Establishment of Endometriosis Model in Rats with Intact Uterine Tissues

Objective To establish the endometriosis models in rats. Methods Twenty-six maturefemale SD rats were used. The rat endometriosis model was established by autotransplantation withuterine tissues. Eight weeks after the autotransplantation,the second laparotomy was performed forobserving the size,conglutination and pathological changes of the autotransplants. Results Saccateautotransplants were found in twenty-one rats, all of which were embedded in the peripheral tissues. Themorphology and structure of most ectopic endometrium were as same as the eutopic endometrium,though there were less epithelium and stroma in ectopic tissues. However, in a few cases, there waseither epithelium or stroma. Conclusion The endometriosis model established is successful, which canprovide an ideal model for further study of the mechanism and medical treatment of endometriosis.