Relationship between MAPK signaling pathway and the pathogenesis of endometriosis

Endometriosis(EM) is an estrogen-dependent disease characterized by extrauterine implantation and ectopic growth of endometrium.The occurrence rate in women of childbearing age is 10%～20%.Estrogen mediates multiple signaling transduction pathways,including MAPK(mitogen activated protein kinase) pathway,which plays important roles in stimulating the proliferation of endometriotic stromal cell,the production of inflammatory factor and the neovascularization.In this paper,we review the relationship between MAPK signaling pathway and the pathogenesis of endometriosis to better understand the mechanism of endometriosis.