Expression and Significance of Chemokine CXCL12 in Uterine Adenomyosis

Juan Li; Geping Yin; Ming Chen; Zhu Tongyu

doi:10.3877/cma.j.issn.1673-5250.2014.03.013

Expression and Significance of Chemokine CXCL12 in Uterine Adenomyosis

Juan Li, Geping Yin, Ming Chen, Zhu Tongyu

In: Chung-Hua Fu Ch'an K'o Tsa Chih · 2014 · vol. 10(3) , pp. 324–327 · doi:10.3877/cma.j.issn.1673-5250.2014.03.013 · W3032676582

OA: closed CC0

Full text JSON View on OpenAlex View at publisher

⚙ AI-generated summary by qwen3.7-flash, 2026-08-21 ⓘ

This study examined uterine adenomyosis and found that CXCL12 protein and mRNA expression were significantly higher in ectopic lesions than in eutopic endometrium or controls, suggesting a role in pathogenesis.

One-sentence paraphrase of the abstract; not a substitute for reading it. No clinical advice. How this works

⚙ AI-generated deep summary by qwen3.7-flash, 2026-09-06 · read from full text ⓘ

This study investigated the expression and significance of chemokine CXCL12 in the pathogenesis of uterine adenomyosis by analyzing tissue samples from 36 patients with the condition and 33 controls with uterine fibroids. The researchers compared CXCL12 protein and mRNA levels across eutopic endometrium, ectopic lesions, surrounding tissues, and control groups, finding significantly higher expression in adenomyosis-related tissues compared to controls. Statistical analysis revealed strong positive correlations between CXCL12 levels in different tissue compartments within the adenomyosis group, supporting the conclusion that CXCL12 may contribute to disease progression by inducing the ectopic migration of endometrial cells. This paper is centrally about adenomyosis — specifically examining the role of CXCL12 in its pathogenesis.

Read from the paper's body, not the abstract. Not a substitute for reading the paper. No clinical advice. How this works

Abstract

Objective To investigate the significance of chemokine CXCL12 in the pathogenesis of uterine adenomyosis. Methods From February 2010 to February 2011, a total of 36 women with uterine adenomyosis were included in the study, and their pathological samples were divided into ectopic lesions group(n=36), surrounding tissues group(n=36) and eutopic endometrium group(n=36). Meanwhile pathological samples from other 33 uterine fibroids patients were included into control endometrium group(n=33) and control myometrium group(n=33). Expression of CXCL12 protein and CXCL12 mRNA content were detected. The study protocol was approved by the Ethical Review Board of Investigation in Human Being of Jinan Millitary General Hospital.Informed consent was obtained from each participants. Results ①CXCL12 protein expression in ectopic lesions group was significantly higher than that of eutopic endometrium group and control endometrium group(P<0.05), and CXCL12 protein expression in eutopic endometrium group was significantly higher than that of control endometrium group(P<0.05). ②There had significant differences in CXCL12 mRNA content between eutopic endometrium group, surrounding tissues group, ectopic lesions group and control endometrium group, respectively(P<0.05). Compared with eutopic endometrium group and surrounding tissues group, CXCL12 mRNA content of ectopic lesions group had remarkably increased(P<0.05). ③CXCL12 protein expression in eutopic endometrium group and ectopic lesions group had significant correlation (r=0.78, P<0.05). CXCL12 mRNA content in eutopic endometrium group had positive correlation with ectopic lesions group and surrounding tissues group(r=0.499, 0.461; P=0.002, 0.005). There had significant correlation between ectopic lesions group and surrounding tissues group (r=0.679, P=0.000). Conclusions CXCL12 may be play an important role in pathogenesis of uterine adenomyosis by inducing ectopic endometrial cells. Key words: Endometriosis; Chemokine CXCL12; Pathogenesis

Full text 6,271 characters · extracted from oa-doi-fallback · 4 sections · click to expand

Objective

To investigate the significance of chemokine CXCL12 in the pathogenesis of uterine adenomyosis.

Methods

From February 2010 to February 2011, a total of 36 women with uterine adenomyosis were included in the study, and their pathological samples were divided into ectopic lesions group(n=36), surrounding tissues group(n=36) and eutopic endometrium group(n=36). Meanwhile pathological samples from other 33 uterine fibroids patients were included into control endometrium group(n=33) and control myometrium group(n=33). Expression of CXCL12 protein and CXCL12 mRNA content were detected. The study protocol was approved by the Ethical Review Board of Investigation in Human Being of Jinan Millitary General Hospital.Informed consent was obtained from each participants.

Results

①CXCL12 protein expression in ectopic lesions group was significantly higher than that of eutopic endometrium group and control endometrium group(P<0.05), and CXCL12 protein expression in eutopic endometrium group was significantly higher than that of control endometrium group(P<0.05). ②There had significant differences in CXCL12 mRNA content between eutopic endometrium group, surrounding tissues group, ectopic lesions group and control endometrium group, respectively(P<0.05). Compared with eutopic endometrium group and surrounding tissues group, CXCL12 mRNA content of ectopic lesions group had remarkably increased(P<0.05). ③CXCL12 protein expression in eutopic endometrium group and ectopic lesions group had significant correlation (r=0.78, P<0.05). CXCL12 mRNA content in eutopic endometrium group had positive correlation with ectopic lesions group and surrounding tissues group(r=0.499, 0.461; P=0.002, 0.005). There had significant correlation between ectopic lesions group and surrounding tissues group (r=0.679, P=0.000).

Conclusions

CXCL12 may be play an important role in pathogenesis of uterine adenomyosis by inducing ectopic endometrial cells. | 1 | Yu L, Cecil J, Peng SB, et al.Identification and expression of novel isoforms of human stromal cell-derived factor[J].Gene, 2006, 374(7):174-179. | | 2 | 白红，赵丽嫣．子宫腺肌病病因与发病机制研究进展[J]．中国妇产科临床，2003，4(6)：61-64. | | 3 | Laing KJ, Secombes CJ.Chemokines[J].Dev Comp Immunol, 2004, 28(5):443. | | 4 | Lortat-Jacob H.The molecular basis and functional implications of chemokine interactions with heparan sulphate[J].Cur Opin Struct Biol, 2009, 19(5):543-548. | | 5 | Laird SM, Widdowson R, El-Sheikhi M, et al.Expression of CXCL12 and CXCR4 in human endometrium; effects of CXCL12 on MMP production by human endometrial cells[J].Hum Reprod, 2011, 26(5):1144-1152. | | 6 | Muller A, Homey B, Soto H, et al.Involvement of chemokine receptors in breast cancer metastasis[J].Nature, 2001, 410(6824):50-56. | | 7 | 李芳，朱怀仕．卵巢癌趋化因子受表达及意义[J]．济宁医学院学报，2003，26(3)：1-3. | | 8 | Kollmar O, Rupertus K, Scheuer C, et al.Stromal cell-derived factor-1 promotes cell Migration and tumor growth of colorectal metastasis[J].Neoplasia, 2007, 9(10):862-870. | | 9 | Guleng B, Tateishi K, Ohta M, et al.Blockade of the stromal cell-derived factor-1/CXCR4 axis attenuates in vivo tumor growth by inhibiting angiogenesis in a vascular endothelial growth factor-independent manner[J].Cancer Res, 2005, 65(13):5864-5871. | | 10 | 韩燕华，周应芳，郑淑蓉．子宫腺肌病患者子宫各部位血管形态的研究[J]．中国实用妇科与产科杂志，2002，18(10)：605-607. | | 11 | Phillips RJ, Burdick MD, Lutz M, et al.The stromal derived factor-1/CXCL12-CXC chemokine receptor 4 biological axis in non-small cell lung cancer metastases[J].Am J Respir Crit Care Med, 2003, 167(12):1676. | | [1] | 曾敬, 吴冬冬, 邵明, 范震波, 王治国, 刘培谊, 兰海峰. 高龄髋部骨折患者不同手术时机的围手术期疗效评估[J/OL]. 中华关节外科杂志(电子版), 2024, 18(04): 445-449. | | [2] | 高旭, 李若凡, 孙立新, 刘佐军, 田广健. Miles手术中预置腹膜前补片预防造口旁疝的效果及安全性[J/OL]. 中华疝和腹壁外科杂志(电子版), 2024, 18(03): 266-272. | | [3] | 刘璐璐, 何羽. 慢性阻塞性肺病患者睡眠障碍的研究进展[J/OL]. 中华肺部疾病杂志(电子版), 2024, 17(05): 836-839. | | [4] | 张蕾, 彭超, 周应芳. 直肠阴道隔子宫内膜异位症腹腔镜手术技巧[J/OL]. 中华腔镜外科杂志(电子版), 2024, 17(05): 257-261. | | [5] | 胡启明, 鄢潇, 尤志学, 黄骁昊. 经瘢痕处单孔腹腔镜下切除多病灶腹壁子宫内膜异位症[J/OL]. 中华腔镜外科杂志(电子版), 2024, 17(05): 314-317. | | [6] | 林科灿, 罗柳平. 肝胰十二指肠切除术在胆囊癌和胆管癌应用中的关键问题[J/OL]. 中华肝脏外科手术学电子杂志, 2024, 13(06): 774-778. | | [7] | 芦煜, 李振宇, 吴承东, 周仲伍. 肛周子宫内膜异位症一例报告[J/OL]. 中华结直肠疾病电子杂志, 2024, 13(05): 431-434. | | [8] | 杨明, 张金珠, 王锡山. 全国肿瘤登记中心发布的2013年至2022年结直肠癌流行数据趋势解读[J/OL]. 中华结直肠疾病电子杂志, 2024, 13(03): 177-181. | | [9] | 赵静, 张嘉欣, 高言, 谢席胜. 微小病变肾病的发病机制及治疗研究进展[J/OL]. 中华肾病研究电子杂志, 2024, 13(04): 207-212. | | [10] | 贾红艳, 王丹, 张冉冉, 马茜, 焦永红. 基于全外显子组测序探寻Möbius综合征发病机制的遗传学研究[J/OL]. 中华眼科医学杂志(电子版), 2024, 14(03): 146-154. | | [11] | 安亚楠, 王端然, 郭甜甜, 武希润. 幽门螺杆菌阴性胃黏膜相关淋巴组织淋巴瘤的研究进展[J/OL]. 中华消化病与影像杂志(电子版), 2024, 14(03): 268-274. | | [12] | 刘琦, 王守凯, 王帅, 苏雨晴, 马壮, 陈海军, 司丕蕾. 乳腺癌肿瘤内微生物组的研究进展[J/OL]. 中华临床医师杂志(电子版), 2024, 18(09): 841-845. | | [13] | 洪凡, 陈敦金, 傅洋, 梁新月, 吴毅, 王晓怡. 体外受精-胚胎移植妊娠合并前置胎盘临床研究[J/OL]. 中华产科急救电子杂志, 2024, 13(03): 176-182. | | [14] | 朱镭, 朱庆义. 金氏菌属：引起婴幼儿侵袭性传染病的新发病原体[J/OL]. 中华临床实验室管理电子杂志, 2024, 12(04): 229-237. | | [15] | 厉若男, 宋进, 王玉忠. 带状疱疹后神经痛的发病机制和诊治研究进展[J/OL]. 中华诊断学电子杂志, 2024, 12(03): 199-205. | | 阅读次数 | ||||| | 全文 | | |||| | 摘要 | | |||| 版权所有中华医学会中华医学电子音像出版社有限责任公司京ICP备14006079号-1 网络出版服务许可证：(署)网出证(京)字第075号 AI 小编 AI小编

Text is read by the "Ask this paper" AI Q&A widget below. Extraction quality varies by source — PMC NXML preserves structure cleanly, OA-HTML may include some navigation residue, and OA-PDF can have broken hyphenation. The publisher copy (via DOI) is the canonical version.

My notes (saved in your browser only)

⚙ Ask this paper AI returns verbatim quotes from the full text · source: oa-doi-fallback ⓘ

Answers must be backed by verbatim quotes from this paper's full text. Hallucinated quotes are dropped automatically; if no verbatim passage answers the question, we say so. How this works

Condition tags

endometriosisadenomyosis

Citation neighborhood (no data yet)

We don't have any in-corpus citations linked to this paper yet. The paper's references may be in our DB but unresolved to ``paper_id`` (resolution happens at ingest when the cited DOI matches a row we already have). Run the cross-source citation reconcile pass to retry.

Source provenance

openalex: last seen: 2026-06-10T17:14:06.276822+00:00

License: CC0 · commercial use OK