Value of Detecting Serum and Peritoneal Fluid Levels of IL-4 and IL-8 in Patients with Endometriosis

Objective To explore the changes and significance of serum and peritoneal fluid levels of IL-4 and IL-8 in patients with endometriosis.Method By using double antibody sandwich enzyme-linked immunosorbent assay(ELISA),we detected the 48 patients with endometriosis(21 patients in I ~ II and 27 patients in III ~ IV)and 18 patients in the control group(who received other gynecological surgery with intraoperative intraperitoneal effusion).Results The peritoneal fluid and serum levels of IL-4 and IL-8 in patients with endometriosis were higher than those in patients without endometriosis in control group(P0.05).In EMs group,the peritoneal fluid and serum levels of IL-4 and IL-8 in patients in Ⅲ ~ Ⅳ stage were higher than those in patients in I ~ II stage(P0.05).Conclusion IL-4 and IL-8 play an important role in the pathogenesis of endometriosis,detecting the changes of IL-4 and IL-8 levels in serum and peritoneal fluid may benefits the diagnosis and treatment of endometriosis.