Incentives for pregnant mothers during antenatal care for better maternal and neonatal health outcomes in low and middle income countries: A Systematic Review and Meta-Analysis

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Objective of this systematic review was to determine if incentive-based interventions influenced maternal and neonatal health outcomes. Methods We conducted a search in various databases from inception. All incentive-based interventional studies conducted on pregnant women in LMICs were included. Evidence from the included trials was synthesized using risk ratios (RRs) to compare the outcomes between groups receiving incentives and not receiving incentives. The meta-analysis was conducted using random-effects model. We assessed the quality of the included studies using the Cochrane Risk of Bias 2.0 tool and reviewed the collected data to determine its suitability for meta-analysis. This study is registered in PROSPERO (CRD42021247681). Results Of the 3,897 records that were identified, 11 met eligibility criteria, all of which exhibited varying degrees of risk of bias, ranging from high to some concerns. Analysis of maternal outcomes across studies revealed no significant differences in the likelihood of delivering at a healthcare facility (RR 1.13, 95% CI: 0.86 to 1.47) and in frequency of prenatal care (RR 0.99, 95% CI: 0.88 to 1.12) between intervention and control groups. However, high levels of statistical heterogeneity were observed for both outcomes indicating variability among study results. Similarly, analysis of tetanus vaccine coverage showed no significant difference between groups (RR 1.00, 95% CI: 0.92 to 1.08), with moderate statistical heterogeneity observed. Conclusion The maternal and neonatal outcomes examined in this review did not have any significant differences in intervention group when compared to the control group. The interventions to address maternal health concerns need to follow a multifactorial approach. There is a need for extensive primary research studies in the future. 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F1000Research 2025, 13 :1512 ( https://doi.org/10.12688/f1000research.159261.2 ) NOTE: If applicable, it is important to ensure the information in square brackets after the title is included in all citations of this article. Close Copy Citation Details Export Export Citation Sciwheel EndNote Ref. Manager Bibtex ProCite Sente EXPORT Select a format first Track Share ▬ ✚ Systematic Review Revised Incentives for pregnant mothers during antenatal care for better maternal and neonatal health outcomes in low and middle income countries: A Systematic Review and Meta-Analysis [version 2; peer review: 2 approved, 1 approved with reservations] Ramesh Holla https://orcid.org/0000-0002-2296-3719 1 , Rosemol Johnson https://orcid.org/0000-0003-0418-5797 1 , Nisha A Khader https://orcid.org/0000-0002-5788-2978 1 , [...] Mithun Rao https://orcid.org/0009-0004-6427-2539 1 , Bhaskaran Unnikrishnan https://orcid.org/0000-0003-0892-8551 1 , Anju Sinha 2 , Darshan BB 1 , Ravishankar N 3 Ramesh Holla https://orcid.org/0000-0002-2296-3719 1 , Rosemol Johnson https://orcid.org/0000-0003-0418-5797 1 , [...] Nisha A Khader https://orcid.org/0000-0002-5788-2978 1 , Mithun Rao https://orcid.org/0009-0004-6427-2539 1 , Bhaskaran Unnikrishnan https://orcid.org/0000-0003-0892-8551 1 , Anju Sinha 2 , Darshan BB 1 , Ravishankar N 3 PUBLISHED 29 May 2025 Author details Author details 1 Kasturba Medical College Mangalore, Manipal Academy of Higher Education, Manipal, India 2 Division of Reproductive, Maternal and Child Health, Indian Council of Medical Research, Ansari Nagar, New Delhi, India 3 Department of Biostatistics, Vallabhbhai Patel Chest Institute, University of Delhi, New Delhi, India Ramesh Holla Roles: Conceptualization, Data Curation, Formal Analysis, Funding Acquisition, Investigation, Methodology, Project Administration, Resources, Software, Supervision, Validation, Visualization, Writing – Original Draft Preparation, Writing – Review & Editing Rosemol Johnson Roles: Formal Analysis, Methodology, Project Administration, Software, Writing – Original Draft Preparation, Writing – Review & Editing Nisha A Khader Roles: Methodology, Software, Writing – Original Draft Preparation, Writing – Review & Editing Mithun Rao Roles: Software, Supervision, Writing – Original Draft Preparation, Writing – Review & Editing Bhaskaran Unnikrishnan Roles: Conceptualization, Methodology, Supervision, Writing – Original Draft Preparation, Writing – Review & Editing Anju Sinha Roles: Methodology, Supervision, Writing – Review & Editing Darshan BB Roles: Conceptualization, Data Curation, Methodology, Software, Writing – Original Draft Preparation, Writing – Review & Editing Ravishankar N Roles: Methodology, Software, Supervision, Writing – Original Draft Preparation, Writing – Review & Editing OPEN PEER REVIEW DETAILS REVIEWER STATUS This article is included in the Manipal Academy of Higher Education gateway. Abstract Background Universal access to maternal, newborn, and child healthcare is essential for achieving Sustainable Development Goal 3, but the effectiveness of various incentive-based programs for pregnant mothers in low- and middle-income countries (LMICs) remains uncertain. Objective of this systematic review was to determine if incentive-based interventions influenced maternal and neonatal health outcomes. Methods We conducted a search in various databases from inception. All incentive-based interventional studies conducted on pregnant women in LMICs were included. Evidence from the included trials was synthesized using risk ratios (RRs) to compare the outcomes between groups receiving incentives and not receiving incentives. The meta-analysis was conducted using random-effects model. We assessed the quality of the included studies using the Cochrane Risk of Bias 2.0 tool and reviewed the collected data to determine its suitability for meta-analysis. This study is registered in PROSPERO (CRD42021247681). Results Of the 3,897 records that were identified, 11 met eligibility criteria, all of which exhibited varying degrees of risk of bias, ranging from high to some concerns. Analysis of maternal outcomes across studies revealed no significant differences in the likelihood of delivering at a healthcare facility (RR 1.13, 95% CI: 0.86 to 1.47) and in frequency of prenatal care (RR 0.99, 95% CI: 0.88 to 1.12) between intervention and control groups. However, high levels of statistical heterogeneity were observed for both outcomes indicating variability among study results. Similarly, analysis of tetanus vaccine coverage showed no significant difference between groups (RR 1.00, 95% CI: 0.92 to 1.08), with moderate statistical heterogeneity observed. Conclusion The maternal and neonatal outcomes examined in this review did not have any significant differences in intervention group when compared to the control group. The interventions to address maternal health concerns need to follow a multifactorial approach. There is a need for extensive primary research studies in the future. READ ALL READ LESS Keywords Pregnancy, incentive-based interventions, public health interventions, trials, maternal outcomes, neonatal outcomes Corresponding Author(s) Ramesh Holla ( [email protected] ) Close Corresponding author: Ramesh Holla Competing interests: One of the authors (AS) has non-financial competing interests as she is an employee of the funding agency. She has read the manuscript and provided critical substantive comments. The other authors declare no potential conflicts of interest with respect to the research, authorship, and/or publication of this article. Grant information: This work was supported by the Indian Council of Medical Research, Ministry of Health and Family Welfare, New Delhi, Government of India. File No. 5/7/1725/CH/Adhoc-RBMCH. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. Copyright: © 2025 Holla R et al . This is an open access article distributed under the terms of the Creative Commons Attribution License , which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. How to cite: Holla R, Johnson R, Khader NA et al. Incentives for pregnant mothers during antenatal care for better maternal and neonatal health outcomes in low and middle income countries: A Systematic Review and Meta-Analysis [version 2; peer review: 2 approved, 1 approved with reservations] . F1000Research 2025, 13 :1512 ( https://doi.org/10.12688/f1000research.159261.2 ) First published: 09 Dec 2024, 13 :1512 ( https://doi.org/10.12688/f1000research.159261.1 ) Latest published: 29 May 2025, 13 :1512 ( https://doi.org/10.12688/f1000research.159261.2 ) Revised Amendments from Version 1 The Introduction and Discussion sections have been modified by incorporating the suggestions from the reviewer which also includes the addition of SDG goals and targets. The Introduction and Discussion sections have been modified by incorporating the suggestions from the reviewer which also includes the addition of SDG goals and targets. See the authors' detailed response to the review by Nicola McMeekin READ REVIEWER RESPONSES Introduction The global data highlights significant disparities in Maternal Mortality Ratio (MMR) and Neonatal Mortality Rates (NMR) between higher-income countries (HICs) and low-and-middle-income countries (LMICs). The Sustainable Development Goal (SDG) - 2030 aims to reduce the MMR to less than 70 per 100000 live births, 1 yet many LMICs remain far from achieving this target. Similarly, NMR continue to be challenge in several regions. The effectiveness of healthcare systems is often gauged by maternal and neonatal mortality rates, key indicators that reflect direct health outcomes and encompass broader aspects like healthcare accessibility, service quality, and social health determinants. 2 These mortality statistics are used as indicators for pregnancy-related complications, perinatal health risks, and the efficacy of pre- and post-natal interventions. 3 Pregnancy-related complications can arise due to conditions unique to pregnancy or preexisting conditions that become exacerbated during gestation. These complications may lead to serious consequences, including miscarriage, preterm labour, premature rupture of membranes, stillbirth, low birth weight, macrosomia, birth defects, and maternal or neonatal morbidity and mortality. Such complications can occur at any stage of pregnancy, during labour, or postpartum, affecting both maternal and foetal health. 4 According to the United Nations Inter-agency Group for Child Mortality Estimation (UN IGME) - 2020, children born in South Africa or Asia are more likely to die compared to children born in developed economies. 5 The Million Death Study (2015) found that, neonatal mortality in India was particularly high in rural areas, largely attributed to premature births and low birth weights. 6 In view of the current trends, it will be difficult for India to achieve the NMR targets for the SDG-2030 and National Health Policy 2025. 7 A gap analysis indicated that Liberia would take an additional 12.5 years beyond 2030 to meet SDG target for MMR, with similar 12.9-year delay projected for NMR. 8 Countries like Mauritania, and Algeria too are far away from reaching the targets of SDG goals. 9 Another study conducted by Iván Mejía-Guevara et al., based on assessments of survey data from 31 countries in the Sub-Saharan African region has demonstrated that only 2 countries out of the 31 would meet the target of NMR by 2030. The model also forecasts that 13 countries would achieve the target between 2030 to 2050; while the remaining 13 countries are likely to succeed after 2050. However, mortality projections were unavailable for 3 countries due to data quality limitations. 10 What is already known? Incentive-based interventions, including Conditional Cash Transfers (CCTs) and vouchers, have been implemented globally with some success in various maternal and neonatal health programs. 11 , 12 These initiatives have been implemented across various settings to overcome healthcare access barriers, contributing to enhanced maternal health practices and positive birth outcomes. 13 – 19 A systematic review on psychosocial interventions among pregnant women for smoking cessation found that incentives influenced smoking reduction but the effect on outcome measures pertaining to low birth weight, preterm births, and mean birth weight was not clear owing to small sample sizes. 20 A previously conducted systematic review has shown only limited evidence that incentives may improve the frequency of prenatal care. This evidence is based on 5 trials and participants were majorly drawn only from low-income communities in Central America and North America. 17 A review of literature by Morgan et al., in 2013 showed that various types of incentives increased the number of antenatal care visits based on evidence from various studies conducted in LMICs. This study examined the allocation of incentives, considering both the demand side involving patients and the supply side involving healthcare providers, government agencies, and other stakeholders. 21 In a systematic review published in 2014, the evidence regarding five modes of demand-side financing was evaluated, focusing on their impact on out-of-pocket expenditure, utilization of health services, and cost-effectiveness. In addition, the study assessed maternal, perinatal, infant mortality, and morbidity among the poor and socially excluded pregnant women from LMICs. The study found that financing modes like cash transfers, conditional cash transfers and vouchers targeted for pregnant women increased the institutional deliveries and utilisation of antenatal and postnatal services. Evidence concerning maternal and neonatal mortality was sparse owing to the small sample size and shorter follow-up periods. 22 This systematic review has considered quantitative studies and qualitative studies. The study fails to clarify the design of intervention studies involved in the reviews and makes it difficult to relate the effect size to the various types of interventions. The evidence generated in some of these reviews regarding the effectiveness of the provision of incentives for pregnant women focuses on a limited number of maternal and neonatal health outcomes like low birth weight, frequency of prenatal care, maternal and neonatal mortality. These reviews do not investigate any of the incentive-based behaviour change interventions that are also known to play a role in the prevention of pregnancy-related complications. This could include incentive-based tobacco and alcohol cessation, diet control intervention studies among pregnant women, etc. Rationale: Why is this important? For an effective continuum of care, it is essential to strengthen the link between the home, the primary health care facility and the referral centres. 8 Studies from various countries have shown that there is a higher risk of poor pregnancy-related outcomes when the antenatal care received is inadequate. 23 – 25 In accordance with the revised antenatal care guidelines 2016, the WHO recommends a minimum of eight contacts to reduce perinatal mortality and pregnancy complications. 26 There are various SBCE (Social Behavioural Community Engagement) interventions that facilitate the mobilisation of individuals, their family members, and communities for improving maternal and newborn health. 27 Demand-side financing is one of the SBCE interventions to promote the utilisation of health services for better health outcomes. 28 These include vouchers, Cash transfers, temporary payments, etc. As per our knowledge, there are no comprehensive reviews focussing on the effectiveness of various incentive-based interventions that are targeted only for pregnant women during the antenatal period regarding broader outcome measures like the proportion of pregnancy, childbirth-related complications, perinatal deaths and proportion of preterm deliveries in resource-constrained settings that follows rigorous methodology of Systematic reviews. We aim to fill in the gap based on the work undertaken in previous reviews regarding the outcomes and the methodology. It is known that behavioural economics has potential in the formulation of effective health policies. Designing the incentives accordingly is one of the tools in the behavioural approach. 29 This review of trials is thus essential to inform the effectiveness of incentive-based programmes targeted for pregnant women in LMICs. It will help the policy makers to utilise the resources more effectively and to integrate the evidence-based public health initiatives into the health system. Our research questions are as follows: 1. Does the provision of incentives to pregnant mothers during the antenatal care period achieve better maternal and neonatal health outcomes than the absence of such services for pregnant women? 1a. What are the effects of incentives (any type) on the uptake of antenatal care services/utilisation of antenatal health care services (frequency of antenatal care, proportion of institutional delivery)? 1b. What are the effects of incentives (any type) on maternal and neonatal morbidity (proportion of preterm deliveries, low birthweight (less than 2500 g), proportion of antenatal and postnatal complications, compliance to Iron and Folic Acid (IFA) tablets intake and Tetanus Toxoid Injection (Inj TT) coverage, coverage and utilisation of maternal incentive based nutritional interventions, cessation of smoking, alcohol, tobacco, or any other unhealthy behavioural practises)? 1c. What are the effects of incentives (any type) on maternal and neonatal mortality (neonatal deaths, maternal deaths)? Objectives of our review • To determine if any of the incentive-based interventions had an effect on maternal outcomes (proportion of antenatal and postnatal complications, proportion of institutional delivery, frequency of antenatal care, maternal deaths, compliance to IFA tablets intake and Inj TT coverage, coverage and utilisation of maternal incentive based nutritional interventions, cessation of smoking, alcohol, tobacco or any other unhealthy behavioural practises) • To determine if any of the incentive-based interventions had an effect on neonatal health outcomes (proportion of preterm deliveries, low birthweight (less than 2500 g), perinatal and neonatal deaths) Method We have published the protocol for this systematic review 30 and followed the guidelines of the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA). 31 Identification, selection, and eligibility criteria We used the following Population, intervention, comparator, and outcome (PICO) format to assess and select articles. 1. Population: We have included all incentive-based interventional studies conducted on pregnant women in LMICs. We have adhered to the definition of low-middle-income economies as per World Bank 2019, “lower-middle-income economies are those with a Gross National Income (GNI) per capita between $1,026 and $3,995”. 32 We excluded studies conducted among pregnant women who belong to low- and middle-income countries but reside in high-income countries during the antenatal and postnatal period. We have excluded studies that involve pregnant women living in developed countries but belonging to low-income families/communities. We define immigrants as people who migrate from one country to another country. So, women who hold citizenship in a low-middle-income country but reside in high, upper-middle and low-income countries during pregnancy will be excluded. 2. We excluded studies that focused on incentives targeted towards healthcare providers, government agencies or other supply stakeholders. 3. Intervention: We have included all interventions that consider incentives given to pregnant mothers linked to their antenatal care, which are usually not offered to pregnant mothers as standard prenatal care. We did not place any restrictions on the modes of financing such as conditional cash transfers, vouchers, transport services, in-kind goods, mama kits (basic supplies that are required at childbirth), co-payments etc. 4. Comparator: The interventions of our interest were compared to routine antenatal care (no incentives), no intervention or any other type of intervention that is not considered as incentive. We did not restrict the definition of usual care/routine antenatal care. 5. Outcomes: The outcomes of interest are categorised as neonatal outcomes and maternal outcomes. Neonatal outcomes of interest are as follows: • Proportion of preterm deliveries (percentage of babies born alive before completing 37 weeks of pregnancy). 33 • Low birthweight (birth weight less than 2500 g). 34 • Perinatal deaths (“Deaths occurring at perinatal period that is lasting from 28 th week of gestation to the seventh day after the birth”). 35 • Neonatal deaths (“Death occurring during the neonatal period, commencing at birth and ending 28 completed days after birth”). 36 Maternal outcomes are as follows: • Frequency of antenatal care (number of visits and the content of care) • Proportion of antenatal and postnatal complications. • Proportion of institutional delivery. • Maternal deaths. • Compliance to IFA tablets, intake and Inj TT coverage. • Coverage and utilisation of maternal incentive-based nutritional interventions. • Cessation of smoking, alcohol, tobacco, or any other unhealthy behavioural practices. We have excluded studies that did not measure at least one of the above outcomes. Search strategy The search strategy is added in the repository and is cited in the data availability statement. Searches were finalised and conducted on different databases from inception until 2021. We searched Medline, CINAHL, SCOPUS, Web of Science, and Embase for relevant records. The PICO acronym was used to describe the search strategy. Additionally, hand searching was carried out on the Cochrane Central database. Records were additionally retrieved from Google Scholar, and the reference lists of included studies were examined. Data collection and analyses The screening process was conducted using the Covidence software ( https://www.covidence.org/ ). Initially, two reviewers screened titles, followed by abstract screening according to specified eligibility criteria. The full-text screening was then independently carried out by two reviewers. Ineligible records were excluded with specific reasons documented in flow chart ( Figure 1 ). Any discrepancies were resolved through discussions between the two reviewers. Additionally, we have documented ongoing trial protocols are added in the repository and is cited in the data availability statement. 37 – 39 Figure 1. Identification of the included studies. The data was extracted by one reviewer in the data extraction form under the following headings: study ID, author details, publication year, country details, participant details, intervention details, comparators, outcomes, type of incentive, funding details and type of setting (rural or urban). A second author verified the extracted information. The data was entered into Review Manager (RevMan) version 5 ( https://revman.cochrane.org/ ) (Cochrane Collaboration) by one author and verified by another author. Predefined outcomes that contained analysable data were as follows: Frequency of antenatal care, compliance to Inj TT coverage, the proportion of institutional delivery, proportion of women who received iron tablets and low birthweight. The risk of bias was assessed using the tools mentioned in the Cochrane Handbook for Systematic Reviews of Interventions. 40 This assessment was independently conducted by two investigators. In case of disagreements, a third investigator was involved for the resolution of the same. The ROB-2 tool (version 2019) ( https://methods.cochrane.org/bias/resources/rob-2-revised-cochrane-risk-bias-tool-randomized-trials was used for the studies with randomised study designs. The variant of the ROB 2 tool adapted for) cluster randomised trials (2021 version) was used for cluster randomised trials. We evaluated and reported the results in ‘Risk of Bias’ tables. (The data on ‘Risk of Bias” tables has been added in the repository and is cited in the data availability statement) We synthesized the evidence both narratively and graphically, using forest plots. Additionally, a meta-analysis was conducted for certain outcomes with available data. We calculated the risk ratio (RR) with a 95% confidence interval (CI) to compare outcomes between the two groups and performed a random-effects meta-analysis. Statistical heterogeneity was evaluated using the I 2 statistic, Tau 2 , and the Chi 2 test. Results Characteristics of included studies A total of 3824 records were imported into Covidence software ( https://www.covidence.org/ ) for screening, sourced from various databases: Embase (1350), CINAHL (217), Web of Science (637), Scopus (460), Medline (960), and Google Scholar (200). After removing 721 duplicates, 3103 records underwent screening based on their titles and abstracts using Covidence software. We could not export records from Cochrane (CENTRAL) to Covidence. Hence those records (73) were screened separately on Excel. We assessed 212 full texts for eligibility. We could retrieve 14 records (10 studies) on Covidence. In addition, 8 records (1 study) were found through backward and forward citation searches. Altogether we have included 11 studies for data extraction ( Figure 1 ). We did not find any studies that focussed on incentive-based behaviour change intervention conducted in LMICs during the antenatal care period among pregnant women for e.g. incentive-based smoking/tobacco cessation interventions, incentivised nutrition-focussed interventions for appropriate dietary behaviour during pregnancy, etc. The detailed characteristics of the included studies are mentioned in the Table 1 . Table 1. Characteristics of included study. Author, Year and Study Duration Country Study Design Participant Characteristics Intervention Details Outcomes Barber, 2009 Study Duration: 6 Years Mexico Cluster-randomised controlled Trial Women with a history of childbirth from 1997-2003 from low-income communities, either in the intervention or control group Age : 15-49 years Cash transfers up to ~$15/month were provided. Additionally, households received bonuses for education. Control group : Received benefits after 2 years Caesarean rate, delivery location, quality of prenatal care, birthweight, child growth, haemoglobin, cognitive development, language, and behavioural problems. Tool used : Administrative records from facilities and surveys Morris, 2004 Study duration: 24 months Honduras Cluster-randomised controlled trial Pregnant women and mothers of children residing in areas recorded in a mid-2000 census Age : Not mentioned Four groups: 1) Household-level package alone (received monthly vouchers worth 55 Lempiras) 2) Service-level package alone (quality improvement teams) 3) Both packages 4) Standard services (control) The service-level package was for system strengthening. Only household level data has been taken into account for this study Adequate use of prenatal care (≥ 5 visits), postpartum check-up within 10 days of delivery, children <3 years taken to a health center in the past 30 days, immunisation rates, and growth monitoring. Tool used : Evaluation surveys (baseline and post-intervention) Okeke, 2019 Study duration: March 2017 to August 2018 Nigeria Cluster-randomised controlled trial Households with 1 st or 2 nd trimester pregnant women Mean age: Intervention: 24.8 years Control: 24.6 years $14 payment was provided to households in the intervention group. Households in control group communities received gifts of nominal value at follow-up for participation Overall child survival, foetal death, early infant death, neonatal deaths, and post-neonatal deaths Tool used: Baseline and follow-up interview Liu, 2019 Study duration: August 1, 2015 to April 19, 2017 Akwa Ibom, Nigeria Individual-level randomised controlled trial Pregnant women testing positive for HIV during antenatal care registration HIV-positive women registering for ANC were eligible to receive up to 3 transfers during their pregnancy through 10 weeks after birth for achieving milestones: 7000 Naira (~US$24) after ANC registration plus 300 Naira (~US$1) of mobile phone credits (“Transfer 1”); 20,000 Naira (~US$70) when the participant gave birth at the same health facility where she registered for ANC (“Transfer 2”); and 6000 Naira (~US$20) when she returned to the facility to obtain an early infant diagnosis (EID) test for HIV (“Transfer 3”). Women in the control group received routine care. Percentage of pregnant women who delivered their baby at the facility in which they were first enrolled for ANC, percentage of mothers who obtained an early infant diagnosis testing 6–8 weeks after giving birth to their child at the facility in which they were first enrolled for ANC. Tool used: Hospital records and additional surveys Briaux, 2020 Northern Togo Parallel cluster randomised controlled trial Mothers and their children, 6-29 months old Mean age : Intervention: 29.3 years Control: 28.7 years The intervention arm benefited from the ICCM-Nut program, CCPWs’ package of activities, and unconditional cash transfers (UCTs) (US$8.40/month) during their child’s “first 1,000 days” of life (from pregnancy to their second birthday) The control arm received benefits from the ICCM-Nut program along with the BCC activities only HAZ, stunting (HAZ < −2 SD) among 6- to 29-month-old children, dietary diversity scores (DDSs) Tool used: Baseline and endline surveys Hemminki, 2021 China Cluster randomised trial Pregnant women who utilised maternity care during the designated period were participants in the financial intervention arm Age: Not mentioned Financial Intervention: Women were given 5 RMB if they had 1-3 check-ups and visit, RMB 10 for those who had 4-5 checkups and visits; RMB 15 for those with 6-7 checkups and visits, and RMB 20 for women with 8 checkups and visits Clinical intervention: Included three sessions of training in each county conducted by the obstetricians, gynaecologists and other health care professionals First visit\3 months, prenatal visits 5, recommendation for hospitalisation, birth at higher level hospital, postnatal visits 1, content of care that includes breastfeeding 4+ (months), caesarean section, ultrasound 3+, anaemia test 1, blood pressure 3+, danger signs advice, no milk substitute Tool used: Mothers’ interviews were conducted to measure these outcomes. Handa, 2016 Zambia Cluster randomised trial Mixed population of women and children below three years of age at program initiation [This program was specifically not designed to cater to the needs of pregnant women.] A fixed amount of 60 Zambian kwacha was given on bimonthly basis to the primary female adult with children under the age of three The program was primarily designed to evaluate the impact on child outcomes, including the following key areas: 1. Morbidity among children aged 0–60 months 2. Use of services among children aged 0–60 months 3. Nutritional status and feeding practices 4. Early childhood development indicators 5. Child needs being met 6. Education outcomes 7. Women’s decision-making For maternal utilization outcomes, the following were assessed: 1. Antenatal care (from a doctor or nurse) 2. At least four antenatal visits 3. Quality of antenatal care, defined by receiving Voluntary Counselling and Testing (VCT) for HIV, tetanus vaccination, and malaria treatment during antenatal care 4. Skilled attendance at birth (from a doctor or nurse) Tool used to measure outcomes: Baseline and follow-up surveys. Wang, 2016 Zambia Cluster randomised trial Women who met the following criteria were included: 1. Delivered at a treatment facility during this time, or 2. Came to deliver at a treatment facility but were referred to another facility for medical reasons. Mean age : Intervention: 25.24 years Control: 24.79 years Mama kit intervention consisted of items worth US$4 that include cloth (chitenge), baby diaper and blanket Facility delivery Tool used: Semi structure interview for preference of items in mama kit intervention and administrative records from facilities Kahn, 2015 Kisoro, Uganda Multi-arm trial Pregnant women over the age of 18 from selected villages were enrolled into the study when they presented for antenatal care at Muramba Health Centre Level III, KDH, or St. Francis Mutolere Hospital Mean age : Intervention groups: 25.4, 26.4, 23.8 years Control: 25.6 years Modest cash transfers for participation in antenatal care. Intervention group 1: Cash incentives: 0.20 USD/ visit, Intervention group 2: Cash incentives: 0.40 USD/visit OR Intervention group 3: Cash incentives: 0.40 USD/once Three or more antenatal visits and delivery in a health facility Tool used: Self-reports from participants and health care workers, record logs that were documented by midwives Grepin, 2019 Kenya Randomised controlled trial 1. Households with pregnant/lactating mothers or married women who were pregnant in the last two years 2. Households with children aged 6-15 years and 3. All other households [Note: we have included the study since the program targeted a mixed population that showed improved utilisation of health care among pregnant women] PKH Program: Quarterly cash transfers ranging from Rp 200,000 to Rp 600,000 were given to households to address the issue of poverty PKH Consists of 1. Cash given to mothers quarterly; 2. Conditionality and cash penalty; 3. Field facilitators; and 4. Improvements in supply-side readiness. First, the cash, collected by mothers through the nearest post office, ranges from $60-220 per household per year depending on the number and age of children. The fixed amount is $20 per year. If a mother is pregnant and/or has children aged 0-6 years, she will receive additional $80 per year, regardless of the number of children. If a mother has one child at primary school, she will receive an additional $40 per year. If a mother has one child at secondary school, she will receive an additional $80 per year Quality of human resources, poverty reduction, improved socio-economic condition of poor households, improved health and nutritional status of pregnant women, access to quality education and health Tool used: Surveys and qualitative studies Kusuma, 2016 Indonesia Cluster randomised controlled trial Households (14,000 for PKH and 12,000 for Generasi) Women, with a focus on maternal health and higher-risk women Age: Not mentioned The study did not have data pertaining to pregnant women alone. However, we have included the study since the program targeted a mixed population that showed improved utilisation of health care among pregnant women Women's health knowledge, preferences for delivery locations, and financial barriers to accessing services, as well as the utilization of health services such as prenatal and postnatal visits, assisted deliveries, and facility deliveries Participant, study design and setting Total number of pregnancies were 19565 from 10 studies. One study by Kusuma et al., 41 did not have data pertaining to pregnant women alone. However, we have included the study since the program targeted a mixed population that showed improved healthcare utilisation among pregnant women. The study duration ranged from 3 months to 6 years. Out of the 11 included trials, 8 studies were cluster RCTs 41 – 48 and the remaining 3 studies were individually randomised parallel controlled trials. 49 – 51 Participants in seven of the studies lived in rural areas 42 , 43 , 46 – 48 , 50 , 51 while three had residents from rural, semi-rural or urban areas 44 , 45 , 49 One study had an urban population. 41 Four studies 41 , 43 , 44 , 47 had a population comprising both pregnant women along with mothers and lactating women. These studies were included since they had done subgroup analysis for pregnant women participants. While seven studies had only pregnant women as participants. 42 , 45 , 46 , 48 – 51 All seven cluster RCTs have followed adequate accounting of cluster unit randomization in their analysis except Kusuma et al., 2016. 41 The studies included in the review were conducted in the following low- and middle-income countries: Uganda, Honduras, China, Kenya, Togo, Mexico, and Indonesia. Two of the studies were conducted in Zambia 44 , 48 and two more in Nigeria. 45 , 49 Eight studies were government-based interventions for the community. 41 , 43 – 48 , 50 One of the studies was carried out by local Non-Governmental Organisations (NGOs) 49 while the other one was funded by an international agency. 42 Maternal outcomes We performed a meta-analysis for the three outcomes listed below, with the effects of the intervention shown in Table 2 . Five RCTs did not have data for the outcome suitable for meta-analysis. 1. Delivered at the facility: There was no clear difference between the two groups [Risk ratio (RR) 1.13, 95% confidence interval (CI) 0.86 to 1.47, 2676 women, two studies]. There was a high level of statistical heterogeneity. (I 2 = 76%, Tau 2 = 0.03 and Chi 2 test for heterogeneity P = 0.04) ( Figure 2 ). 2. Frequency of prenatal care: There was no clear difference between the two groups [RR 0.99, 95% CI 0.88 to 1.12, 2955 women, four studies]. There was a high level of statistical heterogeneity. (I 2 = 76%, Tau 2 = 0.01 and Chi 2 test for heterogeneity (P = 0.006) ( Figure 3 ). Another study provided details about prenatal visits, but we could not access the data due to its unavailability in the published reports. In the intervention households, the frequency of four or more prenatal visits increased by 4 points in percentage. Also, the likelihood of mothers completing 4 prenatal check-ups increased by 21 per cent. 41 In another study by Kahn et al., the odds of women (odds ratio) attending three or more ANC visits was 1.7. 50 3. Received Tetanus vaccine: There was no clear difference between the two groups [RR 1.00, 95% CI 0.92 to 1.08, 1876 women, two studies]. There was a moderate level of statistical heterogeneity. (I 2 = 48%, Tau 2 = 0.00 and Chi 2 test for heterogeneity P = 0.17) ( Figure 4 ). Table 2. Effect of interventions. Outcomes of Interest Effect size Author (Year publication) Maternal Outcomes Delivered at the facility 1.32 (1.04, 1.66) Liu, 2021 1.00 (0.88, 1.14) Wang, 2016 Frequency of prenatal care: 1.04(0.95, 1.15) Briaux, 2020 0.85(0.75, 0.97) Handa, 2016 0.95(0.85, 1.05) Hemminki, 2021 1.18(1.01, 1.38) Morris, 2004 Received Tetanus vaccine: 1.02[0.99, 1.05] Briaux, 2020 0.95 [0.84, 1.08] Morris, 2004 Compliance to IFA tablets intake: 1.53 [0.98, 2.39] Briaux, 2020 Neonatal Outcome Low birthweight: 1.58 [0.94, 2.64] Briaux, 2020 Figure 2. Effect of incentive-based intervention on the maternal outcome delivered at the facility. Figure 3. Effect of incentive-based intervention on frequency of prenatal care. Figure 4. Effect of incentive-based intervention on tetanus vaccine. Whereas, for the compliance to IFA tablet intake only one study has reported data for iron tablet intake by pregnant women, hence no meta-analysis could be performed. Also, no data was available for the outcomes such as maternal death, coverage and utilisation of maternal incentive-based nutritional interventions, proportion of antenatal and postnatal complications, and cessation of smoking, alcohol, tobacco, or any other unhealthy behavioural practices. Neonatal outcomes 1. Low birthweight : Only one study has given details about the same. Another study did not assess birthweight as its primary outcome. 46 The program showed a 127.3 g increase in birthweight among the intervention group and a reduction of 4.6 percentage in the incidence of low birth weight. 46 2. Perinatal and neonatal deaths: Only one study had given details about neonatal deaths. However, the data has not been adequate to conduct any analysis. The study has mentioned that the decrease in foetal deaths drove the increase in child survival. There was a reduction in foetal deaths, with a decrease ranging from 1.1 to 1.3 percentage points or a relative decrease of 23% compared to the control group. 45 The other study has not given specific details regarding mortality rates for newborns. Also, the definitions used in the study were not clear. The study showed that at baseline there were 0.17 mortality events (among 6- to 11-month-olds) per Kecamatan in control areas and only 0.12 mortality events in Program Keluarga Harapan (PKH) areas. At follow-up, those numbers had fallen to 0.09 and 0.08 respectively. So, there was no significant effect on the same. 41 Risk of bias assessment The risk of bias was independently assessed by two reviewers. We evaluated the risk of bias (ROB) of results from 6 RCTs that contributed to our analyses. We made no assessment of bias for 5 studies as they did not report relevant data or outcomes for this review. The completed RoB 2 tool with responses to all assessed signalling questions has been added in the repository and is cited in the data availability statement. 1. Frequency of prenatal care: Among the four studies reporting this outcome, three were assessed to have some concern regarding risk of bias, while the remaining study was considered to have a high risk of bias. 42 – 44 , 47 In two of the studies, the protocol was unavailable, 44 , 47 leaving uncertainty regarding potential deviations from the intended interventions, particularly in Handa’s study from 2016. 44 Morris’s study from 2004 47 was judged to be at high risk of bias due to identified deviations in the study, attributed to lack of legal measures for transportation of resources and other challenges that they encountered during the study period. All of the studies were non-blinded since it is often not feasible in community-level interventions. Hence, they were all judged as having some concerns in risk of bias assessment. 2. Received Tetanus Vaccine: One of the studies had high risk of bias while another study had some concerns. 43 , 47 Protocol was not available in one study. 47 While in the other study, there was no information on concealment of allocation sequence. 43 Hence the study was found to have some concerns of bias. 3. Delivery in a health facility: There was no information on the pre-specified analysis plans prior to the start of the study. Hence the study by Liu et al., 2019 was found to have some concerns of bias. 49 The study by Wang et al., was also found to have some concerns of bias because there was no adequate information regarding the randomization process. 48 Overall, these studies exhibited various concerns regarding risk of bias. Incentives differed, including vouchers, cash transfers, and mama kits, which may limit their generalizability across different communities in LMICs. Additionally, the insufficient data prevented us from conducting a subgroup analysis based on incentive types. The meta-analysis included fewer than ten studies, so we did not perform a funnel plot. There is a potential for publication bias, especially since we did not search trial registries in LMIC regions. Discussion We retrieved 11 studies that involved incentives for pregnant women. Six studies examined the outcome frequency of prenatal care. However, only 4 of the studies had data that could be incorporated into meta-analysis. 42 – 44 , 47 The remaining 2 studies did not have data that could be analysed. 41 , 50 Seven studies examined the outcome of delivered at the facility/skilled attendance at birth but only 2 studies could be incorporated into meta-analysis 48 , 49 and 3 studies examined the receipt of tetanus vaccine during the antenatal period. However, only 2 of the studies could be incorporated into meta-analysis. 43 , 47 In the study by Handa et al., 2016, 44 tetanus vaccine is assessed as part of the quality of antenatal care assessment. No separate data was available, and there was no adequate evidence to show the impact of incentives on maternal and neonatal outcomes. Besides, data was available only for 3 of the outcomes of our interest. Only 6 studies had data that were suitable for meta-analysis. All the studies are from low- and middle-income countries. A study previously conducted in 2015, had included studies worldwide and had included only 5 studies. Only 2 studies out of the 5 had been conducted in low- and middle-income communities. 26 Our study, which was limited to low and middle-income countries, has included 11 studies in the review. Low birth weight was assessed only in one study by Briaux et al. 43 But it was assessed as the intermediary outcome in the study. A systematic review conducted by Toolan et al. in 2021 investigated the impact of incentives, alongside other interventions, on maternal and neonatal health outcomes during the antenatal period. 52 The authors did not perform a meta-analysis due to the heterogeneity of interventions and outcomes, and instead presented their findings narratively. Only two studies in this review examined the effect of cash incentives given to women who attended four or more antenatal care (ANC) visits. 53 , 54 One of these studies was cross-sectional in nature, 53 while the other was qualitative in nature. 54 Bhatt et al.’s study found that both the maternal incentive scheme (MIS) and Aama policies significantly increased the utilization of four ANC visits and institutional deliveries in Nepal. 53 Flueckiger et al.’s study revealed that stakeholders, particularly mothers, perceived the monetary incentive as a motivating factor for attending ANC sessions, which led to increased attendance. In contrast, our study included six studies 41 – 44 , 47 , 50 that assessed the frequency of prenatal care, but only four studies were included in the meta-analysis. While our study did not find a significant difference in the effect of intervention between the two groups, it is important to consider other factors that may have influenced the results, such as the duration of the intervention or the specific intervention strategies used in each group and the design of the study. Previous systematic reviews examining the impact of incentives on maternal and neonatal health outcomes were limited by a small number of studies with small sample sizes, reducing the reliability of their finding. Similarly, our review did not identify a significantly large number of studies; however, most of the included studies were randomized controlled trials (RCTs), which are generally well-proved to detect meaningful effects. This strengthens the overall evidence base and provides a more comprehensive understanding of how incentive-based interventions influence maternal and neonatal health outcomes. Strengths and limitations of this study The current systematic review has followed the methodology adopted in the Cochrane Handbook for Systematic Reviews of Interventions. 55 The results generated out of this systematic review will inform or guide in implementing public health interventions and policies about incentive-based initiatives for pregnant women. No restrictions concerning the publication year were followed for the search strategy. We included all the financing modes implemented for pregnant women without any restrictions, including vouchers, transport incentives, in-kind goods, cash transfers, etc. However, the available evidence is limited to LMICs. The classification of LMICs has undergone significant changes in the past two years, particularly during the pandemic. 56 , 57 We did not have enough resources to include studies conducted in languages other than English in LMICs. We could have missed out on the effects of studies conducted in LMICs in regional languages. Additionally, we did not search registries or explore grey literature sources. The inclusion of studies was restricted to English and those published in scientific journals. Implications for research The current review was limited to studies that were primarily concerned about demand-side incentives. In the future, studies should involve a combination of both demand and supply-side incentives. In addition, focus of trials should be on outcomes like neonatal and maternal mortality, postpartum complications, and skilled attendance at homes alongside institutional delivery. It is likely that the very low number of studies in LMICs could be attributed to the very low incentives, investments, and infrastructure for research activities in the regions compared to high-income countries that leads to substantial disparities in the conduct of research studies. Studies on tobacco and smoking cessation were excluded since they were all conducted in high-income countries. 58 – 62 Most of the studies in the current review were funded by various external sources and some were conducted by the government. While a few were done in collaboration with the national government with the support of external funding. To promote more studies in LMICs in the future, national governments should prioritize extensive primary research. 63 Communities need to be empowered to conduct community-based research activities that enable them to identify issues and develop solutions for the same. 64 The outcomes examined in this review did not have any significant differences in the intervention group when compared to the control group. The interventions to address maternal health concerns need to follow a multifactorial approach. Poverty is not the sole barrier for pregnant women to access healthcare services. Reports of obstetric violence/labour room violence have been commonly seen across India and the globe. 65 – 67 Efforts to address the same needs to be taken. In addition, one needs to address the challenges faced by health care workers, 68 including high patient numbers, resource limitations, and inadequate training in respectful maternity care, which can contribute to negative experiences for pregnant women. 69 Maternal and neonatal health is also influenced by socioeconomic and environmental factors. 70 – 72 In societies dominated by patriarchal norms, women often face lack of autonomy and decision-making power. This limitation frequently hinders their access to timely prenatal care and childbirth services. 73 Moreover, deeply ingrained cultural practices such as inclination towards giving birth at home or the dependence on traditional midwives can further deter facility-based deliveries. 74 Additionally, long travel distances, inadequate transport, and poor healthcare infrastructure create additional barriers, especially in rural and remote areas. 75 , 76 Addressing these multifaceted challenges requires community-based awareness programs, policy reforms, and strengthening of healthcare systems to ensure equitable and respectful maternal healthcare access. Conclusion Despite the extensive search yielding only 11 eligible studies from low- and middle-income countries, the analysis revealed varying degrees of bias across the selected studies. Our examination of maternal outcomes, including facility delivery, prenatal care frequency, and tetanus vaccine coverage, demonstrated no significant differences between intervention and control groups. However, high levels of statistical heterogeneity were observed, indicating considerable variability among study results. These findings underscore the complexity of addressing maternal health concerns and suggest that interventions require a multifactorial approach. Moreover, the moderate statistical heterogeneity observed for tetanus vaccine coverage suggests the need for further exploration. One study reported a modest increase in birthweight and a reduction in low birthweight incidence, but outcomes related to perinatal and neonatal deaths were inconclusive. Prospectively, there is a critical need for comprehensive primary research studies to better inform strategies aimed at improving maternal and neonatal health outcomes. Reporting guidelines Figshare: PRISMA checklist and flowchart: Incentives for pregnant mothers during antenatal care for better maternal and neonatal health outcomes in low and middle income countries: A Systematic Review and Meta-Analysis, https://doi.org/10.6084/m9.figshare.27916326.v1 ; https://doi.org/10.6084/m9.figshare.27915747.v2 . Data are available under the terms of the Creative Commons Attribution 4.0 International license (CC-BY 4.0). Ethics and consent Ethical approval and consent were not required. Data availability Underlying data No data are associated with this article. Extended data Figshare repository- “Extended data of “Incentives for pregnant mothers during antenatal care for better maternal and neonatal health outcomes in low and middle income countries: A Systematic Review and Meta-Analysis””. This project contains the following extended datasets 77 – 79 : • Extended data of SR Incentive. (Contains search strategy, ROB tool and the ongoing protocol details.) 10.6084/m9.figshare.27916326 . • PRISMA Flowchart of SR incentive. (Contains PRISMA flowchart of the systematic review.) 10.6084/m9.figshare.27915747 . • PRISMA checklist of SR Incentive. (Contains PRISMA checklist of the systematic review) 10.6084/m9.figshare.27916326 . Data are available under the terms of the Creative Commons Attribution 4.0 International license (CC-BY 4.0). Acknowledgement We have published the protocol for this systematic review 30 and followed the guidelines of the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA). 31 This work was supported by the Indian Council of Medical Research, Ministry of Health and Family Welfare, New Delhi, Government of India. References 1. Maternal and reproductive health [Internet]. [cited 2025 Feb 27]. Reference Source 2. 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Publisher Full Text Comments on this article Comments (0) Version 2 VERSION 2 PUBLISHED 09 Dec 2024 ADD YOUR COMMENT Comment Author details Author details 1 Kasturba Medical College Mangalore, Manipal Academy of Higher Education, Manipal, India 2 Division of Reproductive, Maternal and Child Health, Indian Council of Medical Research, Ansari Nagar, New Delhi, India 3 Department of Biostatistics, Vallabhbhai Patel Chest Institute, University of Delhi, New Delhi, India Ramesh Holla Roles: Conceptualization, Data Curation, Formal Analysis, Funding Acquisition, Investigation, Methodology, Project Administration, Resources, Software, Supervision, Validation, Visualization, Writing – Original Draft Preparation, Writing – Review & Editing Rosemol Johnson Roles: Formal Analysis, Methodology, Project Administration, Software, Writing – Original Draft Preparation, Writing – Review & Editing Nisha A Khader Roles: Methodology, Software, Writing – Original Draft Preparation, Writing – Review & Editing Mithun Rao Roles: Software, Supervision, Writing – Original Draft Preparation, Writing – Review & Editing Bhaskaran Unnikrishnan Roles: Conceptualization, Methodology, Supervision, Writing – Original Draft Preparation, Writing – Review & Editing Anju Sinha Roles: Methodology, Supervision, Writing – Review & Editing Darshan BB Roles: Conceptualization, Data Curation, Methodology, Software, Writing – Original Draft Preparation, Writing – Review & Editing Ravishankar N Roles: Methodology, Software, Supervision, Writing – Original Draft Preparation, Writing – Review & Editing Competing interests One of the authors (AS) has non-financial competing interests as she is an employee of the funding agency. She has read the manuscript and provided critical substantive comments. The other authors declare no potential conflicts of interest with respect to the research, authorship, and/or publication of this article. Grant information This work was supported by the Indian Council of Medical Research, Ministry of Health and Family Welfare, New Delhi, Government of India. File No. 5/7/1725/CH/Adhoc-RBMCH. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. Article Versions (2) version 2 Revised Published: 29 May 2025, 13:1512 https://doi.org/10.12688/f1000research.159261.2 version 1 Published: 09 Dec 2024, 13:1512 https://doi.org/10.12688/f1000research.159261.1 Copyright © 2025 Holla R et al . This is an open access article distributed under the terms of the Creative Commons Attribution License , which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Download Export To Sciwheel Bibtex EndNote ProCite Ref. Manager (RIS) Sente metrics Views Downloads F1000Research - - PubMed Central info_outline Data from PMC are received and updated monthly. - - Citations open_in_new 0 open_in_new 0 open_in_new SEE MORE DETAILS CITE how to cite this article Holla R, Johnson R, Khader NA et al. Incentives for pregnant mothers during antenatal care for better maternal and neonatal health outcomes in low and middle income countries: A Systematic Review and Meta-Analysis [version 2; peer review: 2 approved, 1 approved with reservations] . F1000Research 2025, 13 :1512 ( https://doi.org/10.12688/f1000research.159261.2 ) NOTE: If applicable, it is important to ensure the information in square brackets after the title is included in all citations of this article. COPY CITATION DETAILS track receive updates on this article Track an article to receive email alerts on any updates to this article. TRACK THIS ARTICLE Share Open Peer Review Current Reviewer Status: ? Key to Reviewer Statuses VIEW HIDE Approved The paper is scientifically sound in its current form and only minor, if any, improvements are suggested Approved with reservations A number of small changes, sometimes more significant revisions are required to address specific details and improve the papers academic merit. Not approved Fundamental flaws in the paper seriously undermine the findings and conclusions Version 2 VERSION 2 PUBLISHED 29 May 2025 Revised Views 0 Cite How to cite this report: Motappa R. Reviewer Report For: Incentives for pregnant mothers during antenatal care for better maternal and neonatal health outcomes in low and middle income countries: A Systematic Review and Meta-Analysis [version 2; peer review: 2 approved, 1 approved with reservations] . F1000Research 2025, 13 :1512 ( https://doi.org/10.5256/f1000research.179546.r418444 ) The direct URL for this report is: https://f1000research.com/articles/13-1512/v2#referee-response-418444 NOTE: it is important to ensure the information in square brackets after the title is included in this citation. Close Copy Citation Details Reviewer Report 09 Oct 2025 Rohith Motappa , ESIC Medical College & PGIMSR and Model Hospital, Bangalore, Karnataka, India Approved VIEWS 0 https://doi.org/10.5256/f1000research.179546.r418444 Introduction: The author can explain a little more on the SDG goals related to the article a little more making the topic highly relevant. Not only this makes the article relevant but also helps in catching the attention of the ... Continue reading READ ALL Introduction: The author can explain a little more on the SDG goals related to the article a little more making the topic highly relevant. Not only this makes the article relevant but also helps in catching the attention of the readers. Few places abbreviations are present in the document without proper expansion. Please make sure that all the abbreviated forms are expanded when it is being used for the first time in the document. The end of the introduction section has mentioned about few less known countries. Either the article can mention about the continent where it is falling in or socio-economic strata they fall into (Underdeveloped/developing). Objectives again contain the abbreviations related to the common medications that are being given. Please expand it so that it is readable as they are objectives. Methodology: Whether all the articles have been included for the study or the only ones in English language has been considered for the study. Please explicitly mention the same. Search strategy abbreviations have to be expanded. Results: The section can undergo a thorough grammar check and modify the sentences where singular has been used in place of plural and vice versa. The reason for exclusion of the studies have to be clearly mentioned in the result section of the document. The subheadings under the maternal outcomes have quoted the relevant statistics extracted from the individual studies but due referencing is not given. Please make sure the citations are done for the individual studies in the result section. Grammar check need to be done In risk of bias, where the sentences can be paraphrased, for ex: We made no assessment of bias for 5 studies as they did not report relevant data or outcomes for this review, can be made as Assessment of risk of bias was not conducted for 5 studies as the studies did not report relevant outcomes. Discussion has been well written where this systematic review has been compared with the other studies of the past and also underlined the importance of the Systematic review. Wherever the results are repeatedly being told, the statistics can be minimized. If the author feel that there is necessity to highlight the statistics again, then can be kept. The limitation that only published articles were considered need to be mentioned as one of the limitations of the study. Please check the reference list for the referencing style. Are the rationale for, and objectives of, the Systematic Review clearly stated? Yes Are sufficient details of the methods and analysis provided to allow replication by others? Partly Is the statistical analysis and its interpretation appropriate? Yes Are the conclusions drawn adequately supported by the results presented in the review? Partly If this is a Living Systematic Review, is the ‘living’ method appropriate and is the search schedule clearly defined and justified? (‘Living Systematic Review’ or a variation of this term should be included in the title.) Not applicable Competing Interests: No competing interests were disclosed. Reviewer Expertise: NCDs, TB and Geriatrics. I confirm that I have read this submission and believe that I have an appropriate level of expertise to confirm that it is of an acceptable scientific standard. Close READ LESS CITE CITE HOW TO CITE THIS REPORT Motappa R. Reviewer Report For: Incentives for pregnant mothers during antenatal care for better maternal and neonatal health outcomes in low and middle income countries: A Systematic Review and Meta-Analysis [version 2; peer review: 2 approved, 1 approved with reservations] . F1000Research 2025, 13 :1512 ( https://doi.org/10.5256/f1000research.179546.r418444 ) The direct URL for this report is: https://f1000research.com/articles/13-1512/v2#referee-response-418444 NOTE: it is important to ensure the information in square brackets after the title is included in all citations of this article. COPY CITATION DETAILS Report a concern Respond or Comment COMMENT ON THIS REPORT Views 0 Cite How to cite this report: Khazi MS. Reviewer Report For: Incentives for pregnant mothers during antenatal care for better maternal and neonatal health outcomes in low and middle income countries: A Systematic Review and Meta-Analysis [version 2; peer review: 2 approved, 1 approved with reservations] . F1000Research 2025, 13 :1512 ( https://doi.org/10.5256/f1000research.179546.r418442 ) The direct URL for this report is: https://f1000research.com/articles/13-1512/v2#referee-response-418442 NOTE: it is important to ensure the information in square brackets after the title is included in this citation. Close Copy Citation Details Reviewer Report 07 Oct 2025 Mohammed Shoyaib Khazi , All India Institute of Medical Sciences, Mangalagiri, Andhra Pradesh, India Approved VIEWS 0 https://doi.org/10.5256/f1000research.179546.r418442 While PRISMA is mentioned, several required elements are missing. The PRISMA flow diagram is inadequately labeled (Figure 1 should clearly show the number excluded at each stage and reasons). Please add total number of studies at each stage. ... Continue reading READ ALL While PRISMA is mentioned, several required elements are missing. The PRISMA flow diagram is inadequately labeled (Figure 1 should clearly show the number excluded at each stage and reasons). Please add total number of studies at each stage. The meta-analysis includes only 2–4 studies per outcome , which undermines the robustness of pooled estimates; kindly provide the reason for the same or mention this as limitation. The conclusion that “incentives showed no significant benefit” should be contextualized, could this be due to short intervention duration, low incentive value, or weak health system readiness? The manuscript contains several grammatical errors and inconsistencies in referencing style. The paragraph content can clearly mention the important results. Minor Comments 1. Abbreviations (e.g., ANC, IFA, TT) should be defined at first mention in both abstract and text. 2. Reference numbering and formatting need standardization per journal guidelines. 3. Figures should have complete captions including data sources. 4. Some references (e.g., SDG targets) are outdated; update to the latest WHO/UN data. 5. The results for neonatal outcomes such as low birth weight and perinatal mortality are mentioned in objectives but not presented, clarify if data were unavailable or excluded. Are the rationale for, and objectives of, the Systematic Review clearly stated? Yes Are sufficient details of the methods and analysis provided to allow replication by others? Yes Is the statistical analysis and its interpretation appropriate? Yes Are the conclusions drawn adequately supported by the results presented in the review? Yes If this is a Living Systematic Review, is the ‘living’ method appropriate and is the search schedule clearly defined and justified? (‘Living Systematic Review’ or a variation of this term should be included in the title.) Yes Competing Interests: No competing interests were disclosed. Reviewer Expertise: Community Medicine, Public Health, Demographic Health Surveys I confirm that I have read this submission and believe that I have an appropriate level of expertise to confirm that it is of an acceptable scientific standard. Close READ LESS CITE CITE HOW TO CITE THIS REPORT Khazi MS. Reviewer Report For: Incentives for pregnant mothers during antenatal care for better maternal and neonatal health outcomes in low and middle income countries: A Systematic Review and Meta-Analysis [version 2; peer review: 2 approved, 1 approved with reservations] . F1000Research 2025, 13 :1512 ( https://doi.org/10.5256/f1000research.179546.r418442 ) The direct URL for this report is: https://f1000research.com/articles/13-1512/v2#referee-response-418442 NOTE: it is important to ensure the information in square brackets after the title is included in all citations of this article. COPY CITATION DETAILS Report a concern Respond or Comment COMMENT ON THIS REPORT Version 1 VERSION 1 PUBLISHED 09 Dec 2024 Views 0 Cite How to cite this report: McMeekin N. Reviewer Report For: Incentives for pregnant mothers during antenatal care for better maternal and neonatal health outcomes in low and middle income countries: A Systematic Review and Meta-Analysis [version 2; peer review: 2 approved, 1 approved with reservations] . F1000Research 2025, 13 :1512 ( https://doi.org/10.5256/f1000research.174960.r361421 ) The direct URL for this report is: https://f1000research.com/articles/13-1512/v1#referee-response-361421 NOTE: it is important to ensure the information in square brackets after the title is included in this citation. Close Copy Citation Details Reviewer Report 24 Feb 2025 Nicola McMeekin , Glasgow Institute of Health & Wellbeing, University of Glasgow, Glasgow, Scotland, UK Approved with Reservations VIEWS 0 https://doi.org/10.5256/f1000research.174960.r361421 Thank you for the opportunity to review this interesting paper. It reports the findings of a systematic review that searched for papers evaluating the impact on maternal and neonatal outcomes of offering incentives to pregnant women in low and middle ... Continue reading READ ALL Thank you for the opportunity to review this interesting paper. It reports the findings of a systematic review that searched for papers evaluating the impact on maternal and neonatal outcomes of offering incentives to pregnant women in low and middle income countries. Overall this paper is very well written and interesting to read. My suggestions for edits are mainly for overall clarification not specific issues, to set the scene for the reader before you go into your well written sections. This is often the case when you know you subject well, but a few small clarifications and scene setting sentences would improve what is interesting and relevant research. Minor Introduction Please could you move the detail of the SDG (MMR less than 70 per 100000 live deaths) to earlier on in the first paragraph in the Introduction? At the moment the reader has to wait till the sentence about Liberia to find out what the detail is. I think this section would benefit too from a sentence or two on the overall issue with LMICs – you start off with describing South Africa and Asia in the second sentence. Could you add a bit to the first sentence along the lines of ‘…..countries and regions, particularly between higher and LMICs’ – or something similar. I was also confused by the last sentence in the first paragraph: ‘ The model also forecasts that 13 countries would achieve the target between 2030 to 2050; while the remaining 13 countries are likely to succeed after 2050’. In the previous sentence you stated that the study looks at data from 31 countries, the 2 comments about 13 countries would suggest that the study you cite looks at 26 countries. Please could you clarify why the 2 amounts in your last sentence don’t add up to 31? In the Introduction you focus on maternal and neonatal mortality rates. It is not immediately obvious to me why you have chosen these outcomes to discuss. Please consider adding a short explanation of why you chose these specific outcomes, you might say that they are key outcomes that are linked to other important maternal/neonatal outcomes, or that they are proxy’s for other outcomes? For example in the second paragraph of the ‘Rationale: Why is this important?’ section in the Introduction in the first sentence you introduce some relevant outcomes such as pregnancy and childbirth-related complications, maybe introduce some of these in the first paragraph of the Introduction? The ‘What is already known’ section could benefit from a short introduction paragraph. At the moment it starts with smoking cessation incentives, it would be good to set the scene with saying something along the lines of how incentives could benefit this area (in terms of reducing smoking and improving engagement with antenatal care for example) and improve maternal and child outcomes. This would help orientate the reader to what to expect in this section before it starts with more specific details. The last paragraph closes this section really nicely, starting with something similar as suggested would benefit it. In the research questions section please could you write out in full what ‘IFA’ and ‘Inj TT’ refer to in 1b? Methods The Methods section is clear and very well written, it included everything I would expect to see in a systematic review. I was unable to see the search strategy in the repository – only PRISMA checklists and flowchart. Please could you check that the strategy is included – I just many not be able to see it - this is why I answered 'partly' to the question - Are sufficient details of the methods and analysis provided to allow replication by others? In Outcomes – please could you clarify your definition of preterm delivery – i.e. born alive before 37 weeks, also for perinatal and neonatal deaths, and maternal deaths. Discussion Fourth paragraph in the Discussion section – the last 2 sentences are very similar – could this be a duplication? Would it be possible to highlight that previously there were a small number of studies and with small sample sizes – and this study has not found a large number of studies – but most studies were RCTs – so assumably suitably powered? It would be good to have that additional information. I really liked your last paragraph in the Discussion section about poverty not being the sole barrier for pregnant women to access healthcare services. Would it be possible to add another sentence or two to this paragraph if there is more evidence available similar to the violence you discussed in the second sentence? In the ‘Implications for research’ section please could you consider moving the 4 th and 5 th paragraphs (evidence limited to LMIC and limited study resources for searching for non-English records) to the ‘Strengths and limitations of the study’ section – they read more like strengths and limitations rather than implications. Typos/grammar I only found a few typos/grammatical errors and mainly in the Results section: In ‘Neonatal outcomes – 2. Perinat and neonatal deaths’ – ‘the data has not been adequate to conduct any analysis’ would read better as ‘the data was not adequate to conduct any analysis’ You also mix present and past tense in the Discussion: Second paragraph – ‘there is no separate data on the same’ should read ‘there was no separate data on the same’, and ‘there is no adequate evidence to show the impact of incentives…’ should read ‘there was no adequate evidence to show the impact of incentives……’ Are the rationale for, and objectives of, the Systematic Review clearly stated? Yes Are sufficient details of the methods and analysis provided to allow replication by others? Partly Is the statistical analysis and its interpretation appropriate? Yes Are the conclusions drawn adequately supported by the results presented in the review? Yes If this is a Living Systematic Review, is the ‘living’ method appropriate and is the search schedule clearly defined and justified? (‘Living Systematic Review’ or a variation of this term should be included in the title.) Not applicable Competing Interests: No competing interests were disclosed. Reviewer Expertise: Health economics I confirm that I have read this submission and believe that I have an appropriate level of expertise to confirm that it is of an acceptable scientific standard, however I have significant reservations, as outlined above. Close READ LESS CITE CITE HOW TO CITE THIS REPORT McMeekin N. Reviewer Report For: Incentives for pregnant mothers during antenatal care for better maternal and neonatal health outcomes in low and middle income countries: A Systematic Review and Meta-Analysis [version 2; peer review: 2 approved, 1 approved with reservations] . F1000Research 2025, 13 :1512 ( https://doi.org/10.5256/f1000research.174960.r361421 ) The direct URL for this report is: https://f1000research.com/articles/13-1512/v1#referee-response-361421 NOTE: it is important to ensure the information in square brackets after the title is included in all citations of this article. COPY CITATION DETAILS Report a concern Author Response 19 Mar 2025 Ramesh Holla , Kasturba Medical College Mangalore, Manipal Academy of Higher Education, Manipal, 576104, India 19 Mar 2025 Author Response Point to point response to the reviewer’s comments: 1. Comment: Please could you move the detail of the SDG (MMR less than 70 per 100,000 live births) to earlier ... Continue reading Point to point response to the reviewer’s comments: 1. Comment: Please could you move the detail of the SDG (MMR less than 70 per 100,000 live births) to earlier on in the first paragraph in the Introduction? At the moment, the reader has to wait till the sentence about Liberia to find out what the detail is. Author’s response: Thank you for your suggestion. We have moved the SDG detail (MMR less than 70 per 100,000 live births) to the first paragraph of the Introduction for better clarity and immediate context. We rephrased the original paragraph to "The Million Death Study (2015) found that neonatal mortality in India was particularly high in rural areas, largely attributed to premature births and low birth weights (6). In view of the current trends, it will be difficult for India to achieve the NMR targets for SDG-2030 and National Health Policy 2025 (7). A gap analysis indicated that Liberia would take an additional 12.5 years beyond 2030 to meet the SDG target for MMR, with a similar 12.9-year delay projected for NMR (8)."to maintain readability. Action taken in the manuscript: The change can be seen in the “Introduction” section, where the SDG goal is now introduced earlier in the first paragraph of the Introduction. The rephrased sentences can be found in the last two paragraphs of introduction section 2. Comment: I think this section would benefit too from a sentence or two on the overall issue with LMICs – you start off with describing South Africa and Asia in the second sentence. Could you add a bit to the first sentence along the lines of ‘.....countries and regions, particularly between higher and LMICs’ – or something similar. Author’s response: Note your suggestion. We have added a phrase to the first sentence of the Introduction to emphasize disparities between higher-income countries (HICs) and low-and-middle-income countries (LMICs). Action taken in the manuscript: The change can be seen in the “Introduction” section, where the first sentence of the introduction section now highlights disparities between HICs and LMICs. 3. Comment: I was also confused by the last sentence in the first paragraph: ‘The model also forecasts that 13 countries would achieve the target between 2030 to 2050; while the remaining 13 countries are likely to succeed after 2050’. In the previous sentence you stated that the study looks at data from 31 countries, the 2 comments about 13 countries would suggest that the study you cite looks at 26 countries. Please could you clarify why the 2 amounts in your last sentence don’t add up to 31? Author’s response: We have added a clarification that mortality projections were unavailable for three countries due to data quality limitations to ensure the total sums up to 31. Action taken in the manuscript: The change can be seen in introduction section, last line of the fourth paragraph 4. Comment: In the Introduction you focus on maternal and neonatal mortality rates. It is not immediately obvious to me why you have chosen these outcomes to discuss. Please consider adding a short explanation of why you chose these specific outcomes, you might say that they are key outcomes that are linked to other important maternal/neonatal outcomes, or that they are proxies for other outcomes Author’s response: Thank you for your valuable comment. We have added an explanation stating that maternal and neonatal mortality rates are key indicators of healthcare system effectiveness, reflecting both direct health outcomes and broader factors such as healthcare accessibility, service quality, and social health determinants. These statistics also serve as indicators of pregnancy-related complications, perinatal health risks, and the efficacy of healthcare interventions Action taken in the manuscript: The change can be seen in second paragraph of the Introduction, where this explanation has been added. New references 2 and 3 has been added. 5. Comment: For example, in the second paragraph of the ‘Rationale: Why is this important?’ section in the Introduction, in the first sentence, you introduce some relevant outcomes such as pregnancy and childbirth-related complications. Maybe introduce some of these in the first paragraph of the Introduction?. Author’s response: Added a sentence introducing pregnancy-related complications, including miscarriage, preterm labour, stillbirth, and maternal or neonatal morbidity and mortality, emphasizing that these complications can occur at any stage of pregnancy, during labour, or postpartum Action taken in the manuscript: The change can be seen in the “Introduction” section, and a new reference (4) has been added 6. Comment: The ‘What is already known’ section could benefit from a short introduction paragraph. At the moment, it starts with smoking cessation incentives. It would be good to set the scene with something along the lines of how incentives could benefit this area (in terms of reducing smoking and improving engagement with antenatal care, for example) and improve maternal and child outcomes. This would help orient the reader to what to expect in this section before it starts with more specific details. Author’s response: Added an introductory paragraph explaining that incentive-based interventions, including conditional cash transfers (CCTs) and vouchers, have been implemented globally with some success in maternal and neonatal health programs. These initiatives aim to overcome healthcare access barriers, improve maternal health practices, and enhance birth outcomes . Action taken in the manuscript: The change can be seen in the first paragraph under the "What is already known" section, and new references (11–21) have been added 7. Comment: In the research questions section please could you write out in full what ‘IFA’ and ‘Inj TT’ refer to in 1b. Author’s response: Expanded the abbreviations to Iron and Folic Acid (IFA) tablets intake and Tetanus Toxoid injection (Inj TT) for clarity Action taken in the manuscript: The change can be seen in 1b in “Our Research Questions” Section 8. Comment: I was unable to see the search strategy in the repository – only PRISMA checklists and flowchart. Author’s response: The search strategy was shared via Figshare and is available under the Data Availability section Action taken in the manuscript: No changes were made 9. Comment: In Outcomes – please could you clarify your definition of preterm delivery – i.e. born alive before 37 weeks, also for perinatal and neonatal deaths, and maternal deaths Author’s response: Thank you for the suggestion. We have incorporated the clear definitions for preterm delivery, low birthweight, perinatal deaths, and neonatal deaths Action taken in the manuscript: The change can be seen in first few lines under the Outcomes section, with new references (36–39) added 10. Comment: Fourth paragraph in the Discussion section – the last 2 sentences are very similar – could this be a duplication. Author’s response: Identified and removed duplicate sentences in the fourth paragraph of the Discussion section Action taken in the manuscript: The change can be seen in the “Discussion” section, where the duplicated content has been deleted 11. Comment: Would it be possible to highlight that previously there were a small number of studies and with small sample sizes – and this study has not found a large number of studies – but most studies were RCTs – so assumably suitably powered? It would be good to have that additional information. Author’s response: Added a clarification that previous reviews had a limited number of studies with small sample sizes, reducing their reliability. Our review also did not find a significantly larger number of studies; however, most were RCTs, which are generally well-powered to detect meaningful effects, strengthening the evidence base Action taken in the manuscript: The change can be seen in last paragraph of the “Discussion” section 12. Comment: Would it be possible to add another sentence or two to this paragraph if there is more evidence available similar to the violence you discussed in the second sentence? Author’s response: Expanded the paragraph to include additional barriers to maternal healthcare access, such as challenges faced by healthcare workers, patriarchal norms limiting women’s autonomy, cultural preferences for home births, and poor healthcare infrastructure . Action taken in the manuscript: The change can be seen in last paragraph under the "Implication of Research" section, with new references (71–79) added 13. Comment: In the ‘Implications for research’ section, please could you consider moving the 4th and 5th paragraphs (evidence limited to LMICs and limited study resources for searching for non-English records) to the ‘Strengths and limitations of the study’ section – they read more like strengths and limitations rather than implications. Author’s response: Thank you for your valuable comment. We have moved the 4th and 5th paragraphs from the "Implications for Research" section to the "Strengths and Limitations of the Study" section for better alignment . Action taken in the manuscript: The change can be seen in the "Strengths and Limitations" section 14. Comment: In ‘Neonatal outcomes – 2. Perinatal and neonatal deaths’ – ‘the data has not been adequate to conduct any analysis’ would read better as ‘the data was not adequate to conduct any analysis’. You also mix present and past tense in the Discussion: Second paragraph – ‘there is no separate data on the same’ should read ‘there was no separate data on the same’, and ‘there is no adequate evidence to show the impact of incentives...’ should read ‘there was no adequate evidence to show the impact of incentives......’. Author’s response: Revised the text to ensure consistent past tense usage: "No separate data was available, and there was no adequate evidence to show the impact of incentives on maternal and neonatal outcomes.". Action taken in the manuscript: The change can be seen in second paragraph of the “Discussion” section. Point to point response to the reviewer’s comments: 1. Comment: Please could you move the detail of the SDG (MMR less than 70 per 100,000 live births) to earlier on in the first paragraph in the Introduction? At the moment, the reader has to wait till the sentence about Liberia to find out what the detail is. Author’s response: Thank you for your suggestion. We have moved the SDG detail (MMR less than 70 per 100,000 live births) to the first paragraph of the Introduction for better clarity and immediate context. We rephrased the original paragraph to "The Million Death Study (2015) found that neonatal mortality in India was particularly high in rural areas, largely attributed to premature births and low birth weights (6). In view of the current trends, it will be difficult for India to achieve the NMR targets for SDG-2030 and National Health Policy 2025 (7). A gap analysis indicated that Liberia would take an additional 12.5 years beyond 2030 to meet the SDG target for MMR, with a similar 12.9-year delay projected for NMR (8)."to maintain readability. Action taken in the manuscript: The change can be seen in the “Introduction” section, where the SDG goal is now introduced earlier in the first paragraph of the Introduction. The rephrased sentences can be found in the last two paragraphs of introduction section 2. Comment: I think this section would benefit too from a sentence or two on the overall issue with LMICs – you start off with describing South Africa and Asia in the second sentence. Could you add a bit to the first sentence along the lines of ‘.....countries and regions, particularly between higher and LMICs’ – or something similar. Author’s response: Note your suggestion. We have added a phrase to the first sentence of the Introduction to emphasize disparities between higher-income countries (HICs) and low-and-middle-income countries (LMICs). Action taken in the manuscript: The change can be seen in the “Introduction” section, where the first sentence of the introduction section now highlights disparities between HICs and LMICs. 3. Comment: I was also confused by the last sentence in the first paragraph: ‘The model also forecasts that 13 countries would achieve the target between 2030 to 2050; while the remaining 13 countries are likely to succeed after 2050’. In the previous sentence you stated that the study looks at data from 31 countries, the 2 comments about 13 countries would suggest that the study you cite looks at 26 countries. Please could you clarify why the 2 amounts in your last sentence don’t add up to 31? Author’s response: We have added a clarification that mortality projections were unavailable for three countries due to data quality limitations to ensure the total sums up to 31. Action taken in the manuscript: The change can be seen in introduction section, last line of the fourth paragraph 4. Comment: In the Introduction you focus on maternal and neonatal mortality rates. It is not immediately obvious to me why you have chosen these outcomes to discuss. Please consider adding a short explanation of why you chose these specific outcomes, you might say that they are key outcomes that are linked to other important maternal/neonatal outcomes, or that they are proxies for other outcomes Author’s response: Thank you for your valuable comment. We have added an explanation stating that maternal and neonatal mortality rates are key indicators of healthcare system effectiveness, reflecting both direct health outcomes and broader factors such as healthcare accessibility, service quality, and social health determinants. These statistics also serve as indicators of pregnancy-related complications, perinatal health risks, and the efficacy of healthcare interventions Action taken in the manuscript: The change can be seen in second paragraph of the Introduction, where this explanation has been added. New references 2 and 3 has been added. 5. Comment: For example, in the second paragraph of the ‘Rationale: Why is this important?’ section in the Introduction, in the first sentence, you introduce some relevant outcomes such as pregnancy and childbirth-related complications. Maybe introduce some of these in the first paragraph of the Introduction?. Author’s response: Added a sentence introducing pregnancy-related complications, including miscarriage, preterm labour, stillbirth, and maternal or neonatal morbidity and mortality, emphasizing that these complications can occur at any stage of pregnancy, during labour, or postpartum Action taken in the manuscript: The change can be seen in the “Introduction” section, and a new reference (4) has been added 6. Comment: The ‘What is already known’ section could benefit from a short introduction paragraph. At the moment, it starts with smoking cessation incentives. It would be good to set the scene with something along the lines of how incentives could benefit this area (in terms of reducing smoking and improving engagement with antenatal care, for example) and improve maternal and child outcomes. This would help orient the reader to what to expect in this section before it starts with more specific details. Author’s response: Added an introductory paragraph explaining that incentive-based interventions, including conditional cash transfers (CCTs) and vouchers, have been implemented globally with some success in maternal and neonatal health programs. These initiatives aim to overcome healthcare access barriers, improve maternal health practices, and enhance birth outcomes . Action taken in the manuscript: The change can be seen in the first paragraph under the "What is already known" section, and new references (11–21) have been added 7. Comment: In the research questions section please could you write out in full what ‘IFA’ and ‘Inj TT’ refer to in 1b. Author’s response: Expanded the abbreviations to Iron and Folic Acid (IFA) tablets intake and Tetanus Toxoid injection (Inj TT) for clarity Action taken in the manuscript: The change can be seen in 1b in “Our Research Questions” Section 8. Comment: I was unable to see the search strategy in the repository – only PRISMA checklists and flowchart. Author’s response: The search strategy was shared via Figshare and is available under the Data Availability section Action taken in the manuscript: No changes were made 9. Comment: In Outcomes – please could you clarify your definition of preterm delivery – i.e. born alive before 37 weeks, also for perinatal and neonatal deaths, and maternal deaths Author’s response: Thank you for the suggestion. We have incorporated the clear definitions for preterm delivery, low birthweight, perinatal deaths, and neonatal deaths Action taken in the manuscript: The change can be seen in first few lines under the Outcomes section, with new references (36–39) added 10. Comment: Fourth paragraph in the Discussion section – the last 2 sentences are very similar – could this be a duplication. Author’s response: Identified and removed duplicate sentences in the fourth paragraph of the Discussion section Action taken in the manuscript: The change can be seen in the “Discussion” section, where the duplicated content has been deleted 11. Comment: Would it be possible to highlight that previously there were a small number of studies and with small sample sizes – and this study has not found a large number of studies – but most studies were RCTs – so assumably suitably powered? It would be good to have that additional information. Author’s response: Added a clarification that previous reviews had a limited number of studies with small sample sizes, reducing their reliability. Our review also did not find a significantly larger number of studies; however, most were RCTs, which are generally well-powered to detect meaningful effects, strengthening the evidence base Action taken in the manuscript: The change can be seen in last paragraph of the “Discussion” section 12. Comment: Would it be possible to add another sentence or two to this paragraph if there is more evidence available similar to the violence you discussed in the second sentence? Author’s response: Expanded the paragraph to include additional barriers to maternal healthcare access, such as challenges faced by healthcare workers, patriarchal norms limiting women’s autonomy, cultural preferences for home births, and poor healthcare infrastructure . Action taken in the manuscript: The change can be seen in last paragraph under the "Implication of Research" section, with new references (71–79) added 13. Comment: In the ‘Implications for research’ section, please could you consider moving the 4th and 5th paragraphs (evidence limited to LMICs and limited study resources for searching for non-English records) to the ‘Strengths and limitations of the study’ section – they read more like strengths and limitations rather than implications. Author’s response: Thank you for your valuable comment. We have moved the 4th and 5th paragraphs from the "Implications for Research" section to the "Strengths and Limitations of the Study" section for better alignment . Action taken in the manuscript: The change can be seen in the "Strengths and Limitations" section 14. Comment: In ‘Neonatal outcomes – 2. Perinatal and neonatal deaths’ – ‘the data has not been adequate to conduct any analysis’ would read better as ‘the data was not adequate to conduct any analysis’. You also mix present and past tense in the Discussion: Second paragraph – ‘there is no separate data on the same’ should read ‘there was no separate data on the same’, and ‘there is no adequate evidence to show the impact of incentives...’ should read ‘there was no adequate evidence to show the impact of incentives......’. Author’s response: Revised the text to ensure consistent past tense usage: "No separate data was available, and there was no adequate evidence to show the impact of incentives on maternal and neonatal outcomes.". Action taken in the manuscript: The change can be seen in second paragraph of the “Discussion” section. Competing Interests: No competing interests were disclosed. Close Report a concern Respond or Comment COMMENTS ON THIS REPORT Author Response 19 Mar 2025 Ramesh Holla , Kasturba Medical College Mangalore, Manipal Academy of Higher Education, Manipal, 576104, India 19 Mar 2025 Author Response Point to point response to the reviewer’s comments: 1. Comment: Please could you move the detail of the SDG (MMR less than 70 per 100,000 live births) to earlier ... Continue reading Point to point response to the reviewer’s comments: 1. Comment: Please could you move the detail of the SDG (MMR less than 70 per 100,000 live births) to earlier on in the first paragraph in the Introduction? At the moment, the reader has to wait till the sentence about Liberia to find out what the detail is. Author’s response: Thank you for your suggestion. We have moved the SDG detail (MMR less than 70 per 100,000 live births) to the first paragraph of the Introduction for better clarity and immediate context. We rephrased the original paragraph to "The Million Death Study (2015) found that neonatal mortality in India was particularly high in rural areas, largely attributed to premature births and low birth weights (6). In view of the current trends, it will be difficult for India to achieve the NMR targets for SDG-2030 and National Health Policy 2025 (7). A gap analysis indicated that Liberia would take an additional 12.5 years beyond 2030 to meet the SDG target for MMR, with a similar 12.9-year delay projected for NMR (8)."to maintain readability. Action taken in the manuscript: The change can be seen in the “Introduction” section, where the SDG goal is now introduced earlier in the first paragraph of the Introduction. The rephrased sentences can be found in the last two paragraphs of introduction section 2. Comment: I think this section would benefit too from a sentence or two on the overall issue with LMICs – you start off with describing South Africa and Asia in the second sentence. Could you add a bit to the first sentence along the lines of ‘.....countries and regions, particularly between higher and LMICs’ – or something similar. Author’s response: Note your suggestion. We have added a phrase to the first sentence of the Introduction to emphasize disparities between higher-income countries (HICs) and low-and-middle-income countries (LMICs). Action taken in the manuscript: The change can be seen in the “Introduction” section, where the first sentence of the introduction section now highlights disparities between HICs and LMICs. 3. Comment: I was also confused by the last sentence in the first paragraph: ‘The model also forecasts that 13 countries would achieve the target between 2030 to 2050; while the remaining 13 countries are likely to succeed after 2050’. In the previous sentence you stated that the study looks at data from 31 countries, the 2 comments about 13 countries would suggest that the study you cite looks at 26 countries. Please could you clarify why the 2 amounts in your last sentence don’t add up to 31? Author’s response: We have added a clarification that mortality projections were unavailable for three countries due to data quality limitations to ensure the total sums up to 31. Action taken in the manuscript: The change can be seen in introduction section, last line of the fourth paragraph 4. Comment: In the Introduction you focus on maternal and neonatal mortality rates. It is not immediately obvious to me why you have chosen these outcomes to discuss. Please consider adding a short explanation of why you chose these specific outcomes, you might say that they are key outcomes that are linked to other important maternal/neonatal outcomes, or that they are proxies for other outcomes Author’s response: Thank you for your valuable comment. We have added an explanation stating that maternal and neonatal mortality rates are key indicators of healthcare system effectiveness, reflecting both direct health outcomes and broader factors such as healthcare accessibility, service quality, and social health determinants. These statistics also serve as indicators of pregnancy-related complications, perinatal health risks, and the efficacy of healthcare interventions Action taken in the manuscript: The change can be seen in second paragraph of the Introduction, where this explanation has been added. New references 2 and 3 has been added. 5. Comment: For example, in the second paragraph of the ‘Rationale: Why is this important?’ section in the Introduction, in the first sentence, you introduce some relevant outcomes such as pregnancy and childbirth-related complications. Maybe introduce some of these in the first paragraph of the Introduction?. Author’s response: Added a sentence introducing pregnancy-related complications, including miscarriage, preterm labour, stillbirth, and maternal or neonatal morbidity and mortality, emphasizing that these complications can occur at any stage of pregnancy, during labour, or postpartum Action taken in the manuscript: The change can be seen in the “Introduction” section, and a new reference (4) has been added 6. Comment: The ‘What is already known’ section could benefit from a short introduction paragraph. At the moment, it starts with smoking cessation incentives. It would be good to set the scene with something along the lines of how incentives could benefit this area (in terms of reducing smoking and improving engagement with antenatal care, for example) and improve maternal and child outcomes. This would help orient the reader to what to expect in this section before it starts with more specific details. Author’s response: Added an introductory paragraph explaining that incentive-based interventions, including conditional cash transfers (CCTs) and vouchers, have been implemented globally with some success in maternal and neonatal health programs. These initiatives aim to overcome healthcare access barriers, improve maternal health practices, and enhance birth outcomes . Action taken in the manuscript: The change can be seen in the first paragraph under the "What is already known" section, and new references (11–21) have been added 7. Comment: In the research questions section please could you write out in full what ‘IFA’ and ‘Inj TT’ refer to in 1b. Author’s response: Expanded the abbreviations to Iron and Folic Acid (IFA) tablets intake and Tetanus Toxoid injection (Inj TT) for clarity Action taken in the manuscript: The change can be seen in 1b in “Our Research Questions” Section 8. Comment: I was unable to see the search strategy in the repository – only PRISMA checklists and flowchart. Author’s response: The search strategy was shared via Figshare and is available under the Data Availability section Action taken in the manuscript: No changes were made 9. Comment: In Outcomes – please could you clarify your definition of preterm delivery – i.e. born alive before 37 weeks, also for perinatal and neonatal deaths, and maternal deaths Author’s response: Thank you for the suggestion. We have incorporated the clear definitions for preterm delivery, low birthweight, perinatal deaths, and neonatal deaths Action taken in the manuscript: The change can be seen in first few lines under the Outcomes section, with new references (36–39) added 10. Comment: Fourth paragraph in the Discussion section – the last 2 sentences are very similar – could this be a duplication. Author’s response: Identified and removed duplicate sentences in the fourth paragraph of the Discussion section Action taken in the manuscript: The change can be seen in the “Discussion” section, where the duplicated content has been deleted 11. Comment: Would it be possible to highlight that previously there were a small number of studies and with small sample sizes – and this study has not found a large number of studies – but most studies were RCTs – so assumably suitably powered? It would be good to have that additional information. Author’s response: Added a clarification that previous reviews had a limited number of studies with small sample sizes, reducing their reliability. Our review also did not find a significantly larger number of studies; however, most were RCTs, which are generally well-powered to detect meaningful effects, strengthening the evidence base Action taken in the manuscript: The change can be seen in last paragraph of the “Discussion” section 12. Comment: Would it be possible to add another sentence or two to this paragraph if there is more evidence available similar to the violence you discussed in the second sentence? Author’s response: Expanded the paragraph to include additional barriers to maternal healthcare access, such as challenges faced by healthcare workers, patriarchal norms limiting women’s autonomy, cultural preferences for home births, and poor healthcare infrastructure . Action taken in the manuscript: The change can be seen in last paragraph under the "Implication of Research" section, with new references (71–79) added 13. Comment: In the ‘Implications for research’ section, please could you consider moving the 4th and 5th paragraphs (evidence limited to LMICs and limited study resources for searching for non-English records) to the ‘Strengths and limitations of the study’ section – they read more like strengths and limitations rather than implications. Author’s response: Thank you for your valuable comment. We have moved the 4th and 5th paragraphs from the "Implications for Research" section to the "Strengths and Limitations of the Study" section for better alignment . Action taken in the manuscript: The change can be seen in the "Strengths and Limitations" section 14. Comment: In ‘Neonatal outcomes – 2. Perinatal and neonatal deaths’ – ‘the data has not been adequate to conduct any analysis’ would read better as ‘the data was not adequate to conduct any analysis’. You also mix present and past tense in the Discussion: Second paragraph – ‘there is no separate data on the same’ should read ‘there was no separate data on the same’, and ‘there is no adequate evidence to show the impact of incentives...’ should read ‘there was no adequate evidence to show the impact of incentives......’. Author’s response: Revised the text to ensure consistent past tense usage: "No separate data was available, and there was no adequate evidence to show the impact of incentives on maternal and neonatal outcomes.". Action taken in the manuscript: The change can be seen in second paragraph of the “Discussion” section. Point to point response to the reviewer’s comments: 1. Comment: Please could you move the detail of the SDG (MMR less than 70 per 100,000 live births) to earlier on in the first paragraph in the Introduction? At the moment, the reader has to wait till the sentence about Liberia to find out what the detail is. Author’s response: Thank you for your suggestion. We have moved the SDG detail (MMR less than 70 per 100,000 live births) to the first paragraph of the Introduction for better clarity and immediate context. We rephrased the original paragraph to "The Million Death Study (2015) found that neonatal mortality in India was particularly high in rural areas, largely attributed to premature births and low birth weights (6). In view of the current trends, it will be difficult for India to achieve the NMR targets for SDG-2030 and National Health Policy 2025 (7). A gap analysis indicated that Liberia would take an additional 12.5 years beyond 2030 to meet the SDG target for MMR, with a similar 12.9-year delay projected for NMR (8)."to maintain readability. Action taken in the manuscript: The change can be seen in the “Introduction” section, where the SDG goal is now introduced earlier in the first paragraph of the Introduction. The rephrased sentences can be found in the last two paragraphs of introduction section 2. Comment: I think this section would benefit too from a sentence or two on the overall issue with LMICs – you start off with describing South Africa and Asia in the second sentence. Could you add a bit to the first sentence along the lines of ‘.....countries and regions, particularly between higher and LMICs’ – or something similar. Author’s response: Note your suggestion. We have added a phrase to the first sentence of the Introduction to emphasize disparities between higher-income countries (HICs) and low-and-middle-income countries (LMICs). Action taken in the manuscript: The change can be seen in the “Introduction” section, where the first sentence of the introduction section now highlights disparities between HICs and LMICs. 3. Comment: I was also confused by the last sentence in the first paragraph: ‘The model also forecasts that 13 countries would achieve the target between 2030 to 2050; while the remaining 13 countries are likely to succeed after 2050’. In the previous sentence you stated that the study looks at data from 31 countries, the 2 comments about 13 countries would suggest that the study you cite looks at 26 countries. Please could you clarify why the 2 amounts in your last sentence don’t add up to 31? Author’s response: We have added a clarification that mortality projections were unavailable for three countries due to data quality limitations to ensure the total sums up to 31. Action taken in the manuscript: The change can be seen in introduction section, last line of the fourth paragraph 4. Comment: In the Introduction you focus on maternal and neonatal mortality rates. It is not immediately obvious to me why you have chosen these outcomes to discuss. Please consider adding a short explanation of why you chose these specific outcomes, you might say that they are key outcomes that are linked to other important maternal/neonatal outcomes, or that they are proxies for other outcomes Author’s response: Thank you for your valuable comment. We have added an explanation stating that maternal and neonatal mortality rates are key indicators of healthcare system effectiveness, reflecting both direct health outcomes and broader factors such as healthcare accessibility, service quality, and social health determinants. These statistics also serve as indicators of pregnancy-related complications, perinatal health risks, and the efficacy of healthcare interventions Action taken in the manuscript: The change can be seen in second paragraph of the Introduction, where this explanation has been added. New references 2 and 3 has been added. 5. Comment: For example, in the second paragraph of the ‘Rationale: Why is this important?’ section in the Introduction, in the first sentence, you introduce some relevant outcomes such as pregnancy and childbirth-related complications. Maybe introduce some of these in the first paragraph of the Introduction?. Author’s response: Added a sentence introducing pregnancy-related complications, including miscarriage, preterm labour, stillbirth, and maternal or neonatal morbidity and mortality, emphasizing that these complications can occur at any stage of pregnancy, during labour, or postpartum Action taken in the manuscript: The change can be seen in the “Introduction” section, and a new reference (4) has been added 6. Comment: The ‘What is already known’ section could benefit from a short introduction paragraph. At the moment, it starts with smoking cessation incentives. It would be good to set the scene with something along the lines of how incentives could benefit this area (in terms of reducing smoking and improving engagement with antenatal care, for example) and improve maternal and child outcomes. This would help orient the reader to what to expect in this section before it starts with more specific details. Author’s response: Added an introductory paragraph explaining that incentive-based interventions, including conditional cash transfers (CCTs) and vouchers, have been implemented globally with some success in maternal and neonatal health programs. These initiatives aim to overcome healthcare access barriers, improve maternal health practices, and enhance birth outcomes . Action taken in the manuscript: The change can be seen in the first paragraph under the "What is already known" section, and new references (11–21) have been added 7. Comment: In the research questions section please could you write out in full what ‘IFA’ and ‘Inj TT’ refer to in 1b. Author’s response: Expanded the abbreviations to Iron and Folic Acid (IFA) tablets intake and Tetanus Toxoid injection (Inj TT) for clarity Action taken in the manuscript: The change can be seen in 1b in “Our Research Questions” Section 8. Comment: I was unable to see the search strategy in the repository – only PRISMA checklists and flowchart. Author’s response: The search strategy was shared via Figshare and is available under the Data Availability section Action taken in the manuscript: No changes were made 9. Comment: In Outcomes – please could you clarify your definition of preterm delivery – i.e. born alive before 37 weeks, also for perinatal and neonatal deaths, and maternal deaths Author’s response: Thank you for the suggestion. We have incorporated the clear definitions for preterm delivery, low birthweight, perinatal deaths, and neonatal deaths Action taken in the manuscript: The change can be seen in first few lines under the Outcomes section, with new references (36–39) added 10. Comment: Fourth paragraph in the Discussion section – the last 2 sentences are very similar – could this be a duplication. Author’s response: Identified and removed duplicate sentences in the fourth paragraph of the Discussion section Action taken in the manuscript: The change can be seen in the “Discussion” section, where the duplicated content has been deleted 11. Comment: Would it be possible to highlight that previously there were a small number of studies and with small sample sizes – and this study has not found a large number of studies – but most studies were RCTs – so assumably suitably powered? It would be good to have that additional information. Author’s response: Added a clarification that previous reviews had a limited number of studies with small sample sizes, reducing their reliability. Our review also did not find a significantly larger number of studies; however, most were RCTs, which are generally well-powered to detect meaningful effects, strengthening the evidence base Action taken in the manuscript: The change can be seen in last paragraph of the “Discussion” section 12. Comment: Would it be possible to add another sentence or two to this paragraph if there is more evidence available similar to the violence you discussed in the second sentence? Author’s response: Expanded the paragraph to include additional barriers to maternal healthcare access, such as challenges faced by healthcare workers, patriarchal norms limiting women’s autonomy, cultural preferences for home births, and poor healthcare infrastructure . Action taken in the manuscript: The change can be seen in last paragraph under the "Implication of Research" section, with new references (71–79) added 13. Comment: In the ‘Implications for research’ section, please could you consider moving the 4th and 5th paragraphs (evidence limited to LMICs and limited study resources for searching for non-English records) to the ‘Strengths and limitations of the study’ section – they read more like strengths and limitations rather than implications. Author’s response: Thank you for your valuable comment. We have moved the 4th and 5th paragraphs from the "Implications for Research" section to the "Strengths and Limitations of the Study" section for better alignment . Action taken in the manuscript: The change can be seen in the "Strengths and Limitations" section 14. Comment: In ‘Neonatal outcomes – 2. Perinatal and neonatal deaths’ – ‘the data has not been adequate to conduct any analysis’ would read better as ‘the data was not adequate to conduct any analysis’. You also mix present and past tense in the Discussion: Second paragraph – ‘there is no separate data on the same’ should read ‘there was no separate data on the same’, and ‘there is no adequate evidence to show the impact of incentives...’ should read ‘there was no adequate evidence to show the impact of incentives......’. Author’s response: Revised the text to ensure consistent past tense usage: "No separate data was available, and there was no adequate evidence to show the impact of incentives on maternal and neonatal outcomes.". Action taken in the manuscript: The change can be seen in second paragraph of the “Discussion” section. Competing Interests: No competing interests were disclosed. Close Report a concern COMMENT ON THIS REPORT Comments on this article Comments (0) Version 2 VERSION 2 PUBLISHED 09 Dec 2024 ADD YOUR COMMENT Comment keyboard_arrow_left keyboard_arrow_right Open Peer Review Reviewer Status info_outline Alongside their report, reviewers assign a status to the article: Approved The paper is scientifically sound in its current form and only minor, if any, improvements are suggested Approved with reservations A number of small changes, sometimes more significant revisions are required to address specific details and improve the papers academic merit. Not approved Fundamental flaws in the paper seriously undermine the findings and conclusions Reviewer Reports Invited Reviewers 1 2 3 Version 2 (revision) 29 May 25 read read Version 1 09 Dec 24 read Nicola McMeekin , University of Glasgow, Glasgow, UK Mohammed Shoyaib Khazi , All India Institute of Medical Sciences, Mangalagiri, India Rohith Motappa , ESIC Medical College & PGIMSR and Model Hospital, Bangalore, India Comments on this article All Comments (0) Add a comment Sign up for content alerts Sign Up You are now signed up to receive this alert Browse by related subjects keyboard_arrow_left Back to all reports Reviewer Report 0 Views copyright © 2025 Motappa R. This is an open access peer review report distributed under the terms of the Creative Commons Attribution License , which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. 09 Oct 2025 | for Version 2 Rohith Motappa , ESIC Medical College & PGIMSR and Model Hospital, Bangalore, Karnataka, India 0 Views copyright © 2025 Motappa R. This is an open access peer review report distributed under the terms of the Creative Commons Attribution License , which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. format_quote Cite this report speaker_notes Responses (0) Approved info_outline Alongside their report, reviewers assign a status to the article: Approved The paper is scientifically sound in its current form and only minor, if any, improvements are suggested Approved with reservations A number of small changes, sometimes more significant revisions are required to address specific details and improve the papers academic merit. Not approved Fundamental flaws in the paper seriously undermine the findings and conclusions Introduction: The author can explain a little more on the SDG goals related to the article a little more making the topic highly relevant. Not only this makes the article relevant but also helps in catching the attention of the readers. Few places abbreviations are present in the document without proper expansion. Please make sure that all the abbreviated forms are expanded when it is being used for the first time in the document. The end of the introduction section has mentioned about few less known countries. Either the article can mention about the continent where it is falling in or socio-economic strata they fall into (Underdeveloped/developing). Objectives again contain the abbreviations related to the common medications that are being given. Please expand it so that it is readable as they are objectives. Methodology: Whether all the articles have been included for the study or the only ones in English language has been considered for the study. Please explicitly mention the same. Search strategy abbreviations have to be expanded. Results: The section can undergo a thorough grammar check and modify the sentences where singular has been used in place of plural and vice versa. The reason for exclusion of the studies have to be clearly mentioned in the result section of the document. The subheadings under the maternal outcomes have quoted the relevant statistics extracted from the individual studies but due referencing is not given. Please make sure the citations are done for the individual studies in the result section. Grammar check need to be done In risk of bias, where the sentences can be paraphrased, for ex: We made no assessment of bias for 5 studies as they did not report relevant data or outcomes for this review, can be made as Assessment of risk of bias was not conducted for 5 studies as the studies did not report relevant outcomes. Discussion has been well written where this systematic review has been compared with the other studies of the past and also underlined the importance of the Systematic review. Wherever the results are repeatedly being told, the statistics can be minimized. If the author feel that there is necessity to highlight the statistics again, then can be kept. The limitation that only published articles were considered need to be mentioned as one of the limitations of the study. Please check the reference list for the referencing style. Are the rationale for, and objectives of, the Systematic Review clearly stated? Yes Are sufficient details of the methods and analysis provided to allow replication by others? Partly Is the statistical analysis and its interpretation appropriate? Yes Are the conclusions drawn adequately supported by the results presented in the review? Partly If this is a Living Systematic Review, is the ‘living’ method appropriate and is the search schedule clearly defined and justified? (‘Living Systematic Review’ or a variation of this term should be included in the title.) Not applicable Competing Interests No competing interests were disclosed. Reviewer Expertise NCDs, TB and Geriatrics. I confirm that I have read this submission and believe that I have an appropriate level of expertise to confirm that it is of an acceptable scientific standard. reply Respond to this report Responses (0) Motappa R. Peer Review Report For: Incentives for pregnant mothers during antenatal care for better maternal and neonatal health outcomes in low and middle income countries: A Systematic Review and Meta-Analysis [version 2; peer review: 2 approved, 1 approved with reservations] . F1000Research 2025, 13 :1512 ( https://doi.org/10.5256/f1000research.179546.r418444) NOTE: it is important to ensure the information in square brackets after the title is included in this citation. The direct URL for this report is: https://f1000research.com/articles/13-1512/v2#referee-response-418444 keyboard_arrow_left Back to all reports Reviewer Report 0 Views copyright © 2025 Khazi M. This is an open access peer review report distributed under the terms of the Creative Commons Attribution License , which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. 07 Oct 2025 | for Version 2 Mohammed Shoyaib Khazi , All India Institute of Medical Sciences, Mangalagiri, Andhra Pradesh, India 0 Views copyright © 2025 Khazi M. This is an open access peer review report distributed under the terms of the Creative Commons Attribution License , which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. format_quote Cite this report speaker_notes Responses (0) Approved info_outline Alongside their report, reviewers assign a status to the article: Approved The paper is scientifically sound in its current form and only minor, if any, improvements are suggested Approved with reservations A number of small changes, sometimes more significant revisions are required to address specific details and improve the papers academic merit. Not approved Fundamental flaws in the paper seriously undermine the findings and conclusions While PRISMA is mentioned, several required elements are missing. The PRISMA flow diagram is inadequately labeled (Figure 1 should clearly show the number excluded at each stage and reasons). Please add total number of studies at each stage. The meta-analysis includes only 2–4 studies per outcome , which undermines the robustness of pooled estimates; kindly provide the reason for the same or mention this as limitation. The conclusion that “incentives showed no significant benefit” should be contextualized, could this be due to short intervention duration, low incentive value, or weak health system readiness? The manuscript contains several grammatical errors and inconsistencies in referencing style. The paragraph content can clearly mention the important results. Minor Comments 1. Abbreviations (e.g., ANC, IFA, TT) should be defined at first mention in both abstract and text. 2. Reference numbering and formatting need standardization per journal guidelines. 3. Figures should have complete captions including data sources. 4. Some references (e.g., SDG targets) are outdated; update to the latest WHO/UN data. 5. The results for neonatal outcomes such as low birth weight and perinatal mortality are mentioned in objectives but not presented, clarify if data were unavailable or excluded. Are the rationale for, and objectives of, the Systematic Review clearly stated? Yes Are sufficient details of the methods and analysis provided to allow replication by others? Yes Is the statistical analysis and its interpretation appropriate? Yes Are the conclusions drawn adequately supported by the results presented in the review? Yes If this is a Living Systematic Review, is the ‘living’ method appropriate and is the search schedule clearly defined and justified? (‘Living Systematic Review’ or a variation of this term should be included in the title.) Yes Competing Interests No competing interests were disclosed. Reviewer Expertise Community Medicine, Public Health, Demographic Health Surveys I confirm that I have read this submission and believe that I have an appropriate level of expertise to confirm that it is of an acceptable scientific standard. reply Respond to this report Responses (0) Khazi MS. Peer Review Report For: Incentives for pregnant mothers during antenatal care for better maternal and neonatal health outcomes in low and middle income countries: A Systematic Review and Meta-Analysis [version 2; peer review: 2 approved, 1 approved with reservations] . F1000Research 2025, 13 :1512 ( https://doi.org/10.5256/f1000research.179546.r418442) NOTE: it is important to ensure the information in square brackets after the title is included in this citation. The direct URL for this report is: https://f1000research.com/articles/13-1512/v2#referee-response-418442 keyboard_arrow_left Back to all reports Reviewer Report 0 Views copyright © 2025 McMeekin N. This is an open access peer review report distributed under the terms of the Creative Commons Attribution License , which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. 24 Feb 2025 | for Version 1 Nicola McMeekin , Glasgow Institute of Health & Wellbeing, University of Glasgow, Glasgow, Scotland, UK 0 Views copyright © 2025 McMeekin N. This is an open access peer review report distributed under the terms of the Creative Commons Attribution License , which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. format_quote Cite this report speaker_notes Responses (1) Approved With Reservations info_outline Alongside their report, reviewers assign a status to the article: Approved The paper is scientifically sound in its current form and only minor, if any, improvements are suggested Approved with reservations A number of small changes, sometimes more significant revisions are required to address specific details and improve the papers academic merit. Not approved Fundamental flaws in the paper seriously undermine the findings and conclusions Thank you for the opportunity to review this interesting paper. It reports the findings of a systematic review that searched for papers evaluating the impact on maternal and neonatal outcomes of offering incentives to pregnant women in low and middle income countries. Overall this paper is very well written and interesting to read. My suggestions for edits are mainly for overall clarification not specific issues, to set the scene for the reader before you go into your well written sections. This is often the case when you know you subject well, but a few small clarifications and scene setting sentences would improve what is interesting and relevant research. Minor Introduction Please could you move the detail of the SDG (MMR less than 70 per 100000 live deaths) to earlier on in the first paragraph in the Introduction? At the moment the reader has to wait till the sentence about Liberia to find out what the detail is. I think this section would benefit too from a sentence or two on the overall issue with LMICs – you start off with describing South Africa and Asia in the second sentence. Could you add a bit to the first sentence along the lines of ‘…..countries and regions, particularly between higher and LMICs’ – or something similar. I was also confused by the last sentence in the first paragraph: ‘ The model also forecasts that 13 countries would achieve the target between 2030 to 2050; while the remaining 13 countries are likely to succeed after 2050’. In the previous sentence you stated that the study looks at data from 31 countries, the 2 comments about 13 countries would suggest that the study you cite looks at 26 countries. Please could you clarify why the 2 amounts in your last sentence don’t add up to 31? In the Introduction you focus on maternal and neonatal mortality rates. It is not immediately obvious to me why you have chosen these outcomes to discuss. Please consider adding a short explanation of why you chose these specific outcomes, you might say that they are key outcomes that are linked to other important maternal/neonatal outcomes, or that they are proxy’s for other outcomes? For example in the second paragraph of the ‘Rationale: Why is this important?’ section in the Introduction in the first sentence you introduce some relevant outcomes such as pregnancy and childbirth-related complications, maybe introduce some of these in the first paragraph of the Introduction? The ‘What is already known’ section could benefit from a short introduction paragraph. At the moment it starts with smoking cessation incentives, it would be good to set the scene with saying something along the lines of how incentives could benefit this area (in terms of reducing smoking and improving engagement with antenatal care for example) and improve maternal and child outcomes. This would help orientate the reader to what to expect in this section before it starts with more specific details. The last paragraph closes this section really nicely, starting with something similar as suggested would benefit it. In the research questions section please could you write out in full what ‘IFA’ and ‘Inj TT’ refer to in 1b? Methods The Methods section is clear and very well written, it included everything I would expect to see in a systematic review. I was unable to see the search strategy in the repository – only PRISMA checklists and flowchart. Please could you check that the strategy is included – I just many not be able to see it - this is why I answered 'partly' to the question - Are sufficient details of the methods and analysis provided to allow replication by others? In Outcomes – please could you clarify your definition of preterm delivery – i.e. born alive before 37 weeks, also for perinatal and neonatal deaths, and maternal deaths. Discussion Fourth paragraph in the Discussion section – the last 2 sentences are very similar – could this be a duplication? Would it be possible to highlight that previously there were a small number of studies and with small sample sizes – and this study has not found a large number of studies – but most studies were RCTs – so assumably suitably powered? It would be good to have that additional information. I really liked your last paragraph in the Discussion section about poverty not being the sole barrier for pregnant women to access healthcare services. Would it be possible to add another sentence or two to this paragraph if there is more evidence available similar to the violence you discussed in the second sentence? In the ‘Implications for research’ section please could you consider moving the 4 th and 5 th paragraphs (evidence limited to LMIC and limited study resources for searching for non-English records) to the ‘Strengths and limitations of the study’ section – they read more like strengths and limitations rather than implications. Typos/grammar I only found a few typos/grammatical errors and mainly in the Results section: In ‘Neonatal outcomes – 2. Perinat and neonatal deaths’ – ‘the data has not been adequate to conduct any analysis’ would read better as ‘the data was not adequate to conduct any analysis’ You also mix present and past tense in the Discussion: Second paragraph – ‘there is no separate data on the same’ should read ‘there was no separate data on the same’, and ‘there is no adequate evidence to show the impact of incentives…’ should read ‘there was no adequate evidence to show the impact of incentives……’ Are the rationale for, and objectives of, the Systematic Review clearly stated? Yes Are sufficient details of the methods and analysis provided to allow replication by others? Partly Is the statistical analysis and its interpretation appropriate? Yes Are the conclusions drawn adequately supported by the results presented in the review? Yes If this is a Living Systematic Review, is the ‘living’ method appropriate and is the search schedule clearly defined and justified? (‘Living Systematic Review’ or a variation of this term should be included in the title.) Not applicable Competing Interests No competing interests were disclosed. Reviewer Expertise Health economics I confirm that I have read this submission and believe that I have an appropriate level of expertise to confirm that it is of an acceptable scientific standard, however I have significant reservations, as outlined above. reply Respond to this report Responses (1) Author Response 19 Mar 2025 Ramesh Holla, Kasturba Medical College Mangalore, Manipal Academy of Higher Education, Manipal, 576104, India Point to point response to the reviewer’s comments: 1. Comment: Please could you move the detail of the SDG (MMR less than 70 per 100,000 live births) to earlier on in the first paragraph in the Introduction? At the moment, the reader has to wait till the sentence about Liberia to find out what the detail is. Author’s response: Thank you for your suggestion. We have moved the SDG detail (MMR less than 70 per 100,000 live births) to the first paragraph of the Introduction for better clarity and immediate context. We rephrased the original paragraph to "The Million Death Study (2015) found that neonatal mortality in India was particularly high in rural areas, largely attributed to premature births and low birth weights (6). In view of the current trends, it will be difficult for India to achieve the NMR targets for SDG-2030 and National Health Policy 2025 (7). A gap analysis indicated that Liberia would take an additional 12.5 years beyond 2030 to meet the SDG target for MMR, with a similar 12.9-year delay projected for NMR (8)."to maintain readability. Action taken in the manuscript: The change can be seen in the “Introduction” section, where the SDG goal is now introduced earlier in the first paragraph of the Introduction. The rephrased sentences can be found in the last two paragraphs of introduction section 2. Comment: I think this section would benefit too from a sentence or two on the overall issue with LMICs – you start off with describing South Africa and Asia in the second sentence. Could you add a bit to the first sentence along the lines of ‘.....countries and regions, particularly between higher and LMICs’ – or something similar. Author’s response: Note your suggestion. We have added a phrase to the first sentence of the Introduction to emphasize disparities between higher-income countries (HICs) and low-and-middle-income countries (LMICs). Action taken in the manuscript: The change can be seen in the “Introduction” section, where the first sentence of the introduction section now highlights disparities between HICs and LMICs. 3. Comment: I was also confused by the last sentence in the first paragraph: ‘The model also forecasts that 13 countries would achieve the target between 2030 to 2050; while the remaining 13 countries are likely to succeed after 2050’. In the previous sentence you stated that the study looks at data from 31 countries, the 2 comments about 13 countries would suggest that the study you cite looks at 26 countries. Please could you clarify why the 2 amounts in your last sentence don’t add up to 31? Author’s response: We have added a clarification that mortality projections were unavailable for three countries due to data quality limitations to ensure the total sums up to 31. Action taken in the manuscript: The change can be seen in introduction section, last line of the fourth paragraph 4. Comment: In the Introduction you focus on maternal and neonatal mortality rates. It is not immediately obvious to me why you have chosen these outcomes to discuss. Please consider adding a short explanation of why you chose these specific outcomes, you might say that they are key outcomes that are linked to other important maternal/neonatal outcomes, or that they are proxies for other outcomes Author’s response: Thank you for your valuable comment. We have added an explanation stating that maternal and neonatal mortality rates are key indicators of healthcare system effectiveness, reflecting both direct health outcomes and broader factors such as healthcare accessibility, service quality, and social health determinants. These statistics also serve as indicators of pregnancy-related complications, perinatal health risks, and the efficacy of healthcare interventions Action taken in the manuscript: The change can be seen in second paragraph of the Introduction, where this explanation has been added. New references 2 and 3 has been added. 5. Comment: For example, in the second paragraph of the ‘Rationale: Why is this important?’ section in the Introduction, in the first sentence, you introduce some relevant outcomes such as pregnancy and childbirth-related complications. Maybe introduce some of these in the first paragraph of the Introduction?. Author’s response: Added a sentence introducing pregnancy-related complications, including miscarriage, preterm labour, stillbirth, and maternal or neonatal morbidity and mortality, emphasizing that these complications can occur at any stage of pregnancy, during labour, or postpartum Action taken in the manuscript: The change can be seen in the “Introduction” section, and a new reference (4) has been added 6. Comment: The ‘What is already known’ section could benefit from a short introduction paragraph. At the moment, it starts with smoking cessation incentives. It would be good to set the scene with something along the lines of how incentives could benefit this area (in terms of reducing smoking and improving engagement with antenatal care, for example) and improve maternal and child outcomes. This would help orient the reader to what to expect in this section before it starts with more specific details. Author’s response: Added an introductory paragraph explaining that incentive-based interventions, including conditional cash transfers (CCTs) and vouchers, have been implemented globally with some success in maternal and neonatal health programs. These initiatives aim to overcome healthcare access barriers, improve maternal health practices, and enhance birth outcomes . Action taken in the manuscript: The change can be seen in the first paragraph under the "What is already known" section, and new references (11–21) have been added 7. Comment: In the research questions section please could you write out in full what ‘IFA’ and ‘Inj TT’ refer to in 1b. Author’s response: Expanded the abbreviations to Iron and Folic Acid (IFA) tablets intake and Tetanus Toxoid injection (Inj TT) for clarity Action taken in the manuscript: The change can be seen in 1b in “Our Research Questions” Section 8. Comment: I was unable to see the search strategy in the repository – only PRISMA checklists and flowchart. Author’s response: The search strategy was shared via Figshare and is available under the Data Availability section Action taken in the manuscript: No changes were made 9. Comment: In Outcomes – please could you clarify your definition of preterm delivery – i.e. born alive before 37 weeks, also for perinatal and neonatal deaths, and maternal deaths Author’s response: Thank you for the suggestion. We have incorporated the clear definitions for preterm delivery, low birthweight, perinatal deaths, and neonatal deaths Action taken in the manuscript: The change can be seen in first few lines under the Outcomes section, with new references (36–39) added 10. Comment: Fourth paragraph in the Discussion section – the last 2 sentences are very similar – could this be a duplication. Author’s response: Identified and removed duplicate sentences in the fourth paragraph of the Discussion section Action taken in the manuscript: The change can be seen in the “Discussion” section, where the duplicated content has been deleted 11. Comment: Would it be possible to highlight that previously there were a small number of studies and with small sample sizes – and this study has not found a large number of studies – but most studies were RCTs – so assumably suitably powered? It would be good to have that additional information. Author’s response: Added a clarification that previous reviews had a limited number of studies with small sample sizes, reducing their reliability. Our review also did not find a significantly larger number of studies; however, most were RCTs, which are generally well-powered to detect meaningful effects, strengthening the evidence base Action taken in the manuscript: The change can be seen in last paragraph of the “Discussion” section 12. Comment: Would it be possible to add another sentence or two to this paragraph if there is more evidence available similar to the violence you discussed in the second sentence? Author’s response: Expanded the paragraph to include additional barriers to maternal healthcare access, such as challenges faced by healthcare workers, patriarchal norms limiting women’s autonomy, cultural preferences for home births, and poor healthcare infrastructure . Action taken in the manuscript: The change can be seen in last paragraph under the "Implication of Research" section, with new references (71–79) added 13. Comment: In the ‘Implications for research’ section, please could you consider moving the 4th and 5th paragraphs (evidence limited to LMICs and limited study resources for searching for non-English records) to the ‘Strengths and limitations of the study’ section – they read more like strengths and limitations rather than implications. Author’s response: Thank you for your valuable comment. We have moved the 4th and 5th paragraphs from the "Implications for Research" section to the "Strengths and Limitations of the Study" section for better alignment . Action taken in the manuscript: The change can be seen in the "Strengths and Limitations" section 14. Comment: In ‘Neonatal outcomes – 2. Perinatal and neonatal deaths’ – ‘the data has not been adequate to conduct any analysis’ would read better as ‘the data was not adequate to conduct any analysis’. You also mix present and past tense in the Discussion: Second paragraph – ‘there is no separate data on the same’ should read ‘there was no separate data on the same’, and ‘there is no adequate evidence to show the impact of incentives...’ should read ‘there was no adequate evidence to show the impact of incentives......’. Author’s response: Revised the text to ensure consistent past tense usage: "No separate data was available, and there was no adequate evidence to show the impact of incentives on maternal and neonatal outcomes.". Action taken in the manuscript: The change can be seen in second paragraph of the “Discussion” section. View more View less Competing Interests No competing interests were disclosed. reply Respond Report a concern McMeekin N. 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