Comparison of Dienogest and Continuous Combined Oral Contraceptive Pills Effects on Pain, Quality of Life, and Endometrioma Recurrence after Surgery for Endometriosis: A randomized Controlled Trial

Maryam Hashemi
2021 · doi:10.17632/k2ffd6j5zj · W6962818685
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A randomized trial in women with endometriosis found that dienogest and combined oral contraceptive pills similarly improved pain, quality of life, and sexual function without significant differences in endometrioma recurrence rates after surgery.

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This prospective randomized clinical trial evaluated the postoperative effects of dienogest versus continuous combined oral contraceptive pills in eighty women who underwent laparoscopic conservative surgery for endometriosis. The study measured outcomes related to pelvic pain, quality of life, and sexual function over a six-month treatment period while monitoring for endometrioma recurrence. Results indicated that both treatments significantly reduced various types of pelvic pain and improved overall quality of life, with no statistically significant differences observed between the two groups regarding symptom relief or disease recurrence rates. This paper is centrally about endometriosis — specifically comparing hormonal suppressive therapies to prevent pain recurrence and improve patient-reported outcomes following surgical intervention.

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Abstract

Abstract Study objective: To compare the effects of dienogest and combined oral contraceptive (COC) pills after laparoscopic conservative surgery on pain, quality of life (QOL), and recurrence of endometrioma in women with endometriosis. Design: Prospective randomized clinical trial study. Setting: Academic tertiary referral center. Patients: Women with endometriosis confirmed by surgery from April 2016 to June 2018. Interventions: Eighty patients who had undergone operative laparoscopy received dienogest or COC pills daily for six months. Measurements and Main Results: Treatment with dienogest was associated with improved self-reported of all types of pelvic pain and QOL after 6 months of treatment (P < 0.05). Improvement of these parameters was also observed in COC groups (P < 0.05), except for dyspareunia (p=0.089). Both of these pills significantly improved the scores of QOL and sexual function, but no remarkable differences were detected between the two groups in this regard (P < 0.05). About recurrence of endometrioma, there were no differences between dienogest and COC users (p=0.1). Conclusion: Postoperative administration of dienogest or COC pills after operative laparoscopy reduced pain and improved QOL in women with endometriosis. So, the choice of regimen can be adjusted according to the patientʼs symptoms, needs, and preferences. Keywords: Dienogest; Combined Oral Contraceptive; Endometriosis; Surgery; Pelvic Pain; Quality of Life
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Comparison of Dienogest and Continuous Combined Oral Contraceptive Pills Effects on Pain, Quality of Life, and Endometrioma Recurrence after Surgery for Endometriosis: A randomized Controlled Trial Description Abstract Study objective: To compare the effects of dienogest and combined oral contraceptive (COC) pills after laparoscopic conservative surgery on pain, quality of life (QOL), and recurrence of endometrioma in women with endometriosis. Design: Prospective randomized clinical trial study. Setting: Academic tertiary referral center. Patients: Women with endometriosis confirmed by surgery from April 2016 to June 2018. Interventions: Eighty patients who had undergone operative laparoscopy received dienogest or COC pills daily for six months. Measurements and Main Results: Treatment with dienogest was associated with improved self-reported of all types of pelvic pain and QOL after 6 months of treatment (P < 0.05). Improvement of these parameters was also observed in COC groups (P < 0.05), except for dyspareunia (p=0.089). Both of these pills significantly improved the scores of QOL and sexual function, but no remarkable differences were detected between the two groups in this regard (P < 0.05). About recurrence of endometrioma, there were no differences between dienogest and COC users (p=0.1). Conclusion: Postoperative administration of dienogest or COC pills after operative laparoscopy reduced pain and improved QOL in women with endometriosis. So, the choice of regimen can be adjusted according to the patientʼs symptoms, needs, and preferences. Keywords: Dienogest; Combined Oral Contraceptive; Endometriosis; Surgery; Pelvic Pain; Quality of Life Files Institutions - Isfahan University of Medical Sciences

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