Changes of sICAM-1 and sHLA-I in endometriosis and its significance

AIM: To investigate the relationship between endometriosis (EMs) and the levels of soluble intercellular adhesion molecule-1 (sICAM-1) and soluble human leucocyte antigen-1 (sHLA-Ⅰ). METHODS: Thirty serum and 30 peritoneal fluid (PF) of patients with EMs (test group) and 30 serum and 30 peritoneal fluid of patients without EMs (control group) were studied. The levels of sICAM-1 and sHLA-Ⅰwere detected by enzyme-linked immunosorbent assay (ELISA). RESULTS: ① Significantly higher levels of sICAM-1 in serum and PF were observed in patients with EMs compared with those in controls (P0.05). ② The levels of sICAM-1 in serum and PF were significantly different and the levels in early-stage EMs group were higher than those in advanced group (P0.05). ③ Serum sHLA-Ⅰ cevel was lower in EMs group (P0.05) but the level in early-stage EMs group was higher than that in advanced group (P0.05). ④ There were no statistically significant differences in the levels of sHLA-Ⅰin PF between the patients and the controls (P0.05). CONCLUSION: Changes of sICAM-1and sHLA-Ⅰmay play a role in the genesis of endometriosis.