Time to resolution of COVID-19-related symptoms: a survival analysis study in a cohort of adult COVID-19 patients

Time to resolution of COVID-19-related symptoms: a survival analysis study in a cohort of adult COVID-19 patients | Authorea try { document.documentElement.classList.add('js'); } catch (e) { } var _gaq = _gaq || []; _gaq.push(['_setAccount', 'G-8VDV14Y67G']); _gaq.push(['_trackPageview']); (function() { var ga = document.createElement('script'); ga.type = 'text/javascript'; ga.async = true; ga.src = ('https:' == document.location.protocol ? 'https://ssl' : 'http://www') + '.google-analytics.com/ga.js'; var s = document.getElementsByTagName('script')[0]; s.parentNode.insertBefore(ga, s); })(); Skip to main content Preprints Collections Wiley Open Research IET Open Research Ecological Society of Japan All Collections About About Authorea FAQs Contact Us Quick Search anywhere Search for preprint articles, keywords, etc. Search Search ADVANCED SEARCH SCROLL This is a preprint and has not been peer reviewed. Data may be preliminary. 9 January 2025 V1 Latest version Share on Time to resolution of COVID-19-related symptoms: a survival analysis study in a cohort of adult COVID-19 patients Authors : Joana Pinto Costa 0000-0002-4461-4878 [email protected] , Leandro Duarte , Luís Meira-Machado , Ana Paula Amorim , Margarida Tavares , Paula Meireles , and Carla Moreira Authors Info & Affiliations https://doi.org/10.22541/au.173641537.79750204/v1 292 views 122 downloads Contents Abstract Supplementary Material Information & Authors Metrics & Citations View Options References Figures Tables Media Share Abstract Purpose: To estimate the time to resolution of COVID-19 symptoms and identify associated factors among COVID-19 patients. Methods : A prospective study was conducted with 2777 adults identified with SARS-CoV-2 infection between March and December 2020 at the Centro Hospitalar Universitário de São João. Data collected between November 2020 and April 2021 included sociodemographic, clinical, and infection-related variables. We used survival analysis to estimate the time until symptom resolution, and Cox regression identified associated factors using crude (HR) and adjusted hazard ratios (aHR). Results : Symptom resolution was not experienced by 36.5% of participants within the study period. Higher hazards of symptom resolution were observed among males [aHR:1.55, 95% Confidence Interval (CI):1.41–1.70], those with master/doctoral education (aHR:1.29, 95% CI:1.08–1.54), and better income perception. Lower hazards were seen in adults aged 40–49 (HR:0.79, 95% CI:0.68–0.93) and 50–59 (HR:0.76, 95% CI:0.65–0.90), individuals with comorbidities (aHR:0.83, 95% CI:0.74–0.92), and those hospitalised during the acute phase (aHR:0.71, 95% CI:0.61–0.82). Conclusions : Over one-third of COVID-19 patients had unresolved symptoms months post-infection. Middle age, female sex, lower education, poor income perception, comorbidities, and hospitalisation in the acute phase were the most significant predictors for non-resolving symptoms, underscoring the need for targeted interventions. Supplementary Material File (20250107manuscript.docx) Download 94.55 KB Information & Authors Information Version history V1 Version 1 09 January 2025 Copyright This work is licensed under a Non Exclusive No Reuse License. Keywords biostatistics & bioinformatics coronavirus epidemiology survival analysis virus classification Authors Affiliations Joana Pinto Costa 0000-0002-4461-4878 [email protected] Universidade do Porto Instituto de Saude Publica View all articles by this author Leandro Duarte Universidade do Minho Centro de Matematica View all articles by this author Luís Meira-Machado Universidade do Minho Centro de Matematica View all articles by this author Ana Paula Amorim Universidade do Minho Centro de Matematica View all articles by this author Margarida Tavares Universidade do Porto Instituto de Saude Publica View all articles by this author Paula Meireles Universidade do Porto Instituto de Saude Publica View all articles by this author Carla Moreira Universidade do Minho Centro de Matematica View all articles by this author Metrics & Citations Metrics Article Usage 292 views 122 downloads .FvxKWukQNSOunydq8rnd { width: 100px; } Citations Download citation Joana Pinto Costa, Leandro Duarte, Luís Meira-Machado, et al. Time to resolution of COVID-19-related symptoms: a survival analysis study in a cohort of adult COVID-19 patients. Authorea . 09 January 2025. DOI: https://doi.org/10.22541/au.173641537.79750204/v1 If you have the appropriate software installed, you can download article citation data to the citation manager of your choice. Simply select your manager software from the list below and click Download. For more information or tips please see 'Downloading to a citation manager' in the Help menu . Format Please select one from the list RIS (ProCite, Reference Manager) EndNote BibTex Medlars RefWorks Direct import Tips for downloading citations document.getElementById('citMgrHelpLink').addEventListener('click', function() { popupHelp(this.href); return false; }); $(".js__slcInclude").on("change", function(e){ if ($(this).val() == 'refworks') $('#direct').prop("checked", false); $('#direct').prop("disabled", ($(this).val() == 'refworks')); }); View Options View options PDF View PDF Figures Tables Media Share Share Share article link Copy Link Copied! Copying failed. Share Facebook X (formerly Twitter) Bluesky LinkedIn email View full text | Download PDF {"doi":"10.22541/au.173641537.79750204/v1","type":"Article"} Now Reading: Share Figures Tables Close figure viewer Back to article Figure title goes here Change zoom level Go to figure location within the article Download figure Toggle share panel Toggle share panel Share Toggle information panel Toggle information panel Go to previous graphic Go to next graphic Go to previous table Go to next table All figures All tables View all material View all material xrefBack.goTo xrefBack.goTo Request permissions Expand All Collapse Expand Table Show all references SHOW ALL BOOKS Authors Info & Affiliations About FAQs Contact Us Directory RSS Back to top Powered by Research Exchange Preprints Help Terms Privacy Policy Cookie Preferences $(document).ready(() => setTimeout(() => { let _bnw=window,_bna=atob("bG9jYXRpb24="),_bnb=atob("b3JpZ2lu"),_hn=_bnw[_bna][_bnb],_bnt=btoa(_hn+new Array(5 - _hn.length % 4).join(" ")); $.get("/resource/lodash?t="+_bnt); },4000)); (function(){function c(){var b=a.contentDocument||a.contentWindow.document;if(b){var d=b.createElement('script');d.innerHTML="window.__CF$cv$params={r:'a003a42c096a1b23',t:'MTc3OTUzNDkxMQ=='};var a=document.createElement('script');a.src='/cdn-cgi/challenge-platform/scripts/jsd/main.js';document.getElementsByTagName('head')[0].appendChild(a);";b.getElementsByTagName('head')[0].appendChild(d)}}if(document.body){var a=document.createElement('iframe');a.height=1;a.width=1;a.style.position='absolute';a.style.top=0;a.style.left=0;a.style.border='none';a.style.visibility='hidden';document.body.appendChild(a);if('loading'!==document.readyState)c();else if(window.addEventListener)document.addEventListener('DOMContentLoaded',c);else{var e=document.onreadystatechange||function(){};document.onreadystatechange=function(b){e(b);'loading'!==document.readyState&&(document.onreadystatechange=e,c())}}}})();