New Oxidovanadium(IV) Mixed Ligand Complexes: Antidibetic, Anticancer activities and Cytotoxicity Study Using MTT Assay

Abstract Five new (HQ-1 to HQ-5) oxidovanadium(IV) mixed ligand complexes using 8-hydroxyquinoline as primary ligand and amino acids like L-cystein, L-alanine, L-phenylalanine, L-threonine and L-serine as secondary ligands in 1:1:1 ratio were synthesized. All the complexes were characterized using various characterization techniques such as elemental analysis, IR, electronic, mass spectra, thermal (TGA/DTA) and powder XRD analysis, molar conductance and magnetic susceptibility measurements. Based on the results obtained all the complexes were proposed to have square pyramidal geometry. All the complexes were screened for their antibacterial activities against E. coli and antifungal activities against C. albicans. In vitro antidibetic activities of all the complexes were studied by screening them for a-amylase inhibition activities. The complexes HQ-4 and HQ-5 were also screened for their anticancer activities against human cancer cells HepG2 using MTT assay.