Multidimensional helical dichroism from a chiral molecular nanoassembly

Multidimensional helical dichroism from a chiral molecular nanoassembly | Research Square window.SnipcartSettings = { analytics: { enabled: false } }; (function() { var accessVector = localStorage.getItem('access_vector') || ''; window.dataLayer = window.dataLayer || []; if (accessVector) { window.dataLayer.push({ user: { profile: { profileInfo: { snid: accessVector } } } }); } })(); (function(w,d,s,l,i){w[l]=w[l]||[];w[l].push({'gtm.start':new Date().getTime(),event:'gtm.js'});var f=d.getElementsByTagName(s)[0],j=d.createElement(s),dl=l!='dataLayer'?'&l='+l:'';j.async=true;j.src='https://www.googletagmanager.com/gtm.js?id='+i+dl;f.parentNode.insertBefore(j,f);})(window,document,'script','dataLayer','GTM-K279D39R'); Browse Preprints In Review Journals COVID-19 Preprints AJE Video Bytes Research Tools Research Promotion AJE Professional Editing AJE Rubriq About Preprint Platform In Review Editorial Policies Our Team Advisory Board Help Center Sign In Submit a Preprint Cite Share Download PDF Article Multidimensional helical dichroism from a chiral molecular nanoassembly Jincheng Ni, Yusheng Jin, Xinghao Wang, Zhijie Xia, Xiaoxu Rao, and 6 more This is a preprint; it has not been peer reviewed by a journal. https://doi.org/ 10.21203/rs.3.rs-8085524/v1 This work is licensed under a CC BY 4.0 License Status: Published Journal Publication published 29 Jan, 2026 Read the published version in Nature Communications → Version 1 posted You are reading this latest preprint version Abstract Detecting the chirality of molecules is of great importance in optics, biomedicine, and materials science. In chiroptical spectroscopy, it’s crucial to achieve strong chiroptical signals with a minimal number of chiral molecules. The molecular chiroptical signals, however, are typically weak for chiral molecular sensing in conventional circular dichroism using photonic spin angular momentum, even in the presence of a large number of chiral molecules (micromoles to millimoles). Here, by involving chiral light-matter interaction with photonic orbital angular momentum, we demonstrate strong chiroptical responses that reflect the molecular chirality in a single chiral nanoassembly. We experimentally present the helical dichroism spectra of chiral nanoassemblies synthesized from L/D-cystines, consistent with electromagnetic simulations. The asymmetry factors in the fundamental wavelength and photoluminescence emission reach values of 0.53 and 1.18, respectively, exceeding those observed in the circular dichroism mechanism. To improve the dimensions of helical dichroism spectroscopy, we analyze helical dichroism in wavelength domain, polarization domain, and momentum space. Our findings not only expand the methods for trace chiral molecular sensing but also provide new insights into chiral light-matter interactions. Physical sciences/Optics and photonics/Optical techniques Physical sciences/Nanoscience and technology/Nanoscale materials Full Text Additional Declarations There is NO Competing Interest. Supplementary Files Supportinginformation20251110.docx Supporting Information Cite Share Download PDF Status: Published Journal Publication published 29 Jan, 2026 Read the published version in Nature Communications → Version 1 posted You are reading this latest preprint version Research Square lets you share your work early, gain feedback from the community, and start making changes to your manuscript prior to peer review in a journal. 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Also discoverable on Platform About Our Team In Review Editorial Policies Advisory Board Help Center Resources Author Services Accessibility API Access RSS feed Manage Cookie Preferences © Research Square 2026 | ISSN 2693-5015 (online) Privacy Policy Terms of Service Do Not Sell My Personal Information {"props":{"pageProps":{"initialData":{"identity":"rs-8085524","acceptedTermsAndConditions":true,"allowDirectSubmit":false,"archivedVersions":[],"articleType":"Article","associatedPublications":[],"authors":[{"id":548789846,"identity":"4ae3b705-e8cd-40bc-9d85-cc1659b17f28","order_by":0,"name":"Jincheng 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