Multidimensional Prognostic Index and Clinical Outcomes in Geriatric Patients Hospitalized for Respiratory Failure

Multidimensional Prognostic Index and Clinical Outcomes in Geriatric Patients Hospitalized for Respiratory Failure | Research Square window.SnipcartSettings = { analytics: { enabled: false } }; (function() { var accessVector = localStorage.getItem('access_vector') || ''; window.dataLayer = window.dataLayer || []; if (accessVector) { window.dataLayer.push({ user: { profile: { profileInfo: { snid: accessVector } } } }); } })(); (function(w,d,s,l,i){w[l]=w[l]||[];w[l].push({'gtm.start':new Date().getTime(),event:'gtm.js'});var f=d.getElementsByTagName(s)[0],j=d.createElement(s),dl=l!='dataLayer'?'&l='+l:'';j.async=true;j.src='https://www.googletagmanager.com/gtm.js?id='+i+dl;f.parentNode.insertBefore(j,f);})(window,document,'script','dataLayer','GTM-K279D39R'); Browse Preprints In Review Journals COVID-19 Preprints AJE Video Bytes Research Tools Research Promotion AJE Professional Editing AJE Rubriq About Preprint Platform In Review Editorial Policies Our Team Advisory Board Help Center Sign In Submit a Preprint Cite Share Download PDF Research Article Multidimensional Prognostic Index and Clinical Outcomes in Geriatric Patients Hospitalized for Respiratory Failure Giorgio Giuliano, Giuliano Pieroni This is a preprint; it has not been peer reviewed by a journal. https://doi.org/ 10.21203/rs.3.rs-7704622/v1 This work is licensed under a CC BY 4.0 License Status: Posted Version 1 posted You are reading this latest preprint version Abstract Background: Respiratory failure in older adults is associated with high mortality. The Multidimensional Prognostic Index (MPI), derived from Comprehensive Geriatric Assessment, is a validated tool for prognostic stratification. This study aimed to evaluate the association between MPI and in-hospital mortality in geriatric patients with respiratory failure. Methods: We conducted a retrospective observational study including older adults hospitalized for respiratory failure. Demographic, clinical data, type of respiratory failure, and MPI at admission were collected. The primary outcome was in-hospital mortality. Logistic regression, bootstrap validation, and penalized models were applied. Discriminative ability was assessed by ROC curve. Results: Higher MPI values at admission were independently associated with increased in-hospital mortality. Each 0.1 increase in MPI significantly increased the risk of death. Bootstrap confirmed robustness of estimates, and penalized regression reduced overfitting. The ROC analysis showed an AUC of 0.74. The type of respiratory failure played a secondary role compared to MPI. Conclusions: MPI is a reliable independent predictor of in-hospital mortality in older patients with respiratory failure. It may serve as a practical tool for risk stratification and clinical decision-making in frail patients. Full Text Additional Declarations No competing interests reported. Cite Share Download PDF Status: Posted Version 1 posted You are reading this latest preprint version Research Square lets you share your work early, gain feedback from the community, and start making changes to your manuscript prior to peer review in a journal. As a division of Research Square Company, we’re committed to making research communication faster, fairer, and more useful. We do this by developing innovative software and high quality services for the global research community. Our growing team is made up of researchers and industry professionals working together to solve the most critical problems facing scientific publishing. Also discoverable on Platform About Our Team In Review Editorial Policies Advisory Board Help Center Resources Author Services Accessibility API Access RSS feed Manage Cookie Preferences © Research Square 2026 | ISSN 2693-5015 (online) Privacy Policy Terms of Service Do Not Sell My Personal Information {"props":{"pageProps":{"initialData":{"identity":"rs-7704622","acceptedTermsAndConditions":true,"allowDirectSubmit":true,"archivedVersions":[],"articleType":"Research Article","associatedPublications":[],"authors":[{"id":542009676,"identity":"e019e9fd-69c7-45a3-bc15-55303458bd98","order_by":0,"name":"Giorgio Giuliano","email":"data:image/png;base64,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","orcid":"","institution":"Matera Hospital, Local Health Authority of Matera (ASM)","correspondingAuthor":true,"prefix":"","firstName":"Giorgio","middleName":"","lastName":"Giuliano","suffix":""},{"id":542009677,"identity":"e2c6ad75-75e5-4ba5-8978-f481c6f942aa","order_by":1,"name":"Giuliano Pieroni","email":"","orcid":"","institution":"Matera Hospital, Local Health Authority of Matera (ASM)","correspondingAuthor":false,"prefix":"","firstName":"Giuliano","middleName":"","lastName":"Pieroni","suffix":""}],"badges":[],"createdAt":"2025-09-24 14:23:09","currentVersionCode":1,"declarations":"","doi":"10.21203/rs.3.rs-7704622/v1","doiUrl":"https://doi.org/10.21203/rs.3.rs-7704622/v1","draftVersion":[],"editorialEvents":[],"editorialNote":"","failedWorkflow":false,"files":[{"id":95787895,"identity":"bbc84f4d-6f9d-412f-ba6e-4c7383dab30d","added_by":"auto","created_at":"2025-11-13 05:58:30","extension":"pdf","order_by":0,"title":"","display":"","copyAsset":false,"role":"acdc-reference","size":229517,"visible":true,"origin":"","legend":"","description":"","filename":"Manuscriptd1.pdf","url":"https://assets-eu.researchsquare.com/files/rs-7704622/v1/e48a6445e44f09977803394a.pdf"},{"id":95787892,"identity":"808f3fc3-7fa4-4462-9dce-d2914fcd6014","added_by":"auto","created_at":"2025-11-13 05:58:29","extension":"json","order_by":1,"title":"","display":"","copyAsset":false,"role":"acdc-reference","size":4148,"visible":true,"origin":"","legend":"","description":"","filename":"3a158c83a67a4ce790b4236e13f7c00b.json","url":"https://assets-eu.researchsquare.com/files/rs-7704622/v1/2147a827ec2f72ae40e53daf.json"},{"id":95787893,"identity":"183edda5-7fe4-4b38-9680-7dc308c697d4","added_by":"auto","created_at":"2025-11-13 05:58:30","extension":"docx","order_by":2,"title":"","display":"","copyAsset":false,"role":"acdc-reference","size":27184,"visible":true,"origin":"","legend":"","description":"","filename":"DeclarationsandContributions.docx","url":"https://assets-eu.researchsquare.com/files/rs-7704622/v1/af2444a5d958a2952921bb0c.docx"},{"id":95787894,"identity":"65111792-caa1-4ed8-8eff-1a313fbaf00f","added_by":"auto","created_at":"2025-11-13 05:58:30","extension":"docx","order_by":3,"title":"","display":"","copyAsset":false,"role":"acdc-reference","size":15325,"visible":true,"origin":"","legend":"","description":"","filename":"coverletterd1.docx","url":"https://assets-eu.researchsquare.com/files/rs-7704622/v1/36c3b3a6d7168bf36ac0a104.docx"},{"id":103516101,"identity":"eb0f55e7-527b-41bc-a3a7-f6fcd78b003f","added_by":"auto","created_at":"2026-02-26 14:26:31","extension":"pdf","order_by":1,"title":"","display":"","copyAsset":false,"role":"manuscript-pdf","size":266711,"visible":true,"origin":"","legend":"","description":"","filename":"Manuscript.pdf","url":"https://assets-eu.researchsquare.com/files/rs-7704622/v1_covered_662d62fc-0f6e-4bc0-bc74-1b7bb542ced9.pdf"}],"financialInterests":"No competing interests reported.","formattedTitle":"Multidimensional Prognostic Index and Clinical Outcomes in Geriatric Patients Hospitalized for Respiratory Failure","fulltext":[],"fulltextSource":"","fullText":"","funders":[],"hasAdminPriorityOnWorkflow":false,"hasManuscriptDocX":false,"hasOptedInToPreprint":true,"hasPassedJournalQc":"","hasAnyPriority":false,"hideJournal":true,"highlight":"","institution":"","isAcceptedByJournal":false,"isAuthorSuppliedPdf":true,"isDeskRejected":"","isHiddenFromSearch":false,"isInQc":false,"isInWorkflow":false,"isPdf":true,"isPdfUpToDate":true,"isWithdrawnOrRetracted":false,"journal":{"display":true,"email":"[email protected]","identity":"researchsquare","isNatureJournal":false,"hasQc":true,"allowDirectSubmit":true,"externalIdentity":"","sideBox":"","snPcode":"","submissionUrl":"/submission","title":"Research Square","twitterHandle":"researchsquare","acdcEnabled":true,"dfaEnabled":false,"editorialSystem":"","reportingPortfolio":"","inReviewEnabled":false,"inReviewRevisionsEnabled":true},"keywords":"","lastPublishedDoi":"10.21203/rs.3.rs-7704622/v1","lastPublishedDoiUrl":"https://doi.org/10.21203/rs.3.rs-7704622/v1","license":{"name":"CC BY 4.0","url":"https://creativecommons.org/licenses/by/4.0/"},"manuscriptAbstract":"\u003cp\u003eBackground: Respiratory failure in older adults is associated with high mortality. The Multidimensional Prognostic Index (MPI), derived from Comprehensive Geriatric Assessment, is a validated tool for prognostic stratification. This study aimed to evaluate the association between MPI and in-hospital mortality in geriatric patients with respiratory failure.\u0026nbsp;\u003c/p\u003e\n\u003cp\u003eMethods: We conducted a retrospective observational study including older adults hospitalized for respiratory failure. Demographic, clinical data, type of respiratory failure, and MPI at admission were collected. The primary outcome was in-hospital mortality. Logistic regression, bootstrap validation, and penalized models were applied. Discriminative ability was assessed by ROC curve.\u0026nbsp;\u003c/p\u003e\n\u003cp\u003eResults: Higher MPI values at admission were independently associated with increased in-hospital mortality. Each 0.1 increase in MPI significantly increased the risk of death. Bootstrap confirmed robustness of estimates, and penalized regression reduced overfitting. The ROC analysis showed an AUC of 0.74. The type of respiratory failure played a secondary role compared to MPI.\u0026nbsp;\u003c/p\u003e\n\u003cp\u003eConclusions: MPI is a reliable independent predictor of in-hospital mortality in older patients with respiratory failure. It may serve as a practical tool for risk stratification and clinical decision-making in frail patients.\u003c/p\u003e","manuscriptTitle":"Multidimensional Prognostic Index and Clinical Outcomes in Geriatric Patients Hospitalized for Respiratory Failure","msid":"","msnumber":"","nonDraftVersions":[{"code":1,"date":"2025-11-13 05:58:25","doi":"10.21203/rs.3.rs-7704622/v1","editorialEvents":[{"type":"communityComments","content":0}],"status":"published","journal":{"display":true,"email":"[email protected]","identity":"researchsquare","isNatureJournal":false,"hasQc":true,"allowDirectSubmit":true,"externalIdentity":"","sideBox":"","snPcode":"","submissionUrl":"/submission","title":"Research Square","twitterHandle":"researchsquare","acdcEnabled":true,"dfaEnabled":false,"editorialSystem":"","reportingPortfolio":"","inReviewEnabled":false,"inReviewRevisionsEnabled":true}}],"origin":"","ownerIdentity":"27013653-97e5-458e-a867-64360a3b37c8","owner":[],"postedDate":"November 13th, 2025","published":true,"recentEditorialEvents":[],"rejectedJournal":[],"revision":"","amendment":"","status":"posted","subjectAreas":[],"tags":[],"updatedAt":"2026-02-26T13:58:24+00:00","versionOfRecord":[],"versionCreatedAt":"2025-11-13 05:58:25","video":"","vorDoi":"","vorDoiUrl":"","workflowStages":[]},"version":"v1","identity":"rs-7704622","journalConfig":"researchsquare"},"__N_SSP":true},"page":"/article/[identity]/[[...version]]","query":{"identity":"rs-7704622","version":["v1"]},"buildId":"8U1c8b4HqxoKbykW_rLl7","isFallback":false,"isExperimentalCompile":false,"dynamicIds":[84888],"gssp":true,"scriptLoader":[]}