Serum Magnesium Level as a Biomarker to Predict the Risk of Labor Epidural Anesthesia Associated Fever

Background: Labor epidural anesthesia-associated fever（LEAF) is the biggest problem for labor epidural anesthesia. This study aimed to evaluate the clinical value of serum magnesium levels to predict the LEAF. Methods: : Finally, overall 528 singleton term-pregnant women who underwent labor epidural anesthesia in Fujian Provincial Maternity and Children's Health Hospital, affiliated hospital of Fujian Medical University from January 2019 to June 2019, were analyzed retrospectively. Using venous blood samples, the serum magnesium level was detected. The relationship between the serum magnesium level and LEAF was interpreted, and the optimal cut-off values of the serum magnesium level to predict LEAF were calculated. Results: : Overall, 65（12.30%）participants had LEAF. And a higher rate of the bulging membrane, gestational hypertension, NICU admission, and the different mode of delivery was significantly associated with LEAF. Also, the serum magnesium level demonstrated higher significantly in LEAF presence than absence (p<0.05). What is more, it indicated that the area under the receiver operating characteristic curve (AUC) for the serum magnesium level was 0.825, and an optimal cut-off of the serum magnesium level was 0.855 mg/dl. Furthermore, it demonstrated that the serum magnesium level had the highest OR (OR= 7.49; 95% CI (4.58-14.35) ). The bulging membrane is an independent risk factor LEAF presence (OR = 1.55; 95% CI (1.01-2.43 ). Conclusions: : Serum magnesium may reduce the incidence of LEAF. Serum magnesium can provide a suitable biomarker to predict LEAF and offer a useful target for LEAF treatment.