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Reporting guidelines have been developed to support complete reporting. However, assessments of reporting guideline adherence remain inconsistent, time-consuming, and difficult to scale. Artificial intelligence (AI) tools, such as traditional natural language processing models and large language models, might provide a potential solution. While numerous AI tools have been developed, no comprehensive synthesis has been undertaken to investigate what they assess, how they are implemented and perform, and their potential utility. Objective This systematic review aims to synthesise the characteristics and findings of studies evaluating AI tools developed to assist or automate assessments of reporting guideline adherence. Methods We will search MEDLINE, Embase, Scopus, Europe PMC, ACM Digital Library, IEEE Xplore, arXiv and Cochrane Colloquium Abstracts, with no restrictions on date, language, or publication type. We will include studies that evaluate AI tools to assess adherence of health-related papers to any reporting guidelines. Two authors will independently screen records, extract data and assess risk of bias. We will extract study characteristics, AI tool details, how reporting guidelines are operationalised for AI assessment, AI implementation details, comparison details, and evaluation outcomes including agreement metrics, classification performance metrics, and utility indicators. We will present and summarise results through structured tables and plots, stratified by reporting guideline and AI tool type. Discussion This systematic review will provide a comprehensive synthesis of AI tools developed to automate assessments of reporting guideline adherence. It will provide interest holders with insights into what AI tools have been used, their implementation approaches, which AI tool types perform well, and any improvements that can be made to AI tools automating assessments of reporting guideline adherence in the future. " } { "@context": "http://schema.org", "@type": "BreadcrumbList", "itemListElement": [ { "@type": "ListItem", "position": "1", "item": { "@id": "https://f1000research.com/", "name": "Home" } }, { "@type": "ListItem", "position": "2", "item": { "@id": "https://f1000research.com/browse/articles", "name": "Browse" } }, { "@type": "ListItem", "position": "3", "item": { "@id": "https://f1000research.com/articles/15-626", "name": "Artificial intelligence tools for automating assessments of reporting..." } } ] } Home Browse Artificial intelligence tools for automating assessments of reporting... ALL Metrics - Views Downloads Get PDF Get XML Cite How to cite this article Zeng M, Liu S, Clark DP et al. Artificial intelligence tools for automating assessments of reporting guideline adherence: a protocol for a systematic review [version 1; peer review: awaiting peer review] . F1000Research 2026, 15 :626 ( https://doi.org/10.12688/f1000research.179775.1 ) NOTE: If applicable, it is important to ensure the information in square brackets after the title is included in all citations of this article. Close Copy Citation Details Export Export Citation Sciwheel EndNote Ref. Manager Bibtex ProCite Sente EXPORT Select a format first Track Share ▬ ✚ Study Protocol Artificial intelligence tools for automating assessments of reporting guideline adherence: a protocol for a systematic review [version 1; peer review: awaiting peer review] Minyan Zeng https://orcid.org/0000-0001-7294-2599 1 , Shiwei Liu https://orcid.org/0009-0006-9382-1538 2 , David PQ Clark 1 , [...] Steve McDonald https://orcid.org/0000-0003-2832-5205 1 , Evan Mayo-Wilson 3 , Xiangji Ying 3 , Joe Menke 2 , Mengfei Lan 2 , Lan Jiang 2 , Kiran Ninan 3 , Jean-Pierre Oberste https://orcid.org/0009-0003-2075-5267 3 , Joanne E McKenzie https://orcid.org/0000-0003-3534-1641 1 , Halil Kilicoglu 2 , Matthew J Page https://orcid.org/0000-0002-4242-7526 1 Minyan Zeng https://orcid.org/0000-0001-7294-2599 1 , Shiwei Liu https://orcid.org/0009-0006-9382-1538 2 , [...] David PQ Clark 1 , Steve McDonald https://orcid.org/0000-0003-2832-5205 1 , Evan Mayo-Wilson 3 , Xiangji Ying 3 , Joe Menke 2 , Mengfei Lan 2 , Lan Jiang 2 , Kiran Ninan 3 , Jean-Pierre Oberste https://orcid.org/0009-0003-2075-5267 3 , Joanne E McKenzie https://orcid.org/0000-0003-3534-1641 1 , Halil Kilicoglu 2 , Matthew J Page https://orcid.org/0000-0002-4242-7526 1 PUBLISHED 28 Apr 2026 Author details Author details 1 Methods in Evidence Synthesis Unit, Monash University School of Public Health and Preventive Medicine, Melbourne, Victoria, Australia 2 School of Information Sciences, University of Illinois Urbana-Champaign, Champaign, USA 3 Department of Epidemiology, University of North Carolina Gillings School of Global Public Health, Chapel Hill, USA Minyan Zeng Roles: Methodology, Writing – Original Draft Preparation Shiwei Liu Roles: Methodology, Writing – Review & Editing David PQ Clark Roles: Methodology, Writing – Review & Editing Steve McDonald Roles: Methodology, Writing – Review & Editing Evan Mayo-Wilson Roles: Methodology, Writing – Review & Editing Xiangji Ying Roles: Methodology, Writing – Review & Editing Joe Menke Roles: Methodology, Writing – Review & Editing Mengfei Lan Roles: Methodology, Writing – Review & Editing Lan Jiang Roles: Methodology, Writing – Review & Editing Kiran Ninan Roles: Methodology, Writing – Review & Editing Jean-Pierre Oberste Roles: Methodology, Writing – Review & Editing Joanne E McKenzie Roles: Methodology, Writing – Review & Editing Halil Kilicoglu Roles: Methodology, Writing – Review & Editing Matthew J Page Roles: Conceptualization, Methodology, Writing – Review & Editing OPEN PEER REVIEW REVIEWER STATUS AWAITING PEER REVIEW This article is included in the Research on Research, Policy & Culture gateway. Abstract Background Complete reporting of health-related research is necessary for users to understand, appraise, and apply research results appropriately. Reporting guidelines have been developed to support complete reporting. However, assessments of reporting guideline adherence remain inconsistent, time-consuming, and difficult to scale. Artificial intelligence (AI) tools, such as traditional natural language processing models and large language models, might provide a potential solution. While numerous AI tools have been developed, no comprehensive synthesis has been undertaken to investigate what they assess, how they are implemented and perform, and their potential utility. Objective This systematic review aims to synthesise the characteristics and findings of studies evaluating AI tools developed to assist or automate assessments of reporting guideline adherence. Methods We will search MEDLINE, Embase, Scopus, Europe PMC, ACM Digital Library, IEEE Xplore, arXiv and Cochrane Colloquium Abstracts, with no restrictions on date, language, or publication type. We will include studies that evaluate AI tools to assess adherence of health-related papers to any reporting guidelines. Two authors will independently screen records, extract data and assess risk of bias. We will extract study characteristics, AI tool details, how reporting guidelines are operationalised for AI assessment, AI implementation details, comparison details, and evaluation outcomes including agreement metrics, classification performance metrics, and utility indicators. We will present and summarise results through structured tables and plots, stratified by reporting guideline and AI tool type. Discussion This systematic review will provide a comprehensive synthesis of AI tools developed to automate assessments of reporting guideline adherence. It will provide interest holders with insights into what AI tools have been used, their implementation approaches, which AI tool types perform well, and any improvements that can be made to AI tools automating assessments of reporting guideline adherence in the future. READ ALL READ LESS Keywords Reporting guidelines, Artificial intelligence, Adherence Corresponding Author(s) Minyan Zeng ( [email protected] ) Close Corresponding author: Minyan Zeng Competing interests: No competing interests were disclosed. Grant information: This research was supported by a Monash University Early Career Research Excellence Program (ECREP) grant. MJP is supported by a National Health and Medical Research Council Investigator Grant (GNT2033917). JEM is supported by a National Health and Medical Research Council Investigator Grant (GNT2009612). The funders had no role in the study design, decision to publish, or preparation of the manuscript. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. Copyright: © 2026 Zeng M et al . This is an open access article distributed under the terms of the Creative Commons Attribution License , which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. How to cite: Zeng M, Liu S, Clark DP et al. Artificial intelligence tools for automating assessments of reporting guideline adherence: a protocol for a systematic review [version 1; peer review: awaiting peer review] . F1000Research 2026, 15 :626 ( https://doi.org/10.12688/f1000research.179775.1 ) First published: 28 Apr 2026, 15 :626 ( https://doi.org/10.12688/f1000research.179775.1 ) Latest published: 28 Apr 2026, 15 :626 ( https://doi.org/10.12688/f1000research.179775.1 ) Introduction Complete reporting of health-related research is necessary for users to understand, appraise, and apply research results appropriately. Reporting guidelines provide recommendations on what should be reported, why it should be reported, and include exemplars of complete reporting to guide authors and other interest holders (e.g. peer reviewers, editors). 1 Reporting guidelines have been developed for different types of research, such as PRISMA (preferred reporting items for systematic reviews and meta-analyses) for systematic reviews, 2 CONSORT (consolidated standards of reporting trials) for randomised trials, 3 TRIPOD (transparent reporting of a multivariable prediction model for individual prognosis or diagnosis) for prediction models, 4 STROBE (strengthening the reporting of observational studies in epidemiology) for observational studies 5 and STARD (standard for reporting of diagnostic accuracy studies) for diagnostic studies. 6 Many of these “core” reporting guidelines have multiple extensions that provide additional reporting recommendations for specific aspects not covered in the core statement (e.g., types of outcomes, specific designs, analytic methods). Routine assessments of reporting guideline adherence have been performed manually by authors, editors, and reviewers to judge whether reporting recommendations have been met. Because reporting guidelines do not specify criteria for evaluating adherence, researchers have had to develop their own assessment criteria and methods. 7 , 8 Researchers must also decide whether to assess all checklist items/recommendations or only a subset, and meta-research studies suggest that most have chosen to focus on selected items. 7 , 9 , 10 These decisions have led to considerable variability in what is assessed and how it is assessed. 7 , 9 , 10 Also, manual evaluation is time-consuming and resource-intensive. 11 Additionally, research questions such as what characteristics (e.g., time, discipline, journal) predict better or worse reporting are difficult to address at scale with a large body of literature using a manual evaluation approach. Therefore, more efficient, consistent, and scalable methods are needed. Artificial intelligence (AI), defined as computational systems capable of performing tasks that typically require human intelligence, such as learning, reasoning, and decision-making, might provide a potential solution. Early attempts to automate assessments of reporting guideline adherence relied on traditional natural language processing (NLP) models. Examples include CONSORT-NLP, 12 which combines rule-based and machine learning-based approaches to automatically complete the CONSORT checklist from randomized clinical trial reports, and the SPIRIT-CONSORT-TM, 13 an annotated corpus designed to train NLP models to automatically assess adherence to reporting recommendations in clinical trial protocols and result publications. However, these traditional NLP systems generally require substantial guideline-specific annotated datasets for development, and are applicable only to the particular guideline for which they were designed. Moreover, most systems focus on detecting local text segments, which could limit their utility for end-to-end evaluation in long research publications with multimodal data components (e.g., text, tables, and figures). The advent of large language models (LLMs) and vision language models (VLMs), such as GPT and Gemini, provides another opportunity to scale up assessments of reporting guideline adherence. Trained on extensive data from articles, books and other online sources, 14 these models are capable of processing complex data components, extracting information, summarising evidence, and generating outputs that are relevant to reporting guideline items. Several studies have used these models to assess reporting guideline adherence. 15 – 17 However, the outputs of LLMs and VLMs are sensitive to how they are implemented. Data preprocessing, prompts, and model inference settings might all influence model performance on specific tasks. For example, empirical work has shown that different prompt templates and formatting can substantially influence LLM outputs, though advanced models (e.g., GPT-4 compared to GPT-3.5-turbo) may demonstrate more robustness to such variations. 18 More importantly, because of the variability in assessment criteria and methods for evaluating adherence, researchers might use different prompts to ask subtly different questions for reporting guideline items (e.g., whether a guideline item is reported or whether it is reported adequately or fully). Additionally, even with identical prompts, fixed model parameters and fixed random seed, models may occasionally generate different outputs across runs due to hardware-level randomness. This leads to difficulties in achieving strict reproducibility. Their “black-box” nature also limits transparency in the process of decision-making, and model hallucinations, although an area of active improvement, may also challenge reliability in high-stakes fields such as health-related research. While numerous AI systems and prototypes have been developed to automate assessment of reporting guideline adherence, 11 – 13 , 15 – 17 no comprehensive synthesis has been undertaken to investigate what they assess, how they are implemented and perform, and their potential utility in research and publication workflows. Objective This systematic review aims to summarise and synthesize the characteristics and findings of studies evaluating AI tools developed to assist or automate assessments of reporting guideline adherence. Methods We have reported this protocol in accordance with the Preferred Reporting Items for Systematic reviews and Meta-analysis Protocols (PRISMA-P) statement 19 and with consideration of the methods items in the more recent PRISMA 2020 statement. 2 We have not registered the review. Eligibility criteria • Study designs We will include studies of any design that evaluate the performance of AI tools developed to assess adherence of health-related research papers to reporting guidelines. Eligible study designs include diagnostic accuracy studies, validation studies, and trials comparing AI tool and human performance, as well as methodological studies comparing different AI approaches. Studies will be included regardless of language, publication date, or publication type (e.g., journal article, conference proceeding). • Reporting guidelines We will include studies regardless of the reporting guideline evaluated, such as PRISMA, CONSORT, TRIPOD, STROBE, and STARD, and any of their extensions. By “reporting guideline”, we mean any document presenting reporting items that should appear in a research paper (regardless of whether presented as a checklist or structured text) and in which the authors explain how the items were developed. 20 • AI tools and comparator We will include any AI application, tool, or algorithm that (i) makes judgements about reporting guideline adherence, or (ii) identifies relevant text about reporting guideline adherence in a paper without making a judgement about adherence. Eligible systems could include any models that learn patterns from text with/without imaging data in the research papers, such as traditional natural language processing models (e.g., rule-based and BERT-like models) as well as LLMs and VLMs (e.g., GPT-5.2 and Gemini 3). We will include studies that compare AI tools with human assessment and studies that compare multiple AI tools with each other. Studies without an explicit comparator will also be eligible. • Outcomes We will include studies regardless of the outcomes assessed or reported. Outcomes of interest to this review include: (i) agreement (overall and for each item/recommendation) between the AI tool and human assessors using raw and chance corrected agreement metrics (e.g., Cohen’s kappa); (ii) classification performance (overall and/or for each item/recommendation) as determined using metrics such as accuracy, F1 score, sensitivity, specificity, positive and negative predictive values, and c-statistic; and (iii) utility indicators (e.g., task completion time, computational/API cost, and token usage across papers). Search methods We will search bibliographic databases and supplementary sources for eligible studies. Databases include MEDLINE (via Ovid), Embase (via Ovid), Scopus, Europe PMC, ACM Digital Library, and IEEE Xplore. We will not limit searches by date, language, publication status or publication format (except for Europe PMC, which will be restricted to preprints). Europe PMC will be used to search across several preprint servers (e.g., medRxiv, bioRxiv, preprints.org , SSRN, etc.) and we will also search the arXiv preprint server, as it is not comprehensively covered by Europe PMC. Additional sources include the abstracts of the Cochrane Colloquium. The final part of the search will involve manually backward citation tracking and forward citation tracking using LENS.org for all studies included in the review. An experienced information specialist (SM) designed the search strategies with input from the review team. The search includes terms related to the concepts of AI, adherence, and reporting. Several seed articles (based on articles known to the review team) 11 , 13 , 15 – 17 , 21 – 24 were used to develop the MEDLINE search. The MEDLINE search was then translated and adapted for use in the other sources. The search strategy was iteratively tested to achieve an optimal balance between recall and precision. Full search strategies are available as Extended data (see Data availability section). 25 Study selection All records will first be deduplicated using the built-in functions of the reference management tools we will use (i.e., EndNote and Covidence). Two reviewers (out of MZ, SL, DPQC, JM, ML, LJ, KN, JO) will then independently screen all titles and abstracts, and records that are considered eligible or uncertain by either reviewer will undergo full-text screening, where those reviewers will independently assess the full text of potentially eligible records. Any disagreements will be resolved by discussion or consulting with a third reviewer. Title and abstract screening of bibliographic databases records will be conducted using Covidence. For arXiv and Cochrane Colloquium Abstracts, a screening form will be created in Microsoft Excel with the link for each record and the search date. Data extraction Two reviewers (out of MZ, SL, DPQC) will independently conduct the data extraction using a data extraction form (available as Extended data; see Data availability section). 25 The data extraction form will be piloted by reviewers on a sample of included studies prior to the full data extraction process. Any discrepancies in the data collected between the two reviewers will be resolved via discussion or by consulting with a third reviewer (MJP or JEM). Data extraction will be conducted using a data extraction tool (REDCap version 15.5.30). 26 Where necessary and available, additional sources will be consulted to supplement information extracted from the included studies, such as published study protocols, registry entries, or primary dataset documentation. If information remains missing or unclear, we will contact the study authors for further information. The information that will be extracted from each included study is provided in Table 1 (available as Extended data; see Data availability section). 25 Quality assessment of included studies To evaluate the quality of the included studies, two reviewers (out of MZ, SL, DPQC) will independently apply a defined set of quality indicators. These indicators are informed by established tools PROBAST+AI 27 and the tool used in a living systematic review of AI tools for risk of bias assessment, 28 which offer relevant concepts for assessing AI tools. The quality indicators will cover the following domains: • AI tool development Whether the AI tool was developed rigorously (e.g., adequate training model and prompt engineering). • Reference standard Whether the reference standard assessment was conducted rigorously (e.g., performed by trained assessors, assessed by at least two assessors independently with consensus procedures in place). • Independence of assessments and risk of data leakage Whether the AI tool was applied to the studies without knowledge of the reference standard assessment and vice versa; Whether the AI tool’s final performance was evaluated on an independent test set that was not used for model training or prompt development/refinement; Whether there was a low risk that the annotation of test corpus was part of the AI model’s training data. • Study planning Whether the study was based on a publicly available protocol or registration record. Each indicator will be judged as low quality, high quality, or unclear quality. Quality assessment form is available as Extended data (see Data availability section). 25 A study will be deemed high quality overall if all quality indicators were deemed high quality, low quality overall if at least one indicator was deemed low quality, and unclear quality overall if at least one indicator was deemed unclear quality, but none were deemed low quality. Disagreements between reviewers will be resolved through discussion or adjudication by a third reviewer. Data syntheses and analyses Given the anticipated diversity in AI tools, reporting guidelines, study designs, and outcome measures, formal meta-analysis is unlikely to be feasible across all outcomes. We will therefore present and summarise results of each of the included studies through structured tables and plots. We will use structured tables to present study characteristics, reporting guidelines assessed and scope, dataset characteristics, dataset sources and formats, reference annotation for datasets, AI tool details, application of the AI tool, AI implementation details, and comparison details. Tables will be organised by reporting guideline evaluated, and then by the type of AI tool (traditional NLP models versus LLM-based/VLM-based models). We will then present AI tool performance and utility findings in tables organised by the reporting guideline evaluated, stratified by the type of AI tool and each outcome category (i.e., classification performance metrics, agreement metrics and utility indicators). Where multiple metrics are reported within the same outcome category, we will extract pre-specified metrics as detailed in the Data extraction form (available as Extended data; see Data availability section). 25 Where preferred metrics are unavailable, we will consider and note the alternative metrics reported by the study authors. We will summarise outcomes at overall level using descriptive statistics (e.g., mean, median, range across items) and also present the overall results in forest plots, stratified by reporting guideline and AI models. When item-level/recommendation-level outcomes are also available (e.g., classification performance metrics of adherence for each PRISMA item), we will summarise specific item-level results to facilitate performance interpretation using pre-specified rules, including the items with high and low performance (e.g., top and bottom five items for agreement metrics, accuracy and F1 score). When there are multiple results available for the same outcome across training, validation and test datasets, we will extract and summarise results identified by study authors as primary and/or the results from the most representative evaluation setting. In this circumstance, we will note that multiple results are available, and our reason for selecting the reported result. We will finally present and summarise the overall quality of studies by the reporting guideline evaluated, stratified by the type of AI tool. Dissemination plan We plan to disseminate the findings of this systematic review through publication in a peer-reviewed scientific journal. The final manuscript will include all methods, results, and interpretations arising from the review to support transparency and reproducibility. In addition to journal publication, we will present the key findings at relevant academic conferences and seminars to reach researchers, and developers working in AI and reporting guidelines. We will also make our data extraction forms, summary tables, and analytical code publicly accessible to facilitate future research in this area. Study status This study is currently at study selection stage. Discussion Complete reporting of health-related research is important for the usability and trustworthiness of research evidence. Reporting guidelines have been widely used to support complete reporting. However, assessments of reporting guideline adherence remain inconsistent, time-consuming, and difficult to scale. AI tools have the potential to address these limitations. As the AI field continues to evolve rapidly, a rigorous evidence synthesis is timely. This systematic review will be the first to comprehensively summarise and synthesise what AI tools have been developed to automate assessments of reporting guideline adherence. It will provide interest holders with insights into what AI tools have been used, their implementation approaches, which AI tool types perform well, and any improvements that can be made to AI tools automating assessments of reporting guideline adherence in the future. Data availability Underlying data No data are associated with this article. Extended data Open Science Framework: Artificial intelligence tools for automating assessments of reporting guideline adherence: a protocol for a systematic review. DOI: https://doi.org/10.17605/OSF.IO/AYSTK . 25 This project contains the following extended data: • Table 1. docx • APPENDIX Section 1 Search strategy.docx • APPENDIX Section 2 Data extraction form.docx • APPENDIX Section 3 Quality assessment form.docx Reporting guidelines Open Science Framework: PRISMA-P checklist for Artificial intelligence tools for automating assessments of reporting guideline adherence: a protocol for a systematic review. DOI: https://doi.org/10.17605/OSF.IO/AYSTK . 25 Data are available under the terms of the Creative Commons Attribution 4.0 International license (CC-BY 4.0) . References 1. EQUATOR Network - What is a reporting guideline: (access on 11 Feb 2026). Reference Source 2. Page MJ, McKenzie JE, Bossuyt PM, et al. : The PRISMA 2020 statement: an updated guideline for reporting systematic reviews. BMJ. 2021; 372 : n71. 3. Hopewell S, Chan A-W, Collins GS, et al. : CONSORT 2025 statement: updated guideline for reporting randomised trials. BMJ. 2025; 389 : e081123. PubMed Abstract | Publisher Full Text | Free Full Text 4. Collins GS, Reitsma JB, Altman DG, et al. : Transparent reporting of a multivariable prediction model for individual prognosis or diagnosis (TRIPOD): the TRIPOD statement. J Br Surg. 2015; 102 (3): 148–158. 5. 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Publisher Full Text Comments on this article Comments (0) Version 1 VERSION 1 PUBLISHED 28 Apr 2026 ADD YOUR COMMENT Comment Author details Author details 1 Methods in Evidence Synthesis Unit, Monash University School of Public Health and Preventive Medicine, Melbourne, Victoria, Australia 2 School of Information Sciences, University of Illinois Urbana-Champaign, Champaign, USA 3 Department of Epidemiology, University of North Carolina Gillings School of Global Public Health, Chapel Hill, USA Minyan Zeng Roles: Methodology, Writing – Original Draft Preparation Shiwei Liu Roles: Methodology, Writing – Review & Editing David PQ Clark Roles: Methodology, Writing – Review & Editing Steve McDonald Roles: Methodology, Writing – Review & Editing Evan Mayo-Wilson Roles: Methodology, Writing – Review & Editing Xiangji Ying Roles: Methodology, Writing – Review & Editing Joe Menke Roles: Methodology, Writing – Review & Editing Mengfei Lan Roles: Methodology, Writing – Review & Editing Lan Jiang Roles: Methodology, Writing – Review & Editing Kiran Ninan Roles: Methodology, Writing – Review & Editing Jean-Pierre Oberste Roles: Methodology, Writing – Review & Editing Joanne E McKenzie Roles: Methodology, Writing – Review & Editing Halil Kilicoglu Roles: Methodology, Writing – Review & Editing Matthew J Page Roles: Conceptualization, Methodology, Writing – Review & Editing Competing interests No competing interests were disclosed. Grant information This research was supported by a Monash University Early Career Research Excellence Program (ECREP) grant. MJP is supported by a National Health and Medical Research Council Investigator Grant (GNT2033917). JEM is supported by a National Health and Medical Research Council Investigator Grant (GNT2009612). The funders had no role in the study design, decision to publish, or preparation of the manuscript. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. Article Versions (1) version 1 Published: 28 Apr 2026, 15:626 https://doi.org/10.12688/f1000research.179775.1 Copyright © 2026 Zeng M et al . This is an open access article distributed under the terms of the Creative Commons Attribution License , which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Download Export To Sciwheel Bibtex EndNote ProCite Ref. 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