Subcutaneously administered repronex in female patients undergoing in vitro fertilization is as effective and well tolerated as intramuscular menotropin treatment

Gocial B, B Gocial, Benjamin Gocial, W R Keye, Keye Wr, William R. Keye, Seymour Fein, S H Fein, Fein SH, Ronald V. Nardi, R V Nardi, Nardi RV
Fertility and sterility · 2000 · vol. 74(1) , pp. 73–79 · doi:10.1016/s0015-0282(00)00605-1 · PMID:10899500 · W1922721494
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Subcutaneous Repronex administration was found to be as effective and well-tolerated as intramuscular menotropin for ovarian stimulation in women undergoing in vitro fertilization.

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Abstract

ObjectiveTo determine the efficacy and safety of Repronex SC as compared with Repronex IM and Pergonal IM in patients undergoing IVF.DesignOpen-label, randomized, parallel-group, multicenter study.SettingFifteen academic and private fertility clinics with IVF experience.Patient(s)Premenopausal women with regular ovulatory menstrual cycles undergoing IVF for infertility attributable to tubal factors, endometriosis (stage I or II), or unknown factors.Intervention(s)Down-regulation with leuprolide acetate followed by up to 12 days of treatments with gonadotropins, hCG administration, oocyte retrieval, and embryo transplant.Main outcome measure(s)Mean number of oocytes retrieved, chemical, clinical, and continuing pregnancies, incidence of oocyte retrieval and embryo transfer, and peak serum E2 concentrations.Result(s)There were no significant differences among the treatment groups except for a higher percentage of continuing pregnancies in the Repronex SC group. Gonadotropin therapy was well tolerated in all three treatment groups. The Repronex SC group had a significantly higher incidence of transient mild/moderate injection site reactions during the first few days of therapy.Conclusion(s)Repronex SC is comparable in therapeutic effectiveness and safety to Repronex IM and Pergonal IM in patients undergoing IVF and provides an alternative route of injection for self-administration of gonadotropin.

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MeSH descriptors

Fertility Agents, Female Fertilization in Vitro Gonadotropins Adolescent Adult Down-Regulation Embryo Transfer Female Fertility Agents, Female Fertility Agents, Female Gonadotropins Gonadotropins Humans Injections, Intramuscular Injections, Subcutaneous Leuprolide Leuprolide Leuprolide Menotropins Menotropins

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