Expression and Significance of Chemokine CXCL12 in Uterine Adenomyosis
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This study examined uterine adenomyosis and found that CXCL12 protein and mRNA expression were significantly higher in ectopic lesions than in eutopic endometrium or controls, suggesting a role in pathogenesis.
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Abstract
Objective
To investigate the significance of chemokine CXCL12 in the pathogenesis of uterine adenomyosis.
Methods
From February 2010 to February 2011, a total of 36 women with uterine adenomyosis were included in the study, and their pathological samples were divided into ectopic lesions group(n=36), surrounding tissues group(n=36) and eutopic endometrium group(n=36). Meanwhile pathological samples from other 33 uterine fibroids patients were included into control endometrium group(n=33) and control myometrium group(n=33). Expression of CXCL12 protein and CXCL12 mRNA content were detected. The study protocol was approved by the Ethical Review Board of Investigation in Human Being of Jinan Millitary General Hospital.Informed consent was obtained from each participants.
Results
①CXCL12 protein expression in ectopic lesions group was significantly higher than that of eutopic endometrium group and control endometrium group(P<0.05), and CXCL12 protein expression in eutopic endometrium group was significantly higher than that of control endometrium group(P<0.05). ②There had significant differences in CXCL12 mRNA content between eutopic endometrium group, surrounding tissues group, ectopic lesions group and control endometrium group, respectively(P<0.05). Compared with eutopic endometrium group and surrounding tissues group, CXCL12 mRNA content of ectopic lesions group had remarkably increased(P<0.05). ③CXCL12 protein expression in eutopic endometrium group and ectopic lesions group had significant correlation (r=0.78, P<0.05). CXCL12 mRNA content in eutopic endometrium group had positive correlation with ectopic lesions group and surrounding tissues group(r=0.499, 0.461; P=0.002, 0.005). There had significant correlation between ectopic lesions group and surrounding tissues group (r=0.679, P=0.000).
Conclusions
CXCL12 may be play an important role in pathogenesis of uterine adenomyosis by inducing ectopic endometrial cells.
Key words:
Endometriosis; Chemokine CXCL12; Pathogenesis
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Objective
To investigate the significance of chemokine CXCL12 in the pathogenesis of uterine adenomyosis.
Methods
From February 2010 to February 2011, a total of 36 women with uterine adenomyosis were included in the study, and their pathological samples were divided into ectopic lesions group(n=36), surrounding tissues group(n=36) and eutopic endometrium group(n=36). Meanwhile pathological samples from other 33 uterine fibroids patients were included into control endometrium group(n=33) and control myometrium group(n=33). Expression of CXCL12 protein and CXCL12 mRNA content were detected. The study protocol was approved by the Ethical Review Board of Investigation in Human Being of Jinan Millitary General Hospital.Informed consent was obtained from each participants.
Results
①CXCL12 protein expression in ectopic lesions group was significantly higher than that of eutopic endometrium group and control endometrium group(P<0.05), and CXCL12 protein expression in eutopic endometrium group was significantly higher than that of control endometrium group(P<0.05). ②There had significant differences in CXCL12 mRNA content between eutopic endometrium group, surrounding tissues group, ectopic lesions group and control endometrium group, respectively(P<0.05). Compared with eutopic endometrium group and surrounding tissues group, CXCL12 mRNA content of ectopic lesions group had remarkably increased(P<0.05). ③CXCL12 protein expression in eutopic endometrium group and ectopic lesions group had significant correlation (r=0.78, P<0.05). CXCL12 mRNA content in eutopic endometrium group had positive correlation with ectopic lesions group and surrounding tissues group(r=0.499, 0.461; P=0.002, 0.005). There had significant correlation between ectopic lesions group and surrounding tissues group (r=0.679, P=0.000).
Conclusions
CXCL12 may be play an important role in pathogenesis of uterine adenomyosis by inducing ectopic endometrial cells.
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