Risks of Respiratory and Circulatory System Diseases Induced by Exposure to PM2.5 in High Humidity and Low Solar Radiation Environments: Disease Types, Genes, and Functions

Abstract Epidemiological investigation has found that PM2.5 from high humidity and low solar radiation environments (HHLR-PM2.5) induces the highest premature mortality rates from respiratory and circulatory diseases in China. However, the disease types and pathogenic mechanisms of the respiratory and circulatory diseases induced by HHLR-PM2.5 have not been completely revealed. In this study, we explore the risks of commonly existing diseases induced by HHLR-PM2.5 in the respiratory and circulatory systems. For neoplasms, HHLR-PM2.5 significantly induces malignant mesothelioma and arteriovenous hemangioma, the former through the CDKN1A and KIT genes, and the latter through IL6, blood vessel morphogenesis, and transforming growth factor beta binding. Patent ductus arteriosus - persisting type and chronic thromboembolic pulmonary hypertension are the most prominent cardiopulmonary diseases caused by HHLR-PM2.5, with the key molecular target being ACTA2 for the former and CDH5 for the latter. For congenital, hereditary, and neonatal diseases and abnormalities, HHLR-PM2.5 obviously contributes to bronchopulmonary dysplasia and congenital arteriovenous malformation, the former by targeting HMOX1, response to glucocorticoid, and heparin binding, and the latter by targeting IL6, blood vessel morphogenesis, and transforming growth factor beta binding. This study helps to clarify the risks of HHLR-PM2.5 to the respiratory and circulatory systems, supporting and supplementing epidemiology data.