A Novel Sustainable Method to Prepare Glutaric Acid from Glucose

This paper proposes a sustainable method to prepare glutaric acid from glucose via an α-keto glutaric acid derived from glucose by fermentation using Corynebacterium glutamicum GKGA. Glutaric acid was prepared from α-keto glutaric acid via the hydrogenation of a 1,3-dithiolane diamide intermediate as the key step. The combination of biotransformation and chemical transformation of glutaric acid provided an efficient and environment-friendly method for the sustainable synthesis of glutaric acid