Antibacterial Activity of Zinc Oxide (ZnO) Biosynthesized from Brown Seaweed Extracts against Pathogenic Bacteria

Nowadays, the main health problem and one of the significant problems in the world is increasing bacterial resistance to antimicrobial agents. Existing research results show that nanoparticle metals could be used to prevent the spread of resistant bacteria in the community. This study was conducted to determine the antibacterial activity of zinc oxide (ZnO) against gram-positive bacteria Staphylococcus aureus and gram-negative bacteria Klebsiella pneumonia and Vibrio parahaemolyticus . ZnO used to be the best ZnO produced from the biosynthesis of brown seaweed ( Sargassum sp. and Padina sp.) extracts with Zn(NO 3 ) 2 .4H 2 O as precursors at each optimum reaction pH of 10. The diffusion and dilution method used paper discs with three repetitions to conduct the antibacterial activity test. Observations were made by forming a clear zone and the ability to inhibit bacterial growth (MIC). The study's novelty is that ZnO biosynthesized from brown seaweed extract of Sargassum sp. and Padina sp. can inhibit bacterial activity. They can potentially be applied to additional material in fishery product packaging.