Predicting Cyclosporine-Related Liver Injury in Pediatric Thalassemia after Hematopoietic Stem Cell Transplantation

Predicting Cyclosporine-Related Liver Injury in Pediatric Thalassemia after Hematopoietic Stem Cell Transplantation | Authorea try { document.documentElement.classList.add('js'); } catch (e) { } var _gaq = _gaq || []; _gaq.push(['_setAccount', 'G-8VDV14Y67G']); _gaq.push(['_trackPageview']); (function() { var ga = document.createElement('script'); ga.type = 'text/javascript'; ga.async = true; ga.src = ('https:' == document.location.protocol ? 'https://ssl' : 'http://www') + '.google-analytics.com/ga.js'; var s = document.getElementsByTagName('script')[0]; s.parentNode.insertBefore(ga, s); })(); Skip to main content Preprints Collections Wiley Open Research IET Open Research Ecological Society of Japan All Collections About About Authorea FAQs Contact Us Quick Search anywhere Search for preprint articles, keywords, etc. Search Search ADVANCED SEARCH SCROLL This is a preprint and has not been peer reviewed. Data may be preliminary. 4 December 2025 V1 Latest version Share on Predicting Cyclosporine-Related Liver Injury in Pediatric Thalassemia after Hematopoietic Stem Cell Transplantation Authors : Fuli Qin , Jiu’an Lan , Jun Luo , and Shuangyi Tang [email protected] Authors Info & Affiliations https://doi.org/10.22541/au.176485154.46953464/v1 110 views 92 downloads Contents Abstract Supplementary Material Information & Authors Metrics & Citations View Options References Figures Tables Media Share Abstract Children with thalassemia often need a stem cell transplant, and cyclosporine is commonly used afterward to prevent transplant rejection. Although effective, cyclosporine can sometimes harm the liver, which may lead to serious health issues if not identified early. In this study, we analyzed clinical information from children who received cyclosporine after transplantation to find factors that might predict liver injury. We found that certain laboratory tests and cyclosporine blood levels were helpful in determining which children were at higher risk. Using these factors, we built a prediction model that accurately identified patients likely to develop liver injury. This tool can help doctors adjust cyclosporine doses sooner and monitor high-risk patients more closely. Our results support safer and more personalized cyclosporine use in children undergoing stem cell transplantation. Supplementary Material File (pds-25-0955-file001.doc) Download 1.03 MB Information & Authors Information Version history V1 Version 1 04 December 2025 Copyright This work is licensed under a Non Exclusive No Reuse License. Keywords cyclosporine a drug-induced liver injury risk prediction thalassemia Authors Affiliations Fuli Qin Affiliated Hospital of Guangxi Medical University View all articles by this author Jiu’an Lan Guangxi Medical University Cancer Hospital View all articles by this author Jun Luo Affiliated Hospital of Guangxi Medical University View all articles by this author Shuangyi Tang [email protected] Affiliated Hospital of Guangxi Medical University View all articles by this author Metrics & Citations Metrics Article Usage 110 views 92 downloads .FvxKWukQNSOunydq8rnd { width: 100px; } Citations Download citation Fuli Qin, Jiu’an Lan, Jun Luo, et al. Predicting Cyclosporine-Related Liver Injury in Pediatric Thalassemia after Hematopoietic Stem Cell Transplantation. Authorea . 04 December 2025. DOI: https://doi.org/10.22541/au.176485154.46953464/v1 If you have the appropriate software installed, you can download article citation data to the citation manager of your choice. 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