Ovulation Induction in the Ovulatory Woman

Kaylen M. Silverberg, K M Silverberg
Seminars in reproductive endocrinology · 1996 · vol. 14(04) , pp. 339–343 · doi:10.1055/s-2008-1067978 · PMID:8988528 · W2036260683
review OA: closed CC0 ⤵ 3 in-corpus citations
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⚙ AI-generated summary by claude@2026-06, 2026-06-09 ⓘ

Controlled ovarian hyperstimulation with clomiphene citrate or gonadotropins combined with intrauterine insemination may improve pregnancy rates compared to expectant management for subfertile women.

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Abstract

Controlled ovarian hyperstimulation is frequently employed as empiric therapy for the treatment of unexplained infertility, mild male factor, cervical factor, and treated endometriosis. Prescribed in the form of either clomiphene citrate or gonadotropins, it is often combined with intrauterine insemination and offered to patients as a less expensive and less invasive alternative to the assisted reproductive technologies. Efficacy studies for these regimens are very important, as patients who would appear to be ideal candidates for this empiric therapy frequently do not suffer from absolute infertility; rather they are often subfertile, and may conceive spontaneously given enough time. Although there are few well-designed, controlled trials that assess the effectiveness of this form of therapy, the majority of the published data do suggest an improvement in pregnancy rates when compared to expectant management.
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Condition tags

endometriosisinfertility

MeSH descriptors

Infertility, Female Ovulation Ovulation Induction Clomiphene Clomiphene Endometriosis Endometriosis Female Fertility Agents, Female Fertility Agents, Female Gonadotropin-Releasing Hormone Gonadotropin-Releasing Hormone Gonadotropins, Pituitary Gonadotropins, Pituitary Humans Infertility, Female Infertility, Female Infertility, Female Infertility, Male Infertility, Male

Citation neighborhood (sparse)

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Cited by (3)

Cited by (3)

Source provenance

europepmc
last seen: 2026-06-11T06:19:48.454388+00:00
openalex
last seen: 2026-06-04T00:00:01.174412+00:00
pubmed
last seen: 2026-05-13T22:10:57.821266+00:00
License: CC0 · commercial use OK