N-Methyl-D-aspartate receptor hypofunction causes recurrent and transient failures of perceptual inference

1 Abstract Perception alternates between an external mode, driven by sensory inputs, and an internal mode, shaped by prior knowledge. We found that the external mode is more prevalent during pharmacologically induced N-Methyl-D-aspartate receptor (NMDAR) hypofunction and in schizophrenia. This NMDAR-dependent increase in external mode suggests that psychotic experiences are caused by recurring dissociations of perception from prior knowledge about the world. Competing Interest Statement The authors have declared no competing interest. Footnotes In the previous version, we could not include the ORCID of one author. After the author has provided us with the ORCID, we are submitting this revision in the hope that you can update the list of authors. Copyright The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under a CC-BY-NC-ND 4.0 International license.