Neuropsychiatric Adverse Events of Levothyrocine and Liothyronine: A Real-World Analysis Pharmacovigilance Assessment

Neuropsychiatric Adverse Events of Levothyrocine and Liothyronine: A Real-World Analysis Pharmacovigilance Assessment | Authorea try { document.documentElement.classList.add('js'); } catch (e) { } var _gaq = _gaq || []; _gaq.push(['_setAccount', 'G-8VDV14Y67G']); _gaq.push(['_trackPageview']); (function() { var ga = document.createElement('script'); ga.type = 'text/javascript'; ga.async = true; ga.src = ('https:' == document.location.protocol ? 'https://ssl' : 'http://www') + '.google-analytics.com/ga.js'; var s = document.getElementsByTagName('script')[0]; s.parentNode.insertBefore(ga, s); })(); Skip to main content Preprints Collections Wiley Open Research IET Open Research Ecological Society of Japan All Collections About About Authorea FAQs Contact Us Quick Search anywhere Search for preprint articles, keywords, etc. Search Search ADVANCED SEARCH SCROLL This is a preprint and has not been peer reviewed. Data may be preliminary. 30 April 2025 V1 Latest version Share on Neuropsychiatric Adverse Events of Levothyrocine and Liothyronine: A Real-World Analysis Pharmacovigilance Assessment Authors : Guimu Guo , Tingting Chen , Jintuo Zhou , Peiguang Niu , Xiaoping Zeng , Ruoxuan Pan , and Jinhua Zhang 0000-0002-5629-0348 [email protected] Authors Info & Affiliations https://doi.org/10.22541/au.174600382.28663161/v1 205 views 94 downloads Contents Abstract Supplementary Material Information & Authors Metrics & Citations View Options References Figures Tables Media Share Abstract Objective: This study utilizes the Food and Drug Administration Adverse Event Reporting System (FAERS) database to identify signals of neuropsychiatric adverse events related to levothyroxine and liothyronine. Methods: This study acquired post-marketing data from the first quarter of 2004 to the third quarter of 2024 from the FAERS database for disproportionality analysis. The potential signals between levothyroxine and liothyronine in relation to neuropsychiatric adverse events were analyzed using the Bayesian Information Component (IC) method. The goodness-of-fit test was used to analyze the distribution of onset times, with venlafaxine as a positive control to confirm the internal validity of the database. Results: From the FAERS database, 28,184 and 506 reports of neuropsychiatric adverse events were respectively associated with levothyroxine and liothyronine. The median onset times were 20.5 and 3.5 days, respectively, and both had shape parameters β greater than 1, indicating wear-out failure. For levothyroxine, major neuropsychiatric adverse events in patients with thyroid diseases included social avoidant behavior (IC 025 =5.11), asocial behavior (IC 025 =4.67), and impatience (IC 025 =4.35). For liothyronine, the strongest signals were psychiatric disorders (IC 025 =1.8), nervous system disorders (IC 025 =1.48), and psychiatric disorders (IC 025 =1.29). Additionally, levothyroxine indicated signals for depression (IC 025 =2.02), suicidal ideation (IC 025 =1.24), loss of libido (IC 025 =3.36), disturbance in attention (IC 025 =3.21), and idiopathic intracranial hypertension (IC 025 =1.71). Conclusions: Based on clinical characteristics, TTO, and disproportionality analysis, this study identified signals between levothyroxine and liothyronine with neuropsychiatric adverse events. Clinicians should monitor thyroid hormone levels when treating thyroid diseases with thyroid hormone therapy to avoid severe neuropsychiatric adverse events. Supplementary Material File (pds-25-0286-file001.docx) Download 92.59 KB File (pds-25-0286-file005.docx) Download 18.08 KB File (pds-25-0286-file006.docx) Download 21.30 KB Information & Authors Information Version history V1 Version 1 30 April 2025 Copyright This work is licensed under a Non Exclusive No Reuse License. Keywords faers database levothyroxine liothyronine neuropsychiatric adverse events thyroid diseases Authors Affiliations Guimu Guo Fujian Provincial Maternity and Children's Hospital Department of Pharmacy View all articles by this author Tingting Chen Fujian Provincial Maternity and Children's Hospital Department of Pharmacy View all articles by this author Jintuo Zhou Fujian Provincial Maternity and Children's Hospital Department of Pharmacy View all articles by this author Peiguang Niu Fujian Provincial Maternity and Children's Hospital Department of Pharmacy View all articles by this author Xiaoping Zeng Fujian Provincial Maternity and Children's Hospital Department of Pharmacy View all articles by this author Ruoxuan Pan Fujian Provincial Maternity and Children's Hospital Department of Pharmacy View all articles by this author Jinhua Zhang 0000-0002-5629-0348 [email protected] Fujian Provincial Maternity and Children's Hospital Department of Pharmacy View all articles by this author Metrics & Citations Metrics Article Usage 205 views 94 downloads .FvxKWukQNSOunydq8rnd { width: 100px; } Citations Download citation Guimu Guo, Tingting Chen, Jintuo Zhou, et al. Neuropsychiatric Adverse Events of Levothyrocine and Liothyronine: A Real-World Analysis Pharmacovigilance Assessment. Authorea . 30 April 2025. DOI: https://doi.org/10.22541/au.174600382.28663161/v1 If you have the appropriate software installed, you can download article citation data to the citation manager of your choice. Simply select your manager software from the list below and click Download. For more information or tips please see 'Downloading to a citation manager' in the Help menu . Format Please select one from the list RIS (ProCite, Reference Manager) EndNote BibTex Medlars RefWorks Direct import Tips for downloading citations document.getElementById('citMgrHelpLink').addEventListener('click', function() { popupHelp(this.href); return false; }); $(".js__slcInclude").on("change", function(e){ if ($(this).val() == 'refworks') $('#direct').prop("checked", false); $('#direct').prop("disabled", ($(this).val() == 'refworks')); }); View Options View options PDF View PDF Figures Tables Media Share Share Share article link Copy Link Copied! Copying failed. Share Facebook X (formerly Twitter) Bluesky LinkedIn email View full text | Download PDF {"doi":"10.22541/au.174600382.28663161/v1","type":"Article"} Now Reading: Share Figures Tables Close figure viewer Back to article Figure title goes here Change zoom level Go to figure location within the article Download figure Toggle share panel Toggle share panel Share Toggle information panel Toggle information panel Go to previous graphic Go to next graphic Go to previous table Go to next table All figures All tables View all material View all material xrefBack.goTo xrefBack.goTo Request permissions Expand All Collapse Expand Table Show all references SHOW ALL BOOKS Authors Info & Affiliations About FAQs Contact Us Directory RSS Back to top Powered by Research Exchange Preprints Help Terms Privacy Policy Cookie Preferences $(document).ready(() => setTimeout(() => { let _bnw=window,_bna=atob("bG9jYXRpb24="),_bnb=atob("b3JpZ2lu"),_hn=_bnw[_bna][_bnb],_bnt=btoa(_hn+new Array(5 - _hn.length % 4).join(" ")); $.get("/resource/lodash?t="+_bnt); },4000)); (function(){function c(){var b=a.contentDocument||a.contentWindow.document;if(b){var d=b.createElement('script');d.innerHTML="window.__CF$cv$params={r:'9ffcbffc08d10db4',t:'MTc3OTQ2MjY1MA=='};var a=document.createElement('script');a.src='/cdn-cgi/challenge-platform/scripts/jsd/main.js';document.getElementsByTagName('head')[0].appendChild(a);";b.getElementsByTagName('head')[0].appendChild(d)}}if(document.body){var a=document.createElement('iframe');a.height=1;a.width=1;a.style.position='absolute';a.style.top=0;a.style.left=0;a.style.border='none';a.style.visibility='hidden';document.body.appendChild(a);if('loading'!==document.readyState)c();else if(window.addEventListener)document.addEventListener('DOMContentLoaded',c);else{var e=document.onreadystatechange||function(){};document.onreadystatechange=function(b){e(b);'loading'!==document.readyState&&(document.onreadystatechange=e,c())}}}})();