Mobility-Informed Environmental Exposure and Cardiovascular Outcomes Across the Life Course

Mobility-Informed Environmental Exposure and Cardiovascular Outcomes Across the Life Course | Research Square window.SnipcartSettings = { analytics: { enabled: false } }; (function() { var accessVector = localStorage.getItem('access_vector') || ''; window.dataLayer = window.dataLayer || []; if (accessVector) { window.dataLayer.push({ user: { profile: { profileInfo: { snid: accessVector } } } }); } })(); (function(w,d,s,l,i){w[l]=w[l]||[];w[l].push({'gtm.start':new Date().getTime(),event:'gtm.js'});var f=d.getElementsByTagName(s)[0],j=d.createElement(s),dl=l!='dataLayer'?'&l='+l:'';j.async=true;j.src='https://www.googletagmanager.com/gtm.js?id='+i+dl;f.parentNode.insertBefore(j,f);})(window,document,'script','dataLayer','GTM-K279D39R'); Browse Preprints In Review Journals COVID-19 Preprints AJE Video Bytes Research Tools Research Promotion AJE Professional Editing AJE Rubriq About Preprint Platform In Review Editorial Policies Our Team Advisory Board Help Center Sign In Submit a Preprint Cite Share Download PDF Article Mobility-Informed Environmental Exposure and Cardiovascular Outcomes Across the Life Course Sanjay Rajagopalan, Jean-Eudes Dazard, Isaac Rooney, Tong Zhang, and 9 more This is a preprint; it has not been peer reviewed by a journal. https://doi.org/ 10.21203/rs.3.rs-8913809/v1 This work is licensed under a CC BY 4.0 License Status: Under Review Version 1 posted You are reading this latest preprint version Abstract Environmental determinants of cardiovascular disease extend beyond static residential exposures, yet most studies rely on static, residence-based proxies such as greenness indices that fail to capture lived mobility. We integrated large-scale anonymized mobility with national mortality data and longitudinal outcomes in nearly 3 million individuals from a regional (University Hospitals) and a national (Veterans Affairs) health system cohort (median follow-up: 7.8 and 8.8 years). Mobility-derived exposures included time in green and recreational spaces, and indices of food environments and movement diversity. Greater engagement with green and recreational environments and higher mobility diversity were consistently associated with lower major adverse cardiovascular event risk, with age-dependent attenuation. Healthier food environments demonstrated stronger protective associations in older adults. Ecological validation demonstrated inverse spatial correlations between beneficial mobility exposures and cardiovascular and all-cause mortality rates. Dynamic mobility metrics provide a scalable framework linking lived environmental experience to cardiovascular risk across populations and geographic scales. Health sciences/Risk factors Health sciences/Medical research/Epidemiology Health sciences/Health care/Public health/Epidemiology Health sciences/Medical research/Experimental models of disease Full Text Additional Declarations There is NO Competing Interest. Supplementary Files SupplementalTable6.pdf Supplemental Table 6 SupplementalTable2.pdf Supplemental Table 2 SupplementalFigure3.pdf Supplemental Figure 3 SupplementalTable5.pdf Supplemental Table 5 SupplementalTable3.pdf Supplemental Table 3 SupplementalFigure2.pdf Supplemental Figure 2 SupplementalTable1.pdf Supplemental Table 1 SupplementalFigure4.pdf Supplemental Figure 4 SupplementalTable4.pdf Supplemental Table 4 SupplementalFigure1.pdf Supplemental Figure 1 SupplementalFigure6.pdf Supplemental Figure 6 SupplementalFigure7.pdf Supplemental Figure 7 SupplementalFigure5.pdf Supplemental Figure 5 Cite Share Download PDF Status: Under Review Version 1 posted You are reading this latest preprint version Research Square lets you share your work early, gain feedback from the community, and start making changes to your manuscript prior to peer review in a journal. As a division of Research Square Company, we’re committed to making research communication faster, fairer, and more useful. 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Also discoverable on Platform About Our Team In Review Editorial Policies Advisory Board Help Center Resources Author Services Accessibility API Access RSS feed Manage Cookie Preferences © Research Square 2026 | ISSN 2693-5015 (online) Privacy Policy Terms of Service Do Not Sell My Personal Information {"props":{"pageProps":{"initialData":{"identity":"rs-8913809","acceptedTermsAndConditions":true,"allowDirectSubmit":false,"archivedVersions":[],"articleType":"Article","associatedPublications":[],"authors":[{"id":594398158,"identity":"e6e510c2-2317-49f4-966a-b74cce801594","order_by":0,"name":"Sanjay 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