Laparoscopic Spleen Preservation Versus Splenectomy For Frantz Tumors: A Systematic Review And Meta-analysis On Perioperative And Oncological Outcomes

Laparoscopic Spleen Preservation Versus Splenectomy For Frantz Tumors: A Systematic Review And Meta-analysis On Perioperative And Oncological Outcomes | Research Square window.SnipcartSettings = { analytics: { enabled: false } }; (function() { var accessVector = localStorage.getItem('access_vector') || ''; window.dataLayer = window.dataLayer || []; if (accessVector) { window.dataLayer.push({ user: { profile: { profileInfo: { snid: accessVector } } } }); } })(); (function(w,d,s,l,i){w[l]=w[l]||[];w[l].push({'gtm.start':new Date().getTime(),event:'gtm.js'});var f=d.getElementsByTagName(s)[0],j=d.createElement(s),dl=l!='dataLayer'?'&l='+l:'';j.async=true;j.src='https://www.googletagmanager.com/gtm.js?id='+i+dl;f.parentNode.insertBefore(j,f);})(window,document,'script','dataLayer','GTM-K279D39R'); Browse Preprints In Review Journals COVID-19 Preprints AJE Video Bytes Research Tools Research Promotion AJE Professional Editing AJE Rubriq About Preprint Platform In Review Editorial Policies Our Team Advisory Board Help Center Sign In Submit a Preprint Cite Share Download PDF Systematic Review Laparoscopic Spleen Preservation Versus Splenectomy For Frantz Tumors: A Systematic Review And Meta-analysis On Perioperative And Oncological Outcomes Miguel Chaves Lenzi, MARIA CECÍLIA ÁZARA PAIM CARVALHO, GIULIA FONSECA SOUZA ROCHA, and 7 more This is a preprint; it has not been peer reviewed by a journal. https://doi.org/ 10.21203/rs.3.rs-6580807/v1 This work is licensed under a CC BY 4.0 License Status: Posted Version 1 posted You are reading this latest preprint version Abstract Introduction : Solid pseudopapillary neoplasms (SPNs), or Frantz tumors, are rare borderline epithelial neoplasms of the pancreas. There is no consensus regarding spleen management in SPNs, and distal pancreatectomy is the standard treatment for body and tail tumors. However, whether spleen-preserving distal pancreatectomy (SPDP) or distal pancreatectomy with splenectomy (SDP) provides better oncological and perioperative outcomes remains uncertain. Methods: We systematically searched Embase, Cochrane, and PubMed databases for studies comparing SPDP and SDP in SPN patients, focusing on overall complications as the main outcome. A random-effects model was used to calculate odds ratios (OR) with 95% confidence intervals (CI). Results: Out of 290 screened articles, five studies met the inclusion criteria, comprising 40 patients who underwent SDP and 23 who underwent SPDP. Meta-analysis showed no significant difference in overall complication rates (OR = 0.55,95% CI: 0.16-1.93, p = 0.35, I² = 0%) or pancreatic fistula incidence (OR = 0.32, 95% CI: 0.06-1.77, p = 0.19). Notably, both techniques demonstrated equivalent oncological outcomes, with no reported recurrence or mortality in either group during long-term follow-up, ranging from a mean of 7.9 to 47 months. Conclusion: SPDP and SDP are equally safe surgeries with similar oncological results, and therefore, choosing between the two should be based on technical feasibility and patient factors rather than oncological concerns General Surgery LAPAROSCOPIC DISTAL PANCREATECTOMY LAPAROSCOPIC SPLENECTOMY MINIMALLY INVASIVE SURGICAL PROCEDURES SOLID PSEUDOPAPILLARY TUMOR OF PANCREAS PANCREATIC NEOPLASMS Full Text Additional Declarations The authors declare no competing interests. Supplementary Files SupplementarymaterialFrantz.docx Cite Share Download PDF Status: Posted Version 1 posted You are reading this latest preprint version Research Square lets you share your work early, gain feedback from the community, and start making changes to your manuscript prior to peer review in a journal. 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Also discoverable on Platform About Our Team In Review Editorial Policies Advisory Board Help Center Resources Author Services Accessibility API Access RSS feed Manage Cookie Preferences © Research Square 2026 | ISSN 2693-5015 (online) Privacy Policy Terms of Service Do Not Sell My Personal Information {"props":{"pageProps":{"initialData":{"identity":"rs-6580807","acceptedTermsAndConditions":true,"allowDirectSubmit":true,"archivedVersions":[],"articleType":"Systematic Review","associatedPublications":[],"authors":[{"id":451278813,"identity":"3b7d4cce-c477-4970-8833-99982d85e3e8","order_by":0,"name":"Miguel Chaves 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Outcomes\u003c/p\u003e","fulltext":[],"fulltextSource":"","fullText":"","funders":[],"hasAdminPriorityOnWorkflow":false,"hasManuscriptDocX":false,"hasOptedInToPreprint":true,"hasPassedJournalQc":"","hasAnyPriority":true,"hideJournal":true,"highlight":"","institution":"State University of Rio Grande do Norte","isAcceptedByJournal":false,"isAuthorSuppliedPdf":true,"isDeskRejected":"","isHiddenFromSearch":false,"isInQc":false,"isInWorkflow":false,"isPdf":true,"isPdfUpToDate":true,"isWithdrawnOrRetracted":false,"journal":{"display":true,"email":"[email protected]","identity":"researchsquare","isNatureJournal":false,"hasQc":true,"allowDirectSubmit":true,"externalIdentity":"","sideBox":"","snPcode":"","submissionUrl":"/submission","title":"Research Square","twitterHandle":"researchsquare","acdcEnabled":true,"dfaEnabled":false,"editorialSystem":"","reportingPortfolio":"","inReviewEnabled":false,"inReviewRevisionsEnabled":true},"keywords":"LAPAROSCOPIC DISTAL PANCREATECTOMY, LAPAROSCOPIC SPLENECTOMY, MINIMALLY INVASIVE SURGICAL PROCEDURES, SOLID PSEUDOPAPILLARY TUMOR OF PANCREAS, PANCREATIC NEOPLASMS","lastPublishedDoi":"10.21203/rs.3.rs-6580807/v1","lastPublishedDoiUrl":"https://doi.org/10.21203/rs.3.rs-6580807/v1","license":{"name":"CC BY 4.0","url":"https://creativecommons.org/licenses/by/4.0/"},"manuscriptAbstract":"\u003cp\u003e\u003cstrong\u003eIntroduction\u003c/strong\u003e: Solid pseudopapillary neoplasms (SPNs), or Frantz tumors, are rare borderline epithelial neoplasms of the pancreas. There is no consensus regarding spleen management in SPNs, and distal pancreatectomy is the standard treatment for body and tail tumors. However, whether spleen-preserving distal pancreatectomy (SPDP) or distal pancreatectomy with splenectomy (SDP) provides better oncological and perioperative outcomes remains uncertain. \u003cstrong\u003eMethods:\u003c/strong\u003e We systematically searched Embase, Cochrane, and PubMed databases for studies comparing SPDP and SDP in SPN patients, focusing on overall complications as the main outcome. A random-effects model was used to calculate odds ratios (OR) with 95% confidence intervals (CI).\u0026nbsp;\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eResults:\u003c/strong\u003e Out of 290 screened articles, five studies met the inclusion criteria, comprising 40 patients who underwent SDP and 23 who underwent SPDP. Meta-analysis showed no significant difference in overall complication rates (OR = 0.55,95% CI: 0.16-1.93, p = 0.35, I² = 0%) or pancreatic fistula incidence (OR = 0.32, 95% CI: 0.06-1.77, p = 0.19). Notably, both techniques demonstrated equivalent oncological outcomes, with no reported recurrence or mortality in either group during long-term follow-up, ranging from a mean of 7.9 to 47 months.\u0026nbsp;\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eConclusion:\u003c/strong\u003e SPDP and SDP are equally safe surgeries with similar oncological results, and therefore, choosing between the two should be based on technical feasibility and patient factors rather than oncological concerns\u003c/p\u003e","manuscriptTitle":"Laparoscopic Spleen Preservation Versus Splenectomy For Frantz Tumors: A Systematic Review And Meta-analysis On Perioperative And Oncological Outcomes","msid":"","msnumber":"","nonDraftVersions":[{"code":1,"date":"2025-05-09 04:31:21","doi":"10.21203/rs.3.rs-6580807/v1","editorialEvents":[{"type":"communityComments","content":0}],"status":"published","journal":{"display":true,"email":"[email protected]","identity":"researchsquare","isNatureJournal":false,"hasQc":true,"allowDirectSubmit":true,"externalIdentity":"","sideBox":"","snPcode":"","submissionUrl":"/submission","title":"Research Square","twitterHandle":"researchsquare","acdcEnabled":true,"dfaEnabled":false,"editorialSystem":"","reportingPortfolio":"","inReviewEnabled":false,"inReviewRevisionsEnabled":true}}],"origin":"","ownerIdentity":"46b40406-8c16-45b0-9181-9f18d3882426","owner":[],"postedDate":"May 9th, 2025","published":true,"recentEditorialEvents":[],"rejectedJournal":[],"revision":"","amendment":"","status":"posted","subjectAreas":[{"id":48139817,"name":"General Surgery"}],"tags":[],"updatedAt":"2025-05-09T04:31:21+00:00","versionOfRecord":[],"versionCreatedAt":"2025-05-09 04:31:21","video":"","vorDoi":"","vorDoiUrl":"","workflowStages":[]},"version":"v1","identity":"rs-6580807","journalConfig":"researchsquare"},"__N_SSP":true},"page":"/article/[identity]/[[...version]]","query":{"redirect":"/article/rs-6580807","identity":"rs-6580807","version":["v1"]},"buildId":"XKTyCvWXoU3ODBz1xrDgd","isFallback":false,"isExperimentalCompile":false,"dynamicIds":[84888],"gssp":true,"scriptLoader":[]}