Identification of candidate genes for feed efficiency and growth traits in Wenchang chickens

Background: Wenchang chickens are one of the most popular local chicken breeds in the Chinese chicken industry. However, the low feed conversion efficiency is the main shortcoming of this breed. Therefore, we urgently need to find a more precise breeding method to improve the feed efficiency of Wenchang chickens. In this study, we explored important candidate genes and variants for feed efficiency and growth traits by genome-wide association study (GWAS) analysis. Results: Estimates of genomic heritability for growth and feed efficiency traits, including residual feed intake (RFI), average daily food intake (ADFI), average daily weight gain (ADG), body weight at 87, 95, 104, 113 days of age (BW87, BW95, BW104 and BW113), ranged from 0.05 to 0.44. Important candidate genes were screened related to feed efficiency and growth traits were screened, including PLCE1, LAP3, MED28, QDPR, LDB2 and SEL1L3 genes. Conclusion: The results identified important candidate genes for feed efficiency and growth traits in Wenchang chickens and provide a theoretical basis for development of new molecular breeding technology.