, 59, 601 Wilkinson, M. J. 682 Wilkowski, D. 574 Willard, F. S. 221 Willmes, D. M. 369 Wilmington, R. 307 Wilson, I. V. 75 Wilson, M. 510, 511, 514 Winder, M. 332 Winhofer, Y. 548 Winter, H. R. 33 Winther, S. 94 Wish, J. 91, 614, 615 Witek, P. 690 Wittbrodt, E. 314 Witte, D. R. 63, 589 Wodschow, H. Z. 114 Wolf, P. 72, 266 Wolff, G. 170 Wollenhaupt, D. 211 Wolters, J. 211 Wolthers, B. 6 Wong, S. 307 Wong, W. K. M. 8 Woo, V. 434 Woo, Y. 132 Wood, R. 530 Woskova, V. 197 Wouters, K. 393 Wright, E. 213 Wright, J. 531 Wróbel, A. 343 Wu, H. 146 Wu, H. 144 Wu, K. 256 Wu, S. 118 Wu, T. 324, 417 Wu, W. 332 Wu, Y. 264 Wullenweber, P. 134, 216 Wyatt, R. C. 219 Wysham, C. 474 Xiao, P. 333, 379 Xu, A. 410 Xu, F. 451 Xu, G. 98 Xu, I. 682 Xu, L. 284 Xu, L. 200 Xu, L. 410 Xu, R. 625 Xu, R. 682 Xu, W. 518 Xu, Y. 352 Xue, F. 463 Xue, M. 200 Xue, M. 632 Yabe, D. 445 Yadav, G. 65 Yadav, R. 307 Yadav, Y. 227, 247, 385, 396 Yaguchi, Y. 581 Yale, J.-F. 436, 446 Yamada, E. 367 Yamada, M. 367, 607 Yamamoto, J. 350 Yamamoto, M. 581 Yamashita, K. 287 Yamazaki, M. 496 Yan, F. 411 Yan, X. 410 Yan, Y. 549, 556 Yang, A. 144 Yang, M. 219 Yang, N. 284 Yang, R. 410 Yang, X. 118 Yao, J. 513 Yao, W. 355 Ye, E. R. 530 Ye, T. 684 Ye, Z. 641 Yerlikaya-Schatten, G. 681 Yeroslaviz-Stolper, R. 377 Yesildag, B. 361 Yin, H. 451 Yıldız Şahin, Ş. 678 Ylinen, A. 302 Ylli, D. 35 Yokoyama, K. 92 Yoo, J. 610 Yoshida, S. 618 Yoshiji, S. 500 You, H. 682 Younes, R. 676 Yu, C. 342 Yu, G. Z. 123 Yu, M. 449, 471, 475 Yu, Y. 503 Yu, Y. 118 Yuan, W. 238 Yuasa, T. 618 Yuen, D. A. 121 Yurchenko, I. 225 Zabala, A. 4 Zagury, R. L. 112 Zaharia, O.-P. 43, 225 Zaïmia, N. 153 Zangerolamo, L. 338 Zaozerska, N. 686 Zargar, A. H. 140 Zarrouk, M. 198 Zatterale, F. 126 Zdravkovic, S. 310 Zee, B. 238, 289 Zeitz, U. 83 Zelaya, F. 259 Zemva, J. 166, 183 Zeniya, M. 92 Zerbini, F. 650, 680 Zermiani, P. 240 Zeuthen, N. 477, 478 Zhan, Y. 241 Zhang, B. 215 Zhang, C. 502 Zhang, E. 323 Zhang, H. 229, 352, 626 Zhang, H. 284 Zhang, J. 684 Zhang, J. 238 Zhang, J. 515 Zhang, L. 416 Zhang, M. 463 Zhang, Q. 134, 216 Zhang, Q. 116 Zhang, X. 451 Zhang, X. 352 Zhang, X. 393 Zhang, X. 395 Zhang, Y. 518 Zhang, Y. 376, 641 Zhang, Y. 463 Zhao, J. 324 Zhao, T. 355 Zhao, X. 98 Zhong, L. 411 Zhou, C. 142 Zhou, C. 411 Zhou, D. 25 Zhou, F. 213 Zhou, R. 451 Zhou, Y. 154 Zhou, Y. 238, 289 Zhu, D. 545 Zhu, M. 524 Zhu, X. 411 Zięba-Parkitny, J. 343 Ziegler, D. 56, 595 Zijlstra, E. 504, 510, 511, 514 Zimmerman, N. M. 449 Zimny, S. 261, 300 Zingg, D. 36 Zinman, B. 54, 489 Zinych, O. V. 634 Zisser, H. 541 Zivehe, F. 629 Zobel, E. H. 188, 587 Zou, G. 694 Zou, Y. 107 Zoumpoulis, P. 667 Zozulińska-Ziółkiewicz, D. 360, 637 Zueger, T. 260 Zuin, M. 240 Zurawska-Klis, M. 344, 347