Successful Pregnancy Following Fertility-Sparing Surgery and Chemotherapy for Ovarian Clear Cell Carcinoma

Ovarian clear cell carcinoma (OCCC) is a rare histologic subtype of epithelial ovarian cancer, often associated with chemoresistance and poor prognosis. Fertility preservation in patients with OCCC remains controversial due to its aggressive biological behavior and limited evidence supporting conservative management. We report a case of a 33-year-old woman with stage IA OCCC who underwent fertility-sparing staging surgery followed by six cycles of adjuvant chemotherapy with liposomal paclitaxel and carboplatin. Gonadotropin-releasing hormone agonist was administered concurrently to protect ovarian function. The patient remained disease-free during follow-up and achieved a successful full-term pregnancy after in vitro fertilization and embryo transfer. This case demonstrates that fertility-sparing surgery combined with adjuvant chemotherapy may be a feasible treatment option in carefully selected young patients with early-stage OCCC. Individualized management, comprehensive counseling, and close surveillance are essential to ensure both oncologic safety and favorable reproductive outcomes.