The study of E-cadherin and CD_(44) varient 6 on pathogenesis in human adenomyosis

Objective To observe the expression of E-cadherin and CD_(44) v6 in human adenomyosis.To explore the correlation between the expression of E-cadherin and CD_(44)v6 in the pathogenesis of adenomyosis. Methods The expression of E-cadherin and CD_ 44 v6 in 50 ectopic and eutopic endometrium of adenomyosis was detected by immunohistochemical method in comparison with 30 normal endometrium. Results were analyzed by SPSS13.0 statistical software. Results The expression of E-cadherin in ectopic and eutopic endometrium of adenomyosis is lower than that in normal endometrium (P0.05). The expression of CD_(44)v6 in ectopic and eutopic endometrium of adenomyosis is higher than that in normal endometrium(P0.05). There was a negative correlation between the expression of E-cadherin and CD_(44) v6 in eutopic endometrium of adenomyosis and ectopic endometrium of adenomyosis (P0.05). There was no correlation between the expression of E-cadherin and CD_(44)v6 in normal endometrium (P0.05). Conclusion The abnormal expression of E-cadherin and CD_(44)v6 in eutopic endometrium and ectopic endometrium has relationship with the etiology of adenomyosis.