Prosthodontic Rehabilitation in a Patient with Fahr’s Syndrome: A Clinical Case Report with Oral Manifestations and Mandibular Prosthetic Challenges

Prosthodontic Rehabilitation in a Patient with Fahr’s Syndrome: A Clinical Case Report with Oral Manifestations and Mandibular Prosthetic Challenges | Research Square window.SnipcartSettings = { analytics: { enabled: false } }; (function() { var accessVector = localStorage.getItem('access_vector') || ''; window.dataLayer = window.dataLayer || []; if (accessVector) { window.dataLayer.push({ user: { profile: { profileInfo: { snid: accessVector } } } }); } })(); (function(w,d,s,l,i){w[l]=w[l]||[];w[l].push({'gtm.start':new Date().getTime(),event:'gtm.js'});var f=d.getElementsByTagName(s)[0],j=d.createElement(s),dl=l!='dataLayer'?'&l='+l:'';j.async=true;j.src='https://www.googletagmanager.com/gtm.js?id='+i+dl;f.parentNode.insertBefore(j,f);})(window,document,'script','dataLayer','GTM-K279D39R'); Browse Preprints In Review Journals COVID-19 Preprints AJE Video Bytes Research Tools Research Promotion AJE Professional Editing AJE Rubriq About Preprint Platform In Review Editorial Policies Our Team Advisory Board Help Center Sign In Submit a Preprint Cite Share Download PDF Case Report Prosthodontic Rehabilitation in a Patient with Fahr’s Syndrome: A Clinical Case Report with Oral Manifestations and Mandibular Prosthetic Challenges Dr. Ruby Singh, Dr. Jitendra Rao, Dr. Shweta Singh, Dr. Sakshi Oswal, and 1 more This is a preprint; it has not been peer reviewed by a journal. https://doi.org/ 10.21203/rs.3.rs-7114323/v1 This work is licensed under a CC BY 4.0 License Status: Under Review Version 1 posted 15 You are reading this latest preprint version Abstract BACKGROUND Fahr's syndrome, sometimes referred to as primary familial brain calcification, is an uncommon neurodegenerative disease that is typified by bilateral, symmetrical intracranial calcifications that primarily affect the cerebral cortex, thalamus, dentate nuclei, and basal ganglia. Cognitive decline and seizures. The condition is often associated with movement disorders, seizures, neuropsychiatric symptoms, and cognitive decline. However, it can sometimes go unnoticed and be discovered by accident when imaging for unrelated conditions. Early symptoms can be detected in non-neurological settings, even though neurologists deal with it most of the time. This highlights the importance of interdisciplinary vigilance in healthcare. Dental professionals, particularly prosthodontists, may occasionally experience systemic manifestations during routine diagnostic evaluations, emphasizing the need for a comprehensive clinical approach, including movement disorders and neuropsychiatric conditions. CASE PRESENTATION A 39-year-old woman presented at the prosthodontics department of KGMU, complaining of difficulty chewing food due to missing posterior teeth. At the time of presentation, she denied experiencing any neurological symptoms and had no noteworthy medical history. The results of a routine pre-prosthetic evaluation, which included panoramic radiography, raised the possibility of abnormal intracranial calcification. Additional evaluation using cranial computed tomography (CT) confirmed bilateral, symmetrical calcifications in the thalamus, subcortical white matter, and basal ganglia that resembled Fahr's syndrome. The patient was referred to the Department of Neurology for further assessment. The patient was referred to the Department of Neurology for further assessment. In order to rule out secondary causes of calcification, other biochemical tests, such as serum calcium level, phosphate, parathyroid hormone, and vitamin D levels, were all within normal ranges. It was determined that idiopathic Fahr's syndrome was the cause. Since the condition is progressive, the patient was recommended to have frequent follow-ups even though there were no additional neurological symptoms. Potential neurological effects were closely monitored during the dental rehabilitation process. CONCLUSION In this case, Fahr’s syndrome was accidentally discovered, which increased the dentist's understanding of the syndrome despite the neurological symptoms being present. Fahr's syndrome intracranial calcification prosthodontics neurological disorders dental diagnosis Full Text Additional Declarations No competing interests reported. Cite Share Download PDF Status: Under Review Version 1 posted Editorial decision: Revision requested 29 Sep, 2025 Reviews received at journal 27 Sep, 2025 Reviewers agreed at journal 27 Sep, 2025 Reviewers agreed at journal 26 Sep, 2025 Reviews received at journal 25 Sep, 2025 Reviews received at journal 24 Sep, 2025 Reviewers agreed at journal 24 Sep, 2025 Reviewers agreed at journal 24 Sep, 2025 Reviewers agreed at journal 22 Sep, 2025 Reviewers agreed at journal 21 Sep, 2025 Reviewers invited by journal 21 Sep, 2025 Editor invited by journal 19 Sep, 2025 Editor assigned by journal 04 Aug, 2025 Submission checks completed at journal 01 Aug, 2025 First submitted to journal 01 Aug, 2025 You are reading this latest preprint version Research Square lets you share your work early, gain feedback from the community, and start making changes to your manuscript prior to peer review in a journal. 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Challenges\u003c/p\u003e","fulltext":[],"fulltextSource":"","fullText":"","funders":[],"hasAdminPriorityOnWorkflow":false,"hasManuscriptDocX":false,"hasOptedInToPreprint":true,"hasPassedJournalQc":"","hasAnyPriority":false,"hideJournal":false,"highlight":"","institution":"","isAcceptedByJournal":true,"isAuthorSuppliedPdf":true,"isDeskRejected":"","isHiddenFromSearch":false,"isInQc":false,"isInWorkflow":false,"isPdf":true,"isPdfUpToDate":true,"isWithdrawnOrRetracted":false,"journal":{"display":true,"email":"[email protected]","identity":"bmc-oral-health","isNatureJournal":false,"hasQc":true,"allowDirectSubmit":false,"externalIdentity":"ohea","sideBox":"Learn more about [BMC Oral Health](http://bmcoralhealth.biomedcentral.com/)","snPcode":"","submissionUrl":"https://www.editorialmanager.com/ohea/default.aspx","title":"BMC Oral Health","twitterHandle":"BMC_series","acdcEnabled":true,"dfaEnabled":false,"editorialSystem":"em","reportingPortfolio":"BMC Series","inReviewEnabled":true,"inReviewRevisionsEnabled":true},"keywords":"Fahr's syndrome, intracranial calcification, prosthodontics, neurological disorders, dental diagnosis","lastPublishedDoi":"10.21203/rs.3.rs-7114323/v1","lastPublishedDoiUrl":"https://doi.org/10.21203/rs.3.rs-7114323/v1","license":{"name":"CC BY 4.0","url":"https://creativecommons.org/licenses/by/4.0/"},"manuscriptAbstract":"\u003ch2\u003eBACKGROUND\u003c/h2\u003e\u003cp\u003eFahr's syndrome, sometimes referred to as primary familial brain calcification, is an uncommon neurodegenerative disease that is typified by bilateral, symmetrical intracranial calcifications that primarily affect the cerebral cortex, thalamus, dentate nuclei, and basal ganglia. Cognitive decline and seizures. The condition is often associated with movement disorders, seizures, neuropsychiatric symptoms, and cognitive decline. However, it can sometimes go unnoticed and be discovered by accident when imaging for unrelated conditions. Early symptoms can be detected in non-neurological settings, even though neurologists deal with it most of the time. This highlights the importance of interdisciplinary vigilance in healthcare. Dental professionals, particularly prosthodontists, may occasionally experience systemic manifestations during routine diagnostic evaluations, emphasizing the need for a comprehensive clinical approach, including movement disorders and neuropsychiatric conditions.\u003c/p\u003e\u003ch2\u003eCASE PRESENTATION\u003c/h2\u003e\u003cp\u003eA 39-year-old woman presented at the prosthodontics department of KGMU, complaining of difficulty chewing food due to missing posterior teeth. At the time of presentation, she denied experiencing any neurological symptoms and had no noteworthy medical history. The results of a routine pre-prosthetic evaluation, which included panoramic radiography, raised the possibility of abnormal intracranial calcification. Additional evaluation using cranial computed tomography (CT) confirmed bilateral, symmetrical calcifications in the thalamus, subcortical white matter, and basal ganglia that resembled Fahr's syndrome. The patient was referred to the Department of Neurology for further assessment. The patient was referred to the Department of Neurology for further assessment. In order to rule out secondary causes of calcification, other biochemical tests, such as serum calcium level, phosphate, parathyroid hormone, and vitamin D levels, were all within normal ranges. It was determined that idiopathic Fahr's syndrome was the cause. Since the condition is progressive, the patient was recommended to have frequent follow-ups even though there were no additional neurological symptoms. Potential neurological effects were closely monitored during the dental rehabilitation process.\u003c/p\u003e\u003ch2\u003eCONCLUSION\u003c/h2\u003e\u003cp\u003eIn this case, Fahr\u0026rsquo;s syndrome was accidentally discovered, which increased the dentist's understanding of the syndrome despite the neurological symptoms being present.\u003c/p\u003e","manuscriptTitle":"Prosthodontic Rehabilitation in a Patient with Fahr’s Syndrome: A Clinical Case Report with Oral Manifestations and Mandibular Prosthetic Challenges","msid":"","msnumber":"","nonDraftVersions":[{"code":1,"date":"2025-10-01 14:24:47","doi":"10.21203/rs.3.rs-7114323/v1","editorialEvents":[{"type":"communityComments","content":0},{"type":"decision","content":"Revision requested","date":"2025-09-29T06:20:40+00:00","index":"","fulltext":""},{"type":"editorInvitedReview","content":"","date":"2025-09-27T17:31:52+00:00","index":"hide","fulltext":""},{"type":"reviewerAgreed","content":"32887508096173694304290565355511479109","date":"2025-09-27T08:57:05+00:00","index":"hide","fulltext":""},{"type":"reviewerAgreed","content":"276808051592465968842663211736028731638","date":"2025-09-26T14:44:53+00:00","index":"hide","fulltext":""},{"type":"editorInvitedReview","content":"","date":"2025-09-25T09:11:23+00:00","index":"hide","fulltext":""},{"type":"editorInvitedReview","content":"","date":"2025-09-25T02:42:09+00:00","index":"hide","fulltext":""},{"type":"reviewerAgreed","content":"247552299641334830107820125569637388229","date":"2025-09-25T02:23:47+00:00","index":"hide","fulltext":""},{"type":"reviewerAgreed","content":"6807906707654136381044362540513736337","date":"2025-09-24T06:01:34+00:00","index":"hide","fulltext":""},{"type":"reviewerAgreed","content":"201549574515166578718698109273021256422","date":"2025-09-22T07:45:53+00:00","index":"hide","fulltext":""},{"type":"reviewerAgreed","content":"294912000238649038447546707550494593797","date":"2025-09-21T14:39:04+00:00","index":"hide","fulltext":""},{"type":"reviewersInvited","content":"","date":"2025-09-21T14:37:28+00:00","index":"","fulltext":""},{"type":"editorInvited","content":"","date":"2025-09-19T08:56:56+00:00","index":"","fulltext":""},{"type":"editorAssigned","content":"","date":"2025-08-04T16:07:51+00:00","index":"","fulltext":""},{"type":"checksComplete","content":"","date":"2025-08-01T19:40:43+00:00","index":"","fulltext":""},{"type":"submitted","content":"BMC Oral Health","date":"2025-08-01T19:38:18+00:00","index":"","fulltext":""}],"status":"published","journal":{"display":true,"email":"[email protected]","identity":"bmc-oral-health","isNatureJournal":false,"hasQc":true,"allowDirectSubmit":false,"externalIdentity":"ohea","sideBox":"Learn more about [BMC Oral Health](http://bmcoralhealth.biomedcentral.com/)","snPcode":"","submissionUrl":"https://www.editorialmanager.com/ohea/default.aspx","title":"BMC Oral Health","twitterHandle":"BMC_series","acdcEnabled":true,"dfaEnabled":false,"editorialSystem":"em","reportingPortfolio":"BMC Series","inReviewEnabled":true,"inReviewRevisionsEnabled":true}}],"origin":"","ownerIdentity":"ee5cfa6d-9eb6-4ada-8356-4c735ade8d0b","owner":[],"postedDate":"October 1st, 2025","published":true,"recentEditorialEvents":[],"rejectedJournal":[],"revision":"","amendment":"","status":"under-review","subjectAreas":[],"tags":[],"updatedAt":"2025-11-03T11:53:16+00:00","versionOfRecord":[],"versionCreatedAt":"2025-10-01 14:24:47","video":"","vorDoi":"","vorDoiUrl":"","workflowStages":[]},"version":"v1","identity":"rs-7114323","journalConfig":"researchsquare"},"__N_SSP":true},"page":"/article/[identity]/[[...version]]","query":{"redirect":"/article/rs-7114323","identity":"rs-7114323","version":["v1"]},"buildId":"8U1c8b4HqxoKbykW_rLl7","isFallback":false,"isExperimentalCompile":false,"dynamicIds":[84888],"gssp":true,"scriptLoader":[]}