Molecular epidemiology of pregnancy using omics data: advances, success stories, and challenges

Abstract Multi-omics approaches have been successfully applied to investigate pregnancy and health outcomes at a molecular and genetic level in several studies. As omics technologies advance, research areas are open to study further. Here we discuss overall trends and examples of successfully using omics technologies and techniques (e.g., genomics, proteomics, metabolomics, and metagenomics) to investigate the molecular epidemiology of pregnancy. In addition, we outline omics applications and study characteristics of pregnancy for understanding fundamental biology, causal health and physiological relationships, risk and prediction modeling, diagnostics, and correlations. Overarching goal: To detail the utility of multi-omics approaches in the study of pregnancy physiology and disease.