Eq-DIAGNOBATCH, a Shiny application for topical product equivalence with batch effect and multivariate outlier analysis

The Eq-DIAGNOBATCH application presented here complements a previous theoretical article about establishing the equivalence of topical products in a parallel linear model, accounting for a batch effect or not. This application provides a very simple way of carrying out the equivalence test for this type of situation, efficiently obtaining the estimates of the parameters of interest (equivalence intervals, geometric mean ratio, and variance components), and allowing calculations to be performed assuming a batch effect or not. It also examines the statistical implications of the presence of outliers in the sample, from both a univariate and multivariate point of view. The operation and mode of use of Eq-DIAGNOBATCH are presented, including examples related with the quality and equivalence of topical products and bioequivalence analysis. Some of these examples come from the literature and others from real-life industry case studies.