Trends in Reported Chlamydia Cases Among Reproductive-Aged Females in the United States, 1996–2014: A Retrospective CDC WONDER Analysis

Trends in Reported Chlamydia Cases Among Reproductive-Aged Females in the United States, 1996–2014: A Retrospective CDC WONDER Analysis | Research Square window.SnipcartSettings = { analytics: { enabled: false } }; (function() { var accessVector = localStorage.getItem('access_vector') || ''; window.dataLayer = window.dataLayer || []; if (accessVector) { window.dataLayer.push({ user: { profile: { profileInfo: { snid: accessVector } } } }); } })(); (function(w,d,s,l,i){w[l]=w[l]||[];w[l].push({'gtm.start':new Date().getTime(),event:'gtm.js'});var f=d.getElementsByTagName(s)[0],j=d.createElement(s),dl=l!='dataLayer'?'&l='+l:'';j.async=true;j.src='https://www.googletagmanager.com/gtm.js?id='+i+dl;f.parentNode.insertBefore(j,f);})(window,document,'script','dataLayer','GTM-K279D39R'); Browse Preprints In Review Journals COVID-19 Preprints AJE Video Bytes Research Tools Research Promotion AJE Professional Editing AJE Rubriq About Preprint Platform In Review Editorial Policies Our Team Advisory Board Help Center Sign In Submit a Preprint Cite Share Download PDF Research Article Trends in Reported Chlamydia Cases Among Reproductive-Aged Females in the United States, 1996–2014: A Retrospective CDC WONDER Analysis Huzaifa Saleem This is a preprint; it has not been peer reviewed by a journal. https://doi.org/ 10.21203/rs.3.rs-8546662/v1 This work is licensed under a CC BY 4.0 License Status: Posted Version 1 posted You are reading this latest preprint version Abstract Background: Chlamydia trachomatis is the most commonly reported notifiable disease in the United States, with significant implications for reproductive health. Understanding its epidemiologic trends is crucial for guiding prevention efforts Objective: To analyze the geographic, demographic, and temporal trends in reported chlamydia cases among females aged 20–39 years in the United States from 1996 to 2014. Methodology: A retrospective analysis was conducted using publicly available data from the CDC WONDER online database. Case counts were aggregated by year, state, race/ethnicity, and age group (20–24, 25–29, 30–34, 35–39 years). Data visualization was performed using Tableau software. Temporal trends were analyzed using Joinpoint Regression Software to identify significant changes in Annual Percent Change (APC). Results: A total of 8,368,977 chlamydia cases among females aged 20–39 were reported from 1996–2014. Geographic analysis revealed higher case counts in southern and western states. The 20–24 year age group accounted for the majority of cases (5,285,914). Black or African American females accounted for the highest case counts, followed by White and Hispanic females across all age groups. Temporal analysis showed a steady national increase from 1996–2013. Joinpoint analysis indicated varying trends by state, with several states (e.g., Alabama, Arkansas) exhibiting multiple significant inflection points, while others showed stable, linear increases. Conclusion: Chlamydia case count remains high among young adult and minority females in the United States, with distinct geographic and demographic patterns. The persistent disparities underscore the need for targeted, culturally competent screening and prevention programs. Epidemiology Obstetrics & Gynecology Chlamydia trachomatis CDC Wonder Retrospective analysis Disease burden Full Text Additional Declarations The authors declare no competing interests. Cite Share Download PDF Status: Posted Version 1 posted You are reading this latest preprint version Research Square lets you share your work early, gain feedback from the community, and start making changes to your manuscript prior to peer review in a journal. As a division of Research Square Company, we’re committed to making research communication faster, fairer, and more useful. We do this by developing innovative software and high quality services for the global research community. Our growing team is made up of researchers and industry professionals working together to solve the most critical problems facing scientific publishing. Also discoverable on Platform About Our Team In Review Editorial Policies Advisory Board Help Center Resources Author Services Accessibility API Access RSS feed Manage Cookie Preferences © Research Square 2026 | ISSN 2693-5015 (online) Privacy Policy Terms of Service Do Not Sell My Personal Information {"props":{"pageProps":{"initialData":{"identity":"rs-8546662","acceptedTermsAndConditions":true,"allowDirectSubmit":true,"archivedVersions":[],"articleType":"Research Article","associatedPublications":[],"authors":[{"id":571186998,"identity":"34693e75-d173-4ee8-bcea-93c301f22034","order_by":0,"name":"Huzaifa 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Analysis\u003c/p\u003e","fulltext":[],"fulltextSource":"","fullText":"","funders":[],"hasAdminPriorityOnWorkflow":false,"hasManuscriptDocX":false,"hasOptedInToPreprint":true,"hasPassedJournalQc":"","hasAnyPriority":true,"hideJournal":true,"highlight":"","institution":"","isAcceptedByJournal":false,"isAuthorSuppliedPdf":true,"isDeskRejected":"","isHiddenFromSearch":false,"isInQc":false,"isInWorkflow":false,"isPdf":true,"isPdfUpToDate":true,"isWithdrawnOrRetracted":false,"journal":{"display":true,"email":"[email protected]","identity":"researchsquare","isNatureJournal":false,"hasQc":true,"allowDirectSubmit":true,"externalIdentity":"","sideBox":"","snPcode":"","submissionUrl":"/submission","title":"Research Square","twitterHandle":"researchsquare","acdcEnabled":true,"dfaEnabled":false,"editorialSystem":"","reportingPortfolio":"","inReviewEnabled":false,"inReviewRevisionsEnabled":true},"keywords":"Chlamydia trachomatis, CDC Wonder, Retrospective analysis, Disease burden","lastPublishedDoi":"10.21203/rs.3.rs-8546662/v1","lastPublishedDoiUrl":"https://doi.org/10.21203/rs.3.rs-8546662/v1","license":{"name":"CC BY 4.0","url":"https://creativecommons.org/licenses/by/4.0/"},"manuscriptAbstract":"\u003cp\u003eBackground:\u003c/p\u003e\n\u003cp\u003eChlamydia trachomatis is the most commonly reported notifiable disease in the United States, with significant implications for reproductive health. Understanding its epidemiologic trends is crucial for guiding prevention efforts\u003c/p\u003e\n\u003cp\u003eObjective:\u003c/p\u003e\n\u003cp\u003eTo analyze the geographic, demographic, and temporal trends in reported chlamydia cases among females aged 20–39 years in the United States from 1996 to 2014.\u003c/p\u003e\n\u003cp\u003eMethodology:\u003c/p\u003e\n\u003cp\u003eA retrospective analysis was conducted using publicly available data from the CDC WONDER online database. Case counts were aggregated by year, state, race/ethnicity, and age group (20–24, 25–29, 30–34, 35–39 years). Data visualization was performed using Tableau software. Temporal trends were analyzed using Joinpoint Regression Software to identify significant changes in Annual Percent Change (APC).\u003c/p\u003e\n\u003cp\u003eResults:\u003c/p\u003e\n\u003cp\u003eA total of 8,368,977 chlamydia cases among females aged 20–39 were reported from 1996–2014. Geographic analysis revealed higher case counts in southern and western states. The 20–24 year age group accounted for the majority of cases (5,285,914). Black or African American females accounted for the highest case counts, followed by White and Hispanic females across all age groups. Temporal analysis showed a steady national increase from 1996–2013. Joinpoint analysis indicated varying trends by state, with several states (e.g., Alabama, Arkansas) exhibiting multiple significant inflection points, while others showed stable, linear increases.\u003c/p\u003e\n\u003cp\u003eConclusion:\u003c/p\u003e\n\u003cp\u003eChlamydia case count remains high among young adult and minority females in the United States, with distinct geographic and demographic patterns. The persistent disparities underscore the need for targeted, culturally competent screening and prevention programs.\u003c/p\u003e","manuscriptTitle":"Trends in Reported Chlamydia Cases Among Reproductive-Aged Females in the United States, 1996–2014: A Retrospective CDC WONDER Analysis","msid":"","msnumber":"","nonDraftVersions":[{"code":1,"date":"2026-01-09 05:24:46","doi":"10.21203/rs.3.rs-8546662/v1","editorialEvents":[{"type":"communityComments","content":0}],"status":"published","journal":{"display":true,"email":"[email protected]","identity":"researchsquare","isNatureJournal":false,"hasQc":true,"allowDirectSubmit":true,"externalIdentity":"","sideBox":"","snPcode":"","submissionUrl":"/submission","title":"Research Square","twitterHandle":"researchsquare","acdcEnabled":true,"dfaEnabled":false,"editorialSystem":"","reportingPortfolio":"","inReviewEnabled":false,"inReviewRevisionsEnabled":true}}],"origin":"","ownerIdentity":"c7135938-c0e5-480a-bb3a-56ffdc875b5d","owner":[],"postedDate":"January 9th, 2026","published":true,"recentEditorialEvents":[],"rejectedJournal":[],"revision":"","amendment":"","status":"posted","subjectAreas":[{"id":60782114,"name":"Epidemiology"},{"id":60782115,"name":"Obstetrics \u0026 Gynecology"}],"tags":[],"updatedAt":"2026-01-09T05:24:46+00:00","versionOfRecord":[],"versionCreatedAt":"2026-01-09 05:24:46","video":"","vorDoi":"","vorDoiUrl":"","workflowStages":[]},"version":"v1","identity":"rs-8546662","journalConfig":"researchsquare"},"__N_SSP":true},"page":"/article/[identity]/[[...version]]","query":{"redirect":"/article/rs-8546662","identity":"rs-8546662","version":["v1"]},"buildId":"XKTyCvWXoU3ODBz1xrDgd","isFallback":false,"isExperimentalCompile":false,"dynamicIds":[84888],"gssp":true,"scriptLoader":[]}