RDW/Albumin ratio (RAR) in premature retinopathy: Evaluation of disease risk and progression

RDW/Albumin ratio (RAR) in premature retinopathy: Evaluation of disease risk and progression | Research Square window.SnipcartSettings = { analytics: { enabled: false } }; (function() { var accessVector = localStorage.getItem('access_vector') || ''; window.dataLayer = window.dataLayer || []; if (accessVector) { window.dataLayer.push({ user: { profile: { profileInfo: { snid: accessVector } } } }); } })(); (function(w,d,s,l,i){w[l]=w[l]||[];w[l].push({'gtm.start':new Date().getTime(),event:'gtm.js'});var f=d.getElementsByTagName(s)[0],j=d.createElement(s),dl=l!='dataLayer'?'&l='+l:'';j.async=true;j.src='https://www.googletagmanager.com/gtm.js?id='+i+dl;f.parentNode.insertBefore(j,f);})(window,document,'script','dataLayer','GTM-K279D39R'); Browse Preprints In Review Journals COVID-19 Preprints AJE Video Bytes Research Tools Research Promotion AJE Professional Editing AJE Rubriq About Preprint Platform In Review Editorial Policies Our Team Advisory Board Help Center Sign In Submit a Preprint Cite Share Download PDF Research Article RDW/Albumin ratio (RAR) in premature retinopathy: Evaluation of disease risk and progression busra caliskan, mustafa yıldırım, mustafa kara This is a preprint; it has not been peer reviewed by a journal. https://doi.org/ 10.21203/rs.3.rs-5468549/v2 This work is licensed under a CC BY 4.0 License Status: Posted Version 2 posted You are reading this latest preprint version Show more versions Abstract Purpose: To determine the role of the RDW-Albumin ratio (RAR), an integrative biomarker of the multidimensional associated with inflammation, oxidative stress, and nutritional status in retinopathy of prematurity (ROP), in the assessment of the risk of disease development and progression. Methods: A total of 110 preterm infants born before the 34th gestational week were included. The medical records were retrospectively analyzed. All demographic, clinical, and laboratory data were recorded. Patients were classified into three groups: those without ROP (No-ROP), those with ROP that regressed without treatment (ROP-reg), and those with ROP requiring treatment (ROP-tx). Blood parameters, including RDW, albumin, and RAR, were analyzed in both the early and late neonatal periods. Results: Gestational age and birth weight were significantly lower, NICU length of stay, respiratory distress syndrome (RDS), mechanical ventilation, sepsis, surfactant therapy, and transfusions were more frequent in ROP cases (p<0.001 for all). Early and late RAR values were highest in the most risky group and there was a significant difference between all groups (p=0.00). Logistic regression analysis identified surfactant therapy (OR: 3.820, p=0.012), blood transfusion (OR: 8.012, p<0.001), and early-period RAR (OR: 2.010, p=0.004) as major risk factors for ROP development. ROC analysis showed that early RAR had a moderate predictive value for ROP (AUC=0.70, 95% CI: 0.601-0.805). Conclusion: Early RAR appears to be a valuable biomarker for assessing the risk of ROP in preterm infants. Its significant association with the development of ROP may provide a potential clinical benefit in early risk stratification. However, further large-scale studies are needed to confirm its clinical utility. Ophthalmology Retinopathy of prematurity RDW Albumin RDW/albumin rate Biomarker Full Text Additional Declarations The authors declare no competing interests. Cite Share Download PDF Status: Posted Version 2 posted You are reading this latest preprint version Show more versions Research Square lets you share your work early, gain feedback from the community, and start making changes to your manuscript prior to peer review in a journal. As a division of Research Square Company, we’re committed to making research communication faster, fairer, and more useful. We do this by developing innovative software and high quality services for the global research community. Our growing team is made up of researchers and industry professionals working together to solve the most critical problems facing scientific publishing. Also discoverable on Platform About Our Team In Review Editorial Policies Advisory Board Help Center Resources Author Services Accessibility API Access RSS feed Manage Cookie Preferences © Research Square 2026 | ISSN 2693-5015 (online) Privacy Policy Terms of Service Do Not Sell My Personal Information {"props":{"pageProps":{"initialData":{"identity":"rs-5468549","acceptedTermsAndConditions":true,"allowDirectSubmit":true,"archivedVersions":[],"articleType":"Research Article","associatedPublications":[],"authors":[{"id":380046625,"identity":"eb6e60b2-dd25-4b12-955f-788fa4afbe63","order_by":0,"name":"busra caliskan","email":"data:image/png;base64,iVBORw0KGgoAAAANSUhEUgAAAZAAAAAyAQMAAABI0h/eAAAABlBMVEX///8AAABVwtN+AAAACXBIWXMAAA7EAAAOxAGVKw4bAAABCUlEQVRIiWNgGAWjYDCCAzxQBjtjA2MDA4McWPABUVqYIVqMwYIJxGlhYABpSWwAcfBp4bt99pjkzz128vzNzM0fZ9TcSZ8fdvgh0BY7Od0G7Fokz+WlSfM8SzaccZixTXLDsWe5G2+nGQC1JBubHcCuxeAMj5k0wwHmBAagFsYHbIdzN85OAGk5kLgNjxbJHwfqE+QPMzZ/fPDvcLrh7PQPBLVI8Bw4nGBwmLFBcmPb4QR56Rz8tkie4Uu25jlw3HAjyC8z+w4bbpDOKTiQYIDbL3xneA/e/HGgWl7uePvjjz3fDsvLz07f/OFDhZ0cLi1YnApWaUCschCQbyBF9SgYBaNgFIwEAADwMWgLiGUpUgAAAABJRU5ErkJggg==","orcid":"","institution":"","correspondingAuthor":true,"prefix":"","firstName":"busra","middleName":"","lastName":"caliskan","suffix":""},{"id":380046626,"identity":"06ebd3a9-fa15-4da1-8fbf-27488e8d98df","order_by":1,"name":"mustafa yıldırım","email":"","orcid":"","institution":"","correspondingAuthor":false,"prefix":"","firstName":"mustafa","middleName":"","lastName":"yıldırım","suffix":""},{"id":406172275,"identity":"781d5b76-18d5-4637-8a06-ca49e433c070","order_by":2,"name":"mustafa kara","email":"","orcid":"","institution":"","correspondingAuthor":false,"prefix":"","firstName":"mustafa","middleName":"","lastName":"kara","suffix":""}],"badges":[],"createdAt":"2024-11-17 06:52:50","currentVersionCode":2,"declarations":{"humanSubjects":false,"vertebrateSubjects":false,"conflictsOfInterestStatement":false,"humanSubjectEthicalGuidelines":false,"humanSubjectConsent":false,"humanSubjectClinicalTrial":false,"humanSubjectCaseReport":false,"vertebrateSubjectEthicalGuidelines":false},"doi":"10.21203/rs.3.rs-5468549/v2","doiUrl":"https://doi.org/10.21203/rs.3.rs-5468549/v2","draftVersion":[],"editorialEvents":[],"editorialNote":"","failedWorkflow":false,"files":[{"id":75751594,"identity":"dd22816e-3a55-4894-b671-bcdf014b2ee4","added_by":"auto","created_at":"2025-02-07 20:50:21","extension":"pdf","order_by":1,"title":"","display":"","copyAsset":false,"role":"manuscript-pdf","size":282660,"visible":true,"origin":"","legend":"","description":"","filename":"makalemsonnn.pdf","url":"https://assets-eu.researchsquare.com/files/rs-5468549/v2_covered_c7e499ee-7604-4837-a31d-2153ceb7aa97.pdf"}],"financialInterests":"The authors declare no competing interests.","formattedTitle":"RDW/Albumin ratio (RAR) in premature retinopathy: Evaluation of disease risk and progression","fulltext":[],"fulltextSource":"","fullText":"","funders":[],"hasAdminPriorityOnWorkflow":false,"hasManuscriptDocX":false,"hasOptedInToPreprint":true,"hasPassedJournalQc":"","hasAnyPriority":true,"hideJournal":true,"highlight":"","institution":"Atatürk University","isAcceptedByJournal":false,"isAuthorSuppliedPdf":true,"isDeskRejected":"","isHiddenFromSearch":false,"isInQc":false,"isInWorkflow":false,"isPdf":true,"isPdfUpToDate":true,"isWithdrawnOrRetracted":false,"journal":{"display":true,"email":"[email protected]","identity":"researchsquare","isNatureJournal":false,"hasQc":true,"allowDirectSubmit":true,"externalIdentity":"","sideBox":"","snPcode":"","submissionUrl":"/submission","title":"Research Square","twitterHandle":"researchsquare","acdcEnabled":true,"dfaEnabled":false,"editorialSystem":"","reportingPortfolio":"","inReviewEnabled":false,"inReviewRevisionsEnabled":true},"keywords":"Retinopathy of prematurity, RDW, Albumin, RDW/albumin rate, Biomarker","lastPublishedDoi":"10.21203/rs.3.rs-5468549/v2","lastPublishedDoiUrl":"https://doi.org/10.21203/rs.3.rs-5468549/v2","license":{"name":"CC BY 4.0","url":"https://creativecommons.org/licenses/by/4.0/"},"manuscriptAbstract":"\u003cp\u003e\u003cstrong\u003ePurpose: \u003c/strong\u003eTo determine the role of the RDW-Albumin ratio (RAR), an integrative biomarker of the multidimensional associated with inflammation, oxidative stress, and nutritional status in retinopathy of prematurity (ROP), in the assessment of the risk of disease development and progression.\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eMethods: \u003c/strong\u003eA total of 110 preterm infants born before the 34th gestational week were included. The medical records were retrospectively analyzed. All demographic, clinical, and laboratory data were recorded. Patients were classified into three groups: those without ROP (No-ROP), those with ROP that regressed without treatment (ROP-reg), and those with ROP requiring treatment (ROP-tx). Blood parameters, including RDW, albumin, and RAR, were analyzed in both the early and late neonatal periods.\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eResults: \u003c/strong\u003eGestational age and birth weight were significantly lower, NICU length of stay, respiratory distress syndrome (RDS), mechanical ventilation, sepsis, surfactant therapy, and transfusions were more frequent in ROP cases (p\u0026lt;0.001 for all). Early and late RAR values were highest in the most risky group and there was a significant difference between all groups (p=0.00). Logistic regression analysis identified surfactant therapy (OR: 3.820, p=0.012), blood transfusion (OR: 8.012, p\u0026lt;0.001), and early-period RAR (OR: 2.010, p=0.004) as major risk factors for ROP development. ROC analysis showed that early RAR had a moderate predictive value for ROP (AUC=0.70, 95% CI: 0.601-0.805).\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eConclusion: \u003c/strong\u003eEarly RAR appears to be a valuable biomarker for assessing the risk of ROP in preterm infants. Its significant association with the development of ROP may provide a potential clinical benefit in early risk stratification. 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