Rodent Animal Models of Endometriosis-Associated Pain: Unmet Needs and Resources Available for Improving Translational Research in Endometriosis

Tejada, Miguel A, Antunez, Carles, Nunez-Badinez, Paulina, De Leo, Bianca, Saunders, Philippa T, Vincent, Katy, Cano, Antonio, Nagel, Jens, Gomez, Raul
2023 · doi:10.5281/zenodo.7645989 · W6894211380
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This systematic review evaluates rodent endometriosis models and behavioral tests, identifying optimal reflex and non-reflex assays to accurately assess endometriosis-associated pain while addressing translational research unmet needs.

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This systematic review evaluates rodent animal models of endometriosis to address the lack of reproducible tools that replicate human pain characteristics. The authors analyze existing studies to classify behavioral tests into reflex-based methods, which measure hypersensitivity to noxious stimuli, and non-reflex methods, which assess emotional components of pain. The paper highlights that inappropriate test selection can lead to erroneous data and identifies specific visceral pain assays suitable for complementing traditional reflex measures in translational research. This paper is centrally about endometriosis — specifically focusing on improving preclinical models to better understand and treat endometriosis-associated chronic pain.

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Abstract

Chronic pain induced by endometriosis is a maladaptive pain experienced by half of women with this disease. The lack of pharmacological treatments suitable for the long-term relief of endometriosis-associated pain, without an impact on fertility, remains an urgent unmet need. Progress has been slowed by the absence of a reproducible rodent endometriosis model that fully replicates human physiopathological characteristics, including pain symptoms. Although pain assessment in rodents is a complicated task requiring qualified researchers, the choice of the behavioral test is no less important, since selecting inappropriate tests can cause erroneous data. Pain is usually measured with reflex tests in which hypersensitivity is evaluated by applying a noxious stimulus, yet this ignores the associated emotional component that could be evaluated via non-reflex tests. We conducted a systematic review of endometriosis models used in rodents and the number of them that studied pain. The type of behavioral test used was also analyzed and classified according to reflex and non-reflex tests. Finally, we determined the most used reflex tests for the study of endometriosis-induced pain and the main non-reflex behavioral tests utilized in visceral pain that can be extrapolated to the study of endometriosis and complement traditional reflex tests.
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Rodent Animal Models of Endometriosis-Associated Pain: Unmet Needs and Resources Available for Improving Translational Research in Endometriosis Authors/Creators - 1. Research Unit on Women's Health-INCLIVA, Institute of Health Research, 46010 Valencia, Spain - 2. Bayer AG. Research & Early Development, Pharmaceuticals, Exploratory Pathobiology, Aprather Weg 18a, 42096 Wuppertal, Germany - 3. Bayer AG. Research & Early Development, Pharmaceuticals, Reproductive Health, Müllerstr. 178, 13342 Berlin, Germany - 4. Centre for Inflammation Research, Queen's Medical Research Institute, The University of Edinburgh, 47 Little France Crescent, Edinburgh EH16 4TJ, UK - 5. Nuffield Department of Women's and Reproductive Health, University of Oxford, Oxford OX3 9DU, UK - 6. Research Unit on Women's Health-INCLIVA, Institute of Health Research, 46010 Valencia, Spain; Department of Pediatrics, Obstetrics and Gynecology, University of Valencia, 46010 Valencia, Spain - 7. Research Unit on Women's Health-INCLIVA, Institute of Health Research, 46010 Valencia, Spain; Department of Pathology, University of Valencia, 46010 Valencia, Spain Description Chronic pain induced by endometriosis is a maladaptive pain experienced by half of women with this disease. The lack of pharmacological treatments suitable for the long-term relief of endometriosis-associated pain, without an impact on fertility, remains an urgent unmet need. Progress has been slowed by the absence of a reproducible rodent endometriosis model that fully replicates human physiopathological characteristics, including pain symptoms. Although pain assessment in rodents is a complicated task requiring qualified researchers, the choice of the behavioral test is no less important, since selecting inappropriate tests can cause erroneous data. Pain is usually measured with reflex tests in which hypersensitivity is evaluated by applying a noxious stimulus, yet this ignores the associated emotional component that could be evaluated via non-reflex tests. We conducted a systematic review of endometriosis models used in rodents and the number of them that studied pain. The type of behavioral test used was also analyzed and classified according to reflex and non-reflex tests. Finally, we determined the most used reflex tests for the study of endometriosis-induced pain and the main non-reflex behavioral tests utilized in visceral pain that can be extrapolated to the study of endometriosis and complement traditional reflex tests. Files ijms-24-02422-v3.pdf Files (1.0 MB) | Name | Size | Download all | |---|---|---| | md5:0b6bacfefce6d085b0253f10136d68b5 | 1.0 MB | Preview Download |

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