Molecular-biochemical factors of toxicity of endometriomas and their influence on ovarian reserve

E.D. Dubinskaya, A Gasparov, А. А. Дутов, О.Э. Барабанова, I.V. Kholban
In: Voprosy ginekologii, akušerstva i perinatologii · 2020 · vol. 19(1) , pp. 45–51 · doi:10.20953/1726-1678-2020-1-45-51 · W3021578930
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This study measured molecular-biochemical toxicity factors in ovarian endometriosis patients and found negative correlations between these factors and anti-Müllerian hormone levels, indicating an influence on ovarian reserve.

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This study examined molecular-biochemical markers associated with endometrioma “toxicity” in 131 patients with ovarian endometriosis undergoing examination and surgical treatment, comparing them with 30 controls undergoing diagnostic laparoscopy without external genital endometriosis. Markers measured in serum and peritoneal fluid included LDH, IL-6, IL-8, and Fe2+, and their correlations with anti-Müllerian hormone (AMH) were assessed, with patients stratified by ovarian reserve status (diminished vs normal). Findings showed inverse correlations between Fe2+ and IL-6 (strong negative) and LDH and IL-8 in peritoneal fluid with AMH, and inverse correlations between IL-6 and AMH and between LDH and AMH in blood serum; the authors interpret this as systemic and local oxidative-inflammatory stress linked to reduced ovarian reserve, noting that the study is based on association/correlation. This paper is centrally about endometriosis — ovarian endometriosis endometriomas and their toxicity-related oxidative-inflammatory markers correlated with ovarian reserve measured by AMH.

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Molecular-biochemical factors of toxicity of endometriomas and their influence on ovarian reserve Ekaterina D. Dubinskaya / Aleksandr S. Gasparov / A.A.Dutov / O.E.Barabanova / Irina V. Kholban / Objective. To study the levels of molecular-biochemical factors of ovarian endometriosis (OE) toxicity on the systemic and local levels and their correlation with the values of anti-Müllerian hormone (AMH). Patients and methods. The study included patients with OE (n = 131), who underwent examination and surgical treatment. The control group comprised 30 patients, who underwent diagnostic laparoscopy due to infertility, which excluded the presence of external genital endometriosis. In the course of preoperative examination, patients with OE were divided into 2 groups depending on the state of their ovarian reserve (OR): the treatment group – 71 (54.2%) patients with diminished OR and the reference group – 60 (45.8%) patients with normal OR. For objective assessment of the «toxicity» of endometriomas the levels of the sought-for molecular-biochemical markers of toxicity (lactate dehydrogenase (LDH), cytokines (interleukin-6 (IL-6), interleukin-8 (IL-8)), ferrous ions (Fe2+)) were examined in blood serum and peritoneal fluid and correlations of these parameters with AMH levels were determined. Results. The results have shown a strong negative correlation between Fe2+ and IL-6 levels, and also a moderate negative correlation between LDH and IL-8 levels in the peritoneal fluid and AMH levels. In blood serum, we have found a strong negative correlation between IL-6 and AMH levels, a moderate negative correlation between LDH and AMH. Conclusion. We have obtained the results that are demonstrative of the presence of oxidative-inflammatory stress in OE on both the systemic and local levels, and its influence of ovarian reserve. We have found a reverse correlation between the severity of the described changes and the degree of OR decrease. Key words: anti-Müllerian hormone, ovarian reserve, oxidative-inflammatory stress, toxicity, endometrioma. For citation: Dubinskaya E.D., Gasparov A.S., Dutov A.A., Barabanova O.E., Kholban I.V. Molecular-biochemical factors of toxicity of endometriomas and their influence on ovarian reserve. Vopr. ginekol. akus. perinatol. (Gynecology, Obstetrics and Perinatology). 2020; 19(1): 45–51. (In Russian). Open access

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