damidBind: an R/Bioconductor package for differential DamID analysis and data exploration

2026 · doi:10.64898/2026.01.06.698059
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Abstract

Summary DamID, and its cell-type specific adaptations, including Targeted DamID (TaDa) and Chromatin Accessibility TaDa (CATaDa), are now widely-adopted as techniques for the genome-wide profiling of DNA binding proteins. Despite this popularity, no dedicated software solution exists for identifying differentially bound or accessible loci, or differentially transcribed genes, between cell types using DamID. The R/Bioconductor package damidBind provides these functions, allowing an end-user to move from processed binding profiles to identifying differentially-bound loci in a reproducible, statistically appropriate and straightforward workflow. Availability and Implementation damidBind is an open-source R/Bioconductor package and freely available from Bioconductor at https://bioconductor.org/packages/-damidBind/ , and from GitHub at https://github.com/marshall-lab/damidBind . It is released under the GPLv3 licence. Contact Owen Marshall ( [email protected] )
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Abstract Summary DamID, and its cell-type specific adaptations, including Targeted DamID (TaDa), Chromatin Accessibility TaDa (CATaDa) and NanoDam, are now widely-adopted as techniques for the genome-wide profiling of DNA binding proteins. Despite this popularity, no software solution exists for identifying differentially bound or accessible loci or transcribed genes between cell types using DamID. The R/Bioconductor package damid-Bind provides these functions, allowing an end-user to move from raw binding profiles to identifying differentially-bound loci in a reproducible, statistically-robust and straightfor-ward workflow. Availability and Implementation damidBind is open-source and freely available from https://bioconductor.org/packages/damidBind/ and https://github.com/marshall-lab/damid-Bind. The package is implemented in R, and is released under the GPLv3 licence. Contact Owen Marshall (owen.marshall{at}utas.edu.au) Competing Interest Statement The authors have declared no competing interest. Footnotes Minor textual corrections to manuscript, and additional citation added.

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last seen: 2026-05-20T01:45:00.602351+00:00