Reactive Extraction of Protocatechuic Acid by Tributyl Phosphate and Examining the Effect of Different Parameters

Reactive Extraction of Protocatechuic Acid by Tributyl Phosphate and Examining the Effect of Different Parameters | Research Square window.SnipcartSettings = { analytics: { enabled: false } }; (function() { var accessVector = localStorage.getItem('access_vector') || ''; window.dataLayer = window.dataLayer || []; if (accessVector) { window.dataLayer.push({ user: { profile: { profileInfo: { snid: accessVector } } } }); } })(); (function(w,d,s,l,i){w[l]=w[l]||[];w[l].push({'gtm.start':new Date().getTime(),event:'gtm.js'});var f=d.getElementsByTagName(s)[0],j=d.createElement(s),dl=l!='dataLayer'?'&l='+l:'';j.async=true;j.src='https://www.googletagmanager.com/gtm.js?id='+i+dl;f.parentNode.insertBefore(j,f);})(window,document,'script','dataLayer','GTM-K279D39R'); Browse Preprints In Review Journals COVID-19 Preprints AJE Video Bytes Research Tools Research Promotion AJE Professional Editing AJE Rubriq About Preprint Platform In Review Editorial Policies Our Team Advisory Board Help Center Sign In Submit a Preprint Cite Share Download PDF Research Article Reactive Extraction of Protocatechuic Acid by Tributyl Phosphate and Examining the Effect of Different Parameters Şah İsmail Kırbaşlar, Esma Baykal, Aslı GÖK This is a preprint; it has not been peer reviewed by a journal. https://doi.org/ 10.21203/rs.3.rs-6777121/v1 This work is licensed under a CC BY 4.0 License Status: Posted Version 1 posted You are reading this latest preprint version Abstract In this study, the reactive extraction of protocatechuic acid (PCA) was investigated with different solvents using tributyl phosphate (TBP). At the end of the studies, the best result was obtained in diisobutyl ketone (DIBK)-TBP combination with 98.70% yield. In the continuation of the study, the effect of different parameters for the reactive extraction of protocatechuic acid from aqueous solutions in the presence of tributyl phosphate using DIBK was investigated. It aimed to find the optimum values by performing experiments that changed the initial acid concentration, water phase: organic phase ratio, and temperature values. As a result of temperature studies, the enthalpy (ΔH) value was calculated as negative, which indicates that the reaction is exothermic. Also, Gibbs free energy (ΔG) gave negative values at the studied temperatures, indicating that the reaction occurs spontaneously. The best extraction yield was obtained with 99.01% at 0.01 mol/L initial acid concentration and a 3:5 water phase to organic phase ratio. In the studies in which the effect of temperature was examined, the highest yield (E%) was obtained with a value of 95.59%. The study was conducted at 293.15 K temperature with 0.01 mol/L initial acid concentration. Protocatechuic acid Reactive extraction Tributyl phosphate Diisobutyl ketone Full Text Supplementary Files ConflictofInterestStatement.pdf Cite Share Download PDF Status: Posted Version 1 posted You are reading this latest preprint version Research Square lets you share your work early, gain feedback from the community, and start making changes to your manuscript prior to peer review in a journal. As a division of Research Square Company, we’re committed to making research communication faster, fairer, and more useful. We do this by developing innovative software and high quality services for the global research community. Our growing team is made up of researchers and industry professionals working together to solve the most critical problems facing scientific publishing. Also discoverable on Platform About Our Team In Review Editorial Policies Advisory Board Help Center Resources Author Services Accessibility API Access RSS feed Manage Cookie Preferences © Research Square 2026 | ISSN 2693-5015 (online) Privacy Policy Terms of Service Do Not Sell My Personal Information {"props":{"pageProps":{"initialData":{"identity":"rs-6777121","acceptedTermsAndConditions":true,"allowDirectSubmit":true,"archivedVersions":[],"articleType":"Research Article","associatedPublications":[],"authors":[{"id":475932699,"identity":"e01365c2-cf47-467b-b070-d9b5a4ccc6d8","order_by":0,"name":"Şah İsmail Kırbaşlar","email":"data:image/png;base64,iVBORw0KGgoAAAANSUhEUgAAAZAAAAAyAQMAAABI0h/eAAAABlBMVEX///8AAABVwtN+AAAACXBIWXMAAA7EAAAOxAGVKw4bAAABCklEQVRIiWNgGAWjYBACNhCRUJDAwyABZDxgYJADCRx4QFCLAVRLAgODMVhLAkG7DIBKoFoSGxggDJyAj/904ocHBmky5rObH39IqLmXPj/s8EOgLXZyug04HCaRu1kiwSCHR+bOMTOJhGPFuRtvpxkAtSQbmx3ApYV3A1BLBY+ERIIZQwJbQu7G2QkgLQcSt+HSwn928w+IlvTPHxL+JaQbzk7/gF8LQ+42sMMkJHIMJBLbEhLkpXMI2CKRu80iwSCNR0LmTJlEYl+C4QbpnIIDCQa4/SLff3bzzR8VyfYS0u2bP3z4liAvPzsdyKiwk8OlBRMYgFUaEKscbG8DKapHwSgYBaNgJAAA3fdeVQhulxAAAAAASUVORK5CYII=","orcid":"https://orcid.org/0000-0001-7237-4480","institution":"Istanbul Universitesi-Cerrahpasa Muhendislik Fakultesi","correspondingAuthor":true,"prefix":"","firstName":"Şah","middleName":"İsmail","lastName":"Kırbaşlar","suffix":""},{"id":475932700,"identity":"a5ff3291-f396-429c-8f0d-46fb7fd310be","order_by":1,"name":"Esma Baykal","email":"","orcid":"","institution":"Istanbul Universitesi-Cerrahpasa Muhendislik Fakultesi","correspondingAuthor":false,"prefix":"","firstName":"Esma","middleName":"","lastName":"Baykal","suffix":""},{"id":475932701,"identity":"fc1e85dd-6c31-464d-963a-e8b4d79a49a6","order_by":2,"name":"Aslı GÖK","email":"","orcid":"","institution":"Istanbul Universitesi-Cerrahpasa Muhendislik Fakultesi","correspondingAuthor":false,"prefix":"","firstName":"Aslı","middleName":"","lastName":"GÖK","suffix":""}],"badges":[],"createdAt":"2025-05-29 13:48:02","currentVersionCode":1,"declarations":"","doi":"10.21203/rs.3.rs-6777121/v1","doiUrl":"https://doi.org/10.21203/rs.3.rs-6777121/v1","draftVersion":[],"editorialEvents":[],"editorialNote":"","failedWorkflow":false,"files":[{"id":98626146,"identity":"3299b076-ac36-4f68-9017-d62bffa26e2c","added_by":"auto","created_at":"2025-12-19 17:09:34","extension":"pdf","order_by":1,"title":"","display":"","copyAsset":false,"role":"manuscript-pdf","size":666913,"visible":true,"origin":"","legend":"","description":"","filename":"ISMPCAManuscriptBRZ.pdf","url":"https://assets-eu.researchsquare.com/files/rs-6777121/v1_covered_3f3a36e8-2bf8-4d69-a3f4-018f80a27a58.pdf"},{"id":85537389,"identity":"b2408883-e64a-4783-9244-1ea804d57ef1","added_by":"auto","created_at":"2025-06-27 05:38:08","extension":"pdf","order_by":5,"title":"","display":"","copyAsset":false,"role":"supplement","size":207341,"visible":true,"origin":"","legend":"","description":"","filename":"ConflictofInterestStatement.pdf","url":"https://assets-eu.researchsquare.com/files/rs-6777121/v1/5a3ca0de08aa8556e0a3a68a.pdf"}],"financialInterests":"","formattedTitle":"Reactive Extraction of Protocatechuic Acid by Tributyl Phosphate and Examining the Effect of Different Parameters","fulltext":[],"fulltextSource":"","fullText":"","funders":[],"hasAdminPriorityOnWorkflow":false,"hasManuscriptDocX":false,"hasOptedInToPreprint":true,"hasPassedJournalQc":"","hasAnyPriority":false,"hideJournal":true,"highlight":"","institution":"","isAcceptedByJournal":false,"isAuthorSuppliedPdf":true,"isDeskRejected":"","isHiddenFromSearch":false,"isInQc":false,"isInWorkflow":false,"isPdf":true,"isPdfUpToDate":true,"isWithdrawnOrRetracted":false,"journal":{"display":true,"email":"[email protected]","identity":"researchsquare","isNatureJournal":false,"hasQc":true,"allowDirectSubmit":true,"externalIdentity":"","sideBox":"","snPcode":"","submissionUrl":"/submission","title":"Research Square","twitterHandle":"researchsquare","acdcEnabled":true,"dfaEnabled":false,"editorialSystem":"","reportingPortfolio":"","inReviewEnabled":false,"inReviewRevisionsEnabled":true},"keywords":"Protocatechuic acid, Reactive extraction, Tributyl phosphate, Diisobutyl ketone","lastPublishedDoi":"10.21203/rs.3.rs-6777121/v1","lastPublishedDoiUrl":"https://doi.org/10.21203/rs.3.rs-6777121/v1","license":{"name":"CC BY 4.0","url":"https://creativecommons.org/licenses/by/4.0/"},"manuscriptAbstract":"In this study, the reactive extraction of protocatechuic acid (PCA) was investigated with different solvents using tributyl phosphate (TBP). 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