Asthma and Cardiovascular Diseases: A Mendelian Randomization Study

Background: A few of cohort studies declared a positive association between asthma and cardiovascular diseases, but the causal relationship is ambiguous. Objective: To evaluate the causal relationship between asthma, and cardiovascular diseases. Methods: We adopted a two-sample Mendelian randomization (MR) analysis, based on inverse variance weighting as the dominate method. Besides, we calculated effect estimates by using random-effects inverse-variance weighting method. Results: ：We found that the suggested proof of a postive association between asthma and two of ten cardiovascular diseases, including type 2 diabetes (OR = 1.09; 95% CI, 1.00–1.17; p =0.038), and atrial fibrillation (OR = 1.06; 95% CI, 1.01–1.10; p =0.011). No associations were discovered for coronary heart disease, hypertension, heart failure, transient ischemic attack, ischemic stroke, pulmonary embolism, peripheral artery disease, and myocardial infarction. Conclusions: A suggestive causal connection between asthma and the risk of type 2 diabetes or atrial fibrillation can be indicated in our research. Any convincing evidence had been failed to find to suggest that asthma is causally related to the risk of other cardiovascular diseases.