Sham surgical embryo transfer affects offspring neurodevelopment and manifestation of hypertensive phenotype in ISIAH rats

Irina N. Rozkova, E. Yu. Brusentsev, Т. Н. Игонина, Д. С. Рагаева, Olga Petrova, М. А. Тихонова, Anna A. Akopyan, Tamara G. Amstislavskaya, Y. Antonov, Sergey Ya. Amstislavsky
In: Hypertension in Pregnancy · 2020 · vol. 39(3) , pp. 283–294 · doi:10.1080/10641955.2020.1762894 · PMID:32400240 · W3024832526
article OA: closed CC0
View on OpenAlex View on PubMed View at publisher
⚙ AI-generated summary by qwen3.7-flash, 2026-09-24 ⓘ

Maternal sham surgery during early pregnancy accelerates neurodevelopment and aggravates hypertension in ISIAH rats, while suppressing exploratory activity and altering hippocampal BDNF expression and neuronal density.

One-sentence paraphrase of the abstract; not a substitute for reading it. No clinical advice. How this works

Abstract

The study investigates how surgery during pregnancy, i.e., sham operation associated with embryo transfer, affects hypertensive phenotype in ISIAH rats genetically predisposed to hypertension. ISIAH rats born after maternal surgery at fourth day of pregnancy were compared with naturally conceived controls. Surgery during pregnancy in ISIAH rats caused acceleration of neurodevelopment in young offspring, as well as aggravating hypertension, suppressing exploratory activity, reducing hippocampal BDNF expression, and compensatory increasing of hippocampal neuronal density in adult ISIAH offspring. Maternal surgery during early pregnancy caused alterations in offspring phenotype in hypertensive ISIAH rat model.

My notes (saved in your browser only)

Citation neighborhood (no data yet)

We don't have any in-corpus citations linked to this paper yet. The paper's references may be in our DB but unresolved to ``paper_id`` (resolution happens at ingest when the cited DOI matches a row we already have). Run the cross-source citation reconcile pass to retry.

References (51)

Source provenance

openalex
last seen: 2026-06-10T17:14:06.276822+00:00
License: CC0 · commercial use OK