Synthesis, computational and biological evaluation of some new pyridine Derivatives

A series of pyridine compounds was prepared by using "3-(dimethylamino)-1-(pyridin-4-yl)prop-2-en-1-one" ( 14 ) as precursor. Reaction of 14 with different reagents afforded different new heterocyclic compounds. All the new compounds were characterized by spectroscopic analyses. Moreover, study of Density Function Theory (DFT) was mentioned to establish the geometry of the tested compounds. The antimicrobial activities of the newly prepared pyridine derivatives were studied against Gram positive bacteria ( B. subtilis and B. thuringiensis) and Gram-negative bacteria ( E. Coil and P. aerugunosa ) and fungi ( F. oxysporum and B. Fabae ) by MIC method. Compounds belonging to pyran 32 , pyridine 33 , indenopyran 34 , thiazolopyridine 35 and chromene 39 series displayed a high antimicrobial activity. It was found that, the experimental results of biological evaluation were in agreement with their molecular modeling study.